Putative CDC16

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Putative CDC16

Gene product:

CDC16, putative

Species:

Leishmania braziliensis

UniProt:

A4HI23_LEIBR

TriTrypDb:

LbrM.30.0800 , LBRM2903_300013800

Length:

546

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0000151	ubiquitin ligase complex	3	1
GO:0000152	nuclear ubiquitin ligase complex	3	1
GO:0005680	anaphase-promoting complex	4	1
GO:0005737	cytoplasm	2	1
GO:0031461	cullin-RING ubiquitin ligase complex	4	1
GO:0032991	protein-containing complex	1	1
GO:0051286	cell tip	3	1
GO:0060187	cell pole	2	1
GO:0110165	cellular anatomical entity	1	2
GO:0140513	nuclear protein-containing complex	2	1
GO:0140535	intracellular protein-containing complex	2	1
GO:1902494	catalytic complex	2	1
GO:1990234	transferase complex	3	1
GO:0016020	membrane	2	1

Expansion

Sequence features

A4HI23

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HI23

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006511	ubiquitin-dependent protein catabolic process	7	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0007088	regulation of mitotic nuclear division	6	1
GO:0007091	metaphase/anaphase transition of mitotic cell cycle	5	1
GO:0007346	regulation of mitotic cell cycle	5	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0009987	cellular process	1	3
GO:0010498	proteasomal protein catabolic process	5	1
GO:0010564	regulation of cell cycle process	5	1
GO:0010638	positive regulation of organelle organization	6	1
GO:0010965	regulation of mitotic sister chromatid separation	6	1
GO:0016567	protein ubiquitination	7	1
GO:0019538	protein metabolic process	3	1
GO:0019941	modification-dependent protein catabolic process	6	1
GO:0022402	cell cycle process	2	1
GO:0030071	regulation of mitotic metaphase/anaphase transition	7	1
GO:0030163	protein catabolic process	4	1
GO:0031145	anaphase-promoting complex-dependent catabolic process	7	1
GO:0032446	protein modification by small protein conjugation	6	1
GO:0033043	regulation of organelle organization	5	1
GO:0033044	regulation of chromosome organization	6	1
GO:0033045	regulation of sister chromatid segregation	5	1
GO:0036211	protein modification process	4	1
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043632	modification-dependent macromolecule catabolic process	5	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044265	obsolete cellular macromolecule catabolic process	4	1
GO:0044770	cell cycle phase transition	3	1
GO:0044772	mitotic cell cycle phase transition	4	1
GO:0044784	metaphase/anaphase transition of cell cycle	4	1
GO:0045787	positive regulation of cell cycle	5	1
GO:0045840	positive regulation of mitotic nuclear division	7	1
GO:0045842	positive regulation of mitotic metaphase/anaphase transition	8	1
GO:0045931	positive regulation of mitotic cell cycle	6	1
GO:0048518	positive regulation of biological process	3	1
GO:0048522	positive regulation of cellular process	4	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051128	regulation of cellular component organization	4	1
GO:0051130	positive regulation of cellular component organization	5	1
GO:0051301	cell division	2	3
GO:0051603	proteolysis involved in protein catabolic process	5	1
GO:0051726	regulation of cell cycle	4	1
GO:0051783	regulation of nuclear division	6	1
GO:0051785	positive regulation of nuclear division	7	1
GO:0051983	regulation of chromosome segregation	4	1
GO:0065007	biological regulation	1	1
GO:0070647	protein modification by small protein conjugation or removal	5	1
GO:0071704	organic substance metabolic process	2	1
GO:0090068	positive regulation of cell cycle process	6	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901565	organonitrogen compound catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1
GO:1901970	positive regulation of mitotic sister chromatid separation	7	1
GO:1901987	regulation of cell cycle phase transition	6	1
GO:1901989	positive regulation of cell cycle phase transition	7	1
GO:1901990	regulation of mitotic cell cycle phase transition	6	1
GO:1901992	positive regulation of mitotic cell cycle phase transition	7	1
GO:1902099	regulation of metaphase/anaphase transition of cell cycle	6	1
GO:1902101	positive regulation of metaphase/anaphase transition of cell cycle	7	1
GO:1903047	mitotic cell cycle process	3	1
GO:1905818	regulation of chromosome separation	5	1
GO:1905820	positive regulation of chromosome separation	6	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	159	163	PF00656	0.236
CLV_C14_Caspase3-7	522	526	PF00656	0.673
CLV_NRD_NRD_1	322	324	PF00675	0.310
CLV_NRD_NRD_1	359	361	PF00675	0.392
CLV_NRD_NRD_1	417	419	PF00675	0.245
CLV_NRD_NRD_1	481	483	PF00675	0.468
CLV_NRD_NRD_1	517	519	PF00675	0.568
CLV_PCSK_KEX2_1	322	324	PF00082	0.310
CLV_PCSK_KEX2_1	481	483	PF00082	0.456
CLV_PCSK_KEX2_1	517	519	PF00082	0.570
CLV_PCSK_PC7_1	477	483	PF00082	0.465
CLV_PCSK_SKI1_1	130	134	PF00082	0.386
CLV_PCSK_SKI1_1	149	153	PF00082	0.178
CLV_PCSK_SKI1_1	213	217	PF00082	0.500
CLV_PCSK_SKI1_1	352	356	PF00082	0.449
CLV_PCSK_SKI1_1	383	387	PF00082	0.397
CLV_PCSK_SKI1_1	41	45	PF00082	0.428
CLV_PCSK_SKI1_1	477	481	PF00082	0.325
CLV_PCSK_SKI1_1	59	63	PF00082	0.299
CLV_PCSK_SKI1_1	80	84	PF00082	0.387
DEG_Nend_UBRbox_2	1	3	PF02207	0.475
DOC_CYCLIN_RxL_1	146	156	PF00134	0.323
DOC_CYCLIN_RxL_1	477	487	PF00134	0.471
DOC_CYCLIN_yClb5_NLxxxL_5	209	216	PF00134	0.248
DOC_MAPK_gen_1	258	267	PF00069	0.411
DOC_MAPK_gen_1	481	488	PF00069	0.481
DOC_MAPK_MEF2A_6	165	172	PF00069	0.278
DOC_MAPK_MEF2A_6	230	239	PF00069	0.274
DOC_MAPK_MEF2A_6	481	488	PF00069	0.481
DOC_MAPK_NFAT4_5	230	238	PF00069	0.419
DOC_MAPK_NFAT4_5	481	489	PF00069	0.488
DOC_PP1_RVXF_1	122	129	PF00149	0.454
DOC_PP1_RVXF_1	491	497	PF00149	0.555
DOC_PP1_RVXF_1	537	544	PF00149	0.701
DOC_PP2B_LxvP_1	164	167	PF13499	0.340
DOC_PP2B_PxIxI_1	167	173	PF00149	0.277
DOC_USP7_MATH_1	101	105	PF00917	0.518
DOC_USP7_MATH_1	363	367	PF00917	0.235
DOC_USP7_MATH_1	392	396	PF00917	0.279
DOC_USP7_MATH_1	438	442	PF00917	0.359
DOC_USP7_MATH_1	501	505	PF00917	0.433
DOC_WW_Pin1_4	243	248	PF00397	0.463
DOC_WW_Pin1_4	503	508	PF00397	0.503
DOC_WW_Pin1_4	529	534	PF00397	0.568
LIG_14-3-3_CanoR_1	174	178	PF00244	0.320
LIG_14-3-3_CanoR_1	213	219	PF00244	0.478
LIG_14-3-3_CanoR_1	230	234	PF00244	0.467
LIG_14-3-3_CanoR_1	289	297	PF00244	0.317
LIG_14-3-3_CanoR_1	437	447	PF00244	0.343
LIG_14-3-3_CanoR_1	491	497	PF00244	0.619
LIG_14-3-3_CanoR_1	500	506	PF00244	0.660
LIG_Actin_WH2_2	44	61	PF00022	0.383
LIG_AP2alpha_2	136	138	PF02296	0.347
LIG_BRCT_BRCA1_1	539	543	PF00533	0.562
LIG_BRCT_BRCA1_1	71	75	PF00533	0.483
LIG_FHA_1	185	191	PF00498	0.493
LIG_FHA_1	194	200	PF00498	0.464
LIG_FHA_1	217	223	PF00498	0.332
LIG_FHA_1	230	236	PF00498	0.352
LIG_FHA_1	244	250	PF00498	0.264
LIG_FHA_1	448	454	PF00498	0.376
LIG_FHA_2	522	528	PF00498	0.673
LIG_LIR_Gen_1	141	151	PF02991	0.372
LIG_LIR_Gen_1	153	161	PF02991	0.264
LIG_LIR_Gen_1	499	510	PF02991	0.401
LIG_LIR_Gen_1	511	519	PF02991	0.355
LIG_LIR_Gen_1	53	61	PF02991	0.492
LIG_LIR_Nem_3	141	146	PF02991	0.364
LIG_LIR_Nem_3	153	158	PF02991	0.268
LIG_LIR_Nem_3	299	304	PF02991	0.312
LIG_LIR_Nem_3	415	420	PF02991	0.278
LIG_LIR_Nem_3	428	433	PF02991	0.197
LIG_LIR_Nem_3	499	505	PF02991	0.435
LIG_LIR_Nem_3	509	515	PF02991	0.447
LIG_LIR_Nem_3	53	57	PF02991	0.488
LIG_NBox_RRM_1	75	85	PF00076	0.366
LIG_Pex14_2	297	301	PF04695	0.270
LIG_SH2_CRK	342	346	PF00017	0.328
LIG_SH2_CRK	393	397	PF00017	0.260
LIG_SH2_CRK	417	421	PF00017	0.338
LIG_SH2_GRB2like	429	432	PF00017	0.321
LIG_SH2_NCK_1	280	284	PF00017	0.294
LIG_SH2_NCK_1	342	346	PF00017	0.490
LIG_SH2_SRC	268	271	PF00017	0.323
LIG_SH2_STAP1	262	266	PF00017	0.434
LIG_SH2_STAP1	423	427	PF00017	0.266
LIG_SH2_STAT3	228	231	PF00017	0.381
LIG_SH2_STAT3	429	432	PF00017	0.388
LIG_SH2_STAT5	185	188	PF00017	0.493
LIG_SH2_STAT5	262	265	PF00017	0.390
LIG_SH2_STAT5	286	289	PF00017	0.448
LIG_SH2_STAT5	296	299	PF00017	0.374
LIG_SH2_STAT5	337	340	PF00017	0.333
LIG_SH2_STAT5	433	436	PF00017	0.251
LIG_SUMO_SIM_anti_2	156	163	PF11976	0.230
LIG_SUMO_SIM_anti_2	196	201	PF11976	0.383
LIG_SUMO_SIM_par_1	156	163	PF11976	0.230
LIG_SUMO_SIM_par_1	373	380	PF11976	0.259
LIG_TYR_ITAM	259	277	PF00017	0.435
LIG_WRC_WIRS_1	502	507	PF05994	0.414
MOD_CK1_1	144	150	PF00069	0.453
MOD_CK1_1	188	194	PF00069	0.423
MOD_CK1_1	217	223	PF00069	0.371
MOD_CK1_1	243	249	PF00069	0.406
MOD_CK1_1	288	294	PF00069	0.390
MOD_CK1_1	403	409	PF00069	0.321
MOD_CK1_1	495	501	PF00069	0.665
MOD_CK1_1	503	509	PF00069	0.591
MOD_CK1_1	511	517	PF00069	0.448
MOD_CK1_1	521	527	PF00069	0.582
MOD_CK2_1	275	281	PF00069	0.319
MOD_CK2_1	503	509	PF00069	0.551
MOD_GlcNHglycan	117	121	PF01048	0.344
MOD_GlcNHglycan	143	146	PF01048	0.346
MOD_GlcNHglycan	15	18	PF01048	0.469
MOD_GlcNHglycan	187	190	PF01048	0.344
MOD_GlcNHglycan	21	24	PF01048	0.407
MOD_GlcNHglycan	453	456	PF01048	0.361
MOD_GSK3_1	184	191	PF00069	0.548
MOD_GSK3_1	329	336	PF00069	0.276
MOD_GSK3_1	447	454	PF00069	0.310
MOD_GSK3_1	459	466	PF00069	0.320
MOD_GSK3_1	521	528	PF00069	0.554
MOD_GSK3_1	529	536	PF00069	0.501
MOD_N-GLC_1	39	44	PF02516	0.401
MOD_N-GLC_1	438	443	PF02516	0.412
MOD_N-GLC_2	259	261	PF02516	0.495
MOD_NEK2_1	160	165	PF00069	0.343
MOD_NEK2_1	240	245	PF00069	0.331
MOD_NEK2_1	273	278	PF00069	0.330
MOD_NEK2_1	340	345	PF00069	0.327
MOD_NEK2_1	355	360	PF00069	0.342
MOD_NEK2_1	447	452	PF00069	0.245
MOD_NEK2_2	173	178	PF00069	0.450
MOD_NEK2_2	459	464	PF00069	0.308
MOD_PKA_2	173	179	PF00069	0.337
MOD_PKA_2	229	235	PF00069	0.404
MOD_PKA_2	288	294	PF00069	0.317
MOD_PKA_2	492	498	PF00069	0.624
MOD_PKB_1	518	526	PF00069	0.598
MOD_Plk_1	355	361	PF00069	0.450
MOD_Plk_1	39	45	PF00069	0.395
MOD_Plk_1	508	514	PF00069	0.424
MOD_Plk_4	333	339	PF00069	0.296
MOD_Plk_4	363	369	PF00069	0.300
MOD_Plk_4	412	418	PF00069	0.307
MOD_Plk_4	53	59	PF00069	0.422
MOD_Plk_4	94	100	PF00069	0.423
MOD_ProDKin_1	243	249	PF00069	0.455
MOD_ProDKin_1	503	509	PF00069	0.499
MOD_ProDKin_1	529	535	PF00069	0.567
MOD_SUMO_for_1	203	206	PF00179	0.461
MOD_SUMO_for_1	309	312	PF00179	0.305
MOD_SUMO_rev_2	84	90	PF00179	0.424
TRG_DiLeu_BaEn_1	156	161	PF01217	0.448
TRG_DiLeu_BaEn_2	250	256	PF01217	0.448
TRG_DiLeu_BaLyEn_6	244	249	PF01217	0.387
TRG_ENDOCYTIC_2	262	265	PF00928	0.441
TRG_ENDOCYTIC_2	274	277	PF00928	0.437
TRG_ENDOCYTIC_2	308	311	PF00928	0.329
TRG_ENDOCYTIC_2	337	340	PF00928	0.300
TRG_ENDOCYTIC_2	342	345	PF00928	0.301
TRG_ENDOCYTIC_2	393	396	PF00928	0.260
TRG_ENDOCYTIC_2	417	420	PF00928	0.338
TRG_ENDOCYTIC_2	502	505	PF00928	0.430
TRG_ER_diArg_1	321	323	PF00400	0.313
TRG_ER_diArg_1	434	437	PF00400	0.351
TRG_ER_diArg_1	480	482	PF00400	0.473
TRG_ER_diArg_1	490	493	PF00400	0.610
TRG_ER_diArg_1	517	520	PF00400	0.578
TRG_NES_CRM1_1	156	169	PF08389	0.342
TRG_NES_CRM1_1	19	32	PF08389	0.401
TRG_NES_CRM1_1	50	63	PF08389	0.372
TRG_NES_CRM1_1	87	102	PF08389	0.398
TRG_Pf-PMV_PEXEL_1	149	153	PF00026	0.364
TRG_Pf-PMV_PEXEL_1	418	422	PF00026	0.218
TRG_Pf-PMV_PEXEL_1	46	50	PF00026	0.378
TRG_Pf-PMV_PEXEL_1	482	487	PF00026	0.329
TRG_Pf-PMV_PEXEL_1	517	522	PF00026	0.401
TRG_Pf-PMV_PEXEL_1	539	544	PF00026	0.638

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM16	Leptomonas seymouri	78%	100%
A0A0S4J8L2	Bodo saltans	39%	76%
A0A1X0P255	Trypanosomatidae	54%	100%
A0A3S5H7M5	Leishmania donovani	93%	100%
A0A422NIF3	Trypanosoma rangeli	55%	100%
A4I5A0	Leishmania infantum	93%	100%
B3DNN5	Arabidopsis thaliana	34%	100%
C9ZQN1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	91%
E9B0J6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
P41889	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	30%	81%
Q13042	Homo sapiens	29%	88%
Q4Q7N6	Leishmania major	92%	100%
Q8R349	Mus musculus	30%	88%
V5AS70	Trypanosoma cruzi	54%	100%