PDZ domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

pdz domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HI17_LEIBR

TriTrypDb:

LbrM.30.0740 , LBRM2903_300013300

Length:

731

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 10

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HI17

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HI17

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	13
GO:0007165	signal transduction	2	13
GO:0008152	metabolic process	1	13
GO:0009987	cellular process	1	13
GO:0035556	intracellular signal transduction	3	13
GO:0044238	primary metabolic process	2	13
GO:0050789	regulation of biological process	2	13
GO:0050794	regulation of cellular process	3	13
GO:0065007	biological regulation	1	13
GO:0071704	organic substance metabolic process	2	13
GO:0048015	phosphatidylinositol-mediated signaling	5	1
GO:0048017	inositol lipid-mediated signaling	4	1
GO:0009056	catabolic process	2	1
GO:0016042	lipid catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	13
GO:0008081	phosphoric diester hydrolase activity	5	13
GO:0016787	hydrolase activity	2	13
GO:0016788	hydrolase activity, acting on ester bonds	3	13
GO:0042578	phosphoric ester hydrolase activity	4	13
GO:0004435	phosphatidylinositol phospholipase C activity	7	2
GO:0004620	phospholipase activity	5	2
GO:0004629	phospholipase C activity	6	2
GO:0016298	lipase activity	4	2
GO:0005488	binding	1	1
GO:0005509	calcium ion binding	5	1
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	576	580	PF00656	0.606
CLV_C14_Caspase3-7	61	65	PF00656	0.442
CLV_C14_Caspase3-7	90	94	PF00656	0.356
CLV_NRD_NRD_1	413	415	PF00675	0.240
CLV_NRD_NRD_1	496	498	PF00675	0.476
CLV_NRD_NRD_1	555	557	PF00675	0.484
CLV_PCSK_KEX2_1	28	30	PF00082	0.775
CLV_PCSK_KEX2_1	314	316	PF00082	0.473
CLV_PCSK_KEX2_1	496	498	PF00082	0.511
CLV_PCSK_PC1ET2_1	28	30	PF00082	0.775
CLV_PCSK_PC1ET2_1	314	316	PF00082	0.473
CLV_PCSK_SKI1_1	133	137	PF00082	0.436
CLV_PCSK_SKI1_1	158	162	PF00082	0.490
CLV_PCSK_SKI1_1	213	217	PF00082	0.422
CLV_PCSK_SKI1_1	249	253	PF00082	0.549
CLV_PCSK_SKI1_1	314	318	PF00082	0.410
CLV_PCSK_SKI1_1	36	40	PF00082	0.758
CLV_PCSK_SKI1_1	415	419	PF00082	0.239
CLV_PCSK_SKI1_1	557	561	PF00082	0.569
CLV_PCSK_SKI1_1	690	694	PF00082	0.494
CLV_PCSK_SKI1_1	78	82	PF00082	0.365
DEG_APCC_DBOX_1	117	125	PF00400	0.504
DEG_APCC_DBOX_1	480	488	PF00400	0.367
DEG_APCC_DBOX_1	496	504	PF00400	0.503
DOC_ANK_TNKS_1	314	321	PF00023	0.455
DOC_CKS1_1	368	373	PF01111	0.360
DOC_CYCLIN_RxL_1	130	141	PF00134	0.467
DOC_CYCLIN_RxL_1	155	165	PF00134	0.493
DOC_CYCLIN_RxL_1	72	82	PF00134	0.384
DOC_MAPK_gen_1	114	123	PF00069	0.422
DOC_MAPK_gen_1	425	432	PF00069	0.487
DOC_MAPK_MEF2A_6	114	123	PF00069	0.438
DOC_MAPK_MEF2A_6	425	432	PF00069	0.463
DOC_MAPK_MEF2A_6	439	446	PF00069	0.246
DOC_MAPK_MEF2A_6	98	105	PF00069	0.406
DOC_MAPK_NFAT4_5	116	124	PF00069	0.561
DOC_MAPK_NFAT4_5	98	106	PF00069	0.486
DOC_PP1_RVXF_1	192	199	PF00149	0.495
DOC_PP1_RVXF_1	597	604	PF00149	0.393
DOC_PP1_RVXF_1	73	80	PF00149	0.286
DOC_PP2B_LxvP_1	135	138	PF13499	0.525
DOC_USP7_MATH_1	17	21	PF00917	0.611
DOC_USP7_MATH_1	284	288	PF00917	0.566
DOC_USP7_MATH_1	518	522	PF00917	0.473
DOC_USP7_MATH_1	545	549	PF00917	0.530
DOC_USP7_MATH_1	645	649	PF00917	0.561
DOC_USP7_MATH_1	707	711	PF00917	0.484
DOC_USP7_UBL2_3	116	120	PF12436	0.476
DOC_WW_Pin1_4	11	16	PF00397	0.651
DOC_WW_Pin1_4	364	369	PF00397	0.385
DOC_WW_Pin1_4	406	411	PF00397	0.330
DOC_WW_Pin1_4	450	455	PF00397	0.309
DOC_WW_Pin1_4	624	629	PF00397	0.503
DOC_WW_Pin1_4	641	646	PF00397	0.564
LIG_14-3-3_CanoR_1	207	212	PF00244	0.410
LIG_14-3-3_CanoR_1	221	229	PF00244	0.444
LIG_14-3-3_CanoR_1	285	293	PF00244	0.514
LIG_14-3-3_CanoR_1	599	604	PF00244	0.390
LIG_14-3-3_CanoR_1	690	700	PF00244	0.501
LIG_14-3-3_CanoR_1	86	92	PF00244	0.387
LIG_Actin_WH2_2	298	316	PF00022	0.317
LIG_Actin_WH2_2	465	483	PF00022	0.360
LIG_BIR_III_4	579	583	PF00653	0.419
LIG_BRCT_BRCA1_1	523	527	PF00533	0.523
LIG_deltaCOP1_diTrp_1	288	297	PF00928	0.444
LIG_deltaCOP1_diTrp_1	47	52	PF00928	0.527
LIG_FHA_1	123	129	PF00498	0.420
LIG_FHA_1	183	189	PF00498	0.488
LIG_FHA_1	284	290	PF00498	0.435
LIG_FHA_1	357	363	PF00498	0.396
LIG_FHA_1	539	545	PF00498	0.469
LIG_FHA_1	549	555	PF00498	0.428
LIG_FHA_1	673	679	PF00498	0.387
LIG_FHA_2	307	313	PF00498	0.516
LIG_FHA_2	343	349	PF00498	0.367
LIG_FHA_2	42	48	PF00498	0.524
LIG_FHA_2	553	559	PF00498	0.526
LIG_FHA_2	571	577	PF00498	0.603
LIG_FHA_2	618	624	PF00498	0.606
LIG_FHA_2	667	673	PF00498	0.449
LIG_GBD_Chelix_1	380	388	PF00786	0.342
LIG_Integrin_isoDGR_2	611	613	PF01839	0.461
LIG_LIR_Gen_1	153	164	PF02991	0.375
LIG_LIR_Gen_1	169	178	PF02991	0.349
LIG_LIR_Gen_1	197	206	PF02991	0.374
LIG_LIR_Gen_1	216	224	PF02991	0.531
LIG_LIR_Gen_1	287	297	PF02991	0.435
LIG_LIR_Gen_1	74	84	PF02991	0.377
LIG_LIR_Gen_1	85	96	PF02991	0.407
LIG_LIR_Nem_3	153	159	PF02991	0.358
LIG_LIR_Nem_3	185	190	PF02991	0.552
LIG_LIR_Nem_3	197	201	PF02991	0.368
LIG_LIR_Nem_3	216	222	PF02991	0.528
LIG_LIR_Nem_3	294	300	PF02991	0.530
LIG_LIR_Nem_3	357	363	PF02991	0.349
LIG_LIR_Nem_3	524	530	PF02991	0.408
LIG_LIR_Nem_3	629	635	PF02991	0.428
LIG_LIR_Nem_3	74	79	PF02991	0.471
LIG_LIR_Nem_3	85	91	PF02991	0.551
LIG_LYPXL_yS_3	360	363	PF13949	0.330
LIG_PCNA_PIPBox_1	180	189	PF02747	0.527
LIG_PCNA_yPIPBox_3	180	194	PF02747	0.561
LIG_Pex14_1	48	52	PF04695	0.527
LIG_Pex14_2	255	259	PF04695	0.419
LIG_Pex14_2	692	696	PF04695	0.343
LIG_PTB_Apo_2	164	171	PF02174	0.518
LIG_PTB_Apo_2	181	188	PF02174	0.525
LIG_PTB_Phospho_1	164	170	PF10480	0.411
LIG_PTB_Phospho_1	181	187	PF10480	0.610
LIG_SH2_CRK	266	270	PF00017	0.498
LIG_SH2_CRK	705	709	PF00017	0.364
LIG_SH2_CRK	727	731	PF00017	0.385
LIG_SH2_GRB2like	530	533	PF00017	0.344
LIG_SH2_STAP1	170	174	PF00017	0.403
LIG_SH2_STAT3	22	25	PF00017	0.618
LIG_SH2_STAT5	187	190	PF00017	0.550
LIG_SH2_STAT5	616	619	PF00017	0.384
LIG_SH2_STAT5	727	730	PF00017	0.382
LIG_SH3_3	365	371	PF00018	0.402
LIG_SUMO_SIM_anti_2	674	680	PF11976	0.383
LIG_SUMO_SIM_par_1	99	104	PF11976	0.402
LIG_TRAF2_1	713	716	PF00917	0.468
LIG_UBA3_1	127	136	PF00899	0.392
MOD_CAAXbox	728	731	PF01239	0.385
MOD_CDK_SPxxK_3	450	457	PF00069	0.309
MOD_CK1_1	228	234	PF00069	0.628
MOD_CK1_1	244	250	PF00069	0.449
MOD_CK1_1	274	280	PF00069	0.423
MOD_CK1_1	367	373	PF00069	0.517
MOD_CK1_1	521	527	PF00069	0.544
MOD_CK1_1	531	537	PF00069	0.546
MOD_CK1_1	548	554	PF00069	0.509
MOD_CK1_1	570	576	PF00069	0.419
MOD_CK1_1	644	650	PF00069	0.483
MOD_CK1_1	664	670	PF00069	0.476
MOD_CK1_1	710	716	PF00069	0.498
MOD_CK2_1	105	111	PF00069	0.400
MOD_CK2_1	342	348	PF00069	0.342
MOD_CK2_1	41	47	PF00069	0.521
MOD_CK2_1	5	11	PF00069	0.688
MOD_CK2_1	710	716	PF00069	0.448
MOD_GlcNHglycan	19	22	PF01048	0.586
MOD_GlcNHglycan	389	392	PF01048	0.354
MOD_GlcNHglycan	518	521	PF01048	0.424
MOD_GlcNHglycan	693	696	PF01048	0.400
MOD_GlcNHglycan	7	10	PF01048	0.579
MOD_GlcNHglycan	71	74	PF01048	0.602
MOD_GlcNHglycan	712	715	PF01048	0.435
MOD_GSK3_1	101	108	PF00069	0.421
MOD_GSK3_1	122	129	PF00069	0.469
MOD_GSK3_1	162	169	PF00069	0.442
MOD_GSK3_1	17	24	PF00069	0.730
MOD_GSK3_1	267	274	PF00069	0.412
MOD_GSK3_1	291	298	PF00069	0.410
MOD_GSK3_1	37	44	PF00069	0.491
MOD_GSK3_1	514	521	PF00069	0.444
MOD_GSK3_1	544	551	PF00069	0.477
MOD_GSK3_1	567	574	PF00069	0.467
MOD_GSK3_1	617	624	PF00069	0.487
MOD_GSK3_1	641	648	PF00069	0.535
MOD_GSK3_1	87	94	PF00069	0.362
MOD_N-GLC_1	271	276	PF02516	0.533
MOD_N-GLC_1	384	389	PF02516	0.237
MOD_N-GLC_1	528	533	PF02516	0.508
MOD_N-GLC_1	641	646	PF02516	0.564
MOD_N-GLC_1	649	654	PF02516	0.555
MOD_N-GLC_1	661	666	PF02516	0.414
MOD_N-GLC_2	107	109	PF02516	0.362
MOD_N-GLC_2	193	195	PF02516	0.321
MOD_NEK2_1	103	108	PF00069	0.325
MOD_NEK2_1	127	132	PF00069	0.430
MOD_NEK2_1	293	298	PF00069	0.503
MOD_NEK2_1	480	485	PF00069	0.386
MOD_NEK2_1	528	533	PF00069	0.429
MOD_NEK2_1	549	554	PF00069	0.554
MOD_NEK2_1	649	654	PF00069	0.583
MOD_NEK2_1	661	666	PF00069	0.447
MOD_NEK2_1	688	693	PF00069	0.338
MOD_NEK2_1	87	92	PF00069	0.456
MOD_NEK2_2	628	633	PF00069	0.329
MOD_NMyristoyl	1	7	PF02799	0.648
MOD_PIKK_1	21	27	PF00454	0.849
MOD_PIKK_1	291	297	PF00454	0.380
MOD_PIKK_1	549	555	PF00454	0.440
MOD_PIKK_1	661	667	PF00454	0.508
MOD_PIKK_1	91	97	PF00454	0.476
MOD_PK_1	207	213	PF00069	0.418
MOD_PKA_1	314	320	PF00069	0.552
MOD_PKA_2	220	226	PF00069	0.438
MOD_PKA_2	284	290	PF00069	0.440
MOD_PKA_2	314	320	PF00069	0.552
MOD_PKA_2	444	450	PF00069	0.313
MOD_PKA_2	480	486	PF00069	0.360
MOD_PKA_2	606	612	PF00069	0.494
MOD_PKA_2	716	722	PF00069	0.566
MOD_Plk_1	140	146	PF00069	0.528
MOD_Plk_1	384	390	PF00069	0.317
MOD_Plk_1	491	497	PF00069	0.324
MOD_Plk_1	570	576	PF00069	0.558
MOD_Plk_1	628	634	PF00069	0.452
MOD_Plk_1	649	655	PF00069	0.597
MOD_Plk_1	671	677	PF00069	0.292
MOD_Plk_1	688	694	PF00069	0.466
MOD_Plk_2-3	342	348	PF00069	0.456
MOD_Plk_2-3	571	577	PF00069	0.384
MOD_Plk_4	182	188	PF00069	0.509
MOD_Plk_4	271	277	PF00069	0.381
MOD_Plk_4	342	348	PF00069	0.369
MOD_Plk_4	545	551	PF00069	0.547
MOD_Plk_4	707	713	PF00069	0.309
MOD_ProDKin_1	11	17	PF00069	0.653
MOD_ProDKin_1	364	370	PF00069	0.385
MOD_ProDKin_1	406	412	PF00069	0.330
MOD_ProDKin_1	450	456	PF00069	0.309
MOD_ProDKin_1	624	630	PF00069	0.490
MOD_ProDKin_1	641	647	PF00069	0.563
MOD_SPalmitoyl_4	1	7	PF01529	0.699
MOD_SUMO_rev_2	130	138	PF00179	0.401
MOD_SUMO_rev_2	308	316	PF00179	0.485
MOD_SUMO_rev_2	498	506	PF00179	0.462
MOD_SUMO_rev_2	531	538	PF00179	0.583
TRG_AP2beta_CARGO_1	217	226	PF09066	0.439
TRG_DiLeu_BaLyEn_6	135	140	PF01217	0.537
TRG_DiLeu_BaLyEn_6	636	641	PF01217	0.497
TRG_ENDOCYTIC_2	170	173	PF00928	0.523
TRG_ENDOCYTIC_2	266	269	PF00928	0.490
TRG_ENDOCYTIC_2	360	363	PF00928	0.330
TRG_ENDOCYTIC_2	705	708	PF00928	0.349
TRG_ENDOCYTIC_2	727	730	PF00928	0.365
TRG_ER_diArg_1	495	497	PF00400	0.456
TRG_ER_diArg_1	605	608	PF00400	0.501
TRG_NES_CRM1_1	424	436	PF08389	0.315
TRG_Pf-PMV_PEXEL_1	78	82	PF00026	0.493

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7S8	Leptomonas seymouri	71%	99%
A0A0S4KHF2	Bodo saltans	42%	100%
A0A1X0P2U3	Trypanosomatidae	45%	100%
A0A3Q8IES3	Leishmania donovani	86%	100%
A0A3R7MG69	Trypanosoma rangeli	44%	96%
A4I027	Leishmania infantum	24%	93%
A4I594	Leishmania infantum	86%	100%
C9ZQM5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
E9B0J1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	99%
Q4Q7P2	Leishmania major	86%	100%
V5AS75	Trypanosoma cruzi	47%	100%