AMP-binding domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

AMP-binding enzyme, putative

Species:

Leishmania braziliensis

UniProt:

A4HI09_LEIBR

TriTrypDb:

LbrM.30.0660 , LBRM2903_300012400

Length:

479

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HI09

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HI09

PDB structure(s): 7aih_Ai , 7ane_Ai

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	194	196	PF00675	0.403
CLV_NRD_NRD_1	211	213	PF00675	0.385
CLV_NRD_NRD_1	28	30	PF00675	0.368
CLV_NRD_NRD_1	322	324	PF00675	0.365
CLV_NRD_NRD_1	51	53	PF00675	0.306
CLV_PCSK_FUR_1	209	213	PF00082	0.383
CLV_PCSK_KEX2_1	211	213	PF00082	0.402
CLV_PCSK_SKI1_1	195	199	PF00082	0.382
CLV_PCSK_SKI1_1	34	38	PF00082	0.341
CLV_PCSK_SKI1_1	366	370	PF00082	0.196
CLV_PCSK_SKI1_1	392	396	PF00082	0.323
CLV_PCSK_SKI1_1	45	49	PF00082	0.272
CLV_PCSK_SKI1_1	461	465	PF00082	0.447
DEG_ODPH_VHL_1	280	293	PF01847	0.342
DEG_SPOP_SBC_1	7	11	PF00917	0.565
DOC_CDC14_PxL_1	150	158	PF14671	0.369
DOC_MAPK_gen_1	323	331	PF00069	0.308
DOC_MAPK_gen_1	365	373	PF00069	0.286
DOC_MAPK_RevD_3	14	30	PF00069	0.358
DOC_PP1_RVXF_1	107	113	PF00149	0.308
DOC_PP1_RVXF_1	194	201	PF00149	0.388
DOC_PP4_FxxP_1	379	382	PF00568	0.308
DOC_SPAK_OSR1_1	264	268	PF12202	0.308
DOC_USP7_MATH_1	285	289	PF00917	0.332
DOC_USP7_MATH_1	457	461	PF00917	0.536
DOC_USP7_UBL2_3	30	34	PF12436	0.381
DOC_USP7_UBL2_3	365	369	PF12436	0.337
DOC_WW_Pin1_4	10	15	PF00397	0.472
DOC_WW_Pin1_4	189	194	PF00397	0.401
LIG_14-3-3_CanoR_1	211	219	PF00244	0.387
LIG_14-3-3_CanoR_1	413	421	PF00244	0.365
LIG_Actin_WH2_2	161	179	PF00022	0.371
LIG_APCC_ABBA_1	293	298	PF00400	0.323
LIG_APCC_ABBA_1	348	353	PF00400	0.268
LIG_APCC_ABBA_1	401	406	PF00400	0.323
LIG_BRCT_BRCA1_1	169	173	PF00533	0.355
LIG_BRCT_BRCA1_1	296	300	PF00533	0.323
LIG_eIF4E_1	441	447	PF01652	0.308
LIG_FHA_1	11	17	PF00498	0.434
LIG_FHA_1	271	277	PF00498	0.337
LIG_FHA_1	446	452	PF00498	0.308
LIG_FHA_1	466	472	PF00498	0.253
LIG_FHA_1	81	87	PF00498	0.318
LIG_FHA_2	457	463	PF00498	0.387
LIG_LIR_Gen_1	126	133	PF02991	0.381
LIG_LIR_Gen_1	147	158	PF02991	0.364
LIG_LIR_Gen_1	326	334	PF02991	0.308
LIG_LIR_Gen_1	339	350	PF02991	0.310
LIG_LIR_Gen_1	35	44	PF02991	0.340
LIG_LIR_Nem_3	126	130	PF02991	0.366
LIG_LIR_Nem_3	147	153	PF02991	0.348
LIG_LIR_Nem_3	170	176	PF02991	0.342
LIG_LIR_Nem_3	326	330	PF02991	0.308
LIG_LIR_Nem_3	339	345	PF02991	0.310
LIG_LIR_Nem_3	35	39	PF02991	0.320
LIG_LIR_Nem_3	390	394	PF02991	0.324
LIG_NRBOX	212	218	PF00104	0.402
LIG_Pex14_1	146	150	PF04695	0.354
LIG_SH2_CRK	150	154	PF00017	0.357
LIG_SH2_CRK	283	287	PF00017	0.308
LIG_SH2_GRB2like	113	116	PF00017	0.308
LIG_SH2_GRB2like	23	26	PF00017	0.338
LIG_SH2_GRB2like	440	443	PF00017	0.308
LIG_SH2_NCK_1	150	154	PF00017	0.357
LIG_SH2_NCK_1	441	445	PF00017	0.308
LIG_SH2_PTP2	23	26	PF00017	0.338
LIG_SH2_SRC	23	26	PF00017	0.338
LIG_SH2_STAP1	206	210	PF00017	0.387
LIG_SH2_STAT3	160	163	PF00017	0.392
LIG_SH2_STAT3	205	208	PF00017	0.404
LIG_SH2_STAT5	113	116	PF00017	0.308
LIG_SH2_STAT5	175	178	PF00017	0.404
LIG_SH2_STAT5	23	26	PF00017	0.335
LIG_SH2_STAT5	363	366	PF00017	0.308
LIG_SH2_STAT5	377	380	PF00017	0.308
LIG_SH3_3	196	202	PF00018	0.386
LIG_SH3_3	216	222	PF00018	0.202
LIG_SUMO_SIM_anti_2	468	475	PF11976	0.566
LIG_SUMO_SIM_par_1	220	228	PF11976	0.374
LIG_TYR_ITSM	146	153	PF00017	0.435
LIG_UBA3_1	252	260	PF00899	0.308
MOD_CDK_SPxK_1	189	195	PF00069	0.402
MOD_CDK_SPxxK_3	189	196	PF00069	0.400
MOD_CK1_1	469	475	PF00069	0.319
MOD_CK2_1	201	207	PF00069	0.395
MOD_CK2_1	456	462	PF00069	0.387
MOD_Cter_Amidation	321	324	PF01082	0.308
MOD_GlcNHglycan	10	13	PF01048	0.462
MOD_GlcNHglycan	105	108	PF01048	0.327
MOD_GlcNHglycan	213	216	PF01048	0.390
MOD_GlcNHglycan	287	290	PF01048	0.323
MOD_GlcNHglycan	474	477	PF01048	0.618
MOD_GSK3_1	2	9	PF00069	0.437
MOD_GSK3_1	294	301	PF00069	0.323
MOD_GSK3_1	383	390	PF00069	0.409
MOD_GSK3_1	457	464	PF00069	0.310
MOD_GSK3_1	465	472	PF00069	0.306
MOD_N-GLC_1	469	474	PF02516	0.507
MOD_NEK2_1	145	150	PF00069	0.387
MOD_NEK2_1	156	161	PF00069	0.352
MOD_NEK2_1	237	242	PF00069	0.379
MOD_NEK2_1	251	256	PF00069	0.323
MOD_NEK2_1	456	461	PF00069	0.385
MOD_NEK2_1	62	67	PF00069	0.308
MOD_PIKK_1	167	173	PF00454	0.362
MOD_PIKK_1	251	257	PF00454	0.349
MOD_PIKK_1	395	401	PF00454	0.455
MOD_PKA_1	211	217	PF00069	0.390
MOD_PKA_1	395	401	PF00069	0.455
MOD_PKA_1	52	58	PF00069	0.308
MOD_PKA_2	211	217	PF00069	0.390
MOD_PKA_2	412	418	PF00069	0.308
MOD_PKB_1	209	217	PF00069	0.386
MOD_Plk_1	369	375	PF00069	0.293
MOD_Plk_1	383	389	PF00069	0.385
MOD_Plk_1	461	467	PF00069	0.476
MOD_Plk_1	469	475	PF00069	0.518
MOD_Plk_2-3	298	304	PF00069	0.323
MOD_Plk_4	145	151	PF00069	0.440
MOD_Plk_4	316	322	PF00069	0.428
MOD_Plk_4	383	389	PF00069	0.423
MOD_Plk_4	80	86	PF00069	0.301
MOD_ProDKin_1	10	16	PF00069	0.462
MOD_ProDKin_1	189	195	PF00069	0.402
MOD_SUMO_for_1	259	262	PF00179	0.323
MOD_SUMO_rev_2	228	237	PF00179	0.417
MOD_SUMO_rev_2	412	421	PF00179	0.381
MOD_SUMO_rev_2	5	10	PF00179	0.460
TRG_DiLeu_BaEn_1	316	321	PF01217	0.428
TRG_ENDOCYTIC_2	150	153	PF00928	0.343
TRG_ENDOCYTIC_2	23	26	PF00928	0.335
TRG_ENDOCYTIC_2	283	286	PF00928	0.308
TRG_ENDOCYTIC_2	33	36	PF00928	0.300
TRG_ENDOCYTIC_2	4	7	PF00928	0.529
TRG_ER_diArg_1	209	212	PF00400	0.403
TRG_NES_CRM1_1	362	375	PF08389	0.308
TRG_Pf-PMV_PEXEL_1	72	77	PF00026	0.308

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7F1	Leptomonas seymouri	91%	91%
A0A0S4JH74	Bodo saltans	78%	96%
A0A1X0P289	Trypanosomatidae	81%	93%
A0A3R7LXH8	Trypanosoma rangeli	81%	93%
A0A3S7X311	Leishmania donovani	96%	100%
A4I586	Leishmania infantum	96%	100%
C9ZQL5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	80%	92%
E9B0I3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
O31826	Bacillus subtilis (strain 168)	22%	87%
Q0P4F7	Danio rerio	21%	79%
Q17QJ1	Bos taurus	22%	78%
Q499N5	Rattus norvegicus	23%	78%
Q4Q7P8	Leishmania major	96%	100%
Q4R4Z9	Macaca fascicularis	22%	78%
Q5R9G9	Pongo abelii	21%	78%
Q8VCW8	Mus musculus	23%	78%
Q96CM8	Homo sapiens	22%	78%
V5BC74	Trypanosoma cruzi	81%	93%