Protein kinase domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein kinase, putative

Species:

Leishmania braziliensis

UniProt:

A4HI11_LEIBR

TriTrypDb:

LbrM.30.0680 , LBRM2903_300012600

Length:

917

Annotations

LeishMANIAdb annotations

A large and apprently artificial collection of diverse kinetoplastid protein kinases. A subfamily has 2TM regions, but the majority is cytoplasmic.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HI11

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HI11

Function

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Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	7
GO:0006793	phosphorus metabolic process	3	7
GO:0006796	phosphate-containing compound metabolic process	4	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0007165	signal transduction	2	1
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	7
GO:0016310	phosphorylation	5	7
GO:0019538	protein metabolic process	3	7
GO:0036211	protein modification process	4	7

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	7
GO:0003824	catalytic activity	1	7
GO:0004672	protein kinase activity	3	7
GO:0005488	binding	1	7
GO:0005524	ATP binding	5	7
GO:0016301	kinase activity	4	7
GO:0016740	transferase activity	2	7
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	7
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	7
GO:0017076	purine nucleotide binding	4	7

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	371	375	PF00656	0.227
CLV_MEL_PAP_1	355	361	PF00089	0.304
CLV_NRD_NRD_1	107	109	PF00675	0.580
CLV_NRD_NRD_1	136	138	PF00675	0.621
CLV_NRD_NRD_1	212	214	PF00675	0.618
CLV_NRD_NRD_1	3	5	PF00675	0.546
CLV_NRD_NRD_1	35	37	PF00675	0.593
CLV_NRD_NRD_1	409	411	PF00675	0.304
CLV_NRD_NRD_1	636	638	PF00675	0.730
CLV_NRD_NRD_1	802	804	PF00675	0.706

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILR5	Leptomonas seymouri	54%	98%
A0A3S7X353	Leishmania donovani	80%	99%
A4I588	Leishmania infantum	80%	99%
E9B0I5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	99%
Q4Q7P6	Leishmania major	80%	100%

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