Sulfhydryl oxidase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Sulfhydryl oxidase

Gene product:

quiescin sulfhydryl oxidase, putative

Species:

Leishmania braziliensis

UniProt:

A4HHZ4_LEIBR

TriTrypDb:

LbrM.30.0510 , LBRM2903_300010900

Length:

554

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 9, no: 1
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	11
GO:0005615	extracellular space	2	1

Expansion

Sequence features

A4HHZ4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHZ4

Function

Biological processes
Term	Name	Level	Count
GO:0006457	protein folding	2	1
GO:0009987	cellular process	1	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0015035	protein-disulfide reductase activity	3	11
GO:0015036	disulfide oxidoreductase activity	4	11
GO:0016491	oxidoreductase activity	2	11
GO:0016667	oxidoreductase activity, acting on a sulfur group of donors	3	11
GO:0016670	oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor	4	11
GO:0016971	flavin-linked sulfhydryl oxidase activity	4	11
GO:0016972	thiol oxidase activity	5	11
GO:0140096	catalytic activity, acting on a protein	2	11
GO:0003756	protein disulfide isomerase activity	3	1
GO:0016853	isomerase activity	2	1
GO:0016860	intramolecular oxidoreductase activity	3	1
GO:0016864	intramolecular oxidoreductase activity, transposing S-S bonds	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	114	116	PF00675	0.445
CLV_NRD_NRD_1	179	181	PF00675	0.592
CLV_NRD_NRD_1	265	267	PF00675	0.557
CLV_NRD_NRD_1	420	422	PF00675	0.528
CLV_NRD_NRD_1	433	435	PF00675	0.592
CLV_NRD_NRD_1	493	495	PF00675	0.617
CLV_NRD_NRD_1	534	536	PF00675	0.375
CLV_NRD_NRD_1	544	546	PF00675	0.402
CLV_PCSK_KEX2_1	114	116	PF00082	0.369
CLV_PCSK_KEX2_1	264	266	PF00082	0.564
CLV_PCSK_KEX2_1	420	422	PF00082	0.508
CLV_PCSK_KEX2_1	435	437	PF00082	0.457
CLV_PCSK_KEX2_1	493	495	PF00082	0.726
CLV_PCSK_KEX2_1	534	536	PF00082	0.366
CLV_PCSK_KEX2_1	542	544	PF00082	0.420
CLV_PCSK_PC1ET2_1	435	437	PF00082	0.513
CLV_PCSK_PC1ET2_1	542	544	PF00082	0.526
CLV_PCSK_SKI1_1	157	161	PF00082	0.574
CLV_PCSK_SKI1_1	163	167	PF00082	0.439
CLV_PCSK_SKI1_1	207	211	PF00082	0.427
CLV_PCSK_SKI1_1	265	269	PF00082	0.479
CLV_PCSK_SKI1_1	317	321	PF00082	0.560
CLV_PCSK_SKI1_1	384	388	PF00082	0.465
CLV_PCSK_SKI1_1	435	439	PF00082	0.544
CLV_PCSK_SKI1_1	545	549	PF00082	0.552
CLV_PCSK_SKI1_1	83	87	PF00082	0.369
DEG_APCC_DBOX_1	202	210	PF00400	0.210
DEG_APCC_DBOX_1	265	273	PF00400	0.287
DOC_CDC14_PxL_1	1	9	PF14671	0.375
DOC_CKS1_1	327	332	PF01111	0.320
DOC_CYCLIN_yCln2_LP_2	126	132	PF00134	0.224
DOC_MAPK_gen_1	264	271	PF00069	0.200
DOC_MAPK_gen_1	403	411	PF00069	0.252
DOC_MAPK_gen_1	542	550	PF00069	0.714
DOC_MAPK_MEF2A_6	403	411	PF00069	0.188
DOC_MAPK_MEF2A_6	542	550	PF00069	0.688
DOC_PP1_RVXF_1	329	336	PF00149	0.324
DOC_PP2B_LxvP_1	126	129	PF13499	0.243
DOC_PP2B_LxvP_1	76	79	PF13499	0.169
DOC_PP2B_PxIxI_1	60	66	PF00149	0.369
DOC_PP4_FxxP_1	438	441	PF00568	0.208
DOC_SPAK_OSR1_1	459	463	PF12202	0.227
DOC_USP7_MATH_1	120	124	PF00917	0.227
DOC_USP7_MATH_1	186	190	PF00917	0.357
DOC_USP7_MATH_1	192	196	PF00917	0.365
DOC_USP7_MATH_1	293	297	PF00917	0.456
DOC_USP7_MATH_1	308	312	PF00917	0.422
DOC_USP7_MATH_1	451	455	PF00917	0.337
DOC_USP7_MATH_1	536	540	PF00917	0.640
DOC_WW_Pin1_4	326	331	PF00397	0.327
LIG_14-3-3_CanoR_1	157	162	PF00244	0.332
LIG_14-3-3_CanoR_1	25	29	PF00244	0.634
LIG_14-3-3_CanoR_1	334	343	PF00244	0.315
LIG_14-3-3_CanoR_1	459	469	PF00244	0.304
LIG_14-3-3_CanoR_1	6	16	PF00244	0.360
LIG_14-3-3_CanoR_1	75	79	PF00244	0.288
LIG_Actin_WH2_2	520	536	PF00022	0.297
LIG_AP2alpha_1	36	40	PF02296	0.332
LIG_APCC_ABBAyCdc20_2	434	440	PF00400	0.212
LIG_BRCT_BRCA1_1	12	16	PF00533	0.458
LIG_Clathr_ClatBox_1	256	260	PF01394	0.239
LIG_CtBP_PxDLS_1	129	133	PF00389	0.317
LIG_eIF4E_1	251	257	PF01652	0.265
LIG_FHA_1	227	233	PF00498	0.369
LIG_FHA_1	358	364	PF00498	0.241
LIG_FHA_1	392	398	PF00498	0.310
LIG_FHA_1	484	490	PF00498	0.489
LIG_FHA_1	521	527	PF00498	0.335
LIG_FHA_2	106	112	PF00498	0.190
LIG_FHA_2	192	198	PF00498	0.422
LIG_FHA_2	451	457	PF00498	0.379
LIG_FHA_2	482	488	PF00498	0.347
LIG_FHA_2	86	92	PF00498	0.271
LIG_LIR_Gen_1	123	132	PF02991	0.282
LIG_LIR_Gen_1	13	23	PF02991	0.505
LIG_LIR_Gen_1	234	245	PF02991	0.321
LIG_LIR_Gen_1	248	259	PF02991	0.247
LIG_LIR_Gen_1	305	313	PF02991	0.373
LIG_LIR_Gen_1	314	322	PF02991	0.365
LIG_LIR_Gen_1	374	383	PF02991	0.338
LIG_LIR_Gen_1	38	45	PF02991	0.320
LIG_LIR_Gen_1	394	401	PF02991	0.126
LIG_LIR_Nem_3	123	128	PF02991	0.324
LIG_LIR_Nem_3	13	19	PF02991	0.437
LIG_LIR_Nem_3	234	240	PF02991	0.336
LIG_LIR_Nem_3	248	254	PF02991	0.242
LIG_LIR_Nem_3	305	310	PF02991	0.379
LIG_LIR_Nem_3	314	318	PF02991	0.365
LIG_LIR_Nem_3	342	348	PF02991	0.282
LIG_LIR_Nem_3	374	380	PF02991	0.338
LIG_LIR_Nem_3	38	43	PF02991	0.374
LIG_LIR_Nem_3	394	399	PF02991	0.201
LIG_LIR_Nem_3	471	476	PF02991	0.215
LIG_MYND_1	441	445	PF01753	0.230
LIG_Pex14_2	36	40	PF04695	0.370
LIG_PTB_Apo_2	296	303	PF02174	0.314
LIG_PTB_Phospho_1	296	302	PF10480	0.319
LIG_SH2_CRK	356	360	PF00017	0.263
LIG_SH2_NCK_1	289	293	PF00017	0.238
LIG_SH2_STAP1	289	293	PF00017	0.380
LIG_SH2_STAP1	382	386	PF00017	0.334
LIG_SH2_STAT5	125	128	PF00017	0.366
LIG_SH2_STAT5	171	174	PF00017	0.227
LIG_SH2_STAT5	205	208	PF00017	0.339
LIG_SH2_STAT5	468	471	PF00017	0.327
LIG_SH2_STAT5	531	534	PF00017	0.601
LIG_SH3_1	543	549	PF00018	0.703
LIG_SH3_2	546	551	PF14604	0.693
LIG_SH3_3	543	549	PF00018	0.703
LIG_SUMO_SIM_anti_2	253	258	PF11976	0.206
LIG_SUMO_SIM_anti_2	523	528	PF11976	0.387
LIG_SUMO_SIM_par_1	41	48	PF11976	0.324
LIG_TRAF2_1	109	112	PF00917	0.169
LIG_TRFH_1	125	129	PF08558	0.322
LIG_TYR_ITIM	354	359	PF00017	0.263
LIG_TYR_ITSM	247	254	PF00017	0.257
LIG_UBA3_1	126	135	PF00899	0.235
MOD_CDK_SPK_2	326	331	PF00069	0.327
MOD_CK2_1	105	111	PF00069	0.256
MOD_CK2_1	130	136	PF00069	0.371
MOD_CK2_1	191	197	PF00069	0.350
MOD_CK2_1	451	457	PF00069	0.395
MOD_CK2_1	481	487	PF00069	0.439
MOD_GlcNHglycan	184	187	PF01048	0.511
MOD_GlcNHglycan	260	263	PF01048	0.606
MOD_GlcNHglycan	320	323	PF01048	0.534
MOD_GlcNHglycan	538	541	PF01048	0.476
MOD_GlcNHglycan	55	58	PF01048	0.498
MOD_GlcNHglycan	67	70	PF01048	0.463
MOD_GlcNHglycan	76	79	PF01048	0.491
MOD_GlcNHglycan	90	94	PF01048	0.362
MOD_GSK3_1	130	137	PF00069	0.356
MOD_GSK3_1	182	189	PF00069	0.343
MOD_GSK3_1	27	34	PF00069	0.414
MOD_GSK3_1	334	341	PF00069	0.278
MOD_GSK3_1	481	488	PF00069	0.464
MOD_GSK3_1	85	92	PF00069	0.322
MOD_LATS_1	332	338	PF00433	0.217
MOD_N-GLC_1	130	135	PF02516	0.586
MOD_N-GLC_1	293	298	PF02516	0.585
MOD_NEK2_1	130	135	PF00069	0.265
MOD_NEK2_1	246	251	PF00069	0.292
MOD_NEK2_1	287	292	PF00069	0.402
MOD_NEK2_1	29	34	PF00069	0.424
MOD_NEK2_1	318	323	PF00069	0.310
MOD_NEK2_1	480	485	PF00069	0.348
MOD_NEK2_1	53	58	PF00069	0.327
MOD_NEK2_1	7	12	PF00069	0.396
MOD_PIKK_1	27	33	PF00454	0.302
MOD_PKA_2	24	30	PF00069	0.475
MOD_PKA_2	506	512	PF00069	0.324
MOD_PKA_2	536	542	PF00069	0.513
MOD_PKA_2	74	80	PF00069	0.298
MOD_Plk_1	135	141	PF00069	0.474
MOD_Plk_1	232	238	PF00069	0.379
MOD_Plk_1	293	299	PF00069	0.433
MOD_Plk_1	79	85	PF00069	0.230
MOD_Plk_1	97	103	PF00069	0.320
MOD_Plk_2-3	107	113	PF00069	0.191
MOD_Plk_4	10	16	PF00069	0.465
MOD_Plk_4	120	126	PF00069	0.323
MOD_Plk_4	186	192	PF00069	0.338
MOD_Plk_4	24	30	PF00069	0.380
MOD_Plk_4	246	252	PF00069	0.268
MOD_Plk_4	31	37	PF00069	0.225
MOD_Plk_4	514	520	PF00069	0.305
MOD_ProDKin_1	326	332	PF00069	0.328
TRG_AP2beta_CARGO_1	374	384	PF09066	0.310
TRG_DiLeu_BaEn_4	111	117	PF01217	0.169
TRG_ENDOCYTIC_2	125	128	PF00928	0.310
TRG_ENDOCYTIC_2	251	254	PF00928	0.260
TRG_ENDOCYTIC_2	345	348	PF00928	0.273
TRG_ENDOCYTIC_2	356	359	PF00928	0.208
TRG_ENDOCYTIC_2	473	476	PF00928	0.213
TRG_ER_diArg_1	114	116	PF00400	0.169
TRG_ER_diArg_1	264	266	PF00400	0.359
TRG_ER_diArg_1	420	422	PF00400	0.328
TRG_ER_diArg_1	433	436	PF00400	0.393
TRG_ER_diArg_1	533	535	PF00400	0.552
TRG_ER_diArg_1	543	545	PF00400	0.617
TRG_NLS_Bipartite_1	420	438	PF00514	0.247
TRG_NLS_MonoCore_2	541	546	PF00514	0.687
TRG_NLS_MonoExtC_3	541	546	PF00514	0.699
TRG_NLS_MonoExtN_4	431	438	PF00514	0.235
TRG_Pf-PMV_PEXEL_1	163	168	PF00026	0.533
TRG_Pf-PMV_PEXEL_1	266	270	PF00026	0.404
TRG_Pf-PMV_PEXEL_1	331	336	PF00026	0.428
TRG_Pf-PMV_PEXEL_1	420	424	PF00026	0.369

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2H4	Leptomonas seymouri	48%	96%
A0A0S4ILW1	Bodo saltans	29%	72%
A0A1X0P2E7	Trypanosomatidae	36%	100%
A0A3S7X306	Leishmania donovani	67%	99%
A0A422NMK4	Trypanosoma rangeli	39%	100%
A4I571	Leishmania infantum	67%	99%
C9ZQJ7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9B0G8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	66%	99%
Q4Q7R5	Leishmania major	68%	100%
Q6IUU3	Rattus norvegicus	24%	74%