SAM domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HI01_LEIBR

TriTrypDb:

LbrM.30.0580 , LBRM2903_300011600

Length:

479

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HI01

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HI01

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	12	14	PF00675	0.583
CLV_NRD_NRD_1	121	123	PF00675	0.636
CLV_NRD_NRD_1	231	233	PF00675	0.449
CLV_NRD_NRD_1	267	269	PF00675	0.581
CLV_PCSK_FUR_1	229	233	PF00082	0.475
CLV_PCSK_KEX2_1	12	14	PF00082	0.585
CLV_PCSK_KEX2_1	231	233	PF00082	0.449
CLV_PCSK_KEX2_1	457	459	PF00082	0.579
CLV_PCSK_PC1ET2_1	457	459	PF00082	0.657
CLV_PCSK_SKI1_1	129	133	PF00082	0.728
CLV_PCSK_SKI1_1	458	462	PF00082	0.532
DEG_APCC_DBOX_1	426	434	PF00400	0.535
DEG_APCC_DBOX_1	457	465	PF00400	0.528
DEG_SCF_FBW7_1	141	148	PF00400	0.671
DEG_SCF_FBW7_1	361	368	PF00400	0.536
DEG_SPOP_SBC_1	175	179	PF00917	0.616
DEG_SPOP_SBC_1	180	184	PF00917	0.517
DOC_CKS1_1	130	135	PF01111	0.677
DOC_CKS1_1	142	147	PF01111	0.641
DOC_CKS1_1	194	199	PF01111	0.600
DOC_CKS1_1	251	256	PF01111	0.535
DOC_MAPK_RevD_3	254	269	PF00069	0.518
DOC_PP1_RVXF_1	267	274	PF00149	0.587
DOC_PP2B_LxvP_1	162	165	PF13499	0.662
DOC_PP2B_LxvP_1	190	193	PF13499	0.703
DOC_PP2B_LxvP_1	337	340	PF13499	0.650
DOC_PP4_FxxP_1	273	276	PF00568	0.650
DOC_PP4_FxxP_1	3	6	PF00568	0.618
DOC_USP7_MATH_1	175	179	PF00917	0.676
DOC_USP7_MATH_1	211	215	PF00917	0.578
DOC_USP7_MATH_1	249	253	PF00917	0.757
DOC_USP7_MATH_1	267	271	PF00917	0.589
DOC_USP7_MATH_1	344	348	PF00917	0.673
DOC_USP7_MATH_1	365	369	PF00917	0.717
DOC_USP7_MATH_1	6	10	PF00917	0.607
DOC_USP7_MATH_1	79	83	PF00917	0.485
DOC_WW_Pin1_4	123	128	PF00397	0.554
DOC_WW_Pin1_4	129	134	PF00397	0.601
DOC_WW_Pin1_4	137	142	PF00397	0.678
DOC_WW_Pin1_4	155	160	PF00397	0.703
DOC_WW_Pin1_4	165	170	PF00397	0.615
DOC_WW_Pin1_4	181	186	PF00397	0.692
DOC_WW_Pin1_4	193	198	PF00397	0.612
DOC_WW_Pin1_4	200	205	PF00397	0.587
DOC_WW_Pin1_4	220	225	PF00397	0.756
DOC_WW_Pin1_4	245	250	PF00397	0.686
DOC_WW_Pin1_4	263	268	PF00397	0.618
DOC_WW_Pin1_4	272	277	PF00397	0.667
DOC_WW_Pin1_4	280	285	PF00397	0.738
DOC_WW_Pin1_4	325	330	PF00397	0.704
DOC_WW_Pin1_4	361	366	PF00397	0.710
DOC_WW_Pin1_4	370	375	PF00397	0.792
DOC_WW_Pin1_4	389	394	PF00397	0.645
DOC_WW_Pin1_4	470	475	PF00397	0.469
DOC_WW_Pin1_4	81	86	PF00397	0.592
LIG_14-3-3_CanoR_1	229	235	PF00244	0.599
LIG_14-3-3_CanoR_1	268	272	PF00244	0.591
LIG_14-3-3_CanoR_1	323	329	PF00244	0.730
LIG_14-3-3_CanoR_1	352	361	PF00244	0.682
LIG_14-3-3_CanoR_1	369	377	PF00244	0.804
LIG_14-3-3_CanoR_1	381	386	PF00244	0.794
LIG_14-3-3_CanoR_1	389	393	PF00244	0.646
LIG_14-3-3_CanoR_1	402	412	PF00244	0.668
LIG_14-3-3_CanoR_1	427	431	PF00244	0.541
LIG_14-3-3_CanoR_1	5	15	PF00244	0.626
LIG_14-3-3_CanoR_1	68	73	PF00244	0.639
LIG_ActinCP_TwfCPI_2	3	13	PF01115	0.626
LIG_BIR_II_1	1	5	PF00653	0.623
LIG_BRCT_BRCA1_1	269	273	PF00533	0.590
LIG_EVH1_1	190	194	PF00568	0.635
LIG_EVH1_1	337	341	PF00568	0.543
LIG_FHA_1	114	120	PF00498	0.546
LIG_FHA_1	130	136	PF00498	0.671
LIG_FHA_1	165	171	PF00498	0.683
LIG_FHA_1	251	257	PF00498	0.532
LIG_FHA_1	283	289	PF00498	0.621
LIG_FHA_1	380	386	PF00498	0.546
LIG_FHA_1	406	412	PF00498	0.523
LIG_FHA_1	67	73	PF00498	0.637
LIG_FHA_2	205	211	PF00498	0.599
LIG_FHA_2	300	306	PF00498	0.794
LIG_GSK3_LRP6_1	193	198	PF00069	0.650
LIG_LIR_Apic_2	2	6	PF02991	0.616
LIG_LIR_Apic_2	270	276	PF02991	0.649
LIG_LIR_Gen_1	49	59	PF02991	0.655
LIG_LIR_Nem_3	49	55	PF02991	0.654
LIG_PCNA_TLS_4	435	442	PF02747	0.552
LIG_SH2_NCK_1	52	56	PF00017	0.643
LIG_SH2_SRC	420	423	PF00017	0.466
LIG_SH2_STAT5	420	423	PF00017	0.534
LIG_SH2_STAT5	441	444	PF00017	0.573
LIG_SH3_2	374	379	PF14604	0.538
LIG_SH3_3	166	172	PF00018	0.731
LIG_SH3_3	182	188	PF00018	0.626
LIG_SH3_3	191	197	PF00018	0.634
LIG_SH3_3	198	204	PF00018	0.692
LIG_SH3_3	248	254	PF00018	0.717
LIG_SH3_3	31	37	PF00018	0.665
LIG_SH3_3	335	341	PF00018	0.616
LIG_SH3_3	371	377	PF00018	0.595
LIG_SH3_3	444	450	PF00018	0.600
LIG_SUMO_SIM_anti_2	332	338	PF11976	0.536
LIG_TRAF2_1	118	121	PF00917	0.555
LIG_TRAF2_1	392	395	PF00917	0.573
LIG_UBA3_1	460	469	PF00899	0.620
MOD_CDC14_SPxK_1	126	129	PF00782	0.575
MOD_CDC14_SPxK_1	266	269	PF00782	0.642
MOD_CDC14_SPxK_1	275	278	PF00782	0.647
MOD_CDC14_SPxK_1	366	369	PF00782	0.791
MOD_CDC14_SPxK_1	376	379	PF00782	0.542
MOD_CDK_SPK_2	263	268	PF00069	0.660
MOD_CDK_SPxK_1	123	129	PF00069	0.560
MOD_CDK_SPxK_1	137	143	PF00069	0.691
MOD_CDK_SPxK_1	263	269	PF00069	0.592
MOD_CDK_SPxK_1	272	278	PF00069	0.603
MOD_CDK_SPxK_1	280	286	PF00069	0.649
MOD_CDK_SPxK_1	325	331	PF00069	0.681
MOD_CDK_SPxK_1	363	369	PF00069	0.789
MOD_CDK_SPxK_1	373	379	PF00069	0.500
MOD_CDK_SPxxK_3	389	396	PF00069	0.537
MOD_CDK_SPxxK_3	81	88	PF00069	0.585
MOD_CK1_1	153	159	PF00069	0.686
MOD_CK1_1	174	180	PF00069	0.673
MOD_CK1_1	220	226	PF00069	0.747
MOD_CK1_1	322	328	PF00069	0.567
MOD_CK1_1	355	361	PF00069	0.650
MOD_CK1_1	368	374	PF00069	0.580
MOD_CK1_1	397	403	PF00069	0.728
MOD_CK1_1	404	410	PF00069	0.584
MOD_CK1_1	428	434	PF00069	0.575
MOD_CK1_1	50	56	PF00069	0.647
MOD_CK2_1	389	395	PF00069	0.573
MOD_CK2_1	83	89	PF00069	0.519
MOD_GlcNHglycan	15	18	PF01048	0.525
MOD_GlcNHglycan	173	176	PF01048	0.563
MOD_GlcNHglycan	28	31	PF01048	0.604
MOD_GlcNHglycan	342	345	PF01048	0.660
MOD_GlcNHglycan	38	41	PF01048	0.559
MOD_GlcNHglycan	385	388	PF01048	0.707
MOD_GlcNHglycan	395	399	PF01048	0.695
MOD_GSK3_1	137	144	PF00069	0.745
MOD_GSK3_1	150	157	PF00069	0.602
MOD_GSK3_1	170	177	PF00069	0.635
MOD_GSK3_1	179	186	PF00069	0.633
MOD_GSK3_1	200	207	PF00069	0.633
MOD_GSK3_1	216	223	PF00069	0.588
MOD_GSK3_1	241	248	PF00069	0.704
MOD_GSK3_1	263	270	PF00069	0.623
MOD_GSK3_1	278	285	PF00069	0.626
MOD_GSK3_1	317	324	PF00069	0.636
MOD_GSK3_1	340	347	PF00069	0.628
MOD_GSK3_1	348	355	PF00069	0.626
MOD_GSK3_1	359	366	PF00069	0.676
MOD_GSK3_1	379	386	PF00069	0.818
MOD_GSK3_1	396	403	PF00069	0.708
MOD_GSK3_1	422	429	PF00069	0.549
MOD_GSK3_1	46	53	PF00069	0.598
MOD_GSK3_1	469	476	PF00069	0.466
MOD_GSK3_1	54	61	PF00069	0.581
MOD_GSK3_1	62	69	PF00069	0.562
MOD_GSK3_1	79	86	PF00069	0.443
MOD_N-GLC_1	352	357	PF02516	0.550
MOD_NEK2_1	113	118	PF00069	0.571
MOD_NEK2_1	152	157	PF00069	0.580
MOD_NEK2_1	230	235	PF00069	0.612
MOD_NEK2_1	385	390	PF00069	0.549
MOD_NEK2_1	44	49	PF00069	0.504
MOD_NEK2_2	211	216	PF00069	0.545
MOD_NEK2_2	267	272	PF00069	0.645
MOD_PIKK_1	121	127	PF00454	0.587
MOD_PIKK_1	145	151	PF00454	0.535
MOD_PIKK_1	204	210	PF00454	0.695
MOD_PIKK_1	236	242	PF00454	0.512
MOD_PK_1	93	99	PF00069	0.520
MOD_PKA_2	121	127	PF00069	0.567
MOD_PKA_2	230	236	PF00069	0.573
MOD_PKA_2	267	273	PF00069	0.587
MOD_PKA_2	322	328	PF00069	0.671
MOD_PKA_2	330	336	PF00069	0.617
MOD_PKA_2	368	374	PF00069	0.836
MOD_PKA_2	388	394	PF00069	0.665
MOD_PKA_2	4	10	PF00069	0.562
MOD_PKA_2	401	407	PF00069	0.697
MOD_PKA_2	426	432	PF00069	0.539
MOD_PKB_1	379	387	PF00069	0.545
MOD_PKB_1	64	72	PF00069	0.656
MOD_Plk_1	211	217	PF00069	0.543
MOD_Plk_1	50	56	PF00069	0.644
MOD_Plk_2-3	300	306	PF00069	0.656
MOD_Plk_4	222	228	PF00069	0.556
MOD_Plk_4	355	361	PF00069	0.532
MOD_Plk_4	93	99	PF00069	0.540
MOD_ProDKin_1	123	129	PF00069	0.560
MOD_ProDKin_1	137	143	PF00069	0.681
MOD_ProDKin_1	155	161	PF00069	0.703
MOD_ProDKin_1	165	171	PF00069	0.612
MOD_ProDKin_1	181	187	PF00069	0.691
MOD_ProDKin_1	193	199	PF00069	0.618
MOD_ProDKin_1	200	206	PF00069	0.586
MOD_ProDKin_1	220	226	PF00069	0.753
MOD_ProDKin_1	245	251	PF00069	0.682
MOD_ProDKin_1	263	269	PF00069	0.616
MOD_ProDKin_1	272	278	PF00069	0.666
MOD_ProDKin_1	280	286	PF00069	0.739
MOD_ProDKin_1	325	331	PF00069	0.706
MOD_ProDKin_1	361	367	PF00069	0.709
MOD_ProDKin_1	370	376	PF00069	0.793
MOD_ProDKin_1	389	395	PF00069	0.646
MOD_ProDKin_1	470	476	PF00069	0.473
MOD_ProDKin_1	81	87	PF00069	0.588
MOD_SUMO_rev_2	106	116	PF00179	0.549
MOD_SUMO_rev_2	120	124	PF00179	0.454
TRG_DiLeu_BaEn_4	307	313	PF01217	0.692
TRG_DiLeu_BaEn_4	444	450	PF01217	0.584
TRG_DiLeu_BaLyEn_6	130	135	PF01217	0.520
TRG_DiLeu_BaLyEn_6	185	190	PF01217	0.543
TRG_ENDOCYTIC_2	52	55	PF00928	0.641
TRG_ER_diArg_1	11	13	PF00400	0.579
TRG_ER_diArg_1	229	232	PF00400	0.440
TRG_ER_diArg_1	463	466	PF00400	0.507
TRG_ER_diArg_1	63	66	PF00400	0.634
TRG_NLS_MonoExtC_3	315	321	PF00514	0.689
TRG_NLS_MonoExtN_4	313	320	PF00514	0.677
TRG_Pf-PMV_PEXEL_1	409	413	PF00026	0.462
TRG_Pf-PMV_PEXEL_1	465	470	PF00026	0.611

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6G4	Leptomonas seymouri	39%	91%
A0A3Q8IRR2	Leishmania donovani	72%	99%
A0A3R7MDG8	Trypanosoma rangeli	30%	100%
A4I578	Leishmania infantum	72%	98%
E9B0H5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	69%	98%
Q4Q7Q6	Leishmania major	71%	100%