LeishMANIAdb
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Heat shock protein grpe

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Heat shock protein grpe
Gene product:
heat shock protein grpe
Species:
Leishmania braziliensis
UniProt:
A4HI26_LEIBR
TriTrypDb:
LbrM.30.0830 , LBRM2903_300014100 *
Length:
257

Annotations

LeishMANIAdb annotations

Homologous to other Eukaryotic mitochondrial proteins. Likely non-TM.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 25
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 13
NetGPI no yes: 0, no: 13
Cellular components
Term Name Level Count
GO:0001405 PAM complex, Tim23 associated import motor 4 2
GO:0032991 protein-containing complex 1 2
GO:0098796 membrane protein complex 2 2
GO:0098798 mitochondrial protein-containing complex 2 2
GO:0098800 inner mitochondrial membrane protein complex 3 2
GO:0005759 mitochondrial matrix 5 6
GO:0031974 membrane-enclosed lumen 2 6
GO:0043233 organelle lumen 3 6
GO:0070013 intracellular organelle lumen 4 6
GO:0110165 cellular anatomical entity 1 7
GO:0016020 membrane 2 1

Expansion

Sequence features

A4HI26
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HI26

Function

Biological processes
Term Name Level Count
GO:0006457 protein folding 2 14
GO:0009987 cellular process 1 14
GO:0006810 transport 3 2
GO:0006839 mitochondrial transport 4 2
GO:0006886 intracellular protein transport 4 2
GO:0008104 protein localization 4 2
GO:0015031 protein transport 4 2
GO:0030150 protein import into mitochondrial matrix 4 2
GO:0033036 macromolecule localization 2 2
GO:0033365 protein localization to organelle 5 2
GO:0044743 protein transmembrane import into intracellular organelle 4 2
GO:0045184 establishment of protein localization 3 2
GO:0046907 intracellular transport 3 2
GO:0051179 localization 1 2
GO:0051234 establishment of localization 2 2
GO:0051641 cellular localization 2 2
GO:0051649 establishment of localization in cell 3 2
GO:0055085 transmembrane transport 2 2
GO:0065002 intracellular protein transmembrane transport 4 2
GO:0070585 protein localization to mitochondrion 6 2
GO:0070727 cellular macromolecule localization 3 2
GO:0071702 organic substance transport 4 2
GO:0071705 nitrogen compound transport 4 2
GO:0071806 protein transmembrane transport 3 2
GO:0072594 establishment of protein localization to organelle 4 2
GO:0072655 establishment of protein localization to mitochondrion 5 2
GO:1990542 mitochondrial transmembrane transport 3 2
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 14
GO:0000774 adenyl-nucleotide exchange factor activity 3 14
GO:0005488 binding 1 14
GO:0005515 protein binding 2 14
GO:0017076 purine nucleotide binding 4 14
GO:0030554 adenyl nucleotide binding 5 14
GO:0036094 small molecule binding 2 14
GO:0042802 identical protein binding 3 14
GO:0042803 protein homodimerization activity 4 14
GO:0046983 protein dimerization activity 3 14
GO:0051087 protein-folding chaperone binding 3 14
GO:0060590 ATPase regulator activity 2 14
GO:0097159 organic cyclic compound binding 2 14
GO:0098772 molecular function regulator activity 1 14
GO:1901265 nucleoside phosphate binding 3 14
GO:1901363 heterocyclic compound binding 2 14
GO:0051082 unfolded protein binding 3 2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 36 40 PF00656 0.427
CLV_NRD_NRD_1 124 126 PF00675 0.287
CLV_NRD_NRD_1 158 160 PF00675 0.193
CLV_NRD_NRD_1 247 249 PF00675 0.308
CLV_NRD_NRD_1 55 57 PF00675 0.622
CLV_NRD_NRD_1 7 9 PF00675 0.515
CLV_NRD_NRD_1 72 74 PF00675 0.494
CLV_PCSK_KEX2_1 194 196 PF00082 0.305
CLV_PCSK_KEX2_1 247 249 PF00082 0.305
CLV_PCSK_KEX2_1 55 57 PF00082 0.617
CLV_PCSK_KEX2_1 7 9 PF00082 0.515
CLV_PCSK_PC1ET2_1 194 196 PF00082 0.305
CLV_PCSK_SKI1_1 125 129 PF00082 0.201
CLV_PCSK_SKI1_1 191 195 PF00082 0.354
CLV_PCSK_SKI1_1 216 220 PF00082 0.250
CLV_PCSK_SKI1_1 74 78 PF00082 0.405
CLV_Separin_Metazoa 94 98 PF03568 0.425
DEG_Nend_Nbox_1 1 3 PF02207 0.427
DOC_CYCLIN_yCln2_LP_2 27 33 PF00134 0.420
DOC_MAPK_gen_1 247 253 PF00069 0.473
DOC_MAPK_MEF2A_6 21 29 PF00069 0.419
DOC_PP2B_LxvP_1 27 30 PF13499 0.435
DOC_PP4_FxxP_1 218 221 PF00568 0.505
DOC_USP7_MATH_1 139 143 PF00917 0.450
DOC_WW_Pin1_4 59 64 PF00397 0.394
LIG_14-3-3_CanoR_1 195 205 PF00244 0.518
LIG_CaM_IQ_9 151 167 PF13499 0.377
LIG_FHA_1 12 18 PF00498 0.431
LIG_FHA_1 156 162 PF00498 0.417
LIG_FHA_1 221 227 PF00498 0.466
LIG_FHA_1 60 66 PF00498 0.467
LIG_FHA_1 81 87 PF00498 0.627
LIG_FHA_2 89 95 PF00498 0.424
LIG_LIR_Apic_2 215 221 PF02991 0.462
LIG_LIR_Gen_1 91 100 PF02991 0.393
LIG_LIR_Nem_3 91 96 PF02991 0.383
LIG_SH2_CRK 54 58 PF00017 0.458
LIG_SH2_NCK_1 116 120 PF00017 0.450
LIG_SH2_STAT5 116 119 PF00017 0.377
LIG_SH3_3 202 208 PF00018 0.416
LIG_SUMO_SIM_anti_2 180 187 PF11976 0.377
LIG_SUMO_SIM_anti_2 82 88 PF11976 0.351
LIG_SUMO_SIM_par_1 13 20 PF11976 0.419
LIG_SUMO_SIM_par_1 146 152 PF11976 0.492
LIG_SUMO_SIM_par_1 222 228 PF11976 0.377
LIG_SUMO_SIM_par_1 23 28 PF11976 0.389
LIG_SUMO_SIM_par_1 82 88 PF11976 0.351
LIG_TRAF2_1 127 130 PF00917 0.450
LIG_TRAF2_1 212 215 PF00917 0.377
LIG_TRAF2_1 225 228 PF00917 0.361
LIG_TYR_ITIM 52 57 PF00017 0.424
LIG_WRC_WIRS_1 140 145 PF05994 0.516
MOD_CK1_1 174 180 PF00069 0.451
MOD_CK1_1 222 228 PF00069 0.480
MOD_CK2_1 222 228 PF00069 0.552
MOD_CK2_1 37 43 PF00069 0.438
MOD_CK2_1 88 94 PF00069 0.424
MOD_GSK3_1 167 174 PF00069 0.459
MOD_GSK3_1 196 203 PF00069 0.467
MOD_GSK3_1 216 223 PF00069 0.526
MOD_GSK3_1 33 40 PF00069 0.649
MOD_N-GLC_1 11 16 PF02516 0.419
MOD_N-GLC_1 167 172 PF02516 0.294
MOD_N-GLC_1 241 246 PF02516 0.305
MOD_NEK2_1 100 105 PF00069 0.593
MOD_NEK2_1 17 22 PF00069 0.684
MOD_NEK2_1 241 246 PF00069 0.446
MOD_NEK2_1 25 30 PF00069 0.427
MOD_NEK2_1 33 38 PF00069 0.411
MOD_NEK2_1 64 69 PF00069 0.570
MOD_PIKK_1 125 131 PF00454 0.450
MOD_PIKK_1 196 202 PF00454 0.450
MOD_PIKK_1 74 80 PF00454 0.694
MOD_PK_1 167 173 PF00069 0.433
MOD_PKA_1 125 131 PF00069 0.450
MOD_PKA_2 166 172 PF00069 0.433
MOD_PKA_2 3 9 PF00069 0.433
MOD_PKB_1 165 173 PF00069 0.377
MOD_Plk_1 11 17 PF00069 0.419
MOD_Plk_1 167 173 PF00069 0.501
MOD_Plk_1 174 180 PF00069 0.510
MOD_Plk_1 241 247 PF00069 0.423
MOD_Plk_4 11 17 PF00069 0.422
MOD_Plk_4 174 180 PF00069 0.484
MOD_Plk_4 200 206 PF00069 0.431
MOD_Plk_4 241 247 PF00069 0.482
MOD_Plk_4 37 43 PF00069 0.459
MOD_Plk_4 82 88 PF00069 0.351
MOD_ProDKin_1 59 65 PF00069 0.393
MOD_SUMO_for_1 212 215 PF00179 0.377
MOD_SUMO_rev_2 210 218 PF00179 0.542
MOD_SUMO_rev_2 85 91 PF00179 0.270
TRG_DiLeu_BaLyEn_6 27 32 PF01217 0.418
TRG_DiLeu_BaLyEn_6 5 10 PF01217 0.427
TRG_DiLeu_BaLyEn_6 60 65 PF01217 0.484
TRG_ENDOCYTIC_2 54 57 PF00928 0.469
TRG_ENDOCYTIC_2 93 96 PF00928 0.438
TRG_ER_diArg_1 164 167 PF00400 0.377
TRG_ER_diArg_1 246 248 PF00400 0.450
TRG_ER_diArg_1 54 56 PF00400 0.617
TRG_ER_diArg_1 7 9 PF00400 0.542

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HZM2 Leptomonas seymouri 45% 100%
A0A0S4JEA6 Bodo saltans 35% 100%
A0A3Q8IEN8 Leishmania donovani 67% 100%
A0A3Q8IJ81 Leishmania donovani 31% 100%
A0A422P4T2 Trypanosoma rangeli 26% 100%
A0Q7F1 Francisella tularensis subsp. novicida (strain U112) 24% 100%
A4HI25 Leishmania braziliensis 32% 100%
A4I5A2 Leishmania infantum 31% 100%
A4I5A3 Leishmania infantum 78% 100%
A4XYF7 Pseudomonas mendocina (strain ymp) 28% 100%
A7NCM8 Francisella tularensis subsp. holarctica (strain FTNF002-00 / FTA) 24% 100%
A9ILE9 Bartonella tribocorum (strain CIP 105476 / IBS 506) 29% 100%
B0TYF1 Francisella philomiragia subsp. philomiragia (strain ATCC 25017 / FSC 153 / O#319-036) 25% 100%
B0UT70 Histophilus somni (strain 2336) 27% 100%
B1J253 Pseudomonas putida (strain W619) 26% 100%
B1Y785 Leptothrix cholodnii (strain ATCC 51168 / LMG 8142 / SP-6) 25% 100%
B2SGV9 Francisella tularensis subsp. mediasiatica (strain FSC147) 24% 100%
C3K276 Pseudomonas fluorescens (strain SBW25) 28% 100%
C5BQ34 Teredinibacter turnerae (strain ATCC 39867 / T7901) 26% 100%
C9ZQN6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 30% 100%
E9B0J8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 31% 100%
E9B0J9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 72% 100%
P48204 Francisella tularensis 24% 100%
P48604 Drosophila melanogaster 26% 100%
P97576 Rattus norvegicus 26% 100%
Q0BLK5 Francisella tularensis subsp. holarctica (strain OSU18) 24% 100%
Q0I2Y4 Haemophilus somnus (strain 129Pt) 27% 100%
Q2A329 Francisella tularensis subsp. holarctica (strain LVS) 24% 100%
Q2NAJ5 Erythrobacter litoralis (strain HTCC2594) 24% 100%
Q3KIA1 Pseudomonas fluorescens (strain Pf0-1) 28% 100%
Q3SZC1 Bos taurus 26% 100%
Q48E61 Pseudomonas savastanoi pv. phaseolicola (strain 1448A / Race 6) 27% 100%
Q4KIH2 Pseudomonas fluorescens (strain ATCC BAA-477 / NRRL B-23932 / Pf-5) 28% 100%
Q4Q7N3 Leishmania major 67% 98%
Q4Q7N4 Leishmania major 31% 100%
Q4ZNP6 Pseudomonas syringae pv. syringae (strain B728a) 27% 100%
Q6G1E4 Bartonella quintana (strain Toulouse) 27% 100%
Q7N1U7 Photorhabdus laumondii subsp. laumondii (strain DSM 15139 / CIP 105565 / TT01) 29% 100%
Q7UA77 Parasynechococcus marenigrum (strain WH8102) 27% 100%
Q7VEJ7 Prochlorococcus marinus (strain SARG / CCMP1375 / SS120) 29% 100%
Q87WN9 Pseudomonas syringae pv. tomato (strain ATCC BAA-871 / DC3000) 27% 100%
Q8DJB3 Thermosynechococcus vestitus (strain NIES-2133 / IAM M-273 / BP-1) 28% 100%
Q99LP6 Mus musculus 26% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS