LeishMANIAdb
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Protein kinase domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Protein kinase domain-containing protein
Gene product:
protein kinase, putative
Species:
Leishmania braziliensis
UniProt:
A4HI11_LEIBR
TriTrypDb:
LbrM.30.0680 , LBRM2903_300012600 *
Length:
917

Annotations

LeishMANIAdb annotations

A large and apprently artificial collection of diverse kinetoplastid protein kinases. A subfamily has 2TM regions, but the majority is cytoplasmic.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HI11
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HI11

Function

Biological processes
Term Name Level Count
GO:0006468 protein phosphorylation 5 7
GO:0006793 phosphorus metabolic process 3 7
GO:0006796 phosphate-containing compound metabolic process 4 7
GO:0006807 nitrogen compound metabolic process 2 7
GO:0008152 metabolic process 1 7
GO:0009987 cellular process 1 7
GO:0016310 phosphorylation 5 7
GO:0019538 protein metabolic process 3 7
GO:0036211 protein modification process 4 7
GO:0043170 macromolecule metabolic process 3 7
GO:0043412 macromolecule modification 4 7
GO:0044237 cellular metabolic process 2 7
GO:0044238 primary metabolic process 2 7
GO:0071704 organic substance metabolic process 2 7
GO:1901564 organonitrogen compound metabolic process 3 7
GO:0007165 signal transduction 2 1
GO:0050789 regulation of biological process 2 1
GO:0050794 regulation of cellular process 3 1
GO:0065007 biological regulation 1 1
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 7
GO:0003824 catalytic activity 1 7
GO:0004672 protein kinase activity 3 7
GO:0005488 binding 1 7
GO:0005524 ATP binding 5 7
GO:0016301 kinase activity 4 7
GO:0016740 transferase activity 2 7
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 7
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 7
GO:0017076 purine nucleotide binding 4 7
GO:0030554 adenyl nucleotide binding 5 7
GO:0032553 ribonucleotide binding 3 7
GO:0032555 purine ribonucleotide binding 4 7
GO:0032559 adenyl ribonucleotide binding 5 7
GO:0035639 purine ribonucleoside triphosphate binding 4 7
GO:0036094 small molecule binding 2 7
GO:0043167 ion binding 2 7
GO:0043168 anion binding 3 7
GO:0097159 organic cyclic compound binding 2 7
GO:0097367 carbohydrate derivative binding 2 7
GO:0140096 catalytic activity, acting on a protein 2 7
GO:1901265 nucleoside phosphate binding 3 7
GO:1901363 heterocyclic compound binding 2 7

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 371 375 PF00656 0.227
CLV_MEL_PAP_1 355 361 PF00089 0.304
CLV_NRD_NRD_1 107 109 PF00675 0.580
CLV_NRD_NRD_1 136 138 PF00675 0.621
CLV_NRD_NRD_1 212 214 PF00675 0.618
CLV_NRD_NRD_1 3 5 PF00675 0.546
CLV_NRD_NRD_1 35 37 PF00675 0.593
CLV_NRD_NRD_1 409 411 PF00675 0.304
CLV_NRD_NRD_1 636 638 PF00675 0.730
CLV_NRD_NRD_1 802 804 PF00675 0.706
CLV_NRD_NRD_1 844 846 PF00675 0.680
CLV_PCSK_FUR_1 134 138 PF00082 0.618
CLV_PCSK_FUR_1 800 804 PF00082 0.708
CLV_PCSK_KEX2_1 107 109 PF00082 0.580
CLV_PCSK_KEX2_1 136 138 PF00082 0.621
CLV_PCSK_KEX2_1 35 37 PF00082 0.593
CLV_PCSK_KEX2_1 409 411 PF00082 0.304
CLV_PCSK_KEX2_1 802 804 PF00082 0.706
CLV_PCSK_KEX2_1 843 845 PF00082 0.690
CLV_PCSK_KEX2_1 907 909 PF00082 0.684
CLV_PCSK_PC1ET2_1 843 845 PF00082 0.626
CLV_PCSK_PC1ET2_1 907 909 PF00082 0.702
CLV_PCSK_PC7_1 132 138 PF00082 0.615
CLV_PCSK_SKI1_1 39 43 PF00082 0.580
CLV_PCSK_SKI1_1 478 482 PF00082 0.350
CLV_PCSK_SKI1_1 663 667 PF00082 0.623
DEG_APCC_DBOX_1 83 91 PF00400 0.593
DEG_SCF_TRCP1_1 55 60 PF00400 0.661
DEG_SPOP_SBC_1 284 288 PF00917 0.541
DEG_SPOP_SBC_1 325 329 PF00917 0.540
DEG_SPOP_SBC_1 685 689 PF00917 0.633
DOC_CKS1_1 514 519 PF01111 0.304
DOC_CKS1_1 855 860 PF01111 0.677
DOC_MAPK_gen_1 347 355 PF00069 0.462
DOC_MAPK_gen_1 478 487 PF00069 0.304
DOC_MAPK_gen_1 823 832 PF00069 0.536
DOC_MAPK_MEF2A_6 11 19 PF00069 0.650
DOC_MAPK_MEF2A_6 424 433 PF00069 0.304
DOC_PP2B_LxvP_1 756 759 PF13499 0.539
DOC_PP2B_PxIxI_1 265 271 PF00149 0.520
DOC_PP4_FxxP_1 519 522 PF00568 0.304
DOC_USP7_MATH_1 140 144 PF00917 0.617
DOC_USP7_MATH_1 162 166 PF00917 0.645
DOC_USP7_MATH_1 191 195 PF00917 0.580
DOC_USP7_MATH_1 284 288 PF00917 0.662
DOC_USP7_MATH_1 304 308 PF00917 0.609
DOC_USP7_MATH_1 325 329 PF00917 0.561
DOC_USP7_MATH_1 400 404 PF00917 0.304
DOC_USP7_MATH_1 53 57 PF00917 0.744
DOC_USP7_MATH_1 661 665 PF00917 0.552
DOC_USP7_MATH_1 685 689 PF00917 0.644
DOC_USP7_MATH_1 761 765 PF00917 0.727
DOC_USP7_MATH_1 78 82 PF00917 0.619
DOC_USP7_MATH_1 879 883 PF00917 0.677
DOC_USP7_MATH_1 910 914 PF00917 0.536
DOC_USP7_UBL2_3 392 396 PF12436 0.304
DOC_USP7_UBL2_3 592 596 PF12436 0.304
DOC_WW_Pin1_4 22 27 PF00397 0.506
DOC_WW_Pin1_4 280 285 PF00397 0.595
DOC_WW_Pin1_4 307 312 PF00397 0.649
DOC_WW_Pin1_4 513 518 PF00397 0.318
DOC_WW_Pin1_4 737 742 PF00397 0.674
DOC_WW_Pin1_4 751 756 PF00397 0.518
DOC_WW_Pin1_4 802 807 PF00397 0.831
DOC_WW_Pin1_4 821 826 PF00397 0.504
DOC_WW_Pin1_4 854 859 PF00397 0.595
DOC_WW_Pin1_4 866 871 PF00397 0.565
LIG_14-3-3_CanoR_1 107 111 PF00244 0.506
LIG_14-3-3_CanoR_1 134 140 PF00244 0.615
LIG_14-3-3_CanoR_1 349 354 PF00244 0.513
LIG_14-3-3_CanoR_1 36 42 PF00244 0.556
LIG_14-3-3_CanoR_1 598 608 PF00244 0.342
LIG_14-3-3_CanoR_1 68 75 PF00244 0.661
LIG_14-3-3_CanoR_1 730 735 PF00244 0.544
LIG_14-3-3_CanoR_1 845 851 PF00244 0.546
LIG_14-3-3_CanoR_1 862 866 PF00244 0.554
LIG_Actin_WH2_2 617 634 PF00022 0.464
LIG_APCC_ABBA_1 429 434 PF00400 0.304
LIG_BRCT_BRCA1_1 100 104 PF00533 0.596
LIG_BRCT_BRCA1_1 223 227 PF00533 0.616
LIG_BRCT_BRCA1_1 686 690 PF00533 0.521
LIG_BRCT_BRCA1_1 732 736 PF00533 0.543
LIG_Clathr_ClatBox_1 51 55 PF01394 0.591
LIG_FHA_1 325 331 PF00498 0.598
LIG_FHA_1 389 395 PF00498 0.437
LIG_FHA_1 458 464 PF00498 0.304
LIG_FHA_1 508 514 PF00498 0.350
LIG_FHA_1 667 673 PF00498 0.572
LIG_FHA_1 69 75 PF00498 0.637
LIG_FHA_2 361 367 PF00498 0.304
LIG_FHA_2 486 492 PF00498 0.338
LIG_FHA_2 755 761 PF00498 0.535
LIG_FHA_2 896 902 PF00498 0.555
LIG_Integrin_RGD_1 874 876 PF01839 0.548
LIG_LIR_Apic_2 516 522 PF02991 0.304
LIG_LIR_Gen_1 180 191 PF02991 0.588
LIG_LIR_Gen_1 468 476 PF02991 0.369
LIG_LIR_LC3C_4 783 788 PF02991 0.548
LIG_LIR_Nem_3 148 154 PF02991 0.639
LIG_LIR_Nem_3 180 186 PF02991 0.600
LIG_LIR_Nem_3 224 230 PF02991 0.691
LIG_LIR_Nem_3 237 242 PF02991 0.530
LIG_LIR_Nem_3 363 367 PF02991 0.304
LIG_LIR_Nem_3 468 472 PF02991 0.369
LIG_LIR_Nem_3 687 693 PF02991 0.525
LIG_MAD2 36 44 PF02301 0.570
LIG_MLH1_MIPbox_1 100 104 PF16413 0.592
LIG_NRP_CendR_1 914 917 PF00754 0.553
LIG_Pex14_1 208 212 PF04695 0.618
LIG_Pex14_2 227 231 PF04695 0.666
LIG_REV1ctd_RIR_1 101 112 PF16727 0.583
LIG_SH2_CRK 183 187 PF00017 0.590
LIG_SH2_CRK 239 243 PF00017 0.527
LIG_SH2_CRK 9 13 PF00017 0.645
LIG_SH2_NCK_1 183 187 PF00017 0.590
LIG_SH2_NCK_1 9 13 PF00017 0.645
LIG_SH2_SRC 469 472 PF00017 0.304
LIG_SH2_SRC 693 696 PF00017 0.606
LIG_SH2_STAP1 459 463 PF00017 0.304
LIG_SH2_STAP1 530 534 PF00017 0.304
LIG_SH2_STAT3 459 462 PF00017 0.304
LIG_SH2_STAT5 183 186 PF00017 0.596
LIG_SH2_STAT5 419 422 PF00017 0.304
LIG_SH2_STAT5 459 462 PF00017 0.331
LIG_SH2_STAT5 469 472 PF00017 0.383
LIG_SH3_1 803 809 PF00018 0.690
LIG_SH3_2 658 663 PF14604 0.655
LIG_SH3_3 267 273 PF00018 0.542
LIG_SH3_3 278 284 PF00018 0.626
LIG_SH3_3 655 661 PF00018 0.691
LIG_SH3_3 803 809 PF00018 0.662
LIG_SH3_3 835 841 PF00018 0.539
LIG_SUMO_SIM_anti_2 783 790 PF11976 0.549
LIG_SUMO_SIM_par_1 278 283 PF11976 0.651
LIG_SUMO_SIM_par_1 377 383 PF11976 0.303
LIG_SUMO_SIM_par_1 754 760 PF11976 0.536
LIG_TRAF2_1 91 94 PF00917 0.595
LIG_TYR_ITIM 467 472 PF00017 0.369
LIG_UBA3_1 563 570 PF00899 0.304
MOD_CDC14_SPxK_1 869 872 PF00782 0.678
MOD_CDK_SPK_2 821 826 PF00069 0.616
MOD_CDK_SPxK_1 866 872 PF00069 0.683
MOD_CDK_SPxxK_3 22 29 PF00069 0.508
MOD_CK1_1 122 128 PF00069 0.623
MOD_CK1_1 138 144 PF00069 0.585
MOD_CK1_1 150 156 PF00069 0.572
MOD_CK1_1 165 171 PF00069 0.588
MOD_CK1_1 177 183 PF00069 0.587
MOD_CK1_1 189 195 PF00069 0.579
MOD_CK1_1 203 209 PF00069 0.598
MOD_CK1_1 226 232 PF00069 0.628
MOD_CK1_1 240 246 PF00069 0.547
MOD_CK1_1 25 31 PF00069 0.504
MOD_CK1_1 283 289 PF00069 0.654
MOD_CK1_1 297 303 PF00069 0.578
MOD_CK1_1 307 313 PF00069 0.658
MOD_CK1_1 321 327 PF00069 0.542
MOD_CK1_1 518 524 PF00069 0.352
MOD_CK1_1 528 534 PF00069 0.352
MOD_CK1_1 636 642 PF00069 0.510
MOD_CK1_1 686 692 PF00069 0.642
MOD_CK1_1 712 718 PF00069 0.619
MOD_CK1_1 73 79 PF00069 0.585
MOD_CK1_1 740 746 PF00069 0.662
MOD_CK1_1 747 753 PF00069 0.609
MOD_CK1_1 754 760 PF00069 0.560
MOD_CK1_1 846 852 PF00069 0.655
MOD_CK1_1 894 900 PF00069 0.778
MOD_CK1_1 99 105 PF00069 0.585
MOD_CK2_1 140 146 PF00069 0.593
MOD_CK2_1 440 446 PF00069 0.304
MOD_CK2_1 566 572 PF00069 0.304
MOD_CK2_1 575 581 PF00069 0.304
MOD_CK2_1 714 720 PF00069 0.590
MOD_CK2_1 754 760 PF00069 0.536
MOD_CK2_1 76 82 PF00069 0.577
MOD_CK2_1 802 808 PF00069 0.697
MOD_CK2_1 910 916 PF00069 0.542
MOD_Cter_Amidation 800 803 PF01082 0.706
MOD_GlcNHglycan 140 143 PF01048 0.661
MOD_GlcNHglycan 170 173 PF01048 0.613
MOD_GlcNHglycan 175 179 PF01048 0.627
MOD_GlcNHglycan 202 205 PF01048 0.502
MOD_GlcNHglycan 239 242 PF01048 0.623
MOD_GlcNHglycan 301 304 PF01048 0.580
MOD_GlcNHglycan 306 309 PF01048 0.691
MOD_GlcNHglycan 335 338 PF01048 0.620
MOD_GlcNHglycan 374 377 PF01048 0.347
MOD_GlcNHglycan 527 530 PF01048 0.304
MOD_GlcNHglycan 55 58 PF01048 0.661
MOD_GlcNHglycan 577 580 PF01048 0.227
MOD_GlcNHglycan 613 616 PF01048 0.562
MOD_GlcNHglycan 732 735 PF01048 0.695
MOD_GlcNHglycan 763 766 PF01048 0.661
MOD_GlcNHglycan 773 776 PF01048 0.638
MOD_GlcNHglycan 796 799 PF01048 0.675
MOD_GlcNHglycan 833 836 PF01048 0.663
MOD_GlcNHglycan 881 884 PF01048 0.604
MOD_GlcNHglycan 887 890 PF01048 0.622
MOD_GSK3_1 115 122 PF00069 0.593
MOD_GSK3_1 152 159 PF00069 0.630
MOD_GSK3_1 162 169 PF00069 0.641
MOD_GSK3_1 177 184 PF00069 0.529
MOD_GSK3_1 18 25 PF00069 0.597
MOD_GSK3_1 189 196 PF00069 0.525
MOD_GSK3_1 203 210 PF00069 0.599
MOD_GSK3_1 280 287 PF00069 0.632
MOD_GSK3_1 290 297 PF00069 0.590
MOD_GSK3_1 321 328 PF00069 0.816
MOD_GSK3_1 440 447 PF00069 0.317
MOD_GSK3_1 453 460 PF00069 0.351
MOD_GSK3_1 509 516 PF00069 0.340
MOD_GSK3_1 53 60 PF00069 0.660
MOD_GSK3_1 64 71 PF00069 0.642
MOD_GSK3_1 708 715 PF00069 0.623
MOD_GSK3_1 716 723 PF00069 0.618
MOD_GSK3_1 736 743 PF00069 0.726
MOD_GSK3_1 747 754 PF00069 0.590
MOD_GSK3_1 78 85 PF00069 0.504
MOD_GSK3_1 845 852 PF00069 0.814
MOD_GSK3_1 861 868 PF00069 0.661
MOD_GSK3_1 891 898 PF00069 0.724
MOD_GSK3_1 93 100 PF00069 0.588
MOD_N-GLC_1 200 205 PF02516 0.506
MOD_N-GLC_1 325 330 PF02516 0.750
MOD_N-GLC_1 340 345 PF02516 0.518
MOD_N-GLC_1 712 717 PF02516 0.635
MOD_N-GLC_1 846 851 PF02516 0.546
MOD_N-GLC_1 891 896 PF02516 0.770
MOD_N-GLC_1 899 904 PF02516 0.653
MOD_NEK2_1 119 124 PF00069 0.611
MOD_NEK2_1 135 140 PF00069 0.615
MOD_NEK2_1 181 186 PF00069 0.731
MOD_NEK2_1 212 217 PF00069 0.531
MOD_NEK2_1 470 475 PF00069 0.334
MOD_NEK2_1 504 509 PF00069 0.328
MOD_NEK2_1 611 616 PF00069 0.393
MOD_NEK2_1 666 671 PF00069 0.593
MOD_NEK2_1 714 719 PF00069 0.577
MOD_NEK2_1 831 836 PF00069 0.609
MOD_NEK2_1 865 870 PF00069 0.572
MOD_NEK2_2 891 896 PF00069 0.614
MOD_PIKK_1 318 324 PF00454 0.539
MOD_PIKK_1 507 513 PF00454 0.222
MOD_PIKK_1 599 605 PF00454 0.304
MOD_PIKK_1 649 655 PF00454 0.539
MOD_PIKK_1 895 901 PF00454 0.611
MOD_PK_1 349 355 PF00069 0.509
MOD_PK_1 444 450 PF00069 0.369
MOD_PKA_1 843 849 PF00069 0.626
MOD_PKA_2 106 112 PF00069 0.532
MOD_PKA_2 122 128 PF00069 0.689
MOD_PKA_2 135 141 PF00069 0.546
MOD_PKA_2 212 218 PF00069 0.577
MOD_PKA_2 221 227 PF00069 0.644
MOD_PKA_2 360 366 PF00069 0.304
MOD_PKA_2 597 603 PF00069 0.272
MOD_PKA_2 636 642 PF00069 0.510
MOD_PKA_2 771 777 PF00069 0.616
MOD_PKA_2 843 849 PF00069 0.626
MOD_PKA_2 861 867 PF00069 0.571
MOD_PKA_2 885 891 PF00069 0.672
MOD_PKA_2 895 901 PF00069 0.762
MOD_PKB_1 347 355 PF00069 0.527
MOD_Plk_1 147 153 PF00069 0.580
MOD_Plk_1 325 331 PF00069 0.688
MOD_Plk_1 340 346 PF00069 0.500
MOD_Plk_1 76 82 PF00069 0.577
MOD_Plk_1 846 852 PF00069 0.548
MOD_Plk_1 860 866 PF00069 0.548
MOD_Plk_1 891 897 PF00069 0.550
MOD_Plk_1 900 906 PF00069 0.541
MOD_Plk_2-3 93 99 PF00069 0.653
MOD_Plk_4 147 153 PF00069 0.569
MOD_Plk_4 156 162 PF00069 0.587
MOD_Plk_4 181 187 PF00069 0.516
MOD_Plk_4 226 232 PF00069 0.599
MOD_Plk_4 374 380 PF00069 0.227
MOD_Plk_4 415 421 PF00069 0.304
MOD_Plk_4 504 510 PF00069 0.333
MOD_Plk_4 515 521 PF00069 0.304
MOD_Plk_4 782 788 PF00069 0.671
MOD_Plk_4 99 105 PF00069 0.585
MOD_ProDKin_1 22 28 PF00069 0.503
MOD_ProDKin_1 280 286 PF00069 0.595
MOD_ProDKin_1 307 313 PF00069 0.650
MOD_ProDKin_1 513 519 PF00069 0.318
MOD_ProDKin_1 737 743 PF00069 0.672
MOD_ProDKin_1 751 757 PF00069 0.521
MOD_ProDKin_1 802 808 PF00069 0.831
MOD_ProDKin_1 821 827 PF00069 0.502
MOD_ProDKin_1 854 860 PF00069 0.596
MOD_ProDKin_1 866 872 PF00069 0.565
MOD_SUMO_rev_2 194 204 PF00179 0.655
MOD_SUMO_rev_2 447 456 PF00179 0.308
MOD_SUMO_rev_2 645 651 PF00179 0.525
TRG_ENDOCYTIC_2 183 186 PF00928 0.596
TRG_ENDOCYTIC_2 239 242 PF00928 0.525
TRG_ENDOCYTIC_2 469 472 PF00928 0.369
TRG_ER_diArg_1 132 135 PF00400 0.608
TRG_ER_diArg_1 347 350 PF00400 0.553
TRG_ER_diArg_1 35 37 PF00400 0.597
TRG_ER_diArg_1 408 410 PF00400 0.304
TRG_ER_diArg_1 800 803 PF00400 0.706
TRG_NLS_MonoExtC_3 905 910 PF00514 0.562
TRG_NLS_MonoExtN_4 841 847 PF00514 0.528
TRG_Pf-PMV_PEXEL_1 478 483 PF00026 0.304

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1ILR5 Leptomonas seymouri 54% 98%
A0A3S7X353 Leishmania donovani 80% 99%
A4I588 Leishmania infantum 80% 99%
E9B0I5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 80% 99%
Q4Q7P6 Leishmania major 80% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS