LMBR1-like membrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

LMBR1-like membrane protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HI06_LEIBR

TriTrypDb:

LbrM.30.0630 , LBRM2903_300012100

Length:

609

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

A4HI06

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HI06

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	410	414	PF00656	0.454
CLV_NRD_NRD_1	302	304	PF00675	0.303
CLV_NRD_NRD_1	521	523	PF00675	0.356
CLV_PCSK_KEX2_1	191	193	PF00082	0.233
CLV_PCSK_KEX2_1	323	325	PF00082	0.278
CLV_PCSK_KEX2_1	33	35	PF00082	0.291
CLV_PCSK_KEX2_1	569	571	PF00082	0.406
CLV_PCSK_KEX2_1	581	583	PF00082	0.381
CLV_PCSK_PC1ET2_1	191	193	PF00082	0.315
CLV_PCSK_PC1ET2_1	323	325	PF00082	0.278
CLV_PCSK_PC1ET2_1	33	35	PF00082	0.271
CLV_PCSK_PC1ET2_1	569	571	PF00082	0.433
CLV_PCSK_PC1ET2_1	581	583	PF00082	0.415
CLV_PCSK_SKI1_1	191	195	PF00082	0.286
CLV_PCSK_SKI1_1	286	290	PF00082	0.302
CLV_PCSK_SKI1_1	313	317	PF00082	0.294
DEG_APCC_DBOX_1	233	241	PF00400	0.478
DOC_CYCLIN_yCln2_LP_2	171	177	PF00134	0.391
DOC_CYCLIN_yCln2_LP_2	427	433	PF00134	0.246
DOC_CYCLIN_yCln2_LP_2	478	484	PF00134	0.340
DOC_CYCLIN_yCln2_LP_2	52	58	PF00134	0.261
DOC_CYCLIN_yCln2_LP_2	533	539	PF00134	0.506
DOC_MAPK_gen_1	283	290	PF00069	0.427
DOC_MAPK_MEF2A_6	363	372	PF00069	0.236
DOC_MAPK_MEF2A_6	426	433	PF00069	0.280
DOC_MAPK_MEF2A_6	459	468	PF00069	0.238
DOC_MAPK_MEF2A_6	474	482	PF00069	0.339
DOC_MAPK_NFAT4_5	426	434	PF00069	0.280
DOC_PP2B_LxvP_1	171	174	PF13499	0.391
DOC_PP2B_LxvP_1	353	356	PF13499	0.236
DOC_PP2B_LxvP_1	427	430	PF13499	0.246
DOC_PP2B_LxvP_1	478	481	PF13499	0.340
DOC_USP7_MATH_1	227	231	PF00917	0.486
DOC_USP7_MATH_1	263	267	PF00917	0.356
DOC_USP7_MATH_1	563	567	PF00917	0.661
DOC_USP7_MATH_1	93	97	PF00917	0.360
DOC_USP7_UBL2_3	285	289	PF12436	0.422
DOC_USP7_UBL2_3	29	33	PF12436	0.454
DOC_WW_Pin1_4	532	537	PF00397	0.585
DOC_WW_Pin1_4	545	550	PF00397	0.641
LIG_14-3-3_CanoR_1	297	303	PF00244	0.460
LIG_Actin_WH2_2	270	287	PF00022	0.515
LIG_BIR_II_1	1	5	PF00653	0.333
LIG_BRCT_BRCA1_1	374	378	PF00533	0.233
LIG_BRCT_BRCA1_1	415	419	PF00533	0.411
LIG_Clathr_ClatBox_1	222	226	PF01394	0.478
LIG_Clathr_ClatBox_1	274	278	PF01394	0.458
LIG_Clathr_ClatBox_1	56	60	PF01394	0.261
LIG_CSL_BTD_1	325	328	PF09270	0.454
LIG_EH1_1	16	24	PF00400	0.300
LIG_EH1_1	422	430	PF00400	0.391
LIG_FHA_1	343	349	PF00498	0.282
LIG_FHA_1	352	358	PF00498	0.287
LIG_FHA_1	420	426	PF00498	0.346
LIG_FHA_2	442	448	PF00498	0.325
LIG_IRF3_LxIS_1	433	439	PF10401	0.391
LIG_LIR_Gen_1	2	13	PF02991	0.330
LIG_LIR_Gen_1	209	218	PF02991	0.454
LIG_LIR_Nem_3	144	150	PF02991	0.287
LIG_LIR_Nem_3	2	8	PF02991	0.278
LIG_LIR_Nem_3	403	408	PF02991	0.453
LIG_LIR_Nem_3	451	457	PF02991	0.222
LIG_LIR_Nem_3	486	491	PF02991	0.353
LIG_LIR_Nem_3	9	15	PF02991	0.269
LIG_LYPXL_S_1	407	411	PF13949	0.315
LIG_LYPXL_yS_3	408	411	PF13949	0.515
LIG_NRBOX	423	429	PF00104	0.391
LIG_PCNA_yPIPBox_3	120	129	PF02747	0.458
LIG_PCNA_yPIPBox_3	313	326	PF02747	0.458
LIG_Pex14_1	82	86	PF04695	0.391
LIG_Pex14_2	13	17	PF04695	0.169
LIG_Pex14_2	419	423	PF04695	0.246
LIG_SH2_CRK	126	130	PF00017	0.360
LIG_SH2_CRK	147	151	PF00017	0.315
LIG_SH2_GRB2like	471	474	PF00017	0.391
LIG_SH2_NCK_1	103	107	PF00017	0.480
LIG_SH2_PTP2	5	8	PF00017	0.391
LIG_SH2_SRC	187	190	PF00017	0.515
LIG_SH2_STAP1	126	130	PF00017	0.290
LIG_SH2_STAP1	335	339	PF00017	0.275
LIG_SH2_STAT5	103	106	PF00017	0.518
LIG_SH2_STAT5	139	142	PF00017	0.318
LIG_SH2_STAT5	27	30	PF00017	0.454
LIG_SH2_STAT5	332	335	PF00017	0.401
LIG_SH2_STAT5	390	393	PF00017	0.261
LIG_SH2_STAT5	405	408	PF00017	0.422
LIG_SH2_STAT5	471	474	PF00017	0.319
LIG_SH2_STAT5	48	51	PF00017	0.375
LIG_SH2_STAT5	5	8	PF00017	0.340
LIG_SH2_STAT5	577	580	PF00017	0.575
LIG_SH2_STAT5	90	93	PF00017	0.291
LIG_SH3_2	549	554	PF14604	0.582
LIG_SH3_3	175	181	PF00018	0.246
LIG_SH3_3	403	409	PF00018	0.436
LIG_SH3_3	500	506	PF00018	0.589
LIG_SH3_3	533	539	PF00018	0.580
LIG_SH3_3	543	549	PF00018	0.655
LIG_SH3_3	92	98	PF00018	0.305
LIG_SUMO_SIM_anti_2	271	276	PF11976	0.531
LIG_SUMO_SIM_anti_2	381	386	PF11976	0.427
LIG_SUMO_SIM_par_1	165	170	PF11976	0.391
LIG_SUMO_SIM_par_1	221	226	PF11976	0.466
LIG_SUMO_SIM_par_1	239	245	PF11976	0.480
LIG_SUMO_SIM_par_1	54	60	PF11976	0.282
LIG_TRAF2_1	604	607	PF00917	0.597
LIG_TYR_ITIM	124	129	PF00017	0.346
LIG_TYR_ITIM	137	142	PF00017	0.261
LIG_TYR_ITIM	406	411	PF00017	0.523
LIG_TYR_ITIM	452	457	PF00017	0.211
LIG_UBA3_1	115	120	PF00899	0.450
LIG_WW_3	551	555	PF00397	0.586
MOD_CK1_1	146	152	PF00069	0.260
MOD_CK1_1	342	348	PF00069	0.290
MOD_CK1_1	351	357	PF00069	0.264
MOD_CK1_1	439	445	PF00069	0.315
MOD_CK1_1	600	606	PF00069	0.645
MOD_CK2_1	441	447	PF00069	0.258
MOD_CK2_1	600	606	PF00069	0.785
MOD_Cter_Amidation	520	523	PF01082	0.344
MOD_GlcNHglycan	2	5	PF01048	0.582
MOD_GlcNHglycan	244	247	PF01048	0.304
MOD_GlcNHglycan	265	268	PF01048	0.205
MOD_GlcNHglycan	438	441	PF01048	0.305
MOD_GlcNHglycan	599	602	PF01048	0.524
MOD_GSK3_1	436	443	PF00069	0.388
MOD_N-GLC_1	298	303	PF02516	0.258
MOD_N-GLC_1	413	418	PF02516	0.222
MOD_N-GLC_1	419	424	PF02516	0.261
MOD_N-GLC_1	445	450	PF02516	0.444
MOD_NEK2_1	115	120	PF00069	0.517
MOD_NEK2_1	167	172	PF00069	0.334
MOD_NEK2_1	193	198	PF00069	0.430
MOD_NEK2_1	339	344	PF00069	0.435
MOD_NEK2_1	372	377	PF00069	0.238
MOD_NEK2_1	378	383	PF00069	0.240
MOD_NEK2_1	419	424	PF00069	0.250
MOD_NEK2_1	436	441	PF00069	0.348
MOD_NEK2_1	467	472	PF00069	0.238
MOD_NEK2_1	483	488	PF00069	0.233
MOD_NEK2_1	489	494	PF00069	0.528
MOD_NEK2_1	86	91	PF00069	0.333
MOD_NEK2_2	107	112	PF00069	0.478
MOD_NEK2_2	298	303	PF00069	0.411
MOD_PIKK_1	193	199	PF00454	0.422
MOD_PIKK_1	489	495	PF00454	0.603
MOD_PIKK_1	69	75	PF00454	0.367
MOD_PK_1	547	553	PF00069	0.578
MOD_Plk_1	107	113	PF00069	0.515
MOD_Plk_1	270	276	PF00069	0.422
MOD_Plk_1	298	304	PF00069	0.429
MOD_Plk_1	351	357	PF00069	0.340
MOD_Plk_1	413	419	PF00069	0.431
MOD_Plk_1	445	451	PF00069	0.197
MOD_Plk_1	61	67	PF00069	0.315
MOD_Plk_2-3	221	227	PF00069	0.498
MOD_Plk_4	167	173	PF00069	0.385
MOD_Plk_4	270	276	PF00069	0.466
MOD_Plk_4	339	345	PF00069	0.270
MOD_Plk_4	378	384	PF00069	0.330
MOD_Plk_4	419	425	PF00069	0.289
MOD_Plk_4	467	473	PF00069	0.236
MOD_Plk_4	483	489	PF00069	0.290
MOD_Plk_4	494	500	PF00069	0.615
MOD_Plk_4	6	12	PF00069	0.350
MOD_Plk_4	86	92	PF00069	0.290
MOD_ProDKin_1	532	538	PF00069	0.585
MOD_ProDKin_1	545	551	PF00069	0.643
MOD_SUMO_for_1	218	221	PF00179	0.422
MOD_SUMO_rev_2	541	549	PF00179	0.643
TRG_DiLeu_BaLyEn_6	111	116	PF01217	0.442
TRG_DiLeu_BaLyEn_6	189	194	PF01217	0.515
TRG_DiLeu_BaLyEn_6	423	428	PF01217	0.246
TRG_DiLeu_BaLyEn_6	52	57	PF01217	0.261
TRG_ENDOCYTIC_2	103	106	PF00928	0.537
TRG_ENDOCYTIC_2	126	129	PF00928	0.303
TRG_ENDOCYTIC_2	139	142	PF00928	0.284
TRG_ENDOCYTIC_2	147	150	PF00928	0.271
TRG_ENDOCYTIC_2	408	411	PF00928	0.468
TRG_ENDOCYTIC_2	454	457	PF00928	0.211
TRG_ENDOCYTIC_2	48	51	PF00928	0.453
TRG_ENDOCYTIC_2	5	8	PF00928	0.311
TRG_ER_diArg_1	514	517	PF00400	0.524
TRG_NES_CRM1_1	490	502	PF08389	0.596
TRG_NLS_Bipartite_1	569	584	PF00514	0.562
TRG_Pf-PMV_PEXEL_1	192	197	PF00026	0.297
TRG_Pf-PMV_PEXEL_1	522	526	PF00026	0.374

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7F3	Leptomonas seymouri	75%	100%
A0A0S4JAG6	Bodo saltans	41%	100%
A0A1X0P250	Trypanosomatidae	47%	100%
A0A3Q8IFN1	Leishmania donovani	90%	100%
A0A422NIP4	Trypanosoma rangeli	48%	100%
A4I583	Leishmania infantum	89%	100%
C9ZQL2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9B0I0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q18695	Caenorhabditis elegans	21%	95%
Q29BL9	Drosophila pseudoobscura pseudoobscura	23%	87%
Q4Q7Q1	Leishmania major	89%	100%
Q54Q92	Dictyostelium discoideum	22%	83%
Q54TM2	Dictyostelium discoideum	23%	77%
Q5F3F5	Gallus gallus	20%	89%
Q61ZW5	Caenorhabditis briggsae	21%	95%
Q68DH5	Homo sapiens	21%	88%
Q6P4P2	Danio rerio	21%	87%
Q7ZYA0	Xenopus laevis	20%	85%
Q8C561	Mus musculus	21%	88%
Q8MRQ4	Drosophila melanogaster	23%	88%
V5D878	Trypanosoma cruzi	48%	100%