TPR_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

N-acetyltransferase B complex (NatB) non catalytic subunit, putative

Species:

Leishmania braziliensis

UniProt:

A4HI03_LEIBR

TriTrypDb:

LbrM.30.0600 , LBRM2903_300011800

Length:

899

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0031248	protein acetyltransferase complex	3	1
GO:0031414	N-terminal protein acetyltransferase complex	4	1
GO:0031416	NatB complex	5	1
GO:0032991	protein-containing complex	1	1
GO:0110165	cellular anatomical entity	1	1
GO:0140535	intracellular protein-containing complex	2	1
GO:1902493	acetyltransferase complex	4	1
GO:1902494	catalytic complex	2	1
GO:1990234	transferase complex	3	1

Expansion

Sequence features

A4HI03

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HI03

Function

Biological processes
Term	Name	Level	Count
GO:0006473	protein acetylation	6	1
GO:0006474	N-terminal protein amino acid acetylation	5	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0017196	N-terminal peptidyl-methionine acetylation	6	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018206	peptidyl-methionine modification	6	1
GO:0019538	protein metabolic process	3	1
GO:0031365	N-terminal protein amino acid modification	5	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043543	protein acylation	5	1
GO:0044238	primary metabolic process	2	1
GO:0051604	protein maturation	4	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	3
GO:0016740	transferase activity	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	12	16	PF00656	0.390
CLV_C14_Caspase3-7	638	642	PF00656	0.431
CLV_NRD_NRD_1	323	325	PF00675	0.314
CLV_NRD_NRD_1	396	398	PF00675	0.233
CLV_NRD_NRD_1	485	487	PF00675	0.221
CLV_NRD_NRD_1	65	67	PF00675	0.550
CLV_NRD_NRD_1	679	681	PF00675	0.446
CLV_NRD_NRD_1	710	712	PF00675	0.667
CLV_PCSK_KEX2_1	323	325	PF00082	0.292
CLV_PCSK_KEX2_1	396	398	PF00082	0.233
CLV_PCSK_KEX2_1	485	487	PF00082	0.258
CLV_PCSK_KEX2_1	65	67	PF00082	0.311
CLV_PCSK_KEX2_1	679	681	PF00082	0.446
CLV_PCSK_SKI1_1	208	212	PF00082	0.431
CLV_PCSK_SKI1_1	396	400	PF00082	0.262
CLV_PCSK_SKI1_1	418	422	PF00082	0.274
CLV_PCSK_SKI1_1	66	70	PF00082	0.513
CLV_PCSK_SKI1_1	682	686	PF00082	0.355
CLV_PCSK_SKI1_1	735	739	PF00082	0.304
CLV_PCSK_SKI1_1	828	832	PF00082	0.249
CLV_PCSK_SKI1_1	862	866	PF00082	0.517
DEG_APCC_DBOX_1	681	689	PF00400	0.407
DEG_APCC_DBOX_1	777	785	PF00400	0.405
DEG_Nend_UBRbox_2	1	3	PF02207	0.535
DEG_SCF_FBW7_1	850	857	PF00400	0.500
DOC_CKS1_1	366	371	PF01111	0.514
DOC_CYCLIN_RxL_1	679	687	PF00134	0.502
DOC_MAPK_FxFP_2	798	801	PF00069	0.296
DOC_MAPK_gen_1	393	401	PF00069	0.362
DOC_PP4_FxxP_1	366	369	PF00568	0.514
DOC_PP4_FxxP_1	798	801	PF00568	0.296
DOC_USP7_MATH_1	152	156	PF00917	0.454
DOC_USP7_MATH_1	296	300	PF00917	0.365
DOC_USP7_MATH_1	427	431	PF00917	0.457
DOC_USP7_MATH_1	598	602	PF00917	0.362
DOC_USP7_MATH_1	695	699	PF00917	0.507
DOC_USP7_MATH_1	707	711	PF00917	0.611
DOC_USP7_MATH_1	751	755	PF00917	0.404
DOC_USP7_MATH_1	771	775	PF00917	0.502
DOC_USP7_MATH_1	854	858	PF00917	0.491
DOC_USP7_MATH_1	89	93	PF00917	0.276
DOC_USP7_UBL2_3	162	166	PF12436	0.373
DOC_USP7_UBL2_3	317	321	PF12436	0.514
DOC_USP7_UBL2_3	817	821	PF12436	0.460
DOC_WW_Pin1_4	365	370	PF00397	0.514
DOC_WW_Pin1_4	383	388	PF00397	0.436
DOC_WW_Pin1_4	408	413	PF00397	0.531
DOC_WW_Pin1_4	464	469	PF00397	0.517
DOC_WW_Pin1_4	725	730	PF00397	0.522
DOC_WW_Pin1_4	850	855	PF00397	0.549
LIG_14-3-3_CanoR_1	104	111	PF00244	0.459
LIG_14-3-3_CanoR_1	132	137	PF00244	0.415
LIG_14-3-3_CanoR_1	17	26	PF00244	0.344
LIG_14-3-3_CanoR_1	240	250	PF00244	0.480
LIG_14-3-3_CanoR_1	432	440	PF00244	0.476
LIG_14-3-3_CanoR_1	735	745	PF00244	0.291
LIG_14-3-3_CanoR_1	841	847	PF00244	0.518
LIG_14-3-3_CanoR_1	862	867	PF00244	0.408
LIG_APCC_ABBA_1	253	258	PF00400	0.447
LIG_Clathr_ClatBox_2	542	547	PF01394	0.474
LIG_deltaCOP1_diTrp_1	248	253	PF00928	0.328
LIG_deltaCOP1_diTrp_1	621	627	PF00928	0.514
LIG_FHA_1	163	169	PF00498	0.373
LIG_FHA_1	273	279	PF00498	0.367
LIG_FHA_1	366	372	PF00498	0.515
LIG_FHA_1	393	399	PF00498	0.478
LIG_FHA_1	449	455	PF00498	0.448
LIG_FHA_1	489	495	PF00498	0.455
LIG_FHA_1	56	62	PF00498	0.340
LIG_FHA_1	598	604	PF00498	0.461
LIG_FHA_1	641	647	PF00498	0.433
LIG_FHA_1	663	669	PF00498	0.352
LIG_FHA_1	726	732	PF00498	0.531
LIG_FHA_1	736	742	PF00498	0.376
LIG_FHA_1	870	876	PF00498	0.432
LIG_FHA_2	184	190	PF00498	0.441
LIG_FHA_2	215	221	PF00498	0.404
LIG_FHA_2	287	293	PF00498	0.447
LIG_FHA_2	540	546	PF00498	0.379
LIG_FHA_2	606	612	PF00498	0.479
LIG_FHA_2	616	622	PF00498	0.412
LIG_FHA_2	636	642	PF00498	0.525
LIG_IRF3_LxIS_1	357	364	PF10401	0.474
LIG_LIR_Apic_2	351	357	PF02991	0.551
LIG_LIR_Apic_2	364	369	PF02991	0.454
LIG_LIR_Apic_2	796	801	PF02991	0.307
LIG_LIR_Gen_1	113	121	PF02991	0.297
LIG_LIR_Gen_1	186	192	PF02991	0.340
LIG_LIR_Gen_1	247	256	PF02991	0.324
LIG_LIR_Gen_1	358	367	PF02991	0.504
LIG_LIR_Gen_1	447	457	PF02991	0.433
LIG_LIR_Gen_1	467	477	PF02991	0.514
LIG_LIR_Gen_1	840	850	PF02991	0.576
LIG_LIR_Gen_1	92	100	PF02991	0.369
LIG_LIR_LC3C_4	43	47	PF02991	0.225
LIG_LIR_Nem_3	186	190	PF02991	0.343
LIG_LIR_Nem_3	247	253	PF02991	0.330
LIG_LIR_Nem_3	358	363	PF02991	0.504
LIG_LIR_Nem_3	447	452	PF02991	0.451
LIG_LIR_Nem_3	467	473	PF02991	0.514
LIG_LIR_Nem_3	491	495	PF02991	0.424
LIG_LIR_Nem_3	549	554	PF02991	0.443
LIG_LIR_Nem_3	840	846	PF02991	0.575
LIG_LIR_Nem_3	92	97	PF02991	0.355
LIG_NRBOX	805	811	PF00104	0.360
LIG_PCNA_yPIPBox_3	343	356	PF02747	0.474
LIG_Pex14_1	547	551	PF04695	0.474
LIG_SH2_CRK	120	124	PF00017	0.408
LIG_SH2_CRK	354	358	PF00017	0.514
LIG_SH2_CRK	470	474	PF00017	0.514
LIG_SH2_NCK_1	120	124	PF00017	0.350
LIG_SH2_NCK_1	354	358	PF00017	0.362
LIG_SH2_PTP2	187	190	PF00017	0.307
LIG_SH2_PTP2	449	452	PF00017	0.433
LIG_SH2_SRC	187	190	PF00017	0.317
LIG_SH2_SRC	360	363	PF00017	0.497
LIG_SH2_SRC	745	748	PF00017	0.431
LIG_SH2_SRC	759	762	PF00017	0.207
LIG_SH2_STAP1	197	201	PF00017	0.361
LIG_SH2_STAP1	470	474	PF00017	0.514
LIG_SH2_STAP1	495	499	PF00017	0.451
LIG_SH2_STAP1	838	842	PF00017	0.399
LIG_SH2_STAT3	552	555	PF00017	0.514
LIG_SH2_STAT3	590	593	PF00017	0.474
LIG_SH2_STAT5	114	117	PF00017	0.362
LIG_SH2_STAT5	187	190	PF00017	0.307
LIG_SH2_STAT5	327	330	PF00017	0.533
LIG_SH2_STAT5	349	352	PF00017	0.489
LIG_SH2_STAT5	360	363	PF00017	0.400
LIG_SH2_STAT5	449	452	PF00017	0.423
LIG_SH2_STAT5	472	475	PF00017	0.516
LIG_SH2_STAT5	569	572	PF00017	0.514
LIG_SH2_STAT5	745	748	PF00017	0.431
LIG_SH2_STAT5	759	762	PF00017	0.207
LIG_SH2_STAT5	780	783	PF00017	0.502
LIG_SH2_STAT5	886	889	PF00017	0.460
LIG_SH3_3	277	283	PF00018	0.411
LIG_SH3_3	666	672	PF00018	0.384
LIG_SUMO_SIM_anti_2	186	192	PF11976	0.435
LIG_SUMO_SIM_anti_2	275	282	PF11976	0.377
LIG_SUMO_SIM_anti_2	330	336	PF11976	0.451
LIG_SUMO_SIM_anti_2	43	50	PF11976	0.338
LIG_SUMO_SIM_anti_2	475	481	PF11976	0.474
LIG_SUMO_SIM_par_1	665	673	PF11976	0.415
LIG_TRAF2_1	299	302	PF00917	0.510
LIG_TRAF2_1	553	556	PF00917	0.562
LIG_TYR_ITIM	527	532	PF00017	0.451
LIG_UBA3_1	159	166	PF00899	0.372
LIG_UBA3_1	809	817	PF00899	0.455
LIG_WRC_WIRS_1	363	368	PF05994	0.514
MOD_CDK_SPK_2	383	388	PF00069	0.362
MOD_CDK_SPK_2	730	735	PF00069	0.274
MOD_CK1_1	244	250	PF00069	0.561
MOD_CK1_1	273	279	PF00069	0.584
MOD_CK1_1	336	342	PF00069	0.514
MOD_CK1_1	355	361	PF00069	0.553
MOD_CK1_1	379	385	PF00069	0.450
MOD_CK1_1	407	413	PF00069	0.393
MOD_CK1_1	667	673	PF00069	0.260
MOD_CK1_1	739	745	PF00069	0.430
MOD_CK1_1	788	794	PF00069	0.459
MOD_CK2_1	17	23	PF00069	0.452
MOD_CK2_1	214	220	PF00069	0.404
MOD_CK2_1	273	279	PF00069	0.555
MOD_CK2_1	296	302	PF00069	0.364
MOD_CK2_1	550	556	PF00069	0.474
MOD_CK2_1	615	621	PF00069	0.372
MOD_CK2_1	759	765	PF00069	0.489
MOD_CK2_1	89	95	PF00069	0.224
MOD_CMANNOS	544	547	PF00535	0.314
MOD_CMANNOS	624	627	PF00535	0.314
MOD_GlcNHglycan	232	235	PF01048	0.439
MOD_GlcNHglycan	272	275	PF01048	0.540
MOD_GlcNHglycan	381	384	PF01048	0.207
MOD_GlcNHglycan	49	52	PF01048	0.534
MOD_GlcNHglycan	600	603	PF01048	0.374
MOD_GlcNHglycan	630	633	PF01048	0.302
MOD_GlcNHglycan	697	700	PF01048	0.452
MOD_GlcNHglycan	719	722	PF01048	0.756
MOD_GlcNHglycan	773	776	PF01048	0.527
MOD_GlcNHglycan	789	793	PF01048	0.477
MOD_GlcNHglycan	806	809	PF01048	0.469
MOD_GlcNHglycan	856	859	PF01048	0.417
MOD_GSK3_1	179	186	PF00069	0.392
MOD_GSK3_1	214	221	PF00069	0.483
MOD_GSK3_1	244	251	PF00069	0.425
MOD_GSK3_1	287	294	PF00069	0.417
MOD_GSK3_1	333	340	PF00069	0.493
MOD_GSK3_1	361	368	PF00069	0.503
MOD_GSK3_1	379	386	PF00069	0.424
MOD_GSK3_1	404	411	PF00069	0.528
MOD_GSK3_1	428	435	PF00069	0.456
MOD_GSK3_1	464	471	PF00069	0.474
MOD_GSK3_1	713	720	PF00069	0.633
MOD_GSK3_1	721	728	PF00069	0.552
MOD_GSK3_1	735	742	PF00069	0.535
MOD_GSK3_1	767	774	PF00069	0.505
MOD_GSK3_1	776	783	PF00069	0.450
MOD_GSK3_1	837	844	PF00069	0.506
MOD_GSK3_1	846	853	PF00069	0.501
MOD_N-GLC_1	248	253	PF02516	0.301
MOD_N-GLC_1	567	572	PF02516	0.314
MOD_N-GLC_1	612	617	PF02516	0.162
MOD_N-GLC_1	66	71	PF02516	0.454
MOD_N-GLC_1	771	776	PF02516	0.287
MOD_N-GLC_1	862	867	PF02516	0.300
MOD_N-GLC_2	83	85	PF02516	0.440
MOD_NEK2_1	110	115	PF00069	0.353
MOD_NEK2_1	161	166	PF00069	0.323
MOD_NEK2_1	214	219	PF00069	0.361
MOD_NEK2_1	313	318	PF00069	0.439
MOD_NEK2_1	333	338	PF00069	0.514
MOD_NEK2_1	361	366	PF00069	0.451
MOD_NEK2_1	434	439	PF00069	0.568
MOD_NEK2_1	55	60	PF00069	0.397
MOD_NEK2_1	567	572	PF00069	0.465
MOD_NEK2_1	630	635	PF00069	0.558
MOD_NEK2_1	664	669	PF00069	0.432
MOD_NEK2_1	684	689	PF00069	0.320
MOD_NEK2_1	736	741	PF00069	0.526
MOD_NEK2_1	842	847	PF00069	0.543
MOD_NEK2_2	886	891	PF00069	0.387
MOD_PIKK_1	17	23	PF00454	0.370
MOD_PIKK_1	241	247	PF00454	0.410
MOD_PIKK_1	605	611	PF00454	0.436
MOD_PKA_2	287	293	PF00069	0.440
MOD_PKA_2	379	385	PF00069	0.366
MOD_PKA_2	520	526	PF00069	0.514
MOD_PKA_2	628	634	PF00069	0.530
MOD_PKA_2	678	684	PF00069	0.436
MOD_Plk_1	248	254	PF00069	0.243
MOD_Plk_1	291	297	PF00069	0.313
MOD_Plk_1	3	9	PF00069	0.320
MOD_Plk_1	35	41	PF00069	0.447
MOD_Plk_1	361	367	PF00069	0.420
MOD_Plk_1	468	474	PF00069	0.555
MOD_Plk_1	557	563	PF00069	0.420
MOD_Plk_1	567	573	PF00069	0.420
MOD_Plk_1	612	618	PF00069	0.414
MOD_Plk_1	862	868	PF00069	0.526
MOD_Plk_2-3	478	484	PF00069	0.457
MOD_Plk_2-3	550	556	PF00069	0.474
MOD_Plk_4	183	189	PF00069	0.414
MOD_Plk_4	256	262	PF00069	0.481
MOD_Plk_4	273	279	PF00069	0.621
MOD_Plk_4	337	343	PF00069	0.362
MOD_Plk_4	35	41	PF00069	0.368
MOD_Plk_4	362	368	PF00069	0.440
MOD_Plk_4	468	474	PF00069	0.474
MOD_Plk_4	478	484	PF00069	0.451
MOD_Plk_4	488	494	PF00069	0.328
MOD_Plk_4	557	563	PF00069	0.420
MOD_Plk_4	585	591	PF00069	0.514
MOD_Plk_4	635	641	PF00069	0.517
MOD_Plk_4	647	653	PF00069	0.422
MOD_Plk_4	664	670	PF00069	0.385
MOD_Plk_4	684	690	PF00069	0.358
MOD_Plk_4	751	757	PF00069	0.307
MOD_Plk_4	780	786	PF00069	0.416
MOD_ProDKin_1	365	371	PF00069	0.514
MOD_ProDKin_1	383	389	PF00069	0.436
MOD_ProDKin_1	408	414	PF00069	0.531
MOD_ProDKin_1	464	470	PF00069	0.517
MOD_ProDKin_1	725	731	PF00069	0.508
MOD_ProDKin_1	850	856	PF00069	0.543
MOD_SUMO_for_1	873	876	PF00179	0.396
TRG_DiLeu_BaEn_1	475	480	PF01217	0.517
TRG_DiLeu_BaEn_4	301	307	PF01217	0.526
TRG_DiLeu_BaLyEn_6	528	533	PF01217	0.499
TRG_ENDOCYTIC_2	114	117	PF00928	0.294
TRG_ENDOCYTIC_2	120	123	PF00928	0.347
TRG_ENDOCYTIC_2	187	190	PF00928	0.307
TRG_ENDOCYTIC_2	360	363	PF00928	0.514
TRG_ENDOCYTIC_2	449	452	PF00928	0.462
TRG_ENDOCYTIC_2	470	473	PF00928	0.541
TRG_ENDOCYTIC_2	529	532	PF00928	0.420
TRG_ENDOCYTIC_2	551	554	PF00928	0.437
TRG_ENDOCYTIC_2	94	97	PF00928	0.331
TRG_ER_diArg_1	396	398	PF00400	0.434
TRG_ER_diArg_1	485	487	PF00400	0.514
TRG_ER_diArg_1	678	680	PF00400	0.453
TRG_NLS_MonoExtN_4	709	715	PF00514	0.565
TRG_Pf-PMV_PEXEL_1	104	108	PF00026	0.444
TRG_Pf-PMV_PEXEL_1	17	21	PF00026	0.441
TRG_Pf-PMV_PEXEL_1	240	245	PF00026	0.410
TRG_Pf-PMV_PEXEL_1	308	312	PF00026	0.324
TRG_Pf-PMV_PEXEL_1	418	423	PF00026	0.355
TRG_Pf-PMV_PEXEL_1	432	436	PF00026	0.173
TRG_Pf-PMV_PEXEL_1	828	832	PF00026	0.249
TRG_Pf-PMV_PEXEL_1	98	103	PF00026	0.514

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I184	Leptomonas seymouri	67%	99%
A0A1X0P396	Trypanosomatidae	43%	100%
A0A3S5IR93	Trypanosoma rangeli	43%	100%
A0A3S7X316	Leishmania donovani	85%	100%
A4I580	Leishmania infantum	85%	100%
C9ZQK9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
E9B0H7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4Q7Q4	Leishmania major	85%	100%
Q7PYI4	Anopheles gambiae	22%	91%
V5BGT7	Trypanosoma cruzi	46%	100%