RRF domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Ribosome recycling factor, putative

Species:

Leishmania braziliensis

UniProt:

A4HHZ5_LEIBR

TriTrypDb:

LbrM.30.0520 , LBRM2903_300011000

Length:

211

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HHZ5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHZ5

Function

Biological processes
Term	Name	Level	Count
GO:0006412	translation	4	10
GO:0006518	peptide metabolic process	4	10
GO:0006807	nitrogen compound metabolic process	2	10
GO:0008152	metabolic process	1	10
GO:0009058	biosynthetic process	2	10
GO:0009059	macromolecule biosynthetic process	4	10
GO:0009987	cellular process	1	10
GO:0019538	protein metabolic process	3	10
GO:0034641	cellular nitrogen compound metabolic process	3	10
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	10
GO:0043043	peptide biosynthetic process	5	10
GO:0043170	macromolecule metabolic process	3	10
GO:0043603	amide metabolic process	3	10
GO:0043604	amide biosynthetic process	4	10
GO:0044237	cellular metabolic process	2	10
GO:0044238	primary metabolic process	2	10
GO:0044249	cellular biosynthetic process	3	10
GO:0044260	obsolete cellular macromolecule metabolic process	3	10
GO:0044271	cellular nitrogen compound biosynthetic process	4	10
GO:0071704	organic substance metabolic process	2	10
GO:1901564	organonitrogen compound metabolic process	3	10
GO:1901566	organonitrogen compound biosynthetic process	4	10
GO:1901576	organic substance biosynthetic process	3	10

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0043021	ribonucleoprotein complex binding	3	1
GO:0043023	ribosomal large subunit binding	4	1
GO:0044877	protein-containing complex binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	97	103	PF00089	0.330
CLV_NRD_NRD_1	128	130	PF00675	0.276
CLV_PCSK_KEX2_1	128	130	PF00082	0.276
CLV_PCSK_SKI1_1	118	122	PF00082	0.269
CLV_PCSK_SKI1_1	153	157	PF00082	0.400
DEG_APCC_DBOX_1	117	125	PF00400	0.444
DOC_CYCLIN_RxL_1	47	61	PF00134	0.308
DOC_MAPK_gen_1	100	110	PF00069	0.447
DOC_MAPK_gen_1	148	157	PF00069	0.530
DOC_MAPK_MEF2A_6	112	121	PF00069	0.447
DOC_MAPK_MEF2A_6	53	62	PF00069	0.458
DOC_MAPK_MEF2A_6	78	86	PF00069	0.500
DOC_PP2B_PxIxI_1	114	120	PF00149	0.389
DOC_USP7_MATH_1	35	39	PF00917	0.467
DOC_USP7_UBL2_3	112	116	PF12436	0.447
DOC_USP7_UBL2_3	36	40	PF12436	0.494
DOC_WW_Pin1_4	84	89	PF00397	0.504
LIG_BRCT_BRCA1_1	89	93	PF00533	0.530
LIG_Clathr_ClatBox_1	57	61	PF01394	0.465
LIG_FHA_1	150	156	PF00498	0.474
LIG_FHA_1	65	71	PF00498	0.549
LIG_FHA_1	81	87	PF00498	0.453
LIG_FHA_2	130	136	PF00498	0.530
LIG_LIR_Nem_3	141	146	PF02991	0.389
LIG_SH3_3	116	122	PF00018	0.448
LIG_SUMO_SIM_anti_2	170	178	PF11976	0.285
LIG_SUMO_SIM_anti_2	189	196	PF11976	0.399
LIG_SUMO_SIM_anti_2	67	72	PF11976	0.542
LIG_SUMO_SIM_par_1	170	178	PF11976	0.277
LIG_SUMO_SIM_par_1	56	61	PF11976	0.469
LIG_SUMO_SIM_par_1	82	87	PF11976	0.499
LIG_TRAF2_1	132	135	PF00917	0.389
LIG_UBA3_1	142	148	PF00899	0.389
MOD_CK1_1	177	183	PF00069	0.343
MOD_CK1_1	205	211	PF00069	0.448
MOD_CK2_1	129	135	PF00069	0.530
MOD_GlcNHglycan	105	108	PF01048	0.216
MOD_GlcNHglycan	179	182	PF01048	0.343
MOD_GlcNHglycan	43	46	PF01048	0.420
MOD_GlcNHglycan	89	92	PF01048	0.333
MOD_GSK3_1	76	83	PF00069	0.483
MOD_GSK3_1	89	96	PF00069	0.453
MOD_GSK3_1	99	106	PF00069	0.469
MOD_N-GLC_1	41	46	PF02516	0.418
MOD_N-GLC_1	80	85	PF02516	0.227
MOD_NEK2_1	93	98	PF00069	0.507
MOD_PIKK_1	71	77	PF00454	0.389
MOD_PKA_2	7	13	PF00069	0.608
MOD_PKA_2	99	105	PF00069	0.447
MOD_Plk_1	129	135	PF00069	0.549
MOD_Plk_1	41	47	PF00069	0.418
MOD_Plk_1	80	86	PF00069	0.418
MOD_Plk_2-3	191	197	PF00069	0.449
MOD_Plk_4	64	70	PF00069	0.533
MOD_Plk_4	93	99	PF00069	0.511
MOD_ProDKin_1	84	90	PF00069	0.504
MOD_SUMO_rev_2	130	139	PF00179	0.389
TRG_DiLeu_BaEn_1	135	140	PF01217	0.530
TRG_NES_CRM1_1	191	206	PF08389	0.480
TRG_Pf-PMV_PEXEL_1	144	149	PF00026	0.250

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILR8	Leptomonas seymouri	74%	73%
A0A0S4KKH0	Bodo saltans	42%	79%
A0A1X0P2I0	Trypanosomatidae	57%	75%
A0A3Q8IJ57	Leishmania donovani	86%	73%
A0A422N514	Trypanosoma rangeli	56%	74%
A4I572	Leishmania infantum	87%	100%
E9B0G9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4Q7R4	Leishmania major	88%	100%