LeishMANIAdb
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Importin subunit alpha

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Importin subunit alpha
Gene product:
hypothetical protein, conserved
Species:
Leishmania braziliensis
UniProt:
A4HI31_LEIBR
TriTrypDb:
LbrM.30.0880 , LBRM2903_300014500 *
Length:
1142

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4HI31
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HI31

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 1007 1011 PF00656 0.602
CLV_C14_Caspase3-7 204 208 PF00656 0.441
CLV_C14_Caspase3-7 581 585 PF00656 0.500
CLV_MEL_PAP_1 1037 1043 PF00089 0.720
CLV_NRD_NRD_1 1003 1005 PF00675 0.715
CLV_NRD_NRD_1 1043 1045 PF00675 0.725
CLV_NRD_NRD_1 1049 1051 PF00675 0.732
CLV_NRD_NRD_1 1106 1108 PF00675 0.782
CLV_NRD_NRD_1 1124 1126 PF00675 0.501
CLV_NRD_NRD_1 384 386 PF00675 0.482
CLV_NRD_NRD_1 428 430 PF00675 0.503
CLV_NRD_NRD_1 597 599 PF00675 0.360
CLV_NRD_NRD_1 878 880 PF00675 0.421
CLV_NRD_NRD_1 947 949 PF00675 0.798
CLV_NRD_NRD_1 974 976 PF00675 0.648
CLV_PCSK_KEX2_1 1003 1005 PF00082 0.715
CLV_PCSK_KEX2_1 1043 1045 PF00082 0.719
CLV_PCSK_KEX2_1 1048 1050 PF00082 0.739
CLV_PCSK_KEX2_1 1106 1108 PF00082 0.719
CLV_PCSK_KEX2_1 1124 1126 PF00082 0.499
CLV_PCSK_KEX2_1 384 386 PF00082 0.257
CLV_PCSK_KEX2_1 39 41 PF00082 0.356
CLV_PCSK_KEX2_1 428 430 PF00082 0.503
CLV_PCSK_KEX2_1 597 599 PF00082 0.360
CLV_PCSK_KEX2_1 641 643 PF00082 0.484
CLV_PCSK_KEX2_1 947 949 PF00082 0.675
CLV_PCSK_KEX2_1 973 975 PF00082 0.651
CLV_PCSK_PC1ET2_1 39 41 PF00082 0.335
CLV_PCSK_PC1ET2_1 641 643 PF00082 0.484
CLV_PCSK_PC7_1 1044 1050 PF00082 0.532
CLV_PCSK_PC7_1 1120 1126 PF00082 0.657
CLV_PCSK_PC7_1 969 975 PF00082 0.628
CLV_PCSK_SKI1_1 1058 1062 PF00082 0.743
CLV_PCSK_SKI1_1 139 143 PF00082 0.395
CLV_PCSK_SKI1_1 178 182 PF00082 0.462
CLV_PCSK_SKI1_1 209 213 PF00082 0.492
CLV_PCSK_SKI1_1 320 324 PF00082 0.448
CLV_PCSK_SKI1_1 669 673 PF00082 0.323
CLV_PCSK_SKI1_1 797 801 PF00082 0.335
CLV_PCSK_SKI1_1 828 832 PF00082 0.308
CLV_PCSK_SKI1_1 875 879 PF00082 0.434
CLV_Separin_Metazoa 337 341 PF03568 0.351
DEG_APCC_DBOX_1 138 146 PF00400 0.237
DEG_Nend_UBRbox_2 1 3 PF02207 0.354
DEG_SCF_FBW7_1 22 28 PF00400 0.368
DOC_CKS1_1 22 27 PF01111 0.371
DOC_CKS1_1 903 908 PF01111 0.741
DOC_CKS1_1 910 915 PF01111 0.756
DOC_CYCLIN_RxL_1 732 742 PF00134 0.332
DOC_CYCLIN_RxL_1 872 882 PF00134 0.411
DOC_CYCLIN_yCln2_LP_2 910 916 PF00134 0.668
DOC_MAPK_gen_1 641 648 PF00069 0.480
DOC_MAPK_gen_1 685 695 PF00069 0.444
DOC_MAPK_MEF2A_6 458 466 PF00069 0.354
DOC_MAPK_MEF2A_6 611 618 PF00069 0.316
DOC_MAPK_MEF2A_6 641 648 PF00069 0.489
DOC_MAPK_MEF2A_6 673 681 PF00069 0.457
DOC_MAPK_MEF2A_6 688 695 PF00069 0.490
DOC_PP1_RVXF_1 873 879 PF00149 0.402
DOC_PP4_FxxP_1 121 124 PF00568 0.375
DOC_USP7_MATH_1 790 794 PF00917 0.346
DOC_USP7_MATH_1 959 963 PF00917 0.521
DOC_USP7_UBL2_3 688 692 PF12436 0.505
DOC_WW_Pin1_4 21 26 PF00397 0.368
DOC_WW_Pin1_4 248 253 PF00397 0.437
DOC_WW_Pin1_4 472 477 PF00397 0.285
DOC_WW_Pin1_4 617 622 PF00397 0.385
DOC_WW_Pin1_4 687 692 PF00397 0.496
DOC_WW_Pin1_4 70 75 PF00397 0.366
DOC_WW_Pin1_4 881 886 PF00397 0.491
DOC_WW_Pin1_4 890 895 PF00397 0.540
DOC_WW_Pin1_4 9 14 PF00397 0.354
DOC_WW_Pin1_4 902 907 PF00397 0.533
DOC_WW_Pin1_4 909 914 PF00397 0.634
LIG_14-3-3_CanoR_1 197 202 PF00244 0.378
LIG_14-3-3_CanoR_1 611 617 PF00244 0.308
LIG_14-3-3_CanoR_1 65 74 PF00244 0.331
LIG_14-3-3_CanoR_1 685 691 PF00244 0.481
LIG_14-3-3_CanoR_1 784 791 PF00244 0.312
LIG_14-3-3_CanoR_1 879 887 PF00244 0.573
LIG_APCC_ABBA_1 115 120 PF00400 0.328
LIG_BIR_III_2 760 764 PF00653 0.474
LIG_BIR_III_4 207 211 PF00653 0.479
LIG_BRCT_BRCA1_1 201 205 PF00533 0.358
LIG_BRCT_BRCA1_1 292 296 PF00533 0.426
LIG_Clathr_ClatBox_1 303 307 PF01394 0.446
LIG_deltaCOP1_diTrp_1 288 296 PF00928 0.354
LIG_eIF4E_1 473 479 PF01652 0.328
LIG_FHA_1 1087 1093 PF00498 0.685
LIG_FHA_1 112 118 PF00498 0.403
LIG_FHA_1 162 168 PF00498 0.421
LIG_FHA_1 179 185 PF00498 0.216
LIG_FHA_1 226 232 PF00498 0.341
LIG_FHA_1 233 239 PF00498 0.322
LIG_FHA_1 327 333 PF00498 0.348
LIG_FHA_1 365 371 PF00498 0.325
LIG_FHA_1 59 65 PF00498 0.445
LIG_FHA_1 613 619 PF00498 0.323
LIG_FHA_1 817 823 PF00498 0.356
LIG_FHA_1 861 867 PF00498 0.538
LIG_FHA_1 886 892 PF00498 0.475
LIG_FHA_1 903 909 PF00498 0.778
LIG_FHA_2 181 187 PF00498 0.376
LIG_FHA_2 210 216 PF00498 0.505
LIG_FHA_2 297 303 PF00498 0.356
LIG_FHA_2 48 54 PF00498 0.346
LIG_HCF-1_HBM_1 926 929 PF13415 0.744
LIG_LIR_Apic_2 1061 1067 PF02991 0.611
LIG_LIR_Apic_2 119 124 PF02991 0.388
LIG_LIR_Apic_2 470 476 PF02991 0.323
LIG_LIR_Apic_2 926 932 PF02991 0.706
LIG_LIR_Gen_1 116 126 PF02991 0.378
LIG_LIR_Gen_1 196 206 PF02991 0.250
LIG_LIR_Gen_1 2 13 PF02991 0.345
LIG_LIR_Gen_1 24 35 PF02991 0.333
LIG_LIR_Gen_1 288 296 PF02991 0.342
LIG_LIR_Gen_1 357 366 PF02991 0.347
LIG_LIR_Gen_1 625 636 PF02991 0.389
LIG_LIR_Gen_1 729 739 PF02991 0.378
LIG_LIR_LC3C_4 301 305 PF02991 0.454
LIG_LIR_Nem_3 116 121 PF02991 0.382
LIG_LIR_Nem_3 149 154 PF02991 0.345
LIG_LIR_Nem_3 186 190 PF02991 0.318
LIG_LIR_Nem_3 196 201 PF02991 0.346
LIG_LIR_Nem_3 288 292 PF02991 0.364
LIG_LIR_Nem_3 357 361 PF02991 0.329
LIG_LIR_Nem_3 625 631 PF02991 0.404
LIG_LIR_Nem_3 729 734 PF02991 0.399
LIG_PCNA_PIPBox_1 466 475 PF02747 0.337
LIG_PCNA_yPIPBox_3 846 855 PF02747 0.414
LIG_SH2_CRK 473 477 PF00017 0.287
LIG_SH2_CRK 550 554 PF00017 0.333
LIG_SH2_NCK_1 473 477 PF00017 0.272
LIG_SH2_NCK_1 519 523 PF00017 0.348
LIG_SH2_SRC 941 944 PF00017 0.587
LIG_SH2_STAP1 941 945 PF00017 0.517
LIG_SH2_STAT5 108 111 PF00017 0.356
LIG_SH2_STAT5 230 233 PF00017 0.351
LIG_SH2_STAT5 256 259 PF00017 0.334
LIG_SH2_STAT5 27 30 PF00017 0.328
LIG_SH2_STAT5 286 289 PF00017 0.358
LIG_SH2_STAT5 3 6 PF00017 0.291
LIG_SH2_STAT5 327 330 PF00017 0.368
LIG_SH2_STAT5 358 361 PF00017 0.335
LIG_SH2_STAT5 473 476 PF00017 0.347
LIG_SH2_STAT5 532 535 PF00017 0.317
LIG_SH2_STAT5 832 835 PF00017 0.318
LIG_SH2_STAT5 929 932 PF00017 0.576
LIG_SH3_3 19 25 PF00018 0.404
LIG_SH3_3 889 895 PF00018 0.641
LIG_SH3_3 910 916 PF00018 0.700
LIG_Sin3_3 633 640 PF02671 0.441
LIG_SUMO_SIM_anti_2 301 307 PF11976 0.325
LIG_SUMO_SIM_anti_2 615 620 PF11976 0.332
LIG_SUMO_SIM_anti_2 678 683 PF11976 0.356
LIG_SUMO_SIM_par_1 110 120 PF11976 0.361
LIG_SUMO_SIM_par_1 301 307 PF11976 0.435
LIG_SUMO_SIM_par_1 60 66 PF11976 0.281
LIG_SUMO_SIM_par_1 612 617 PF11976 0.306
LIG_TRAF2_1 223 226 PF00917 0.385
LIG_TRAF2_1 347 350 PF00917 0.321
LIG_TRAF2_1 468 471 PF00917 0.418
LIG_TRAF2_1 919 922 PF00917 0.811
LIG_TRFH_1 928 932 PF08558 0.506
LIG_UBA3_1 423 432 PF00899 0.349
LIG_UBA3_1 680 688 PF00899 0.323
LIG_Vh1_VBS_1 808 826 PF01044 0.249
LIG_WRC_WIRS_1 358 363 PF05994 0.346
MOD_CDK_SPK_2 687 692 PF00069 0.496
MOD_CDK_SPxxK_3 617 624 PF00069 0.371
MOD_CDK_SPxxK_3 883 890 PF00069 0.557
MOD_CDK_SPxxK_3 902 909 PF00069 0.685
MOD_CK1_1 1091 1097 PF00069 0.668
MOD_CK1_1 1115 1121 PF00069 0.732
MOD_CK1_1 116 122 PF00069 0.349
MOD_CK1_1 172 178 PF00069 0.470
MOD_CK1_1 354 360 PF00069 0.307
MOD_CK1_1 401 407 PF00069 0.322
MOD_CK1_1 51 57 PF00069 0.326
MOD_CK1_1 531 537 PF00069 0.321
MOD_CK1_1 578 584 PF00069 0.458
MOD_CK1_1 617 623 PF00069 0.357
MOD_CK1_1 70 76 PF00069 0.284
MOD_CK1_1 979 985 PF00069 0.704
MOD_CK1_1 990 996 PF00069 0.608
MOD_CK2_1 116 122 PF00069 0.477
MOD_CK2_1 180 186 PF00069 0.431
MOD_CK2_1 209 215 PF00069 0.432
MOD_CK2_1 220 226 PF00069 0.432
MOD_CK2_1 296 302 PF00069 0.349
MOD_CK2_1 366 372 PF00069 0.470
MOD_CK2_1 47 53 PF00069 0.336
MOD_CK2_1 70 76 PF00069 0.374
MOD_Cter_Amidation 1001 1004 PF01082 0.662
MOD_Cter_Amidation 1041 1044 PF01082 0.659
MOD_Cter_Amidation 429 432 PF01082 0.542
MOD_GlcNHglycan 1006 1009 PF01048 0.698
MOD_GlcNHglycan 1054 1057 PF01048 0.665
MOD_GlcNHglycan 1126 1129 PF01048 0.721
MOD_GlcNHglycan 240 243 PF01048 0.376
MOD_GlcNHglycan 345 348 PF01048 0.364
MOD_GlcNHglycan 372 375 PF01048 0.481
MOD_GlcNHglycan 394 397 PF01048 0.328
MOD_GlcNHglycan 400 403 PF01048 0.336
MOD_GlcNHglycan 498 503 PF01048 0.389
MOD_GlcNHglycan 53 57 PF01048 0.326
MOD_GlcNHglycan 581 584 PF01048 0.412
MOD_GlcNHglycan 701 704 PF01048 0.306
MOD_GlcNHglycan 802 805 PF01048 0.333
MOD_GlcNHglycan 981 984 PF01048 0.723
MOD_GlcNHglycan 991 995 PF01048 0.669
MOD_GSK3_1 107 114 PF00069 0.412
MOD_GSK3_1 21 28 PF00069 0.374
MOD_GSK3_1 232 239 PF00069 0.270
MOD_GSK3_1 360 367 PF00069 0.354
MOD_GSK3_1 47 54 PF00069 0.343
MOD_GSK3_1 575 582 PF00069 0.456
MOD_GSK3_1 63 70 PF00069 0.265
MOD_GSK3_1 683 690 PF00069 0.421
MOD_GSK3_1 739 746 PF00069 0.297
MOD_GSK3_1 812 819 PF00069 0.311
MOD_GSK3_1 879 886 PF00069 0.528
MOD_N-GLC_1 236 241 PF02516 0.337
MOD_N-GLC_1 296 301 PF02516 0.469
MOD_N-GLC_1 406 411 PF02516 0.450
MOD_N-GLC_1 575 580 PF02516 0.434
MOD_N-GLC_1 58 63 PF02516 0.383
MOD_N-GLC_1 600 605 PF02516 0.499
MOD_N-GLC_2 169 171 PF02516 0.410
MOD_N-GLC_2 438 440 PF02516 0.321
MOD_N-GLC_2 481 483 PF02516 0.293
MOD_N-GLC_2 696 698 PF02516 0.311
MOD_NEK2_1 1088 1093 PF00069 0.612
MOD_NEK2_1 113 118 PF00069 0.409
MOD_NEK2_1 296 301 PF00069 0.427
MOD_NEK2_1 341 346 PF00069 0.335
MOD_NEK2_1 392 397 PF00069 0.310
MOD_NEK2_1 63 68 PF00069 0.284
MOD_NEK2_1 706 711 PF00069 0.377
MOD_NEK2_1 739 744 PF00069 0.299
MOD_NEK2_1 778 783 PF00069 0.310
MOD_NEK2_1 800 805 PF00069 0.325
MOD_NEK2_1 878 883 PF00069 0.578
MOD_NEK2_2 291 296 PF00069 0.365
MOD_PIKK_1 1112 1118 PF00454 0.511
MOD_PIKK_1 158 164 PF00454 0.313
MOD_PIKK_1 199 205 PF00454 0.468
MOD_PIKK_1 281 287 PF00454 0.354
MOD_PIKK_1 67 73 PF00454 0.536
MOD_PIKK_1 784 790 PF00454 0.310
MOD_PIKK_1 835 841 PF00454 0.393
MOD_PK_1 197 203 PF00069 0.258
MOD_PKA_1 1124 1130 PF00069 0.573
MOD_PKA_1 879 885 PF00069 0.496
MOD_PKA_2 1112 1118 PF00069 0.775
MOD_PKA_2 1124 1130 PF00069 0.691
MOD_PKA_2 232 238 PF00069 0.229
MOD_PKA_2 878 884 PF00069 0.592
MOD_PKA_2 959 965 PF00069 0.526
MOD_Plk_1 111 117 PF00069 0.261
MOD_Plk_1 172 178 PF00069 0.425
MOD_Plk_1 185 191 PF00069 0.246
MOD_Plk_1 225 231 PF00069 0.339
MOD_Plk_1 25 31 PF00069 0.339
MOD_Plk_1 58 64 PF00069 0.411
MOD_Plk_1 706 712 PF00069 0.369
MOD_Plk_1 835 841 PF00069 0.393
MOD_Plk_1 95 101 PF00069 0.412
MOD_Plk_2-3 220 226 PF00069 0.376
MOD_Plk_4 113 119 PF00069 0.340
MOD_Plk_4 143 149 PF00069 0.393
MOD_Plk_4 172 178 PF00069 0.412
MOD_Plk_4 186 192 PF00069 0.260
MOD_Plk_4 226 232 PF00069 0.480
MOD_Plk_4 25 31 PF00069 0.339
MOD_Plk_4 291 297 PF00069 0.352
MOD_Plk_4 351 357 PF00069 0.297
MOD_Plk_4 528 534 PF00069 0.303
MOD_Plk_4 58 64 PF00069 0.399
MOD_Plk_4 614 620 PF00069 0.328
MOD_Plk_4 675 681 PF00069 0.352
MOD_Plk_4 739 745 PF00069 0.298
MOD_Plk_4 828 834 PF00069 0.302
MOD_Plk_4 840 846 PF00069 0.362
MOD_ProDKin_1 21 27 PF00069 0.356
MOD_ProDKin_1 248 254 PF00069 0.430
MOD_ProDKin_1 472 478 PF00069 0.279
MOD_ProDKin_1 617 623 PF00069 0.376
MOD_ProDKin_1 687 693 PF00069 0.490
MOD_ProDKin_1 70 76 PF00069 0.362
MOD_ProDKin_1 881 887 PF00069 0.497
MOD_ProDKin_1 890 896 PF00069 0.542
MOD_ProDKin_1 9 15 PF00069 0.367
MOD_ProDKin_1 902 908 PF00069 0.537
MOD_ProDKin_1 909 915 PF00069 0.627
MOD_SUMO_rev_2 202 211 PF00179 0.466
MOD_SUMO_rev_2 450 454 PF00179 0.349
TRG_DiLeu_BaEn_1 351 356 PF01217 0.387
TRG_DiLeu_BaEn_1 372 377 PF01217 0.461
TRG_DiLeu_BaEn_2 306 312 PF01217 0.329
TRG_DiLeu_BaLyEn_6 804 809 PF01217 0.343
TRG_ENDOCYTIC_2 191 194 PF00928 0.512
TRG_ENDOCYTIC_2 27 30 PF00928 0.328
TRG_ENDOCYTIC_2 358 361 PF00928 0.335
TRG_ENDOCYTIC_2 550 553 PF00928 0.335
TRG_ENDOCYTIC_2 628 631 PF00928 0.414
TRG_ER_diArg_1 1043 1045 PF00400 0.773
TRG_ER_diArg_1 1047 1050 PF00400 0.769
TRG_ER_diArg_1 1123 1125 PF00400 0.634
TRG_ER_diArg_1 1129 1132 PF00400 0.630
TRG_ER_diArg_1 383 385 PF00400 0.252
TRG_ER_diArg_1 427 429 PF00400 0.497
TRG_ER_diArg_1 596 598 PF00400 0.355
TRG_ER_diArg_1 733 736 PF00400 0.363
TRG_ER_diArg_1 973 975 PF00400 0.651
TRG_NES_CRM1_1 307 321 PF08389 0.406
TRG_NLS_MonoExtN_4 428 435 PF00514 0.507
TRG_Pf-PMV_PEXEL_1 1076 1080 PF00026 0.705
TRG_Pf-PMV_PEXEL_1 182 186 PF00026 0.310
TRG_Pf-PMV_PEXEL_1 467 471 PF00026 0.389
TRG_Pf-PMV_PEXEL_1 484 488 PF00026 0.300
TRG_Pf-PMV_PEXEL_1 784 788 PF00026 0.321
TRG_Pf-PMV_PEXEL_1 797 802 PF00026 0.324

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0S4JAU2 Bodo saltans 57% 95%
A0A1X0P218 Trypanosomatidae 61% 100%
A0A3Q8IET2 Leishmania donovani 93% 100%
A0A422P4T6 Trypanosoma rangeli 60% 100%
A4I5A7 Leishmania infantum 93% 100%
C6K3W4 Leptomonas seymouri 78% 99%
C9ZQP1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 59% 100%
E9B0K3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 100%
Q4Q7M9 Leishmania major 92% 100%
V5BPP6 Trypanosoma cruzi 59% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS