Putative nuclear movement protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

nuclear movement protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HI21_LEIBR

TriTrypDb:

LbrM.30.0780 , LBRM2903_300013700

Length:

161

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HI21

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HI21

Function

Biological processes
Term	Name	Level	Count
GO:0006457	protein folding	2	1
GO:0009987	cellular process	1	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0051082	unfolded protein binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	132	136	PF00656	0.494
CLV_PCSK_KEX2_1	152	154	PF00082	0.603
CLV_PCSK_PC1ET2_1	152	154	PF00082	0.603
CLV_PCSK_SKI1_1	122	126	PF00082	0.545
CLV_PCSK_SKI1_1	34	38	PF00082	0.334
DEG_ODPH_VHL_1	42	55	PF01847	0.421
DEG_SCF_TRCP1_1	135	141	PF00400	0.415
DOC_CYCLIN_yCln2_LP_2	75	81	PF00134	0.453
DOC_MAPK_DCC_7	122	131	PF00069	0.523
DOC_MAPK_gen_1	122	131	PF00069	0.523
DOC_MAPK_gen_1	47	55	PF00069	0.421
DOC_MAPK_gen_1	56	64	PF00069	0.381
DOC_MAPK_HePTP_8	119	131	PF00069	0.521
DOC_MAPK_JIP1_4	56	62	PF00069	0.353
DOC_MAPK_MEF2A_6	122	131	PF00069	0.523
DOC_MAPK_MEF2A_6	34	42	PF00069	0.404
DOC_MAPK_MEF2A_6	47	55	PF00069	0.380
DOC_MAPK_MEF2A_6	56	64	PF00069	0.381
DOC_PP1_RVXF_1	115	122	PF00149	0.419
DOC_PP2B_LxvP_1	124	127	PF13499	0.573
LIG_14-3-3_CanoR_1	47	52	PF00244	0.571
LIG_BIR_II_1	1	5	PF00653	0.469
LIG_BRCT_BRCA1_1	127	131	PF00533	0.521
LIG_FHA_1	35	41	PF00498	0.420
LIG_FHA_1	83	89	PF00498	0.452
LIG_FHA_1	9	15	PF00498	0.468
LIG_LIR_Gen_1	128	138	PF02991	0.516
LIG_LIR_LC3C_4	93	96	PF02991	0.471
LIG_LIR_Nem_3	106	112	PF02991	0.398
LIG_LIR_Nem_3	120	124	PF02991	0.485
LIG_LIR_Nem_3	128	134	PF02991	0.509
LIG_LIR_Nem_3	23	27	PF02991	0.460
LIG_LIR_Nem_3	74	79	PF02991	0.397
LIG_PCNA_yPIPBox_3	139	153	PF02747	0.514
LIG_SH2_CRK	76	80	PF00017	0.397
LIG_SH2_STAP1	105	109	PF00017	0.524
LIG_SH2_STAT5	24	27	PF00017	0.653
LIG_SH2_STAT5	59	62	PF00017	0.353
LIG_SH3_3	38	44	PF00018	0.400
LIG_SUMO_SIM_anti_2	93	99	PF11976	0.421
LIG_SUMO_SIM_par_1	77	85	PF11976	0.438
LIG_WRC_WIRS_1	26	31	PF05994	0.256
MOD_CK1_1	66	72	PF00069	0.378
MOD_CK2_1	29	35	PF00069	0.461
MOD_GlcNHglycan	135	138	PF01048	0.452
MOD_GSK3_1	125	132	PF00069	0.518
MOD_GSK3_1	25	32	PF00069	0.286
MOD_GSK3_1	43	50	PF00069	0.354
MOD_GSK3_1	77	84	PF00069	0.374
MOD_NEK2_1	98	103	PF00069	0.586
MOD_NEK2_2	22	27	PF00069	0.492
MOD_PIKK_1	3	9	PF00454	0.487
MOD_PK_1	125	131	PF00069	0.524
MOD_PK_1	77	83	PF00069	0.353
MOD_PKA_2	129	135	PF00069	0.519
MOD_Plk_1	22	28	PF00069	0.516
MOD_Plk_1	34	40	PF00069	0.390
MOD_Plk_1	82	88	PF00069	0.396
MOD_Plk_4	22	28	PF00069	0.489
MOD_Plk_4	66	72	PF00069	0.479
MOD_SUMO_rev_2	116	124	PF00179	0.480
MOD_SUMO_rev_2	50	57	PF00179	0.421
TRG_ENDOCYTIC_2	59	62	PF00928	0.470
TRG_ENDOCYTIC_2	76	79	PF00928	0.387

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4KHK6	Bodo saltans	57%	89%
A0A1X0P2C4	Trypanosomatidae	58%	92%
A0A3R7L0Q9	Trypanosoma rangeli	57%	92%
A0A3S7X365	Leishmania donovani	87%	100%
A4I598	Leishmania infantum	87%	100%
E9B0J4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
O60166	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	41%	97%
P17624	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	32%	81%
Q4Q7N8	Leishmania major	85%	100%
Q54M64	Dictyostelium discoideum	30%	94%