Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HI22_LEIBR

TriTrypDb:

LbrM.30.0790

Length:

266

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HI22

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HI22

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0008684	2-oxopent-4-enoate hydratase activity	5	1
GO:0016829	lyase activity	2	1
GO:0016835	carbon-oxygen lyase activity	3	1
GO:0016836	hydro-lyase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	125	129	PF00656	0.363
CLV_NRD_NRD_1	95	97	PF00675	0.424
CLV_PCSK_KEX2_1	180	182	PF00082	0.579
CLV_PCSK_PC1ET2_1	180	182	PF00082	0.554
CLV_PCSK_SKI1_1	118	122	PF00082	0.355
CLV_PCSK_SKI1_1	188	192	PF00082	0.483
CLV_PCSK_SKI1_1	222	226	PF00082	0.424
CLV_PCSK_SKI1_1	230	234	PF00082	0.423
DEG_APCC_DBOX_1	1	9	PF00400	0.532
DEG_Nend_UBRbox_1	1	4	PF02207	0.630
DOC_CKS1_1	207	212	PF01111	0.449
DOC_CKS1_1	241	246	PF01111	0.378
DOC_PP4_FxxP_1	150	153	PF00568	0.357
DOC_USP7_MATH_1	228	232	PF00917	0.443
DOC_USP7_UBL2_3	225	229	PF12436	0.489
DOC_WW_Pin1_4	135	140	PF00397	0.386
DOC_WW_Pin1_4	206	211	PF00397	0.395
DOC_WW_Pin1_4	237	242	PF00397	0.323
LIG_14-3-3_CanoR_1	188	198	PF00244	0.495
LIG_14-3-3_CanoR_1	2	6	PF00244	0.547
LIG_14-3-3_CanoR_1	259	265	PF00244	0.454
LIG_14-3-3_CanoR_1	96	100	PF00244	0.493
LIG_deltaCOP1_diTrp_1	253	257	PF00928	0.382
LIG_FHA_1	185	191	PF00498	0.471
LIG_FHA_1	259	265	PF00498	0.444
LIG_FHA_1	80	86	PF00498	0.343
LIG_LIR_Gen_1	208	219	PF02991	0.438
LIG_LIR_Gen_1	261	266	PF02991	0.451
LIG_LIR_Nem_3	146	151	PF02991	0.373
LIG_LIR_Nem_3	17	21	PF02991	0.435
LIG_LIR_Nem_3	208	214	PF02991	0.436
LIG_LIR_Nem_3	253	257	PF02991	0.407
LIG_LIR_Nem_3	261	265	PF02991	0.346
LIG_LIR_Nem_3	58	64	PF02991	0.421
LIG_LYPXL_yS_3	61	64	PF13949	0.359
LIG_Pex14_2	90	94	PF04695	0.316
LIG_SH2_CRK	262	266	PF00017	0.352
LIG_SH2_STAP1	220	224	PF00017	0.336
LIG_SH2_STAP1	250	254	PF00017	0.436
LIG_SH2_STAP1	3	7	PF00017	0.402
LIG_SH2_STAT3	21	24	PF00017	0.491
LIG_SH2_STAT5	108	111	PF00017	0.377
LIG_SH2_STAT5	18	21	PF00017	0.374
LIG_SH3_3	238	244	PF00018	0.378
LIG_SH3_3	65	71	PF00018	0.300
LIG_SH3_3	82	88	PF00018	0.322
LIG_SH3_5	14	18	PF00018	0.250
LIG_Sin3_3	211	218	PF02671	0.427
LIG_TRAF2_1	55	58	PF00917	0.368
LIG_TYR_ITIM	260	265	PF00017	0.364
LIG_UBA3_1	89	97	PF00899	0.376
MOD_CDK_SPK_2	237	242	PF00069	0.328
MOD_CK1_1	131	137	PF00069	0.402
MOD_CK1_1	175	181	PF00069	0.418
MOD_CK1_1	183	189	PF00069	0.377
MOD_CK1_1	240	246	PF00069	0.348
MOD_CK2_1	28	34	PF00069	0.489
MOD_GlcNHglycan	142	146	PF01048	0.403
MOD_GlcNHglycan	201	204	PF01048	0.382
MOD_GlcNHglycan	211	214	PF01048	0.330
MOD_GlcNHglycan	8	11	PF01048	0.619
MOD_GSK3_1	131	138	PF00069	0.361
MOD_GSK3_1	166	173	PF00069	0.371
MOD_GSK3_1	180	187	PF00069	0.398
MOD_GSK3_1	75	82	PF00069	0.429
MOD_NEK2_1	1	6	PF00069	0.485
MOD_NEK2_1	141	146	PF00069	0.385
MOD_NEK2_1	184	189	PF00069	0.378
MOD_NEK2_1	260	265	PF00069	0.364
MOD_NEK2_1	48	53	PF00069	0.444
MOD_NEK2_1	79	84	PF00069	0.444
MOD_NEK2_1	8	13	PF00069	0.439
MOD_NEK2_2	228	233	PF00069	0.259
MOD_NEK2_2	75	80	PF00069	0.486
MOD_PIKK_1	79	85	PF00454	0.389
MOD_PK_1	170	176	PF00069	0.246
MOD_PK_1	97	103	PF00069	0.432
MOD_PKA_1	180	186	PF00069	0.402
MOD_PKA_2	1	7	PF00069	0.576
MOD_PKA_2	180	186	PF00069	0.402
MOD_PKA_2	258	264	PF00069	0.429
MOD_PKA_2	79	85	PF00069	0.334
MOD_PKA_2	95	101	PF00069	0.346
MOD_Plk_1	122	128	PF00069	0.496
MOD_Plk_2-3	123	129	PF00069	0.482
MOD_Plk_2-3	28	34	PF00069	0.512
MOD_Plk_4	228	234	PF00069	0.358
MOD_Plk_4	260	266	PF00069	0.387
MOD_ProDKin_1	135	141	PF00069	0.384
MOD_ProDKin_1	206	212	PF00069	0.394
MOD_ProDKin_1	237	243	PF00069	0.323
TRG_DiLeu_BaEn_1	116	121	PF01217	0.367
TRG_DiLeu_BaLyEn_6	3	8	PF01217	0.423
TRG_DiLeu_BaLyEn_6	59	64	PF01217	0.373
TRG_ENDOCYTIC_2	262	265	PF00928	0.342
TRG_ENDOCYTIC_2	61	64	PF00928	0.468
TRG_Pf-PMV_PEXEL_1	118	122	PF00026	0.355

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7W6	Leptomonas seymouri	65%	100%
A0A0S4KNC9	Bodo saltans	24%	100%
A0A1X0P382	Trypanosomatidae	40%	100%
A0A3Q8IFI2	Leishmania donovani	91%	100%
A0A422NIG2	Trypanosoma rangeli	38%	100%
A4I599	Leishmania infantum	91%	100%
C9ZQN0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9B0J5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q7N7	Leishmania major	90%	100%
Q584U2	Trypanosoma brucei brucei (strain 927/4 GUTat10.1)	38%	100%
V5BC65	Trypanosoma cruzi	37%	100%