Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HHZ8_LEIBR

TriTrypDb:

LbrM.30.0550 , LBRM2903_300011300

Length:

546

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 20
NetGPI	no	yes: 0, no: 20

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HHZ8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHZ8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	150	154	PF00656	0.397
CLV_C14_Caspase3-7	309	313	PF00656	0.736
CLV_NRD_NRD_1	195	197	PF00675	0.383
CLV_NRD_NRD_1	254	256	PF00675	0.457
CLV_NRD_NRD_1	422	424	PF00675	0.427
CLV_NRD_NRD_1	461	463	PF00675	0.446
CLV_NRD_NRD_1	505	507	PF00675	0.468
CLV_NRD_NRD_1	518	520	PF00675	0.541
CLV_NRD_NRD_1	525	527	PF00675	0.399
CLV_PCSK_FUR_1	192	196	PF00082	0.393
CLV_PCSK_KEX2_1	194	196	PF00082	0.379
CLV_PCSK_KEX2_1	223	225	PF00082	0.523
CLV_PCSK_KEX2_1	253	255	PF00082	0.491
CLV_PCSK_KEX2_1	422	424	PF00082	0.427
CLV_PCSK_KEX2_1	461	463	PF00082	0.396
CLV_PCSK_KEX2_1	48	50	PF00082	0.368
CLV_PCSK_KEX2_1	505	507	PF00082	0.424
CLV_PCSK_KEX2_1	517	519	PF00082	0.490
CLV_PCSK_KEX2_1	525	527	PF00082	0.399
CLV_PCSK_PC1ET2_1	223	225	PF00082	0.523
CLV_PCSK_PC1ET2_1	253	255	PF00082	0.483
CLV_PCSK_PC1ET2_1	48	50	PF00082	0.362
CLV_PCSK_PC1ET2_1	525	527	PF00082	0.682
CLV_PCSK_PC7_1	249	255	PF00082	0.294
CLV_PCSK_SKI1_1	306	310	PF00082	0.757
CLV_PCSK_SKI1_1	519	523	PF00082	0.690
DEG_APCC_DBOX_1	426	434	PF00400	0.447
DEG_Nend_Nbox_1	1	3	PF02207	0.412
DEG_ODPH_VHL_1	395	408	PF01847	0.522
DEG_SCF_FBW7_2	235	242	PF00400	0.389
DEG_SPOP_SBC_1	291	295	PF00917	0.606
DEG_SPOP_SBC_1	320	324	PF00917	0.796
DOC_CKS1_1	117	122	PF01111	0.563
DOC_CKS1_1	348	353	PF01111	0.684
DOC_MAPK_DCC_7	195	205	PF00069	0.403
DOC_MAPK_DCC_7	376	386	PF00069	0.538
DOC_MAPK_gen_1	128	137	PF00069	0.544
DOC_MAPK_gen_1	461	469	PF00069	0.502
DOC_MAPK_gen_1	522	532	PF00069	0.688
DOC_PP1_RVXF_1	40	47	PF00149	0.364
DOC_PP2B_LxvP_1	13	16	PF13499	0.338
DOC_PP2B_LxvP_1	288	291	PF13499	0.439
DOC_PP4_FxxP_1	117	120	PF00568	0.457
DOC_USP7_MATH_1	310	314	PF00917	0.778
DOC_USP7_MATH_1	320	324	PF00917	0.814
DOC_USP7_MATH_1	338	342	PF00917	0.613
DOC_USP7_MATH_1	446	450	PF00917	0.430
DOC_USP7_UBL2_3	439	443	PF12436	0.408
DOC_WW_Pin1_4	116	121	PF00397	0.593
DOC_WW_Pin1_4	210	215	PF00397	0.419
DOC_WW_Pin1_4	235	240	PF00397	0.381
DOC_WW_Pin1_4	283	288	PF00397	0.599
DOC_WW_Pin1_4	316	321	PF00397	0.664
DOC_WW_Pin1_4	347	352	PF00397	0.609
DOC_WW_Pin1_4	442	447	PF00397	0.429
LIG_14-3-3_CanoR_1	134	138	PF00244	0.523
LIG_14-3-3_CanoR_1	140	145	PF00244	0.486
LIG_14-3-3_CanoR_1	254	260	PF00244	0.513
LIG_14-3-3_CanoR_1	387	395	PF00244	0.451
LIG_14-3-3_CanoR_1	422	430	PF00244	0.413
LIG_14-3-3_CanoR_1	83	87	PF00244	0.427
LIG_APCC_ABBA_1	66	71	PF00400	0.536
LIG_BRCT_BRCA1_1	406	410	PF00533	0.406
LIG_Clathr_ClatBox_1	381	385	PF01394	0.498
LIG_CtBP_PxDLS_1	383	387	PF00389	0.554
LIG_CtBP_PxDLS_1	429	433	PF00389	0.499
LIG_eIF4E_1	447	453	PF01652	0.314
LIG_FHA_1	15	21	PF00498	0.333
LIG_FHA_1	210	216	PF00498	0.475
LIG_FHA_1	272	278	PF00498	0.535
LIG_FHA_1	348	354	PF00498	0.643
LIG_FHA_1	370	376	PF00498	0.448
LIG_FHA_1	415	421	PF00498	0.448
LIG_FHA_1	8	14	PF00498	0.393
LIG_FHA_1	91	97	PF00498	0.577
LIG_FHA_2	134	140	PF00498	0.554
LIG_FHA_2	148	154	PF00498	0.456
LIG_FHA_2	223	229	PF00498	0.503
LIG_FHA_2	307	313	PF00498	0.706
LIG_FHA_2	360	366	PF00498	0.352
LIG_FHA_2	83	89	PF00498	0.672
LIG_IRF3_LxIS_1	287	293	PF10401	0.441
LIG_LIR_Gen_1	148	155	PF02991	0.440
LIG_LIR_Gen_1	17	26	PF02991	0.489
LIG_LIR_Gen_1	184	193	PF02991	0.381
LIG_LIR_Gen_1	238	247	PF02991	0.420
LIG_LIR_Gen_1	280	290	PF02991	0.470
LIG_LIR_Gen_1	362	370	PF02991	0.386
LIG_LIR_Nem_3	10	14	PF02991	0.413
LIG_LIR_Nem_3	148	152	PF02991	0.412
LIG_LIR_Nem_3	162	168	PF02991	0.467
LIG_LIR_Nem_3	17	22	PF02991	0.450
LIG_LIR_Nem_3	184	189	PF02991	0.390
LIG_LIR_Nem_3	238	244	PF02991	0.393
LIG_LIR_Nem_3	258	262	PF02991	0.396
LIG_LIR_Nem_3	280	285	PF02991	0.403
LIG_LIR_Nem_3	362	367	PF02991	0.395
LIG_MYND_1	198	202	PF01753	0.422
LIG_Pex14_2	165	169	PF04695	0.410
LIG_Pex14_2	406	410	PF04695	0.406
LIG_Pex14_2	46	50	PF04695	0.497
LIG_PTB_Apo_2	358	365	PF02174	0.388
LIG_PTB_Phospho_1	358	364	PF10480	0.521
LIG_Rb_LxCxE_1	100	110	PF01857	0.528
LIG_Rb_pABgroove_1	358	366	PF01858	0.376
LIG_REV1ctd_RIR_1	44	50	PF16727	0.390
LIG_SH2_CRK	370	374	PF00017	0.499
LIG_SH2_CRK	437	441	PF00017	0.469
LIG_SH2_GRB2like	168	171	PF00017	0.408
LIG_SH2_NCK_1	437	441	PF00017	0.411
LIG_SH2_STAT5	14	17	PF00017	0.439
LIG_SH2_STAT5	168	171	PF00017	0.419
LIG_SH2_STAT5	19	22	PF00017	0.442
LIG_SH2_STAT5	405	408	PF00017	0.399
LIG_SH2_STAT5	437	440	PF00017	0.433
LIG_SH2_STAT5	84	87	PF00017	0.445
LIG_SH2_STAT5	95	98	PF00017	0.508
LIG_SH3_3	117	123	PF00018	0.601
LIG_SH3_3	327	333	PF00018	0.716
LIG_SH3_3	345	351	PF00018	0.440
LIG_SH3_3	93	99	PF00018	0.567
LIG_SUMO_SIM_anti_2	132	139	PF11976	0.345
LIG_SUMO_SIM_anti_2	55	61	PF11976	0.417
LIG_SUMO_SIM_par_1	201	207	PF11976	0.414
LIG_SUMO_SIM_par_1	55	61	PF11976	0.417
LIG_TRAF2_1	154	157	PF00917	0.543
LIG_TRAF2_1	3	6	PF00917	0.419
LIG_TRAF2_1	512	515	PF00917	0.343
LIG_UBA3_1	175	181	PF00899	0.447
LIG_WRC_WIRS_1	19	24	PF05994	0.408
LIG_WRC_WIRS_1	256	261	PF05994	0.434
MOD_CK1_1	293	299	PF00069	0.590
MOD_CK1_1	314	320	PF00069	0.670
MOD_CK1_1	322	328	PF00069	0.642
MOD_CK1_1	342	348	PF00069	0.731
MOD_CK2_1	155	161	PF00069	0.447
MOD_CK2_1	320	326	PF00069	0.595
MOD_GlcNHglycan	312	316	PF01048	0.608
MOD_GlcNHglycan	335	338	PF01048	0.638
MOD_GlcNHglycan	341	344	PF01048	0.673
MOD_GlcNHglycan	424	427	PF01048	0.315
MOD_GlcNHglycan	448	451	PF01048	0.441
MOD_GlcNHglycan	60	63	PF01048	0.470
MOD_GSK3_1	14	21	PF00069	0.558
MOD_GSK3_1	206	213	PF00069	0.427
MOD_GSK3_1	222	229	PF00069	0.467
MOD_GSK3_1	266	273	PF00069	0.401
MOD_GSK3_1	291	298	PF00069	0.583
MOD_GSK3_1	306	313	PF00069	0.496
MOD_GSK3_1	314	321	PF00069	0.646
MOD_GSK3_1	338	345	PF00069	0.740
MOD_GSK3_1	386	393	PF00069	0.539
MOD_GSK3_1	442	449	PF00069	0.599
MOD_GSK3_1	539	546	PF00069	0.686
MOD_N-GLC_1	296	301	PF02516	0.700
MOD_NEK2_1	155	160	PF00069	0.515
MOD_NEK2_1	277	282	PF00069	0.480
MOD_NEK2_1	386	391	PF00069	0.501
MOD_NEK2_1	539	544	PF00069	0.508
MOD_PKA_1	422	428	PF00069	0.429
MOD_PKA_2	133	139	PF00069	0.518
MOD_PKA_2	310	316	PF00069	0.710
MOD_PKA_2	386	392	PF00069	0.436
MOD_PKA_2	422	428	PF00069	0.429
MOD_PKA_2	82	88	PF00069	0.531
MOD_Plk_1	147	153	PF00069	0.505
MOD_Plk_1	155	161	PF00069	0.462
MOD_Plk_1	206	212	PF00069	0.444
MOD_Plk_1	500	506	PF00069	0.331
MOD_Plk_2-3	133	139	PF00069	0.333
MOD_Plk_2-3	206	212	PF00069	0.548
MOD_Plk_2-3	82	88	PF00069	0.385
MOD_Plk_4	133	139	PF00069	0.440
MOD_Plk_4	14	20	PF00069	0.385
MOD_Plk_4	24	30	PF00069	0.414
MOD_Plk_4	277	283	PF00069	0.484
MOD_Plk_4	359	365	PF00069	0.509
MOD_Plk_4	7	13	PF00069	0.369
MOD_Plk_4	91	97	PF00069	0.674
MOD_ProDKin_1	116	122	PF00069	0.590
MOD_ProDKin_1	210	216	PF00069	0.424
MOD_ProDKin_1	235	241	PF00069	0.383
MOD_ProDKin_1	283	289	PF00069	0.607
MOD_ProDKin_1	316	322	PF00069	0.665
MOD_ProDKin_1	347	353	PF00069	0.603
MOD_ProDKin_1	442	448	PF00069	0.431
MOD_SUMO_for_1	97	100	PF00179	0.584
TRG_DiLeu_BaEn_1	217	222	PF01217	0.517
TRG_DiLeu_BaLyEn_6	39	44	PF01217	0.449
TRG_ENDOCYTIC_2	19	22	PF00928	0.410
TRG_ENDOCYTIC_2	241	244	PF00928	0.413
TRG_ENDOCYTIC_2	364	367	PF00928	0.451
TRG_ENDOCYTIC_2	370	373	PF00928	0.484
TRG_ENDOCYTIC_2	405	408	PF00928	0.383
TRG_ENDOCYTIC_2	437	440	PF00928	0.394
TRG_ER_diArg_1	127	130	PF00400	0.679
TRG_ER_diArg_1	192	195	PF00400	0.409
TRG_ER_diArg_1	254	256	PF00400	0.453
TRG_ER_diArg_1	40	43	PF00400	0.441
TRG_ER_diArg_1	421	423	PF00400	0.411
TRG_ER_diArg_1	460	462	PF00400	0.469
TRG_ER_diArg_1	504	506	PF00400	0.455
TRG_ER_diArg_1	517	519	PF00400	0.515
TRG_NLS_MonoExtC_3	252	257	PF00514	0.446
TRG_Pf-PMV_PEXEL_1	474	478	PF00026	0.445
TRG_Pf-PMV_PEXEL_1	505	509	PF00026	0.473

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7T4	Leptomonas seymouri	56%	88%
A0A0S4IL03	Bodo saltans	39%	93%
A0A1X0NR90	Trypanosomatidae	29%	76%
A0A1X0P2A9	Trypanosomatidae	46%	86%
A0A3S7X1J9	Leishmania donovani	26%	73%
A0A3S7X313	Leishmania donovani	83%	100%
A0A422N566	Trypanosoma rangeli	48%	90%
A0A422NYX8	Trypanosoma rangeli	27%	80%
A4HGM0	Leishmania braziliensis	25%	85%
A4I3P5	Leishmania infantum	26%	73%
A4I575	Leishmania infantum	84%	100%
C9ZQK1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	90%
D0A8B9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	82%
E9AZY6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	68%
E9B0H2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	82%
Q4Q7R1	Leishmania major	82%	100%
Q4Q899	Leishmania major	26%	73%
V5B7S2	Trypanosoma cruzi	47%	90%
V5BJS6	Trypanosoma cruzi	27%	81%