Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HI00_LEIBR

TriTrypDb:

LbrM.30.0570 , LBRM2903_300011500

Length:

709

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HI00

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HI00

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	231	235	PF00656	0.756
CLV_MEL_PAP_1	489	495	PF00089	0.471
CLV_NRD_NRD_1	12	14	PF00675	0.695
CLV_NRD_NRD_1	219	221	PF00675	0.593
CLV_NRD_NRD_1	477	479	PF00675	0.646
CLV_NRD_NRD_1	616	618	PF00675	0.565
CLV_NRD_NRD_1	663	665	PF00675	0.522
CLV_NRD_NRD_1	666	668	PF00675	0.537
CLV_NRD_NRD_1	681	683	PF00675	0.524
CLV_NRD_NRD_1	93	95	PF00675	0.792
CLV_PCSK_FUR_1	661	665	PF00082	0.522
CLV_PCSK_KEX2_1	12	14	PF00082	0.620
CLV_PCSK_KEX2_1	219	221	PF00082	0.593
CLV_PCSK_KEX2_1	477	479	PF00082	0.646
CLV_PCSK_KEX2_1	520	522	PF00082	0.675
CLV_PCSK_KEX2_1	577	579	PF00082	0.497
CLV_PCSK_KEX2_1	618	620	PF00082	0.500
CLV_PCSK_KEX2_1	663	665	PF00082	0.522
CLV_PCSK_KEX2_1	670	672	PF00082	0.540
CLV_PCSK_KEX2_1	681	683	PF00082	0.524
CLV_PCSK_KEX2_1	690	692	PF00082	0.319
CLV_PCSK_KEX2_1	93	95	PF00082	0.792
CLV_PCSK_PC1ET2_1	520	522	PF00082	0.636
CLV_PCSK_PC1ET2_1	577	579	PF00082	0.537
CLV_PCSK_PC1ET2_1	618	620	PF00082	0.500
CLV_PCSK_PC1ET2_1	670	672	PF00082	0.540
CLV_PCSK_PC1ET2_1	690	692	PF00082	0.319
CLV_PCSK_SKI1_1	201	205	PF00082	0.617
CLV_PCSK_SKI1_1	382	386	PF00082	0.583
CLV_PCSK_SKI1_1	477	481	PF00082	0.490
CLV_PCSK_SKI1_1	570	574	PF00082	0.540
CLV_PCSK_SKI1_1	578	582	PF00082	0.421
CLV_PCSK_SKI1_1	690	694	PF00082	0.552
DEG_APCC_DBOX_1	19	27	PF00400	0.706
DEG_COP1_1	95	103	PF00400	0.555
DEG_SCF_FBW7_1	72	79	PF00400	0.567
DEG_SIAH_1	318	326	PF03145	0.572
DEG_SPOP_SBC_1	281	285	PF00917	0.499
DEG_SPOP_SBC_1	289	293	PF00917	0.531
DEG_SPOP_SBC_1	33	37	PF00917	0.606
DOC_CYCLIN_RxL_1	474	484	PF00134	0.504
DOC_CYCLIN_RxL_1	545	555	PF00134	0.637
DOC_MAPK_gen_1	681	688	PF00069	0.622
DOC_MAPK_MEF2A_6	264	271	PF00069	0.526
DOC_PP4_FxxP_1	498	501	PF00568	0.653
DOC_USP7_MATH_1	115	119	PF00917	0.826
DOC_USP7_MATH_1	123	127	PF00917	0.736
DOC_USP7_MATH_1	173	177	PF00917	0.804
DOC_USP7_MATH_1	281	285	PF00917	0.597
DOC_USP7_MATH_1	289	293	PF00917	0.731
DOC_USP7_MATH_1	302	306	PF00917	0.727
DOC_USP7_MATH_1	309	313	PF00917	0.593
DOC_USP7_MATH_1	461	465	PF00917	0.592
DOC_USP7_MATH_1	560	564	PF00917	0.580
DOC_USP7_MATH_1	80	84	PF00917	0.556
DOC_WW_Pin1_4	126	131	PF00397	0.800
DOC_WW_Pin1_4	160	165	PF00397	0.720
DOC_WW_Pin1_4	183	188	PF00397	0.755
DOC_WW_Pin1_4	303	308	PF00397	0.659
DOC_WW_Pin1_4	365	370	PF00397	0.686
DOC_WW_Pin1_4	448	453	PF00397	0.761
DOC_WW_Pin1_4	68	73	PF00397	0.741
DOC_WW_Pin1_4	701	706	PF00397	0.703
DOC_WW_Pin1_4	76	81	PF00397	0.714
LIG_14-3-3_CanoR_1	175	179	PF00244	0.628
LIG_14-3-3_CanoR_1	219	225	PF00244	0.585
LIG_14-3-3_CanoR_1	280	290	PF00244	0.521
LIG_14-3-3_CanoR_1	691	699	PF00244	0.704
LIG_14-3-3_CanoR_1	93	101	PF00244	0.546
LIG_14-3-3_CterR_2	707	709	PF00244	0.833
LIG_Actin_WH2_2	668	683	PF00022	0.629
LIG_BIR_II_1	1	5	PF00653	0.752
LIG_BRCT_BRCA1_1	101	105	PF00533	0.687
LIG_BRCT_BRCA1_1	221	225	PF00533	0.646
LIG_BRCT_BRCA1_1	81	85	PF00533	0.814
LIG_CaM_IQ_9	479	494	PF13499	0.423
LIG_FAT_LD_1	271	279	PF03623	0.455
LIG_FHA_1	102	108	PF00498	0.715
LIG_FHA_1	318	324	PF00498	0.633
LIG_FHA_1	387	393	PF00498	0.784
LIG_FHA_1	424	430	PF00498	0.710
LIG_FHA_1	547	553	PF00498	0.626
LIG_FHA_1	623	629	PF00498	0.405
LIG_FHA_1	691	697	PF00498	0.546
LIG_FHA_2	261	267	PF00498	0.667
LIG_FHA_2	268	274	PF00498	0.725
LIG_FHA_2	376	382	PF00498	0.756
LIG_FHA_2	532	538	PF00498	0.560
LIG_LIR_Apic_2	496	501	PF02991	0.755
LIG_LIR_Gen_1	652	658	PF02991	0.516
LIG_LIR_LC3C_4	516	519	PF02991	0.399
LIG_LIR_LC3C_4	593	598	PF02991	0.375
LIG_LIR_Nem_3	222	228	PF02991	0.682
LIG_LIR_Nem_3	236	241	PF02991	0.558
LIG_LIR_Nem_3	473	479	PF02991	0.475
LIG_LIR_Nem_3	652	657	PF02991	0.516
LIG_MLH1_MIPbox_1	82	86	PF16413	0.562
LIG_SH2_CRK	476	480	PF00017	0.536
LIG_SH2_NCK_1	24	28	PF00017	0.634
LIG_SH2_NCK_1	509	513	PF00017	0.410
LIG_SH2_STAT5	249	252	PF00017	0.637
LIG_SH2_STAT5	488	491	PF00017	0.556
LIG_SH3_1	697	703	PF00018	0.667
LIG_SH3_2	187	192	PF14604	0.826
LIG_SH3_2	702	707	PF14604	0.690
LIG_SH3_3	111	117	PF00018	0.580
LIG_SH3_3	135	141	PF00018	0.731
LIG_SH3_3	184	190	PF00018	0.828
LIG_SH3_3	697	703	PF00018	0.667
LIG_SH3_CIN85_PxpxPR_1	499	504	PF14604	0.745
LIG_SUMO_SIM_anti_2	652	660	PF11976	0.512
LIG_SUMO_SIM_par_1	440	446	PF11976	0.529
LIG_SUMO_SIM_par_1	478	484	PF11976	0.509
LIG_TRAF2_1	263	266	PF00917	0.679
LIG_TRAF2_1	378	381	PF00917	0.826
LIG_TRAF2_1	503	506	PF00917	0.621
LIG_TRAF2_1	636	639	PF00917	0.649
LIG_UBA3_1	479	487	PF00899	0.649
LIG_WRC_WIRS_1	100	105	PF05994	0.571
LIG_WW_3	704	708	PF00397	0.700
MOD_CDC14_SPxK_1	168	171	PF00782	0.824
MOD_CDC14_SPxK_1	704	707	PF00782	0.695
MOD_CDK_SPxK_1	165	171	PF00069	0.826
MOD_CDK_SPxK_1	701	707	PF00069	0.688
MOD_CDK_SPxxK_3	303	310	PF00069	0.821
MOD_CK1_1	126	132	PF00069	0.673
MOD_CK1_1	160	166	PF00069	0.806
MOD_CK1_1	174	180	PF00069	0.635
MOD_CK1_1	2	8	PF00069	0.724
MOD_CK1_1	283	289	PF00069	0.531
MOD_CK1_1	313	319	PF00069	0.715
MOD_CK1_1	329	335	PF00069	0.674
MOD_CK1_1	336	342	PF00069	0.636
MOD_CK1_1	390	396	PF00069	0.767
MOD_CK1_1	402	408	PF00069	0.634
MOD_CK1_1	79	85	PF00069	0.666
MOD_CK2_1	260	266	PF00069	0.681
MOD_CK2_1	374	380	PF00069	0.751
MOD_CK2_1	385	391	PF00069	0.505
MOD_Cter_Amidation	575	578	PF01082	0.632
MOD_GlcNHglycan	117	120	PF01048	0.710
MOD_GlcNHglycan	159	162	PF01048	0.649
MOD_GlcNHglycan	180	183	PF01048	0.773
MOD_GlcNHglycan	201	204	PF01048	0.781
MOD_GlcNHglycan	315	318	PF01048	0.724
MOD_GlcNHglycan	36	39	PF01048	0.845
MOD_GlcNHglycan	401	404	PF01048	0.825
MOD_GlcNHglycan	405	408	PF01048	0.791
MOD_GlcNHglycan	409	412	PF01048	0.722
MOD_GlcNHglycan	42	45	PF01048	0.675
MOD_GlcNHglycan	434	437	PF01048	0.774
MOD_GlcNHglycan	456	459	PF01048	0.688
MOD_GlcNHglycan	464	467	PF01048	0.572
MOD_GlcNHglycan	506	509	PF01048	0.415
MOD_GlcNHglycan	82	85	PF01048	0.621
MOD_GSK3_1	167	174	PF00069	0.767
MOD_GSK3_1	208	215	PF00069	0.789
MOD_GSK3_1	309	316	PF00069	0.665
MOD_GSK3_1	326	333	PF00069	0.671
MOD_GSK3_1	365	372	PF00069	0.692
MOD_GSK3_1	380	387	PF00069	0.620
MOD_GSK3_1	397	404	PF00069	0.823
MOD_GSK3_1	483	490	PF00069	0.578
MOD_GSK3_1	56	63	PF00069	0.738
MOD_GSK3_1	645	652	PF00069	0.515
MOD_GSK3_1	68	75	PF00069	0.742
MOD_GSK3_1	76	83	PF00069	0.483
MOD_N-GLC_1	423	428	PF02516	0.708
MOD_NEK2_1	157	162	PF00069	0.740
MOD_NEK2_1	290	295	PF00069	0.558
MOD_NEK2_1	337	342	PF00069	0.538
MOD_NEK2_1	384	389	PF00069	0.581
MOD_NEK2_1	86	91	PF00069	0.658
MOD_NEK2_2	560	565	PF00069	0.629
MOD_PIKK_1	2	8	PF00454	0.724
MOD_PIKK_1	214	220	PF00454	0.579
MOD_PIKK_1	357	363	PF00454	0.788
MOD_PIKK_1	690	696	PF00454	0.571
MOD_PKA_1	219	225	PF00069	0.585
MOD_PKA_1	520	526	PF00069	0.690
MOD_PKA_1	690	696	PF00069	0.571
MOD_PKA_2	174	180	PF00069	0.830
MOD_PKA_2	191	197	PF00069	0.551
MOD_PKA_2	218	224	PF00069	0.584
MOD_PKA_2	309	315	PF00069	0.627
MOD_PKA_2	520	526	PF00069	0.690
MOD_PKA_2	690	696	PF00069	0.672
MOD_PKA_2	92	98	PF00069	0.538
MOD_Plk_1	310	316	PF00069	0.607
MOD_Plk_1	380	386	PF00069	0.789
MOD_Plk_1	546	552	PF00069	0.637
MOD_Plk_1	684	690	PF00069	0.374
MOD_Plk_2-3	380	386	PF00069	0.833
MOD_Plk_4	174	180	PF00069	0.616
MOD_Plk_4	650	656	PF00069	0.511
MOD_Plk_4	684	690	PF00069	0.374
MOD_Plk_4	87	93	PF00069	0.591
MOD_ProDKin_1	126	132	PF00069	0.797
MOD_ProDKin_1	160	166	PF00069	0.721
MOD_ProDKin_1	183	189	PF00069	0.754
MOD_ProDKin_1	303	309	PF00069	0.660
MOD_ProDKin_1	365	371	PF00069	0.691
MOD_ProDKin_1	448	454	PF00069	0.764
MOD_ProDKin_1	68	74	PF00069	0.737
MOD_ProDKin_1	701	707	PF00069	0.709
MOD_ProDKin_1	76	82	PF00069	0.716
MOD_SUMO_rev_2	631	637	PF00179	0.396
TRG_DiLeu_BaEn_1	513	518	PF01217	0.405
TRG_DiLeu_BaLyEn_6	475	480	PF01217	0.637
TRG_DiLeu_BaLyEn_6	623	628	PF01217	0.405
TRG_ENDOCYTIC_2	476	479	PF00928	0.517
TRG_ER_diArg_1	12	14	PF00400	0.695
TRG_ER_diArg_1	351	354	PF00400	0.726
TRG_ER_diArg_1	476	478	PF00400	0.644
TRG_ER_diArg_1	538	541	PF00400	0.567
TRG_ER_diArg_1	616	619	PF00400	0.645
TRG_ER_diArg_1	663	665	PF00400	0.522
TRG_ER_diArg_1	680	682	PF00400	0.524
TRG_ER_diArg_1	92	94	PF00400	0.791
TRG_NES_CRM1_1	645	660	PF08389	0.514
TRG_Pf-PMV_PEXEL_1	12	16	PF00026	0.610
TRG_Pf-PMV_PEXEL_1	151	155	PF00026	0.685
TRG_Pf-PMV_PEXEL_1	382	386	PF00026	0.583
TRG_Pf-PMV_PEXEL_1	478	483	PF00026	0.542
TRG_Pf-PMV_PEXEL_1	500	505	PF00026	0.713
TRG_Pf-PMV_PEXEL_1	626	631	PF00026	0.416
TRG_Pf-PMV_PEXEL_1	681	685	PF00026	0.373

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDA1	Leptomonas seymouri	42%	100%
A0A3S7X301	Leishmania donovani	75%	99%
A4I577	Leishmania infantum	75%	99%
E9B0H4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	71%	100%
Q4Q7Q7	Leishmania major	73%	100%