Type I restriction endonuclease subunit S

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HI24_LEIBR

TriTrypDb:

LbrM.30.0810 , LBRM2903_300013900

Length:

204

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HI24

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HI24

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	184	186	PF00675	0.349
CLV_PCSK_KEX2_1	157	159	PF00082	0.461
CLV_PCSK_KEX2_1	93	95	PF00082	0.458
CLV_PCSK_PC1ET2_1	157	159	PF00082	0.451
CLV_PCSK_PC1ET2_1	93	95	PF00082	0.482
DEG_MDM2_SWIB_1	177	184	PF02201	0.343
DEG_Nend_UBRbox_2	1	3	PF02207	0.338
DEG_ODPH_VHL_1	20	32	PF01847	0.335
DEG_SCF_FBW7_1	130	137	PF00400	0.469
DOC_CKS1_1	131	136	PF01111	0.397
DOC_CKS1_1	189	194	PF01111	0.454
DOC_CYCLIN_yClb3_PxF_3	104	110	PF00134	0.394
DOC_CYCLIN_yCln2_LP_2	201	204	PF00134	0.405
DOC_MAPK_DCC_7	101	109	PF00069	0.528
DOC_MAPK_gen_1	157	163	PF00069	0.463
DOC_MAPK_MEF2A_6	101	109	PF00069	0.583
DOC_MAPK_MEF2A_6	116	124	PF00069	0.317
DOC_PP1_RVXF_1	162	169	PF00149	0.416
DOC_PP2B_LxvP_1	201	204	PF13499	0.405
DOC_USP7_MATH_1	62	66	PF00917	0.290
DOC_WW_Pin1_4	130	135	PF00397	0.411
DOC_WW_Pin1_4	188	193	PF00397	0.486
DOC_WW_Pin1_4	95	100	PF00397	0.492
LIG_14-3-3_CanoR_1	116	121	PF00244	0.360
LIG_APCC_ABBAyCdc20_2	132	138	PF00400	0.405
LIG_CtBP_PxDLS_1	192	196	PF00389	0.541
LIG_deltaCOP1_diTrp_1	2	7	PF00928	0.492
LIG_FHA_1	25	31	PF00498	0.454
LIG_FHA_2	1	7	PF00498	0.605
LIG_FHA_2	189	195	PF00498	0.409
LIG_LIR_Apic_2	187	192	PF02991	0.484
LIG_LIR_Gen_1	133	144	PF02991	0.344
LIG_LIR_Gen_1	2	11	PF02991	0.444
LIG_LIR_Nem_3	133	139	PF02991	0.374
LIG_LIR_Nem_3	2	7	PF02991	0.447
LIG_PCNA_PIPBox_1	29	38	PF02747	0.422
LIG_Pex14_2	109	113	PF04695	0.388
LIG_Pex14_2	177	181	PF04695	0.344
LIG_PTB_Apo_2	162	169	PF02174	0.439
LIG_SH2_STAP1	179	183	PF00017	0.413
LIG_SH3_3	102	108	PF00018	0.462
LIG_SUMO_SIM_anti_2	121	126	PF11976	0.309
LIG_SUMO_SIM_anti_2	85	91	PF11976	0.512
LIG_SUMO_SIM_par_1	191	197	PF11976	0.423
LIG_SUMO_SIM_par_1	85	91	PF11976	0.436
LIG_TRAF2_1	3	6	PF00917	0.521
MOD_CDK_SPxK_1	95	101	PF00069	0.409
MOD_CK1_1	137	143	PF00069	0.336
MOD_CK1_1	188	194	PF00069	0.418
MOD_CK1_1	67	73	PF00069	0.354
MOD_CK2_1	188	194	PF00069	0.461
MOD_CK2_1	69	75	PF00069	0.431
MOD_GlcNHglycan	52	55	PF01048	0.416
MOD_GSK3_1	116	123	PF00069	0.342
MOD_GSK3_1	126	133	PF00069	0.408
MOD_N-GLC_1	50	55	PF02516	0.461
MOD_NEK2_1	148	153	PF00069	0.353
MOD_NEK2_1	16	21	PF00069	0.327
MOD_NEK2_1	88	93	PF00069	0.451
MOD_PIKK_1	64	70	PF00454	0.468
MOD_PK_1	116	122	PF00069	0.346
MOD_PKA_1	185	191	PF00069	0.355
MOD_PKA_2	115	121	PF00069	0.330
MOD_Plk_1	137	143	PF00069	0.365
MOD_Plk_4	120	126	PF00069	0.315
MOD_Plk_4	185	191	PF00069	0.355
MOD_Plk_4	82	88	PF00069	0.395
MOD_ProDKin_1	130	136	PF00069	0.403
MOD_ProDKin_1	188	194	PF00069	0.494
MOD_ProDKin_1	95	101	PF00069	0.491
MOD_SUMO_for_1	100	103	PF00179	0.463
MOD_SUMO_for_1	156	159	PF00179	0.331
MOD_SUMO_rev_2	121	130	PF00179	0.391
TRG_DiLeu_BaEn_1	197	202	PF01217	0.393
TRG_ENDOCYTIC_2	146	149	PF00928	0.306
TRG_ER_FFAT_1	53	65	PF00635	0.463
TRG_NLS_MonoExtC_3	91	97	PF00514	0.498

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEC7	Leptomonas seymouri	75%	74%
A0A1X0P267	Trypanosomatidae	52%	70%
A0A422P4V6	Trypanosoma rangeli	54%	70%
A4I5A1	Leishmania infantum	88%	74%
C9ZQN5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	69%
E9B0J7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	74%
Q4Q7N5	Leishmania major	89%	100%