Putative 4-methyl-5(Beta-hydroxyethyl)-thiazole monophosphate synthesis protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

4-methyl-5(beta-hydroxyethyl)-thiazole monophosphate synthesis protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HI30_LEIBR

TriTrypDb:

LbrM.30.0870 , LBRM2903_300014400

Length:

180

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HI30

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HI30

Function

Biological processes
Term	Name	Level	Count
GO:0006081	cellular aldehyde metabolic process	3	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0044237	cellular metabolic process	2	1
GO:0071704	organic substance metabolic process	2	1
GO:1903189	glyoxal metabolic process	4	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	161	165	PF00082	0.430
CLV_PCSK_SKI1_1	21	25	PF00082	0.428
CLV_PCSK_SKI1_1	67	71	PF00082	0.356
DEG_Nend_Nbox_1	1	3	PF02207	0.204
DOC_MAPK_MEF2A_6	7	14	PF00069	0.337
DOC_USP7_MATH_1	145	149	PF00917	0.370
DOC_WW_Pin1_4	149	154	PF00397	0.520
DOC_WW_Pin1_4	83	88	PF00397	0.237
LIG_14-3-3_CanoR_1	112	118	PF00244	0.336
LIG_Actin_WH2_2	51	69	PF00022	0.357
LIG_FHA_1	119	125	PF00498	0.463
LIG_GBD_Chelix_1	155	163	PF00786	0.442
LIG_LIR_Gen_1	43	51	PF02991	0.376
LIG_LIR_Nem_3	104	109	PF02991	0.311
LIG_LIR_Nem_3	138	144	PF02991	0.379
LIG_LIR_Nem_3	43	48	PF02991	0.312
LIG_SH2_CRK	45	49	PF00017	0.335
LIG_SH2_CRK	80	84	PF00017	0.311
LIG_SH2_STAP1	119	123	PF00017	0.303
LIG_SH2_STAP1	45	49	PF00017	0.357
LIG_SH2_STAT5	141	144	PF00017	0.357
LIG_SH3_3	45	51	PF00018	0.311
LIG_SH3_3	87	93	PF00018	0.340
LIG_UBA3_1	69	78	PF00899	0.232
MOD_CK1_1	115	121	PF00069	0.236
MOD_CK2_1	13	19	PF00069	0.371
MOD_Cter_Amidation	75	78	PF01082	0.357
MOD_GlcNHglycan	121	124	PF01048	0.230
MOD_GlcNHglycan	126	129	PF01048	0.235
MOD_GlcNHglycan	39	43	PF01048	0.366
MOD_GSK3_1	113	120	PF00069	0.480
MOD_GSK3_1	13	20	PF00069	0.359
MOD_GSK3_1	145	152	PF00069	0.438
MOD_NEK2_1	10	15	PF00069	0.347
MOD_NEK2_1	60	65	PF00069	0.247
MOD_Plk_4	13	19	PF00069	0.325
MOD_Plk_4	145	151	PF00069	0.380
MOD_ProDKin_1	149	155	PF00069	0.519
MOD_ProDKin_1	83	89	PF00069	0.237
MOD_SUMO_rev_2	16	23	PF00179	0.466
TRG_ENDOCYTIC_2	106	109	PF00928	0.311
TRG_ENDOCYTIC_2	141	144	PF00928	0.486
TRG_ENDOCYTIC_2	45	48	PF00928	0.335
TRG_ENDOCYTIC_2	80	83	PF00928	0.311
TRG_NES_CRM1_1	154	166	PF08389	0.412
TRG_Pf-PMV_PEXEL_1	68	72	PF00026	0.215

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4JDE5	Bodo saltans	43%	90%
A0A1X0P220	Trypanosomatidae	54%	91%
A0A3Q8IHS5	Leishmania donovani	80%	92%
A0A422P4U5	Trypanosoma rangeli	53%	91%
A1Z9J4	Drosophila melanogaster	37%	83%
A4I5A6	Leishmania infantum	79%	92%
C6K3W3	Leptomonas seymouri	66%	92%
C9ZQP0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	91%
E9B0K2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	92%
O06006	Bacillus subtilis (strain 168)	33%	100%
O16228	Caenorhabditis elegans	34%	97%
O59413	Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)	31%	100%
O88767	Rattus norvegicus	39%	95%
P47275	Mycoplasma genitalium (strain ATCC 33530 / DSM 19775 / NCTC 10195 / G37)	28%	97%
P55880	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	32%	92%
P90994	Caenorhabditis elegans	37%	96%
Q10356	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	31%	94%
Q46948	Escherichia coli (strain K12)	35%	92%
Q4Q7N0	Leishmania major	79%	100%
Q51732	Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)	32%	100%
Q58377	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	29%	88%
Q5E946	Bos taurus	40%	95%
Q5JGM7	Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)	28%	100%
Q5XJ36	Danio rerio	36%	95%
Q7TQ35	Mesocricetus auratus	40%	95%
Q8UW59	Gallus gallus	38%	95%
Q95LI9	Chlorocebus aethiops	39%	95%
Q99497	Homo sapiens	39%	95%
Q99LX0	Mus musculus	41%	95%
Q9V1F8	Pyrococcus abyssi (strain GE5 / Orsay)	30%	100%
Q9VA37	Drosophila melanogaster	35%	96%