Putative nitrate reductase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

nitrate reductase, putative

Species:

Leishmania braziliensis

UniProt:

A4HI12_LEIBR

TriTrypDb:

LbrM.30.0690 , LBRM2903_300012700

Length:

537

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HI12

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HI12

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0005488	binding	1	10
GO:0008940	nitrate reductase activity	4	8
GO:0009703	nitrate reductase (NADH) activity	6	8
GO:0016491	oxidoreductase activity	2	11
GO:0016661	oxidoreductase activity, acting on other nitrogenous compounds as donors	3	8
GO:0020037	heme binding	4	10
GO:0043167	ion binding	2	10
GO:0043169	cation binding	3	10
GO:0046857	oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor	4	8
GO:0046872	metal ion binding	4	10
GO:0046906	tetrapyrrole binding	3	10
GO:0050463	nitrate reductase [NAD(P)H] activity	5	8
GO:0097159	organic cyclic compound binding	2	10
GO:1901363	heterocyclic compound binding	2	10
GO:0004128	cytochrome-b5 reductase activity, acting on NAD(P)H	5	1
GO:0016651	oxidoreductase activity, acting on NAD(P)H	3	1
GO:0016653	oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	470	474	PF00656	0.227
CLV_NRD_NRD_1	195	197	PF00675	0.327
CLV_NRD_NRD_1	362	364	PF00675	0.542
CLV_NRD_NRD_1	69	71	PF00675	0.556
CLV_NRD_NRD_1	81	83	PF00675	0.494
CLV_PCSK_KEX2_1	195	197	PF00082	0.250
CLV_PCSK_SKI1_1	132	136	PF00082	0.413
CLV_PCSK_SKI1_1	196	200	PF00082	0.336
CLV_PCSK_SKI1_1	70	74	PF00082	0.588
CLV_PCSK_SKI1_1	82	86	PF00082	0.591
DEG_SCF_FBW7_1	406	411	PF00400	0.298
DEG_SCF_FBW7_1	50	56	PF00400	0.700
DEG_SPOP_SBC_1	476	480	PF00917	0.344
DOC_CKS1_1	430	435	PF01111	0.441
DOC_CKS1_1	50	55	PF01111	0.698
DOC_MAPK_gen_1	195	202	PF00069	0.238
DOC_MAPK_gen_1	212	221	PF00069	0.480
DOC_MAPK_gen_1	363	371	PF00069	0.305
DOC_MAPK_gen_1	393	400	PF00069	0.367
DOC_MAPK_MEF2A_6	195	202	PF00069	0.301
DOC_MAPK_MEF2A_6	214	223	PF00069	0.324
DOC_MAPK_MEF2A_6	457	466	PF00069	0.449
DOC_MAPK_NFAT4_5	195	203	PF00069	0.354
DOC_PP2B_LxvP_1	158	161	PF13499	0.595
DOC_PP2B_LxvP_1	72	75	PF13499	0.753
DOC_PP4_FxxP_1	371	374	PF00568	0.534
DOC_USP7_MATH_1	120	124	PF00917	0.374
DOC_USP7_MATH_1	125	129	PF00917	0.324
DOC_USP7_MATH_1	263	267	PF00917	0.537
DOC_USP7_MATH_1	354	358	PF00917	0.545
DOC_USP7_MATH_1	6	10	PF00917	0.684
DOC_WW_Pin1_4	10	15	PF00397	0.589
DOC_WW_Pin1_4	206	211	PF00397	0.429
DOC_WW_Pin1_4	259	264	PF00397	0.657
DOC_WW_Pin1_4	404	409	PF00397	0.253
DOC_WW_Pin1_4	429	434	PF00397	0.441
DOC_WW_Pin1_4	49	54	PF00397	0.794
LIG_14-3-3_CanoR_1	188	193	PF00244	0.443
LIG_14-3-3_CanoR_1	332	337	PF00244	0.287
LIG_14-3-3_CanoR_1	457	461	PF00244	0.411
LIG_14-3-3_CanoR_1	468	476	PF00244	0.281
LIG_14-3-3_CanoR_1	490	496	PF00244	0.496
LIG_14-3-3_CanoR_1	82	88	PF00244	0.570
LIG_Actin_WH2_2	250	267	PF00022	0.513
LIG_BIR_III_2	11	15	PF00653	0.552
LIG_BRCT_BRCA1_1	356	360	PF00533	0.434
LIG_BRCT_BRCA1_1	477	481	PF00533	0.363
LIG_CtBP_PxDLS_1	66	71	PF00389	0.551
LIG_FHA_1	111	117	PF00498	0.392
LIG_FHA_1	171	177	PF00498	0.722
LIG_FHA_1	185	191	PF00498	0.549
LIG_FHA_1	296	302	PF00498	0.446
LIG_FHA_1	31	37	PF00498	0.547
LIG_FHA_1	457	463	PF00498	0.408
LIG_FHA_1	99	105	PF00498	0.454
LIG_FHA_2	143	149	PF00498	0.354
LIG_FHA_2	430	436	PF00498	0.480
LIG_FHA_2	84	90	PF00498	0.424
LIG_Integrin_isoDGR_2	226	228	PF01839	0.480
LIG_LIR_Apic_2	368	374	PF02991	0.418
LIG_LIR_Gen_1	232	242	PF02991	0.356
LIG_LIR_Gen_1	459	466	PF02991	0.227
LIG_LIR_LC3C_4	99	104	PF02991	0.227
LIG_LIR_Nem_3	113	118	PF02991	0.227
LIG_LIR_Nem_3	232	237	PF02991	0.320
LIG_LIR_Nem_3	300	306	PF02991	0.525
LIG_LIR_Nem_3	307	312	PF02991	0.541
LIG_LIR_Nem_3	330	336	PF02991	0.437
LIG_LIR_Nem_3	459	463	PF02991	0.349
LIG_LIR_Nem_3	80	84	PF02991	0.573
LIG_MLH1_MIPbox_1	356	360	PF16413	0.434
LIG_NRBOX	218	224	PF00104	0.349
LIG_PDZ_Class_2	532	537	PF00595	0.348
LIG_Pex14_2	333	337	PF04695	0.532
LIG_Pex14_2	371	375	PF04695	0.375
LIG_REV1ctd_RIR_1	358	368	PF16727	0.466
LIG_SH2_CRK	323	327	PF00017	0.498
LIG_SH2_CRK	81	85	PF00017	0.545
LIG_SH2_GRB2like	323	326	PF00017	0.534
LIG_SH2_PTP2	319	322	PF00017	0.387
LIG_SH2_STAP1	204	208	PF00017	0.227
LIG_SH2_STAP1	449	453	PF00017	0.480
LIG_SH2_STAT5	303	306	PF00017	0.512
LIG_SH2_STAT5	319	322	PF00017	0.350
LIG_SH2_STAT5	334	337	PF00017	0.406
LIG_SH2_STAT5	359	362	PF00017	0.452
LIG_SH3_3	114	120	PF00018	0.306
LIG_SH3_3	33	39	PF00018	0.626
LIG_SH3_3	371	377	PF00018	0.403
LIG_SH3_3	427	433	PF00018	0.441
LIG_SH3_3	47	53	PF00018	0.791
LIG_SUMO_SIM_anti_2	101	107	PF11976	0.381
LIG_SUMO_SIM_par_1	101	107	PF11976	0.480
LIG_SUMO_SIM_par_1	461	467	PF11976	0.468
LIG_TRAF2_1	167	170	PF00917	0.740
LIG_TRAF2_1	65	68	PF00917	0.789
LIG_TRFH_1	249	253	PF08558	0.480
LIG_UBA3_1	289	293	PF00899	0.307
LIG_WRC_WIRS_1	112	117	PF05994	0.408
LIG_WRC_WIRS_1	303	308	PF05994	0.512
LIG_WRC_WIRS_1	341	346	PF05994	0.465
MOD_CDC14_SPxK_1	13	16	PF00782	0.547
MOD_CDC14_SPxK_1	262	265	PF00782	0.685
MOD_CDK_SPxK_1	10	16	PF00069	0.553
MOD_CDK_SPxK_1	206	212	PF00069	0.429
MOD_CDK_SPxK_1	259	265	PF00069	0.685
MOD_CK1_1	140	146	PF00069	0.487
MOD_CK1_1	274	280	PF00069	0.472
MOD_CK1_1	297	303	PF00069	0.555
MOD_CK1_1	411	417	PF00069	0.480
MOD_CK1_1	429	435	PF00069	0.431
MOD_CK1_1	467	473	PF00069	0.493
MOD_CK1_1	475	481	PF00069	0.451
MOD_CK2_1	142	148	PF00069	0.354
MOD_CK2_1	83	89	PF00069	0.541
MOD_GlcNHglycan	123	126	PF01048	0.459
MOD_GlcNHglycan	142	145	PF01048	0.480
MOD_GlcNHglycan	164	167	PF01048	0.735
MOD_GlcNHglycan	26	30	PF01048	0.746
MOD_GlcNHglycan	265	268	PF01048	0.611
MOD_GlcNHglycan	273	276	PF01048	0.647
MOD_GlcNHglycan	285	288	PF01048	0.512
MOD_GlcNHglycan	356	359	PF01048	0.542
MOD_GlcNHglycan	422	425	PF01048	0.330
MOD_GlcNHglycan	55	58	PF01048	0.755
MOD_GlcNHglycan	8	11	PF01048	0.810
MOD_GSK3_1	121	128	PF00069	0.434
MOD_GSK3_1	184	191	PF00069	0.578
MOD_GSK3_1	259	266	PF00069	0.611
MOD_GSK3_1	332	339	PF00069	0.455
MOD_GSK3_1	350	357	PF00069	0.448
MOD_GSK3_1	404	411	PF00069	0.327
MOD_GSK3_1	416	423	PF00069	0.342
MOD_GSK3_1	44	51	PF00069	0.781
MOD_GSK3_1	472	479	PF00069	0.480
MOD_GSK3_1	6	13	PF00069	0.659
MOD_N-GLC_1	162	167	PF02516	0.646
MOD_N-GLC_1	295	300	PF02516	0.508
MOD_NEK2_1	222	227	PF00069	0.266
MOD_NEK2_1	294	299	PF00069	0.507
MOD_NEK2_1	304	309	PF00069	0.488
MOD_NEK2_1	426	431	PF00069	0.328
MOD_NEK2_1	464	469	PF00069	0.411
MOD_NEK2_2	137	142	PF00069	0.482
MOD_PIKK_1	274	280	PF00454	0.548
MOD_PIKK_1	416	422	PF00454	0.480
MOD_PIKK_1	467	473	PF00454	0.227
MOD_PIKK_1	529	535	PF00454	0.494
MOD_PK_1	188	194	PF00069	0.332
MOD_PKA_1	70	76	PF00069	0.543
MOD_PKA_2	354	360	PF00069	0.506
MOD_PKA_2	456	462	PF00069	0.298
MOD_PKA_2	467	473	PF00069	0.252
MOD_PKA_2	489	495	PF00069	0.480
MOD_Plk_1	110	116	PF00069	0.337
MOD_Plk_1	339	345	PF00069	0.285
MOD_Plk_1	440	446	PF00069	0.227
MOD_Plk_1	472	478	PF00069	0.480
MOD_Plk_1	98	104	PF00069	0.425
MOD_Plk_4	111	117	PF00069	0.482
MOD_Plk_4	332	338	PF00069	0.292
MOD_Plk_4	422	428	PF00069	0.370
MOD_ProDKin_1	10	16	PF00069	0.589
MOD_ProDKin_1	206	212	PF00069	0.429
MOD_ProDKin_1	259	265	PF00069	0.657
MOD_ProDKin_1	404	410	PF00069	0.253
MOD_ProDKin_1	429	435	PF00069	0.441
MOD_ProDKin_1	49	55	PF00069	0.794
MOD_SUMO_for_1	337	340	PF00179	0.305
MOD_SUMO_rev_2	286	295	PF00179	0.364
TRG_DiLeu_BaEn_1	89	94	PF01217	0.480
TRG_DiLeu_BaEn_4	440	446	PF01217	0.383
TRG_DiLeu_BaEn_4	67	73	PF01217	0.665
TRG_ENDOCYTIC_2	303	306	PF00928	0.512
TRG_ENDOCYTIC_2	319	322	PF00928	0.373
TRG_ENDOCYTIC_2	323	326	PF00928	0.203
TRG_ENDOCYTIC_2	334	337	PF00928	0.253
TRG_ENDOCYTIC_2	81	84	PF00928	0.567
TRG_ER_diArg_1	194	196	PF00400	0.364
TRG_Pf-PMV_PEXEL_1	188	193	PF00026	0.511

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZN6	Leptomonas seymouri	42%	85%
A0A1X0P389	Trypanosomatidae	32%	100%
A0A3Q8IJ69	Leishmania donovani	71%	100%
A0A422NIH2	Trypanosoma rangeli	32%	100%
A4I589	Leishmania infantum	71%	100%
C9ZQM0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9B0I6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	71%	100%
Q4Q7P5	Leishmania major	70%	100%
V5B7R2	Trypanosoma cruzi	33%	100%