Nuclear cap-binding protein subunit 2

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

nuclear cap binding protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HI05_LEIBR

TriTrypDb:

LbrM.30.0620 , LBRM2903_300012000

Length:

188

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	10
GO:0005846	nuclear cap binding complex	3	11
GO:0032991	protein-containing complex	1	11
GO:0034518	RNA cap binding complex	2	11
GO:0043226	organelle	2	10
GO:0043227	membrane-bounded organelle	3	10
GO:0043229	intracellular organelle	3	10
GO:0043231	intracellular membrane-bounded organelle	4	10
GO:0110165	cellular anatomical entity	1	11
GO:0140535	intracellular protein-containing complex	2	11
GO:0005654	nucleoplasm	2	1

Expansion

Sequence features

A4HI05

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HI05

Function

Biological processes
Term	Name	Level	Count
GO:0000375	RNA splicing, via transesterification reactions	8	11
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	11
GO:0000398	mRNA splicing, via spliceosome	8	11
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006396	RNA processing	6	11
GO:0006397	mRNA processing	7	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0008380	RNA splicing	7	11
GO:0009987	cellular process	1	11
GO:0016070	RNA metabolic process	5	11
GO:0016071	mRNA metabolic process	6	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0043170	macromolecule metabolic process	3	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0045292	mRNA cis splicing, via spliceosome	9	11
GO:0046483	heterocycle metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:0090304	nucleic acid metabolic process	4	11
GO:1901360	organic cyclic compound metabolic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0000339	RNA cap binding	5	11
GO:0003676	nucleic acid binding	3	11
GO:0003723	RNA binding	4	11
GO:0005488	binding	1	11
GO:0097159	organic cyclic compound binding	2	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	125	127	PF00675	0.360
CLV_NRD_NRD_1	155	157	PF00675	0.381
CLV_NRD_NRD_1	182	184	PF00675	0.566
CLV_NRD_NRD_1	33	35	PF00675	0.431
CLV_PCSK_KEX2_1	125	127	PF00082	0.366
CLV_PCSK_KEX2_1	155	157	PF00082	0.390
CLV_PCSK_KEX2_1	181	183	PF00082	0.505
CLV_PCSK_KEX2_1	33	35	PF00082	0.431
CLV_PCSK_PC1ET2_1	181	183	PF00082	0.505
CLV_PCSK_SKI1_1	156	160	PF00082	0.501
CLV_PCSK_SKI1_1	183	187	PF00082	0.535
CLV_PCSK_SKI1_1	22	26	PF00082	0.374
CLV_Separin_Metazoa	19	23	PF03568	0.406
DEG_APCC_DBOX_1	147	155	PF00400	0.318
DOC_CYCLIN_RxL_1	17	29	PF00134	0.395
DOC_MAPK_gen_1	155	161	PF00069	0.409
DOC_WW_Pin1_4	60	65	PF00397	0.485
LIG_14-3-3_CanoR_1	111	116	PF00244	0.452
LIG_14-3-3_CanoR_1	22	30	PF00244	0.409
LIG_14-3-3_CterR_2	183	188	PF00244	0.658
LIG_BIR_II_1	1	5	PF00653	0.482
LIG_BIR_III_4	157	161	PF00653	0.439
LIG_FHA_1	41	47	PF00498	0.267
LIG_FHA_2	163	169	PF00498	0.523
LIG_FHA_2	24	30	PF00498	0.435
LIG_FHA_2	51	57	PF00498	0.428
LIG_GBD_Chelix_1	136	144	PF00786	0.318
LIG_LIR_Gen_1	172	180	PF02991	0.526
LIG_LIR_Gen_1	56	64	PF02991	0.474
LIG_LIR_Nem_3	172	176	PF02991	0.511
LIG_LIR_Nem_3	56	62	PF02991	0.407
LIG_NRBOX	20	26	PF00104	0.454
LIG_PTB_Apo_2	45	52	PF02174	0.397
LIG_SH2_STAP1	173	177	PF00017	0.457
LIG_SH2_STAP1	40	44	PF00017	0.423
LIG_SH2_STAT5	14	17	PF00017	0.489
LIG_SH2_STAT5	45	48	PF00017	0.423
LIG_SH2_STAT5	52	55	PF00017	0.430
LIG_SH3_3	173	179	PF00018	0.577
LIG_SUMO_SIM_par_1	109	116	PF11976	0.410
LIG_TRAF2_1	165	168	PF00917	0.524
LIG_TRAF2_1	26	29	PF00917	0.497
LIG_TRAF2_1	53	56	PF00917	0.453
LIG_TYR_ITIM	171	176	PF00017	0.431
MOD_CK1_1	23	29	PF00069	0.491
MOD_CK1_1	50	56	PF00069	0.428
MOD_CK1_1	60	66	PF00069	0.424
MOD_CK2_1	161	167	PF00069	0.419
MOD_CK2_1	23	29	PF00069	0.491
MOD_CK2_1	50	56	PF00069	0.431
MOD_GSK3_1	159	166	PF00069	0.314
MOD_GSK3_1	20	27	PF00069	0.522
MOD_GSK3_1	47	54	PF00069	0.430
MOD_N-GLC_1	38	43	PF02516	0.314
MOD_N-GLC_1	47	52	PF02516	0.189
MOD_NEK2_1	103	108	PF00069	0.423
MOD_NEK2_1	159	164	PF00069	0.390
MOD_NEK2_1	20	25	PF00069	0.357
MOD_NEK2_1	38	43	PF00069	0.314
MOD_NEK2_2	40	45	PF00069	0.317
MOD_NEK2_2	47	52	PF00069	0.378
MOD_PIKK_1	89	95	PF00454	0.453
MOD_PK_1	111	117	PF00069	0.535
MOD_Plk_1	47	53	PF00069	0.397
MOD_Plk_2-3	169	175	PF00069	0.332
MOD_Plk_4	103	109	PF00069	0.410
MOD_Plk_4	40	46	PF00069	0.327
MOD_Plk_4	47	53	PF00069	0.436
MOD_ProDKin_1	60	66	PF00069	0.485
TRG_ENDOCYTIC_2	173	176	PF00928	0.490
TRG_ENDOCYTIC_2	59	62	PF00928	0.474
TRG_ER_diArg_1	125	127	PF00400	0.366
TRG_ER_diArg_1	154	156	PF00400	0.395
TRG_NLS_MonoExtN_4	179	185	PF00514	0.561

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I9K6	Leptomonas seymouri	87%	100%
A0A0S4INS3	Bodo saltans	55%	92%
A0A1X0P277	Trypanosomatidae	71%	100%
A0A3R7NEF8	Trypanosoma rangeli	70%	100%
A0A3S7X351	Leishmania donovani	91%	100%
A2SW84	Siniperca chuatsi	45%	100%
A4I582	Leishmania infantum	92%	100%
A6PVI3	Homo sapiens	42%	100%
B0W939	Culex quinquefasciatus	50%	100%
B3LYP1	Drosophila ananassae	52%	100%
B3P0D7	Drosophila erecta	51%	100%
B4GLK8	Drosophila persimilis	50%	100%
B4IBA4	Drosophila sechellia	50%	100%
B4JUT1	Drosophila grimshawi	52%	100%
B4KCD5	Drosophila mojavensis	51%	100%
B4LZ88	Drosophila virilis	52%	100%
B4NB54	Drosophila willistoni	50%	100%
B4PL68	Drosophila yakuba	50%	100%
B4QV17	Drosophila simulans	50%	100%
B5G279	Taeniopygia guttata	46%	100%
B7P877	Ixodes scapularis	48%	100%
C0H859	Salmo salar	43%	100%
C1BY64	Esox lucius	44%	100%
C9ZQL1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	72%	100%
E9B0H9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
P52299	Xenopus laevis	45%	100%
Q08920	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	39%	90%
Q177H0	Aedes aegypti	50%	100%
Q293V6	Drosophila pseudoobscura pseudoobscura	50%	100%
Q4Q7Q2	Leishmania major	91%	100%
Q54KR9	Dictyostelium discoideum	45%	80%
Q5ZKR5	Gallus gallus	44%	100%
Q6DES0	Xenopus tropicalis	44%	100%
Q7QCB6	Anopheles gambiae	51%	100%
Q84L14	Oryza sativa subsp. japonica	46%	77%
Q8JGR6	Danio rerio	43%	100%
Q9P383	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	43%	100%
Q9V3L6	Drosophila melanogaster	50%	100%
Q9XFD1	Arabidopsis thaliana	53%	73%