Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HI15_LEIBR

TriTrypDb:

LbrM.30.0720 , LBRM2903_300013100

Length:

198

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HI15

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HI15

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	102	104	PF00675	0.545
CLV_NRD_NRD_1	164	166	PF00675	0.575
CLV_NRD_NRD_1	193	195	PF00675	0.502
CLV_PCSK_KEX2_1	164	166	PF00082	0.575
CLV_PCSK_KEX2_1	193	195	PF00082	0.543
CLV_PCSK_SKI1_1	115	119	PF00082	0.682
DEG_Nend_Nbox_1	1	3	PF02207	0.589
DOC_MAPK_gen_1	164	171	PF00069	0.564
DOC_MAPK_JIP1_4	165	171	PF00069	0.598
DOC_PP2B_LxvP_1	160	163	PF13499	0.537
DOC_PP2B_PxIxI_1	183	189	PF00149	0.464
DOC_USP7_MATH_1	121	125	PF00917	0.692
DOC_WW_Pin1_4	14	19	PF00397	0.546
LIG_14-3-3_CanoR_1	3	8	PF00244	0.604
LIG_14-3-3_CanoR_1	60	66	PF00244	0.410
LIG_AP2alpha_2	196	198	PF02296	0.511
LIG_BRCT_BRCA1_1	15	19	PF00533	0.574
LIG_FHA_1	15	21	PF00498	0.561
LIG_FHA_2	187	193	PF00498	0.476
LIG_LIR_Nem_3	127	132	PF02991	0.482
LIG_LIR_Nem_3	51	56	PF02991	0.521
LIG_NRBOX	96	102	PF00104	0.553
LIG_Pex14_2	59	63	PF04695	0.389
LIG_REV1ctd_RIR_1	115	123	PF16727	0.659
LIG_REV1ctd_RIR_1	50	58	PF16727	0.549
LIG_SH2_CRK	80	84	PF00017	0.501
LIG_SH2_NCK_1	125	129	PF00017	0.483
LIG_SH2_STAP1	125	129	PF00017	0.483
LIG_SH2_STAP1	75	79	PF00017	0.399
LIG_SH2_STAT5	85	88	PF00017	0.446
LIG_SH3_3	150	156	PF00018	0.503
LIG_SH3_3	160	166	PF00018	0.595
LIG_SH3_3	55	61	PF00018	0.543
MOD_CK1_1	124	130	PF00069	0.735
MOD_CK2_1	186	192	PF00069	0.474
MOD_Cter_Amidation	101	104	PF01082	0.594
MOD_GlcNHglycan	126	129	PF01048	0.678
MOD_GlcNHglycan	134	137	PF01048	0.616
MOD_GSK3_1	120	127	PF00069	0.689
MOD_GSK3_1	143	150	PF00069	0.540
MOD_GSK3_1	3	10	PF00069	0.614
MOD_GSK3_1	61	68	PF00069	0.414
MOD_N-GLC_1	14	19	PF02516	0.585
MOD_NEK2_1	13	18	PF00069	0.560
MOD_PK_1	3	9	PF00069	0.643
MOD_Plk_1	144	150	PF00069	0.429
MOD_Plk_4	3	9	PF00069	0.604
MOD_ProDKin_1	14	20	PF00069	0.536
TRG_DiLeu_BaLyEn_6	89	94	PF01217	0.513
TRG_ENDOCYTIC_2	80	83	PF00928	0.421
TRG_ENDOCYTIC_2	85	88	PF00928	0.404
TRG_ER_diArg_1	163	165	PF00400	0.582

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7F0	Leptomonas seymouri	78%	100%
A0A0S4JPS5	Bodo saltans	37%	100%
A0A1X0P291	Trypanosomatidae	56%	100%
A0A3S7X362	Leishmania donovani	88%	100%
A0A422NIE5	Trypanosoma rangeli	57%	100%
A4I592	Leishmania infantum	88%	100%
C9ZQM3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	100%
E9B0I9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4Q7Q9	Leishmania major	86%	100%