Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HI29_LEIBR

TriTrypDb:

LbrM.30.0860 , LBRM2903_300014300

Length:

280

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HI29

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HI29

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	102	106	PF00656	0.508
CLV_NRD_NRD_1	112	114	PF00675	0.402
CLV_NRD_NRD_1	55	57	PF00675	0.717
CLV_NRD_NRD_1	6	8	PF00675	0.550
CLV_NRD_NRD_1	94	96	PF00675	0.524
CLV_PCSK_FUR_1	92	96	PF00082	0.516
CLV_PCSK_KEX2_1	112	114	PF00082	0.409
CLV_PCSK_KEX2_1	55	57	PF00082	0.765
CLV_PCSK_KEX2_1	91	93	PF00082	0.643
CLV_PCSK_KEX2_1	94	96	PF00082	0.625
CLV_PCSK_PC1ET2_1	91	93	PF00082	0.643
CLV_PCSK_SKI1_1	127	131	PF00082	0.614
CLV_PCSK_SKI1_1	95	99	PF00082	0.564
DEG_Nend_Nbox_1	1	3	PF02207	0.638
DOC_CDC14_PxL_1	157	165	PF14671	0.507
DOC_USP7_MATH_1	116	120	PF00917	0.563
DOC_USP7_MATH_1	190	194	PF00917	0.649
DOC_USP7_MATH_1	212	216	PF00917	0.313
DOC_USP7_MATH_1	231	235	PF00917	0.555
DOC_USP7_MATH_1	24	28	PF00917	0.614
DOC_USP7_MATH_1	62	66	PF00917	0.721
DOC_WW_Pin1_4	140	145	PF00397	0.635
DOC_WW_Pin1_4	178	183	PF00397	0.454
DOC_WW_Pin1_4	7	12	PF00397	0.453
LIG_14-3-3_CanoR_1	112	118	PF00244	0.414
LIG_14-3-3_CanoR_1	127	133	PF00244	0.445
LIG_14-3-3_CanoR_1	70	76	PF00244	0.564
LIG_FHA_1	113	119	PF00498	0.505
LIG_FHA_1	194	200	PF00498	0.566
LIG_FHA_1	99	105	PF00498	0.504
LIG_FHA_2	37	43	PF00498	0.412
LIG_LIR_Gen_1	146	155	PF02991	0.599
LIG_LIR_Gen_1	39	48	PF02991	0.422
LIG_LIR_Nem_3	146	150	PF02991	0.560
LIG_LIR_Nem_3	39	44	PF02991	0.413
LIG_NRBOX	103	109	PF00104	0.540
LIG_SH2_CRK	205	209	PF00017	0.443
LIG_SH2_NCK_1	205	209	PF00017	0.414
LIG_SH2_PTP2	263	266	PF00017	0.468
LIG_SH2_SRC	123	126	PF00017	0.607
LIG_SH2_STAT5	123	126	PF00017	0.489
LIG_SH2_STAT5	263	266	PF00017	0.468
LIG_SH3_1	56	62	PF00018	0.505
LIG_SH3_3	184	190	PF00018	0.501
LIG_SH3_3	56	62	PF00018	0.527
LIG_SUMO_SIM_anti_2	183	189	PF11976	0.425
LIG_SUMO_SIM_anti_2	272	277	PF11976	0.293
LIG_TRAF2_1	100	103	PF00917	0.604
LIG_TRAF2_1	143	146	PF00917	0.648
MOD_CDK_SPK_2	7	12	PF00069	0.453
MOD_CK1_1	111	117	PF00069	0.539
MOD_CK1_1	166	172	PF00069	0.454
MOD_CK1_1	181	187	PF00069	0.371
MOD_CK1_1	193	199	PF00069	0.509
MOD_CK1_1	46	52	PF00069	0.543
MOD_CK2_1	131	137	PF00069	0.481
MOD_CK2_1	140	146	PF00069	0.516
MOD_CK2_1	150	156	PF00069	0.607
MOD_CMANNOS	15	18	PF00535	0.635
MOD_GlcNHglycan	119	122	PF01048	0.656
MOD_GlcNHglycan	134	137	PF01048	0.432
MOD_GlcNHglycan	165	168	PF01048	0.540
MOD_GlcNHglycan	227	230	PF01048	0.413
MOD_GlcNHglycan	63	67	PF01048	0.711
MOD_GSK3_1	108	115	PF00069	0.634
MOD_GSK3_1	128	135	PF00069	0.575
MOD_GSK3_1	166	173	PF00069	0.548
MOD_GSK3_1	176	183	PF00069	0.397
MOD_GSK3_1	18	25	PF00069	0.676
MOD_GSK3_1	219	226	PF00069	0.489
MOD_GSK3_1	248	255	PF00069	0.374
MOD_GSK3_1	43	50	PF00069	0.604
MOD_GSK3_1	62	69	PF00069	0.706
MOD_GSK3_1	74	81	PF00069	0.407
MOD_N-GLC_1	108	113	PF02516	0.524
MOD_N-GLC_1	269	274	PF02516	0.345
MOD_NEK2_1	108	113	PF00069	0.524
MOD_NEK2_1	150	155	PF00069	0.572
MOD_NEK2_1	163	168	PF00069	0.636
MOD_NEK2_2	36	41	PF00069	0.411
MOD_NEK2_2	47	52	PF00069	0.660
MOD_PK_1	22	28	PF00069	0.744
MOD_PKA_1	112	118	PF00069	0.457
MOD_PKA_2	111	117	PF00069	0.573
MOD_PKA_2	163	169	PF00069	0.645
MOD_Plk_1	269	275	PF00069	0.345
MOD_Plk_1	47	53	PF00069	0.662
MOD_Plk_4	128	134	PF00069	0.571
MOD_Plk_4	170	176	PF00069	0.386
MOD_Plk_4	183	189	PF00069	0.411
MOD_Plk_4	269	275	PF00069	0.448
MOD_Plk_4	36	42	PF00069	0.500
MOD_Plk_4	74	80	PF00069	0.423
MOD_ProDKin_1	140	146	PF00069	0.638
MOD_ProDKin_1	178	184	PF00069	0.461
MOD_ProDKin_1	7	13	PF00069	0.451
TRG_DiLeu_BaEn_1	103	108	PF01217	0.579
TRG_ER_diArg_1	92	95	PF00400	0.613
TRG_NLS_MonoExtC_3	90	95	PF00514	0.517
TRG_NLS_MonoExtN_4	89	95	PF00514	0.515
TRG_Pf-PMV_PEXEL_1	95	99	PF00026	0.481

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PFH4	Leptomonas seymouri	51%	100%
A0A1X0P245	Trypanosomatidae	36%	90%
A0A3S7X369	Leishmania donovani	85%	100%
A0A422P4T3	Trypanosoma rangeli	34%	99%
A4I5A5	Leishmania infantum	85%	100%
C9ZQN9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	97%
E9B0K1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q4Q7N1	Leishmania major	86%	100%
V5BUA0	Trypanosoma cruzi	34%	100%