Putative mitochondrial oligo_U binding protein TBRGG1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mitochondrial oligo_U binding protein TBRGG1, putative

Species:

Leishmania braziliensis

UniProt:

A4HI33_LEIBR

TriTrypDb:

LbrM.30.0900 , LBRM2903_300014700

Length:

699

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HI33

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HI33

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009058	biosynthetic process	2	1
GO:0009059	macromolecule biosynthetic process	4	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0018130	heterocycle biosynthetic process	4	1
GO:0019438	aromatic compound biosynthetic process	4	1
GO:0032774	RNA biosynthetic process	5	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034654	nucleobase-containing compound biosynthetic process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044271	cellular nitrogen compound biosynthetic process	4	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1901362	organic cyclic compound biosynthetic process	4	1
GO:1901576	organic substance biosynthetic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0005488	binding	1	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	135	137	PF00675	0.671
CLV_NRD_NRD_1	149	151	PF00675	0.717
CLV_NRD_NRD_1	175	177	PF00675	0.663
CLV_NRD_NRD_1	213	215	PF00675	0.485
CLV_NRD_NRD_1	217	219	PF00675	0.522
CLV_NRD_NRD_1	95	97	PF00675	0.549
CLV_PCSK_KEX2_1	135	137	PF00082	0.671
CLV_PCSK_KEX2_1	149	151	PF00082	0.717
CLV_PCSK_KEX2_1	175	177	PF00082	0.672
CLV_PCSK_KEX2_1	213	215	PF00082	0.559
CLV_PCSK_KEX2_1	217	219	PF00082	0.513
CLV_PCSK_KEX2_1	42	44	PF00082	0.608
CLV_PCSK_KEX2_1	95	97	PF00082	0.549
CLV_PCSK_PC1ET2_1	42	44	PF00082	0.460
CLV_PCSK_PC7_1	213	219	PF00082	0.438
CLV_PCSK_PC7_1	38	44	PF00082	0.463
CLV_PCSK_SKI1_1	188	192	PF00082	0.463
CLV_PCSK_SKI1_1	197	201	PF00082	0.557
CLV_PCSK_SKI1_1	213	217	PF00082	0.493
CLV_PCSK_SKI1_1	48	52	PF00082	0.678
CLV_PCSK_SKI1_1	501	505	PF00082	0.525
CLV_PCSK_SKI1_1	57	61	PF00082	0.698
CLV_PCSK_SKI1_1	571	575	PF00082	0.418
CLV_PCSK_SKI1_1	622	626	PF00082	0.407
DEG_APCC_DBOX_1	212	220	PF00400	0.328
DEG_APCC_DBOX_1	621	629	PF00400	0.416
DEG_Nend_UBRbox_1	1	4	PF02207	0.448
DOC_MAPK_DCC_7	663	673	PF00069	0.316
DOC_MAPK_gen_1	213	221	PF00069	0.540
DOC_MAPK_HePTP_8	298	310	PF00069	0.279
DOC_MAPK_MEF2A_6	2	9	PF00069	0.433
DOC_MAPK_MEF2A_6	301	310	PF00069	0.496
DOC_MAPK_MEF2A_6	404	413	PF00069	0.366
DOC_PP4_FxxP_1	241	244	PF00568	0.554
DOC_PP4_FxxP_1	467	470	PF00568	0.412
DOC_SPAK_OSR1_1	205	209	PF12202	0.552
DOC_USP7_MATH_1	14	18	PF00917	0.399
DOC_USP7_MATH_1	174	178	PF00917	0.614
DOC_USP7_MATH_1	480	484	PF00917	0.543
DOC_USP7_MATH_1	509	513	PF00917	0.473
DOC_USP7_MATH_1	535	539	PF00917	0.562
DOC_USP7_MATH_1	551	555	PF00917	0.515
DOC_USP7_MATH_1	681	685	PF00917	0.596
DOC_USP7_UBL2_3	193	197	PF12436	0.476
DOC_WW_Pin1_4	262	267	PF00397	0.434
DOC_WW_Pin1_4	27	32	PF00397	0.441
DOC_WW_Pin1_4	596	601	PF00397	0.335
DOC_WW_Pin1_4	657	662	PF00397	0.531
DOC_WW_Pin1_4	666	671	PF00397	0.573
LIG_14-3-3_CanoR_1	2	6	PF00244	0.439
LIG_14-3-3_CanoR_1	317	326	PF00244	0.376
LIG_14-3-3_CanoR_1	436	442	PF00244	0.569
LIG_14-3-3_CanoR_1	501	506	PF00244	0.373
LIG_14-3-3_CanoR_1	515	521	PF00244	0.419
LIG_14-3-3_CanoR_1	545	551	PF00244	0.587
LIG_14-3-3_CanoR_1	57	62	PF00244	0.691
LIG_14-3-3_CanoR_1	622	631	PF00244	0.484
LIG_14-3-3_CanoR_1	641	649	PF00244	0.305
LIG_14-3-3_CanoR_1	663	672	PF00244	0.496
LIG_14-3-3_CterR_2	695	699	PF00244	0.490
LIG_Actin_WH2_2	202	219	PF00022	0.455
LIG_Actin_WH2_2	303	321	PF00022	0.272
LIG_Actin_WH2_2	601	616	PF00022	0.575
LIG_AP2alpha_1	672	676	PF02296	0.280
LIG_BRCT_BRCA1_1	19	23	PF00533	0.415
LIG_BRCT_BRCA1_1	575	579	PF00533	0.537
LIG_BRCT_BRCA1_1	668	672	PF00533	0.438
LIG_FHA_1	2	8	PF00498	0.432
LIG_FHA_1	238	244	PF00498	0.474
LIG_FHA_1	245	251	PF00498	0.520
LIG_FHA_1	445	451	PF00498	0.544
LIG_FHA_1	520	526	PF00498	0.561
LIG_FHA_2	223	229	PF00498	0.446
LIG_FHA_2	319	325	PF00498	0.447
LIG_FHA_2	457	463	PF00498	0.567
LIG_FHA_2	47	53	PF00498	0.446
LIG_FHA_2	579	585	PF00498	0.511
LIG_FHA_2	605	611	PF00498	0.550
LIG_HCF-1_HBM_1	101	104	PF13415	0.541
LIG_LIR_Apic_2	240	244	PF02991	0.551
LIG_LIR_Apic_2	465	470	PF02991	0.415
LIG_LIR_Gen_1	251	261	PF02991	0.555
LIG_LIR_Gen_1	3	14	PF02991	0.423
LIG_LIR_Gen_1	507	518	PF02991	0.441
LIG_LIR_Nem_3	20	26	PF02991	0.374
LIG_LIR_Nem_3	204	209	PF02991	0.461
LIG_LIR_Nem_3	251	257	PF02991	0.391
LIG_LIR_Nem_3	3	9	PF02991	0.428
LIG_LIR_Nem_3	504	508	PF02991	0.495
LIG_LIR_Nem_3	576	582	PF02991	0.440
LIG_MLH1_MIPbox_1	19	23	PF16413	0.415
LIG_NRBOX	8	14	PF00104	0.419
LIG_PCNA_PIPBox_1	327	336	PF02747	0.558
LIG_PCNA_yPIPBox_3	285	293	PF02747	0.499
LIG_PCNA_yPIPBox_3	403	412	PF02747	0.496
LIG_Pex14_1	67	71	PF04695	0.480
LIG_Pex14_2	672	676	PF04695	0.280
LIG_SH2_GRB2like	104	107	PF00017	0.762
LIG_SH2_GRB2like	111	114	PF00017	0.768
LIG_SH2_GRB2like	132	135	PF00017	0.783
LIG_SH2_NCK_1	479	483	PF00017	0.557
LIG_SH2_PTP2	6	9	PF00017	0.425
LIG_SH2_SRC	104	107	PF00017	0.680
LIG_SH2_SRC	111	114	PF00017	0.791
LIG_SH2_SRC	34	37	PF00017	0.463
LIG_SH2_SRC	479	482	PF00017	0.554
LIG_SH2_STAP1	575	579	PF00017	0.435
LIG_SH2_STAP1	71	75	PF00017	0.671
LIG_SH2_STAT3	181	184	PF00017	0.586
LIG_SH2_STAT5	181	184	PF00017	0.586
LIG_SH2_STAT5	24	27	PF00017	0.376
LIG_SH2_STAT5	34	37	PF00017	0.434
LIG_SH2_STAT5	6	9	PF00017	0.425
LIG_SH3_2	543	548	PF14604	0.630
LIG_SH3_3	275	281	PF00018	0.527
LIG_SH3_3	436	442	PF00018	0.567
LIG_SH3_3	538	544	PF00018	0.570
LIG_SUMO_SIM_anti_2	230	235	PF11976	0.459
LIG_SUMO_SIM_anti_2	307	313	PF11976	0.393
LIG_SUMO_SIM_anti_2	388	394	PF11976	0.410
LIG_SUMO_SIM_par_1	529	534	PF11976	0.421
LIG_TRAF2_1	490	493	PF00917	0.548
LIG_UBA3_1	189	197	PF00899	0.446
LIG_UBA3_1	457	463	PF00899	0.521
LIG_UBA3_1	516	524	PF00899	0.548
LIG_WRC_WIRS_1	502	507	PF05994	0.569
LIG_WW_3	542	546	PF00397	0.554
MOD_CDC14_SPxK_1	30	33	PF00782	0.455
MOD_CDC14_SPxK_1	660	663	PF00782	0.336
MOD_CDK_SPxK_1	27	33	PF00069	0.444
MOD_CDK_SPxK_1	657	663	PF00069	0.474
MOD_CK1_1	17	23	PF00069	0.411
MOD_CK1_1	259	265	PF00069	0.568
MOD_CK1_1	357	363	PF00069	0.631
MOD_CK1_1	440	446	PF00069	0.564
MOD_CK1_1	519	525	PF00069	0.552
MOD_CK1_1	666	672	PF00069	0.514
MOD_CK2_1	222	228	PF00069	0.464
MOD_CK2_1	318	324	PF00069	0.487
MOD_CK2_1	329	335	PF00069	0.513
MOD_CK2_1	456	462	PF00069	0.558
MOD_CK2_1	480	486	PF00069	0.579
MOD_CK2_1	578	584	PF00069	0.470
MOD_CK2_1	604	610	PF00069	0.530
MOD_CK2_1	681	687	PF00069	0.548
MOD_GlcNHglycan	261	264	PF01048	0.288
MOD_GlcNHglycan	464	467	PF01048	0.489
MOD_GlcNHglycan	471	474	PF01048	0.389
MOD_GlcNHglycan	488	491	PF01048	0.379
MOD_GlcNHglycan	526	529	PF01048	0.581
MOD_GlcNHglycan	91	94	PF01048	0.542
MOD_GSK3_1	1	8	PF00069	0.436
MOD_GSK3_1	13	20	PF00069	0.369
MOD_GSK3_1	344	351	PF00069	0.482
MOD_GSK3_1	440	447	PF00069	0.592
MOD_GSK3_1	452	459	PF00069	0.458
MOD_GSK3_1	491	498	PF00069	0.459
MOD_GSK3_1	531	538	PF00069	0.308
MOD_N-GLC_1	259	264	PF02516	0.296
MOD_N-GLC_1	535	540	PF02516	0.563
MOD_N-GLC_1	641	646	PF02516	0.494
MOD_NEK2_1	1	6	PF00069	0.444
MOD_NEK2_1	25	30	PF00069	0.431
MOD_NEK2_1	495	500	PF00069	0.465
MOD_NEK2_1	516	521	PF00069	0.533
MOD_NEK2_1	531	536	PF00069	0.297
MOD_NEK2_1	604	609	PF00069	0.455
MOD_NEK2_1	676	681	PF00069	0.552
MOD_PIKK_1	222	228	PF00454	0.464
MOD_PIKK_1	399	405	PF00454	0.549
MOD_PIKK_1	519	525	PF00454	0.553
MOD_PKA_2	1	7	PF00069	0.440
MOD_PKA_2	174	180	PF00069	0.641
MOD_PKA_2	318	324	PF00069	0.354
MOD_PKA_2	89	95	PF00069	0.531
MOD_Plk_1	17	23	PF00069	0.411
MOD_Plk_1	227	233	PF00069	0.430
MOD_Plk_1	535	541	PF00069	0.572
MOD_Plk_4	1	7	PF00069	0.440
MOD_Plk_4	348	354	PF00069	0.482
MOD_Plk_4	495	501	PF00069	0.420
MOD_Plk_4	649	655	PF00069	0.416
MOD_Plk_4	8	14	PF00069	0.399
MOD_ProDKin_1	262	268	PF00069	0.429
MOD_ProDKin_1	27	33	PF00069	0.444
MOD_ProDKin_1	596	602	PF00069	0.340
MOD_ProDKin_1	657	663	PF00069	0.529
MOD_ProDKin_1	666	672	PF00069	0.563
MOD_SUMO_for_1	192	195	PF00179	0.505
MOD_SUMO_for_1	245	248	PF00179	0.572
TRG_AP2beta_CARGO_1	204	213	PF09066	0.332
TRG_DiLeu_BaEn_1	211	216	PF01217	0.484
TRG_DiLeu_BaEn_1	388	393	PF01217	0.409
TRG_DiLeu_BaLyEn_6	36	41	PF01217	0.463
TRG_DiLeu_LyEn_5	211	216	PF01217	0.523
TRG_ENDOCYTIC_2	24	27	PF00928	0.376
TRG_ENDOCYTIC_2	6	9	PF00928	0.425
TRG_ER_diArg_1	174	176	PF00400	0.737
TRG_ER_diArg_1	213	215	PF00400	0.466
TRG_ER_diArg_1	216	218	PF00400	0.475
TRG_ER_diArg_1	317	320	PF00400	0.395
TRG_ER_diArg_1	433	436	PF00400	0.300
TRG_ER_diArg_1	81	84	PF00400	0.671
TRG_ER_diArg_1	94	96	PF00400	0.555
TRG_NES_CRM1_1	302	316	PF08389	0.446
TRG_Pf-PMV_PEXEL_1	606	610	PF00026	0.580

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I169	Leptomonas seymouri	43%	100%
A0A0S4JB89	Bodo saltans	25%	94%
A0A1X0P251	Trypanosomatidae	37%	100%
A0A3S7X349	Leishmania donovani	80%	100%
A0A422P4U2	Trypanosoma rangeli	36%	100%
A4I5A9	Leishmania infantum	80%	100%
C9ZQP3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	94%
E9B0K5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
Q4Q7M7	Leishmania major	78%	97%