Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HI16_LEIBR

TriTrypDb:

LbrM.30.0730 , LBRM2903_300013200

Length:

397

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HI16

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HI16

PDB structure(s): 7ane_aj

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	171	175	PF00656	0.515
CLV_NRD_NRD_1	264	266	PF00675	0.392
CLV_NRD_NRD_1	3	5	PF00675	0.600
CLV_PCSK_KEX2_1	3	5	PF00082	0.600
CLV_PCSK_KEX2_1	389	391	PF00082	0.616
CLV_PCSK_PC1ET2_1	389	391	PF00082	0.622
CLV_PCSK_SKI1_1	179	183	PF00082	0.450
CLV_PCSK_SKI1_1	184	188	PF00082	0.490
CLV_PCSK_SKI1_1	218	222	PF00082	0.412
CLV_PCSK_SKI1_1	257	261	PF00082	0.383
CLV_PCSK_SKI1_1	265	269	PF00082	0.370
CLV_PCSK_SKI1_1	384	388	PF00082	0.522
DEG_APCC_DBOX_1	217	225	PF00400	0.441
DEG_APCC_KENBOX_2	289	293	PF00400	0.445
DEG_Nend_Nbox_1	1	3	PF02207	0.614
DEG_SCF_FBW7_2	92	99	PF00400	0.468
DOC_CKS1_1	196	201	PF01111	0.491
DOC_CKS1_1	93	98	PF01111	0.467
DOC_CYCLIN_RxL_1	254	264	PF00134	0.374
DOC_CYCLIN_yCln2_LP_2	48	54	PF00134	0.631
DOC_MAPK_gen_1	265	272	PF00069	0.407
DOC_PP1_RVXF_1	263	270	PF00149	0.390
DOC_PP1_RVXF_1	312	319	PF00149	0.465
DOC_PP2B_LxvP_1	285	288	PF13499	0.456
DOC_PP2B_LxvP_1	48	51	PF13499	0.615
DOC_PP4_FxxP_1	196	199	PF00568	0.502
DOC_USP7_MATH_1	369	373	PF00917	0.707
DOC_USP7_MATH_1	54	58	PF00917	0.504
DOC_WW_Pin1_4	10	15	PF00397	0.524
DOC_WW_Pin1_4	105	110	PF00397	0.461
DOC_WW_Pin1_4	17	22	PF00397	0.459
DOC_WW_Pin1_4	190	195	PF00397	0.401
DOC_WW_Pin1_4	309	314	PF00397	0.434
DOC_WW_Pin1_4	318	323	PF00397	0.455
DOC_WW_Pin1_4	92	97	PF00397	0.466
LIG_14-3-3_CanoR_1	271	275	PF00244	0.405
LIG_14-3-3_CanoR_1	3	12	PF00244	0.542
LIG_14-3-3_CanoR_1	40	45	PF00244	0.514
LIG_BRCT_BRCA1_1	387	391	PF00533	0.707
LIG_Clathr_ClatBox_1	76	80	PF01394	0.539
LIG_deltaCOP1_diTrp_1	118	125	PF00928	0.439
LIG_deltaCOP1_diTrp_1	177	182	PF00928	0.448
LIG_deltaCOP1_diTrp_1	188	196	PF00928	0.355
LIG_eIF4E_1	254	260	PF01652	0.386
LIG_FHA_1	181	187	PF00498	0.530
LIG_FHA_2	271	277	PF00498	0.441
LIG_LIR_Apic_2	193	199	PF02991	0.506
LIG_LIR_Gen_1	102	111	PF02991	0.501
LIG_LIR_Gen_1	198	208	PF02991	0.367
LIG_LIR_Gen_1	273	282	PF02991	0.432
LIG_LIR_Nem_3	102	107	PF02991	0.473
LIG_LIR_Nem_3	176	181	PF02991	0.423
LIG_LIR_Nem_3	198	204	PF02991	0.391
LIG_LIR_Nem_3	273	277	PF02991	0.392
LIG_LIR_Nem_3	293	299	PF02991	0.200
LIG_LIR_Nem_3	367	373	PF02991	0.616
LIG_LIR_Nem_3	377	382	PF02991	0.603
LIG_Pex14_1	178	182	PF04695	0.380
LIG_SH2_CRK	12	16	PF00017	0.503
LIG_SH2_CRK	252	256	PF00017	0.455
LIG_SH2_CRK	32	36	PF00017	0.267
LIG_SH2_NCK_1	12	16	PF00017	0.503
LIG_SH2_NCK_1	32	36	PF00017	0.267
LIG_SH2_SRC	52	55	PF00017	0.618
LIG_SH2_STAP1	241	245	PF00017	0.469
LIG_SH2_STAP1	364	368	PF00017	0.621
LIG_SH2_STAT5	12	15	PF00017	0.512
LIG_SH2_STAT5	192	195	PF00017	0.403
LIG_SH2_STAT5	203	206	PF00017	0.386
LIG_SH2_STAT5	254	257	PF00017	0.382
LIG_SH2_STAT5	258	261	PF00017	0.369
LIG_SH2_STAT5	317	320	PF00017	0.452
LIG_SH2_STAT5	357	360	PF00017	0.522
LIG_SH3_1	90	96	PF00018	0.483
LIG_SH3_3	11	17	PF00018	0.501
LIG_SH3_3	155	161	PF00018	0.474
LIG_SH3_3	48	54	PF00018	0.631
LIG_SH3_3	90	96	PF00018	0.483
LIG_TRAF2_1	374	377	PF00917	0.592
LIG_TYR_ITIM	10	15	PF00017	0.524
LIG_TYR_ITIM	272	277	PF00017	0.415
LIG_WW_2	158	161	PF00397	0.462
MOD_CDK_SPK_2	309	314	PF00069	0.446
MOD_CK1_1	173	179	PF00069	0.366
MOD_CK1_1	195	201	PF00069	0.540
MOD_CK1_1	328	334	PF00069	0.690
MOD_CK2_1	130	136	PF00069	0.496
MOD_GlcNHglycan	132	135	PF01048	0.483
MOD_GlcNHglycan	155	158	PF01048	0.587
MOD_GlcNHglycan	327	330	PF01048	0.651
MOD_GlcNHglycan	393	396	PF01048	0.729
MOD_GSK3_1	195	202	PF00069	0.459
MOD_GSK3_1	325	332	PF00069	0.605
MOD_GSK3_1	40	47	PF00069	0.558
MOD_N-GLC_1	190	195	PF02516	0.406
MOD_N-GLC_1	291	296	PF02516	0.537
MOD_N-GLC_1	44	49	PF02516	0.516
MOD_NEK2_1	130	135	PF00069	0.516
MOD_NEK2_1	168	173	PF00069	0.375
MOD_NEK2_1	2	7	PF00069	0.610
MOD_NEK2_1	204	209	PF00069	0.397
MOD_NEK2_1	23	28	PF00069	0.518
MOD_NEK2_1	270	275	PF00069	0.417
MOD_NEK2_1	325	330	PF00069	0.568
MOD_NEK2_2	301	306	PF00069	0.387
MOD_PIKK_1	23	29	PF00454	0.449
MOD_PK_1	40	46	PF00069	0.572
MOD_PKA_1	3	9	PF00069	0.575
MOD_PKA_2	2	8	PF00069	0.571
MOD_PKA_2	270	276	PF00069	0.417
MOD_PKA_2	39	45	PF00069	0.589
MOD_Plk_1	291	297	PF00069	0.543
MOD_Plk_1	44	50	PF00069	0.515
MOD_Plk_4	291	297	PF00069	0.543
MOD_ProDKin_1	10	16	PF00069	0.516
MOD_ProDKin_1	105	111	PF00069	0.453
MOD_ProDKin_1	17	23	PF00069	0.455
MOD_ProDKin_1	190	196	PF00069	0.395
MOD_ProDKin_1	309	315	PF00069	0.437
MOD_ProDKin_1	318	324	PF00069	0.461
MOD_ProDKin_1	92	98	PF00069	0.469
TRG_DiLeu_BaEn_1	235	240	PF01217	0.480
TRG_DiLeu_BaLyEn_6	106	111	PF01217	0.475
TRG_DiLeu_BaLyEn_6	5	10	PF01217	0.711
TRG_ENDOCYTIC_2	12	15	PF00928	0.512
TRG_ENDOCYTIC_2	252	255	PF00928	0.366
TRG_ENDOCYTIC_2	274	277	PF00928	0.374
TRG_ENDOCYTIC_2	62	65	PF00928	0.413
TRG_ER_diArg_1	2	4	PF00400	0.612
TRG_Pf-PMV_PEXEL_1	314	319	PF00026	0.473

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I176	Leptomonas seymouri	84%	100%
A0A0S4KKK6	Bodo saltans	50%	100%
A0A1X0P238	Trypanosomatidae	74%	100%
A0A3S7X327	Leishmania donovani	95%	100%
A0A422NIE7	Trypanosoma rangeli	73%	100%
A4I593	Leishmania infantum	95%	100%
C9ZQM4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	71%	100%
E9B0J0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4Q7Q8	Leishmania major	95%	100%
V5D870	Trypanosoma cruzi	73%	100%