Putative spliceosome-associated protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

spliceosome-associated protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HI08_LEIBR

TriTrypDb:

LbrM.30.0650 , LBRM2903_300012300

Length:

478

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	10
GO:0043226	organelle	2	10
GO:0043227	membrane-bounded organelle	3	10
GO:0043229	intracellular organelle	3	10
GO:0043231	intracellular membrane-bounded organelle	4	10
GO:0110165	cellular anatomical entity	1	10
GO:0005681	spliceosomal complex	3	1
GO:0005684	U2-type spliceosomal complex	4	1
GO:0005686	U2 snRNP	5	1
GO:0030532	small nuclear ribonucleoprotein complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0071011	precatalytic spliceosome	4	1
GO:0071013	catalytic step 2 spliceosome	3	1
GO:0097525	spliceosomal snRNP complex	4	1
GO:0120114	Sm-like protein family complex	2	1
GO:0140513	nuclear protein-containing complex	2	1
GO:1902494	catalytic complex	2	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

A4HI08

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HI08

Function

Biological processes
Term	Name	Level	Count
GO:0000375	RNA splicing, via transesterification reactions	8	1
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	1
GO:0000398	mRNA splicing, via spliceosome	8	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006396	RNA processing	6	1
GO:0006397	mRNA processing	7	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0008380	RNA splicing	7	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0016071	mRNA metabolic process	6	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	12	14	PF00675	0.519
CLV_NRD_NRD_1	127	129	PF00675	0.591
CLV_NRD_NRD_1	241	243	PF00675	0.499
CLV_NRD_NRD_1	298	300	PF00675	0.354
CLV_NRD_NRD_1	76	78	PF00675	0.541
CLV_PCSK_KEX2_1	12	14	PF00082	0.528
CLV_PCSK_KEX2_1	274	276	PF00082	0.479
CLV_PCSK_KEX2_1	298	300	PF00082	0.354
CLV_PCSK_KEX2_1	76	78	PF00082	0.418
CLV_PCSK_PC1ET2_1	274	276	PF00082	0.479
CLV_PCSK_SKI1_1	102	106	PF00082	0.727
CLV_PCSK_SKI1_1	187	191	PF00082	0.354
CLV_PCSK_SKI1_1	216	220	PF00082	0.448
CLV_PCSK_SKI1_1	277	281	PF00082	0.354
CLV_PCSK_SKI1_1	29	33	PF00082	0.586
CLV_PCSK_SKI1_1	8	12	PF00082	0.531
CLV_Separin_Metazoa	331	335	PF03568	0.589
DEG_APCC_DBOX_1	101	109	PF00400	0.629
DEG_SIAH_1	426	434	PF03145	0.692
DEG_SPOP_SBC_1	380	384	PF00917	0.649
DOC_CKS1_1	409	414	PF01111	0.706
DOC_CKS1_1	50	55	PF01111	0.702
DOC_CYCLIN_yCln2_LP_2	312	318	PF00134	0.459
DOC_MAPK_DCC_7	407	415	PF00069	0.607
DOC_MAPK_FxFP_2	340	343	PF00069	0.494
DOC_MAPK_gen_1	242	249	PF00069	0.479
DOC_MAPK_gen_1	274	282	PF00069	0.449
DOC_PP2B_LxvP_1	307	310	PF13499	0.344
DOC_PP2B_LxvP_1	312	315	PF13499	0.324
DOC_PP4_FxxP_1	340	343	PF00568	0.494
DOC_USP7_MATH_1	351	355	PF00917	0.726
DOC_USP7_MATH_1	37	41	PF00917	0.436
DOC_USP7_MATH_1	378	382	PF00917	0.803
DOC_USP7_UBL2_3	21	25	PF12436	0.419
DOC_USP7_UBL2_3	260	264	PF12436	0.507
DOC_USP7_UBL2_3	5	9	PF12436	0.612
DOC_WW_Pin1_4	235	240	PF00397	0.470
DOC_WW_Pin1_4	265	270	PF00397	0.563
DOC_WW_Pin1_4	408	413	PF00397	0.586
DOC_WW_Pin1_4	429	434	PF00397	0.627
DOC_WW_Pin1_4	461	466	PF00397	0.695
DOC_WW_Pin1_4	49	54	PF00397	0.687
LIG_14-3-3_CanoR_1	118	125	PF00244	0.703
LIG_14-3-3_CanoR_1	242	246	PF00244	0.566
LIG_14-3-3_CanoR_1	262	271	PF00244	0.317
LIG_BIR_II_1	1	5	PF00653	0.630
LIG_BRCT_BRCA1_1	338	342	PF00533	0.610
LIG_EVH1_1	472	476	PF00568	0.518
LIG_EVH1_1	49	53	PF00568	0.708
LIG_FHA_1	148	154	PF00498	0.414
LIG_FHA_1	174	180	PF00498	0.362
LIG_FHA_1	242	248	PF00498	0.579
LIG_FHA_1	266	272	PF00498	0.408
LIG_FHA_1	40	46	PF00498	0.482
LIG_FHA_1	445	451	PF00498	0.576
LIG_FHA_2	132	138	PF00498	0.588
LIG_FHA_2	353	359	PF00498	0.700
LIG_FHA_2	430	436	PF00498	0.657
LIG_FHA_2	50	56	PF00498	0.685
LIG_FHA_2	9	15	PF00498	0.400
LIG_LIR_Apic_2	326	332	PF02991	0.487
LIG_LIR_Apic_2	337	343	PF02991	0.511
LIG_LIR_Apic_2	44	50	PF02991	0.655
LIG_LIR_Apic_2	470	475	PF02991	0.666
LIG_LIR_Gen_1	134	143	PF02991	0.495
LIG_LIR_Gen_1	435	441	PF02991	0.582
LIG_LIR_Nem_3	134	138	PF02991	0.502
LIG_LIR_Nem_3	339	345	PF02991	0.503
LIG_LIR_Nem_3	358	364	PF02991	0.389
LIG_LIR_Nem_3	435	439	PF02991	0.586
LIG_LYPXL_yS_3	304	307	PF13949	0.335
LIG_Pex14_2	230	234	PF04695	0.481
LIG_PTAP_UEV_1	283	288	PF05743	0.440
LIG_SH2_CRK	47	51	PF00017	0.732
LIG_SH2_NCK_1	47	51	PF00017	0.699
LIG_SH2_PTP2	436	439	PF00017	0.580
LIG_SH2_STAT3	292	295	PF00017	0.335
LIG_SH2_STAT3	420	423	PF00017	0.689
LIG_SH2_STAT5	420	423	PF00017	0.577
LIG_SH2_STAT5	436	439	PF00017	0.580
LIG_SH2_STAT5	452	455	PF00017	0.613
LIG_SH2_STAT5	47	50	PF00017	0.580
LIG_SH3_1	299	305	PF00018	0.354
LIG_SH3_1	47	53	PF00018	0.722
LIG_SH3_3	100	106	PF00018	0.630
LIG_SH3_3	174	180	PF00018	0.335
LIG_SH3_3	281	287	PF00018	0.342
LIG_SH3_3	299	305	PF00018	0.311
LIG_SH3_3	406	412	PF00018	0.650
LIG_SH3_3	450	456	PF00018	0.536
LIG_SH3_3	462	468	PF00018	0.533
LIG_SH3_3	47	53	PF00018	0.722
LIG_SH3_3	470	476	PF00018	0.475
LIG_TRAF2_1	134	137	PF00917	0.602
LIG_TRAF2_1	370	373	PF00917	0.769
LIG_TRAF2_1	432	435	PF00917	0.600
LIG_TRAF2_1	58	61	PF00917	0.687
LIG_TRFH_1	47	51	PF08558	0.699
LIG_WW_1	301	304	PF00397	0.335
LIG_WW_3	331	335	PF00397	0.477
MOD_CDK_SPxxK_3	235	242	PF00069	0.475
MOD_CDK_SPxxK_3	464	471	PF00069	0.529
MOD_CK1_1	293	299	PF00069	0.479
MOD_CK1_1	381	387	PF00069	0.563
MOD_CK1_1	467	473	PF00069	0.524
MOD_CK2_1	1	7	PF00069	0.653
MOD_CK2_1	131	137	PF00069	0.578
MOD_CK2_1	367	373	PF00069	0.551
MOD_CK2_1	37	43	PF00069	0.531
MOD_CK2_1	429	435	PF00069	0.656
MOD_CK2_1	49	55	PF00069	0.655
MOD_CK2_1	67	73	PF00069	0.343
MOD_CK2_1	8	14	PF00069	0.608
MOD_Cter_Amidation	126	129	PF01082	0.686
MOD_GlcNHglycan	383	386	PF01048	0.734
MOD_GSK3_1	104	111	PF00069	0.718
MOD_GSK3_1	229	236	PF00069	0.481
MOD_GSK3_1	367	374	PF00069	0.574
MOD_GSK3_1	380	387	PF00069	0.720
MOD_GSK3_1	440	447	PF00069	0.565
MOD_GSK3_1	45	52	PF00069	0.708
MOD_N-GLC_1	441	446	PF02516	0.683
MOD_NEK2_1	1	6	PF00069	0.694
MOD_NEK2_1	185	190	PF00069	0.415
MOD_NEK2_2	164	169	PF00069	0.378
MOD_NEK2_2	229	234	PF00069	0.491
MOD_PIKK_1	20	26	PF00454	0.599
MOD_PIKK_1	352	358	PF00454	0.710
MOD_PIKK_1	459	465	PF00454	0.769
MOD_PKA_1	20	26	PF00069	0.594
MOD_PKA_1	8	14	PF00069	0.510
MOD_PKA_2	241	247	PF00069	0.609
MOD_Plk_1	336	342	PF00069	0.578
MOD_Plk_1	444	450	PF00069	0.622
MOD_Plk_2-3	39	45	PF00069	0.668
MOD_Plk_4	120	126	PF00069	0.589
MOD_Plk_4	336	342	PF00069	0.524
MOD_ProDKin_1	235	241	PF00069	0.477
MOD_ProDKin_1	265	271	PF00069	0.563
MOD_ProDKin_1	408	414	PF00069	0.576
MOD_ProDKin_1	429	435	PF00069	0.631
MOD_ProDKin_1	461	467	PF00069	0.693
MOD_ProDKin_1	49	55	PF00069	0.686
MOD_SUMO_for_1	170	173	PF00179	0.447
MOD_SUMO_rev_2	136	140	PF00179	0.598
MOD_SUMO_rev_2	4	11	PF00179	0.654
TRG_DiLeu_BaEn_1	149	154	PF01217	0.432
TRG_DiLeu_BaEn_2	335	341	PF01217	0.507
TRG_DiLeu_BaEn_3	197	203	PF01217	0.447
TRG_DiLeu_BaLyEn_6	363	368	PF01217	0.470
TRG_ENDOCYTIC_2	304	307	PF00928	0.335
TRG_ENDOCYTIC_2	436	439	PF00928	0.595
TRG_ENDOCYTIC_2	452	455	PF00928	0.613
TRG_ER_diArg_1	297	299	PF00400	0.354
TRG_Pf-PMV_PEXEL_1	29	34	PF00026	0.454

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7T1	Leptomonas seymouri	70%	99%
A0A1X0P248	Trypanosomatidae	48%	100%
A0A3R7MML5	Trypanosoma rangeli	49%	100%
A0A3S5H7M4	Leishmania donovani	86%	100%
A4I585	Leishmania infantum	86%	100%
C9ZQL4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
E9B0I2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4Q7P9	Leishmania major	86%	100%
V5B7R6	Trypanosoma cruzi	48%	100%