Bardet-Biedl syndrome 2 protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Bardet-Biedl syndrome 2 protein

Species:

Leishmania braziliensis

UniProt:

A4HI10_LEIBR

TriTrypDb:

LbrM.30.0670 , LBRM2903_300012500

Length:

655

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	12
GO:0005856	cytoskeleton	5	11
GO:0032991	protein-containing complex	1	12
GO:0034464	BBSome	2	12
GO:0043226	organelle	2	12
GO:0043228	non-membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043232	intracellular non-membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	12
GO:0005815	microtubule organizing center	2	1
GO:0005929	cilium	4	1
GO:0012506	vesicle membrane	4	1
GO:0016020	membrane	2	1
GO:0020018	ciliary pocket membrane	6	1
GO:0030659	cytoplasmic vesicle membrane	5	1
GO:0030662	coated vesicle membrane	5	1
GO:0030665	clathrin-coated vesicle membrane	6	1
GO:0030666	endocytic vesicle membrane	5	1
GO:0030669	clathrin-coated endocytic vesicle membrane	6	1
GO:0031090	organelle membrane	3	1
GO:0031253	cell projection membrane	4	1
GO:0031514	motile cilium	5	1
GO:0036064	ciliary basal body	3	1
GO:0042995	cell projection	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0060170	ciliary membrane	5	1
GO:0098588	bounding membrane of organelle	4	1
GO:0098590	plasma membrane region	3	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

A4HI10

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HI10

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	12
GO:0009987	cellular process	1	12
GO:0016043	cellular component organization	3	12
GO:0022607	cellular component assembly	4	12
GO:0030030	cell projection organization	4	12
GO:0030031	cell projection assembly	5	12
GO:0044782	cilium organization	5	12
GO:0060271	cilium assembly	6	12
GO:0070925	organelle assembly	5	12
GO:0071840	cellular component organization or biogenesis	2	12
GO:0120031	plasma membrane bounded cell projection assembly	6	12
GO:0120036	plasma membrane bounded cell projection organization	5	12
GO:1905515	non-motile cilium assembly	7	12

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	51	55	PF00656	0.631
CLV_C14_Caspase3-7	549	553	PF00656	0.476
CLV_NRD_NRD_1	227	229	PF00675	0.328
CLV_NRD_NRD_1	263	265	PF00675	0.294
CLV_PCSK_KEX2_1	306	308	PF00082	0.357
CLV_PCSK_KEX2_1	596	598	PF00082	0.259
CLV_PCSK_PC1ET2_1	306	308	PF00082	0.357
CLV_PCSK_PC1ET2_1	596	598	PF00082	0.259
CLV_PCSK_SKI1_1	220	224	PF00082	0.323
CLV_PCSK_SKI1_1	418	422	PF00082	0.299
CLV_PCSK_SKI1_1	471	475	PF00082	0.279
CLV_PCSK_SKI1_1	530	534	PF00082	0.338
CLV_PCSK_SKI1_1	558	562	PF00082	0.263
CLV_PCSK_SKI1_1	605	609	PF00082	0.271
CLV_PCSK_SKI1_1	635	639	PF00082	0.299
DEG_APCC_KENBOX_2	638	642	PF00400	0.538
DOC_CYCLIN_RxL_1	217	227	PF00134	0.512
DOC_CYCLIN_RxL_1	415	424	PF00134	0.538
DOC_CYCLIN_RxL_1	555	565	PF00134	0.538
DOC_MAPK_gen_1	135	143	PF00069	0.557
DOC_MAPK_gen_1	306	312	PF00069	0.563
DOC_MAPK_MEF2A_6	203	211	PF00069	0.557
DOC_MAPK_MEF2A_6	292	300	PF00069	0.481
DOC_MAPK_MEF2A_6	418	425	PF00069	0.541
DOC_MAPK_MEF2A_6	446	455	PF00069	0.376
DOC_MAPK_MEF2A_6	519	526	PF00069	0.557
DOC_MAPK_NFAT4_5	418	426	PF00069	0.538
DOC_MAPK_NFAT4_5	519	527	PF00069	0.557
DOC_PP4_FxxP_1	346	349	PF00568	0.526
DOC_PP4_FxxP_1	434	437	PF00568	0.488
DOC_USP7_MATH_1	108	112	PF00917	0.557
DOC_USP7_MATH_1	336	340	PF00917	0.508
DOC_USP7_MATH_1	473	477	PF00917	0.557
DOC_USP7_MATH_1	48	52	PF00917	0.554
DOC_USP7_UBL2_3	605	609	PF12436	0.463
LIG_14-3-3_CanoR_1	137	142	PF00244	0.476
LIG_14-3-3_CanoR_1	220	225	PF00244	0.523
LIG_14-3-3_CanoR_1	32	37	PF00244	0.479
LIG_14-3-3_CanoR_1	431	435	PF00244	0.501
LIG_14-3-3_CanoR_1	471	480	PF00244	0.542
LIG_Actin_WH2_2	416	433	PF00022	0.557
LIG_Actin_WH2_2	515	532	PF00022	0.522
LIG_APCC_ABBAyCdc20_2	418	424	PF00400	0.459
LIG_BRCT_BRCA1_1	143	147	PF00533	0.452
LIG_BRCT_BRCA1_1	182	186	PF00533	0.529
LIG_BRCT_BRCA1_1	65	69	PF00533	0.463
LIG_Clathr_ClatBox_1	420	424	PF01394	0.538
LIG_deltaCOP1_diTrp_1	427	434	PF00928	0.538
LIG_FHA_1	261	267	PF00498	0.514
LIG_FHA_1	289	295	PF00498	0.463
LIG_FHA_1	374	380	PF00498	0.548
LIG_FHA_1	447	453	PF00498	0.557
LIG_FHA_2	221	227	PF00498	0.501
LIG_FHA_2	271	277	PF00498	0.472
LIG_FHA_2	322	328	PF00498	0.504
LIG_FHA_2	643	649	PF00498	0.519
LIG_FHA_2	80	86	PF00498	0.496
LIG_Integrin_isoDGR_2	164	166	PF01839	0.292
LIG_Integrin_RGD_1	307	309	PF01839	0.338
LIG_LIR_Apic_2	405	409	PF02991	0.485
LIG_LIR_Apic_2	433	437	PF02991	0.491
LIG_LIR_Gen_1	144	155	PF02991	0.452
LIG_LIR_Gen_1	291	300	PF02991	0.563
LIG_LIR_Gen_1	538	546	PF02991	0.475
LIG_LIR_Gen_1	579	586	PF02991	0.538
LIG_LIR_Nem_3	144	150	PF02991	0.452
LIG_LIR_Nem_3	291	296	PF02991	0.486
LIG_LIR_Nem_3	31	36	PF02991	0.445
LIG_LIR_Nem_3	414	420	PF02991	0.391
LIG_LIR_Nem_3	538	542	PF02991	0.475
LIG_LIR_Nem_3	579	583	PF02991	0.522
LIG_SH2_CRK	115	119	PF00017	0.557
LIG_SH2_CRK	385	389	PF00017	0.523
LIG_SH2_CRK	406	410	PF00017	0.526
LIG_SH2_CRK	580	584	PF00017	0.452
LIG_SH2_SRC	370	373	PF00017	0.496
LIG_SH2_STAP1	115	119	PF00017	0.557
LIG_SH2_STAP1	190	194	PF00017	0.538
LIG_SH2_STAP1	580	584	PF00017	0.463
LIG_SH2_STAT5	117	120	PF00017	0.463
LIG_SH3_3	204	210	PF00018	0.473
LIG_SH3_3	359	365	PF00018	0.491
LIG_SH3_3	445	451	PF00018	0.499
LIG_SUMO_SIM_anti_2	645	652	PF11976	0.539
LIG_SUMO_SIM_par_1	295	301	PF11976	0.376
LIG_SUMO_SIM_par_1	350	357	PF11976	0.473
LIG_SUMO_SIM_par_1	521	527	PF11976	0.544
LIG_TRAF2_1	257	260	PF00917	0.512
LIG_TRAF2_2	98	103	PF00917	0.376
LIG_UBA3_1	569	578	PF00899	0.512
MOD_CK1_1	4	10	PF00069	0.711
MOD_CK1_1	99	105	PF00069	0.476
MOD_CK2_1	220	226	PF00069	0.481
MOD_CK2_1	254	260	PF00069	0.511
MOD_CK2_1	270	276	PF00069	0.504
MOD_CK2_1	642	648	PF00069	0.527
MOD_CK2_1	649	655	PF00069	0.625
MOD_CK2_1	79	85	PF00069	0.475
MOD_CK2_1	99	105	PF00069	0.321
MOD_GlcNHglycan	143	146	PF01048	0.265
MOD_GlcNHglycan	191	194	PF01048	0.301
MOD_GlcNHglycan	276	279	PF01048	0.336
MOD_GlcNHglycan	285	288	PF01048	0.340
MOD_GlcNHglycan	356	359	PF01048	0.365
MOD_GlcNHglycan	475	478	PF01048	0.333
MOD_GlcNHglycan	497	500	PF01048	0.297
MOD_GlcNHglycan	54	57	PF01048	0.612
MOD_GlcNHglycan	580	583	PF01048	0.276
MOD_GlcNHglycan	6	9	PF01048	0.710
MOD_GSK3_1	137	144	PF00069	0.538
MOD_GSK3_1	211	218	PF00069	0.457
MOD_GSK3_1	220	227	PF00069	0.444
MOD_GSK3_1	270	277	PF00069	0.509
MOD_GSK3_1	48	55	PF00069	0.502
MOD_GSK3_1	572	579	PF00069	0.538
MOD_LATS_1	459	465	PF00433	0.538
MOD_N-GLC_1	120	125	PF02516	0.263
MOD_N-GLC_1	18	23	PF02516	0.493
MOD_N-GLC_1	471	476	PF02516	0.176
MOD_N-GLC_2	410	412	PF02516	0.287
MOD_N-GLC_2	612	614	PF02516	0.357
MOD_NEK2_1	186	191	PF00069	0.476
MOD_NEK2_1	224	229	PF00069	0.509
MOD_NEK2_1	354	359	PF00069	0.461
MOD_NEK2_1	430	435	PF00069	0.479
MOD_NEK2_1	576	581	PF00069	0.516
MOD_NEK2_1	630	635	PF00069	0.501
MOD_NEK2_2	18	23	PF00069	0.493
MOD_NEK2_2	79	84	PF00069	0.538
MOD_PIKK_1	96	102	PF00454	0.482
MOD_PK_1	137	143	PF00069	0.557
MOD_PK_1	180	186	PF00069	0.412
MOD_PK_1	2	8	PF00069	0.566
MOD_PKA_2	186	192	PF00069	0.492
MOD_PKA_2	269	275	PF00069	0.376
MOD_PKA_2	430	436	PF00069	0.508
MOD_PKA_2	96	102	PF00069	0.473
MOD_PKB_1	135	143	PF00069	0.544
MOD_Plk_1	18	24	PF00069	0.451
MOD_Plk_1	270	276	PF00069	0.463
MOD_Plk_1	373	379	PF00069	0.511
MOD_Plk_1	571	577	PF00069	0.489
MOD_Plk_4	18	24	PF00069	0.467
MOD_Plk_4	180	186	PF00069	0.431
MOD_Plk_4	220	226	PF00069	0.473
MOD_Plk_4	42	48	PF00069	0.388
MOD_Plk_4	556	562	PF00069	0.539
MOD_Plk_4	58	64	PF00069	0.421
MOD_Plk_4	642	648	PF00069	0.489
MOD_SUMO_rev_2	439	448	PF00179	0.497
MOD_SUMO_rev_2	602	607	PF00179	0.517
TRG_DiLeu_BaEn_1	565	570	PF01217	0.463
TRG_DiLeu_BaLyEn_6	350	355	PF01217	0.473
TRG_DiLeu_LyEn_5	565	570	PF01217	0.476
TRG_ENDOCYTIC_2	115	118	PF00928	0.557
TRG_ENDOCYTIC_2	33	36	PF00928	0.460
TRG_ENDOCYTIC_2	580	583	PF00928	0.452
TRG_ENDOCYTIC_2	601	604	PF00928	0.476
TRG_ER_diArg_1	134	137	PF00400	0.545
TRG_ER_diArg_1	396	399	PF00400	0.376
TRG_NES_CRM1_1	424	439	PF08389	0.538
TRG_Pf-PMV_PEXEL_1	568	572	PF00026	0.256
TRG_Pf-PMV_PEXEL_1	613	617	PF00026	0.301

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCK5	Leptomonas seymouri	72%	80%
A0A0S4JJZ6	Bodo saltans	37%	91%
A0A1X0P2D4	Trypanosomatidae	43%	87%
A0A3Q8IE31	Leishmania donovani	89%	100%
A0A422NII3	Trypanosoma rangeli	43%	87%
A4I587	Leishmania infantum	88%	79%
C9ZQL6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	88%
E9B0I4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q19640	Caenorhabditis elegans	24%	92%
Q4Q7P7	Leishmania major	89%	100%
Q98SP7	Danio rerio	31%	92%
Q99MH9	Rattus norvegicus	31%	91%
Q9BXC9	Homo sapiens	30%	91%
Q9CWF6	Mus musculus	31%	91%
V5D873	Trypanosoma cruzi	41%	87%