Ribosome biogenesis regulatory protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ribosome biogenesis regulatory protein (RRS1), putative

Species:

Leishmania braziliensis

UniProt:

A4HI13_LEIBR

TriTrypDb:

LbrM.30.0700 , LBRM2903_300012800

Length:

216

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	10
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	10
GO:0043229	intracellular organelle	3	11
GO:0043231	intracellular membrane-bounded organelle	4	10
GO:0110165	cellular anatomical entity	1	11
GO:0005730	nucleolus	5	1
GO:0030684	preribosome	3	1
GO:0030687	preribosome, large subunit precursor	4	1
GO:0032991	protein-containing complex	1	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

A4HI13

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HI13

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	11
GO:0022613	ribonucleoprotein complex biogenesis	4	11
GO:0042254	ribosome biogenesis	5	10
GO:0044085	cellular component biogenesis	3	11
GO:0071840	cellular component organization or biogenesis	2	11
GO:0000054	ribosomal subunit export from nucleus	3	1
GO:0000055	ribosomal large subunit export from nucleus	4	1
GO:0000447	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	10	1
GO:0000469	cleavage involved in rRNA processing	7	1
GO:0000478	endonucleolytic cleavage involved in rRNA processing	8	1
GO:0000479	endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	9	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0006810	transport	3	1
GO:0006913	nucleocytoplasmic transport	5	1
GO:0008152	metabolic process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0031503	protein-containing complex localization	2	1
GO:0033750	ribosome localization	3	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0042273	ribosomal large subunit biogenesis	5	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0046907	intracellular transport	3	1
GO:0051168	nuclear export	6	1
GO:0051169	nuclear transport	4	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051640	organelle localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0051656	establishment of organelle localization	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:0090305	nucleic acid phosphodiester bond hydrolysis	5	1
GO:0090501	RNA phosphodiester bond hydrolysis	6	1
GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic	7	1
GO:1901360	organic cyclic compound metabolic process	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	172	174	PF00675	0.588
CLV_NRD_NRD_1	24	26	PF00675	0.378
CLV_NRD_NRD_1	99	101	PF00675	0.303
CLV_PCSK_KEX2_1	120	122	PF00082	0.303
CLV_PCSK_KEX2_1	171	173	PF00082	0.603
CLV_PCSK_KEX2_1	206	208	PF00082	0.668
CLV_PCSK_KEX2_1	213	215	PF00082	0.693
CLV_PCSK_KEX2_1	24	26	PF00082	0.378
CLV_PCSK_PC1ET2_1	120	122	PF00082	0.303
CLV_PCSK_PC1ET2_1	171	173	PF00082	0.603
CLV_PCSK_PC1ET2_1	206	208	PF00082	0.668
CLV_PCSK_PC1ET2_1	213	215	PF00082	0.707
CLV_PCSK_SKI1_1	133	137	PF00082	0.415
CLV_PCSK_SKI1_1	206	210	PF00082	0.662
CLV_PCSK_SKI1_1	38	42	PF00082	0.326
CLV_PCSK_SKI1_1	82	86	PF00082	0.323
DOC_CYCLIN_RxL_1	35	43	PF00134	0.317
DOC_MAPK_gen_1	171	177	PF00069	0.487
DOC_USP7_UBL2_3	162	166	PF12436	0.323
DOC_USP7_UBL2_3	206	210	PF12436	0.571
DOC_USP7_UBL2_3	76	80	PF12436	0.303
DOC_USP7_UBL2_3	89	93	PF12436	0.303
LIG_14-3-3_CanoR_1	172	176	PF00244	0.672
LIG_14-3-3_CanoR_1	192	202	PF00244	0.625
LIG_AP2alpha_2	147	149	PF02296	0.303
LIG_BIR_II_1	1	5	PF00653	0.324
LIG_deltaCOP1_diTrp_1	113	118	PF00928	0.317
LIG_FHA_1	210	216	PF00498	0.720
LIG_FHA_1	32	38	PF00498	0.323
LIG_FHA_1	58	64	PF00498	0.294
LIG_FHA_2	10	16	PF00498	0.415
LIG_FHA_2	52	58	PF00498	0.448
LIG_LIR_Gen_1	127	135	PF02991	0.346
LIG_LIR_Gen_1	43	51	PF02991	0.415
LIG_LIR_Gen_1	85	92	PF02991	0.303
LIG_LIR_Nem_3	127	132	PF02991	0.346
LIG_LIR_Nem_3	43	47	PF02991	0.448
LIG_LIR_Nem_3	85	90	PF02991	0.303
LIG_NRBOX	36	42	PF00104	0.415
LIG_SH2_NCK_1	56	60	PF00017	0.397
LIG_SH3_3	16	22	PF00018	0.353
LIG_SH3_3	42	48	PF00018	0.402
LIG_SH3_3	60	66	PF00018	0.168
LIG_SUMO_SIM_par_1	9	15	PF11976	0.376
LIG_TRAF2_1	180	183	PF00917	0.583
MOD_CK1_1	17	23	PF00069	0.319
MOD_CK1_1	188	194	PF00069	0.563
MOD_CK1_1	195	201	PF00069	0.492
MOD_CK1_1	31	37	PF00069	0.415
MOD_CK1_1	58	64	PF00069	0.415
MOD_CK2_1	51	57	PF00069	0.415
MOD_Cter_Amidation	118	121	PF01082	0.303
MOD_GlcNHglycan	136	139	PF01048	0.443
MOD_GlcNHglycan	187	190	PF01048	0.658
MOD_GlcNHglycan	19	22	PF01048	0.303
MOD_GlcNHglycan	57	60	PF01048	0.415
MOD_GSK3_1	11	18	PF00069	0.365
MOD_GSK3_1	188	195	PF00069	0.547
MOD_GSK3_1	51	58	PF00069	0.415
MOD_LATS_1	169	175	PF00433	0.593
MOD_N-GLC_1	192	197	PF02516	0.612
MOD_NEK2_1	29	34	PF00069	0.323
MOD_PK_1	171	177	PF00069	0.487
MOD_PKA_1	100	106	PF00069	0.225
MOD_PKA_1	171	177	PF00069	0.595
MOD_PKA_1	209	215	PF00069	0.682
MOD_PKA_2	171	177	PF00069	0.595
MOD_Plk_1	14	20	PF00069	0.323
MOD_Plk_4	58	64	PF00069	0.323
MOD_SUMO_rev_2	130	137	PF00179	0.415
MOD_SUMO_rev_2	182	187	PF00179	0.645
TRG_DiLeu_BaEn_4	182	188	PF01217	0.574
TRG_ENDOCYTIC_2	129	132	PF00928	0.376
TRG_ER_diArg_1	23	25	PF00400	0.408
TRG_NLS_MonoExtC_3	205	210	PF00514	0.592
TRG_NLS_MonoExtC_3	51	57	PF00514	0.304
TRG_NLS_MonoExtN_4	204	210	PF00514	0.626

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCW0	Leptomonas seymouri	90%	100%
A0A0S4JMK3	Bodo saltans	63%	100%
A0A1X0P2F9	Trypanosomatidae	68%	100%
A0A3Q8IEM7	Leishmania donovani	93%	100%
A0A3R7KCB8	Trypanosoma rangeli	68%	100%
A4I590	Leishmania infantum	93%	100%
C9ZQM1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	66%	100%
E9B0I7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q08746	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	35%	100%
Q4Q7P4	Leishmania major	92%	100%
Q9SH88	Arabidopsis thaliana	32%	68%