Putative eukaryotic translation initiation factor 4e

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Eukaryotic translation initiation factor 4E-4

Species:

Leishmania braziliensis

UniProt:

A4HHZ6_LEIBR

TriTrypDb:

LbrM.30.0530 , LBRM2903_300011100

Length:

305

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 16
NetGPI	no	yes: 0, no: 16

Cellular components
Term	Name	Level	Count
GO:0000932	P-body	5	1
GO:0005737	cytoplasm	2	2
GO:0010494	cytoplasmic stress granule	5	2
GO:0016281	eukaryotic translation initiation factor 4F complex	2	2
GO:0032991	protein-containing complex	1	2
GO:0035770	ribonucleoprotein granule	3	2
GO:0036464	cytoplasmic ribonucleoprotein granule	4	2
GO:0043226	organelle	2	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0097165	nuclear stress granule	4	1
GO:0099080	supramolecular complex	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A4HHZ6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHZ6

PDB structure(s): 6h7b_B , 6h7b_D

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	17
GO:0003723	RNA binding	4	17
GO:0003743	translation initiation factor activity	4	17
GO:0005488	binding	1	17
GO:0008135	translation factor activity, RNA binding	3	17
GO:0045182	translation regulator activity	1	17
GO:0090079	translation regulator activity, nucleic acid binding	2	17
GO:0097159	organic cyclic compound binding	2	17
GO:1901363	heterocyclic compound binding	2	17
GO:0000339	RNA cap binding	5	2
GO:0000340	RNA 7-methylguanosine cap binding	6	2
GO:0000342	RNA cap 4 binding	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	219	223	PF00656	0.559
CLV_NRD_NRD_1	303	305	PF00675	0.545
CLV_NRD_NRD_1	51	53	PF00675	0.718
CLV_PCSK_FUR_1	297	301	PF00082	0.366
CLV_PCSK_KEX2_1	299	301	PF00082	0.528
CLV_PCSK_KEX2_1	302	304	PF00082	0.555
CLV_PCSK_KEX2_1	51	53	PF00082	0.718
CLV_PCSK_PC1ET2_1	299	301	PF00082	0.594
CLV_PCSK_SKI1_1	97	101	PF00082	0.670
DEG_Nend_UBRbox_3	1	3	PF02207	0.528
DEG_ODPH_VHL_1	108	121	PF01847	0.544
DOC_MAPK_FxFP_2	130	133	PF00069	0.390
DOC_MAPK_gen_1	240	248	PF00069	0.503
DOC_MAPK_MEF2A_6	242	250	PF00069	0.533
DOC_PP4_FxxP_1	130	133	PF00568	0.464
DOC_USP7_MATH_1	10	14	PF00917	0.629
DOC_USP7_MATH_1	50	54	PF00917	0.744
DOC_WW_Pin1_4	101	106	PF00397	0.564
DOC_WW_Pin1_4	165	170	PF00397	0.390
DOC_WW_Pin1_4	222	227	PF00397	0.503
DOC_WW_Pin1_4	42	47	PF00397	0.540
DOC_WW_Pin1_4	54	59	PF00397	0.616
LIG_14-3-3_CanoR_1	51	55	PF00244	0.677
LIG_14-3-3_CanoR_1	64	68	PF00244	0.602
LIG_APCC_ABBA_1	177	182	PF00400	0.518
LIG_CSL_BTD_1	264	267	PF09270	0.480
LIG_deltaCOP1_diTrp_1	124	132	PF00928	0.477
LIG_FHA_1	174	180	PF00498	0.518
LIG_FHA_1	273	279	PF00498	0.507
LIG_FHA_1	4	10	PF00498	0.493
LIG_FHA_2	133	139	PF00498	0.588
LIG_FHA_2	217	223	PF00498	0.482
LIG_LIR_Apic_2	185	191	PF02991	0.480
LIG_LIR_Gen_1	124	133	PF02991	0.477
LIG_LIR_Gen_1	209	220	PF02991	0.494
LIG_LIR_Nem_3	124	130	PF02991	0.453
LIG_LIR_Nem_3	158	163	PF02991	0.493
LIG_LIR_Nem_3	209	215	PF02991	0.519
LIG_LIR_Nem_3	263	268	PF02991	0.545
LIG_MAD2	161	169	PF02301	0.554
LIG_MAD2	97	105	PF02301	0.621
LIG_MYND_1	267	271	PF01753	0.390
LIG_PAM2_1	80	92	PF00658	0.559
LIG_PCNA_PIPBox_1	258	267	PF02747	0.554
LIG_PCNA_yPIPBox_3	252	265	PF02747	0.554
LIG_Pex14_1	127	131	PF04695	0.518
LIG_SH2_SRC	42	45	PF00017	0.494
LIG_SH2_STAT3	89	92	PF00017	0.666
LIG_SH2_STAT5	131	134	PF00017	0.493
LIG_SH2_STAT5	178	181	PF00017	0.471
LIG_SH2_STAT5	277	280	PF00017	0.396
LIG_SH2_STAT5	89	92	PF00017	0.666
LIG_WRC_WIRS_1	156	161	PF05994	0.475
MOD_CDK_SPxxK_3	222	229	PF00069	0.480
MOD_CK1_1	155	161	PF00069	0.496
MOD_CK1_1	272	278	PF00069	0.472
MOD_CK1_1	53	59	PF00069	0.646
MOD_CK1_1	63	69	PF00069	0.572
MOD_CK1_1	77	83	PF00069	0.446
MOD_CK2_1	132	138	PF00069	0.497
MOD_CK2_1	165	171	PF00069	0.431
MOD_CK2_1	224	230	PF00069	0.553
MOD_CK2_1	66	72	PF00069	0.495
MOD_GlcNHglycan	204	207	PF01048	0.350
MOD_GlcNHglycan	253	257	PF01048	0.385
MOD_GlcNHglycan	68	71	PF01048	0.626
MOD_GlcNHglycan	79	82	PF01048	0.505
MOD_GSK3_1	216	223	PF00069	0.475
MOD_GSK3_1	224	231	PF00069	0.466
MOD_GSK3_1	248	255	PF00069	0.536
MOD_GSK3_1	269	276	PF00069	0.513
MOD_GSK3_1	50	57	PF00069	0.714
MOD_N-GLC_1	3	8	PF02516	0.616
MOD_NEK2_1	172	177	PF00069	0.579
MOD_NEK2_1	216	221	PF00069	0.518
MOD_NEK2_1	273	278	PF00069	0.526
MOD_NEK2_2	50	55	PF00069	0.505
MOD_PK_1	152	158	PF00069	0.518
MOD_PKA_2	228	234	PF00069	0.475
MOD_PKA_2	50	56	PF00069	0.714
MOD_PKA_2	63	69	PF00069	0.569
MOD_Plk_1	252	258	PF00069	0.579
MOD_Plk_4	145	151	PF00069	0.523
MOD_Plk_4	155	161	PF00069	0.490
MOD_Plk_4	173	179	PF00069	0.528
MOD_Plk_4	273	279	PF00069	0.568
MOD_ProDKin_1	101	107	PF00069	0.562
MOD_ProDKin_1	165	171	PF00069	0.390
MOD_ProDKin_1	222	228	PF00069	0.503
MOD_ProDKin_1	42	48	PF00069	0.541
MOD_ProDKin_1	54	60	PF00069	0.614
MOD_SUMO_for_1	140	143	PF00179	0.554
MOD_SUMO_for_1	186	189	PF00179	0.475
TRG_DiLeu_BaEn_1	210	215	PF01217	0.554
TRG_ER_diArg_1	300	303	PF00400	0.538
TRG_NLS_MonoExtC_3	298	303	PF00514	0.588
TRG_NLS_MonoExtN_4	297	303	PF00514	0.542
TRG_Pf-PMV_PEXEL_1	218	222	PF00026	0.293
TRG_Pf-PMV_PEXEL_1	259	263	PF00026	0.327

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7F6	Leptomonas seymouri	75%	68%
A0A1X0P285	Trypanosomatidae	48%	73%
A0A3Q8IE78	Leishmania donovani	27%	100%
A0A3Q8IEL7	Leishmania donovani	89%	68%
A0A3R7L212	Trypanosoma rangeli	25%	67%
A0A422N533	Trypanosoma rangeli	49%	75%
A4HFT8	Leishmania braziliensis	27%	100%
A4I2V4	Leishmania infantum	27%	100%
A4I573	Leishmania infantum	89%	99%
C9ZQJ9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	71%
D0A951	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	69%
E9ADE1	Leishmania major	28%	100%
E9AZ65	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9B0H0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	99%
Q4Q7R3	Leishmania major	89%	100%