DAGKc domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Diacylglycerol kinase catalytic domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HHZ3_LEIBR

TriTrypDb:

LbrM.30.0500 , LBRM2903_300010800

Length:

367

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0016020	membrane	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HHZ3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHZ3

Function

Biological processes
Term	Name	Level	Count
GO:0006066	alcohol metabolic process	3	1
GO:0006629	lipid metabolic process	3	1
GO:0006643	membrane lipid metabolic process	4	1
GO:0006665	sphingolipid metabolic process	4	1
GO:0006670	sphingosine metabolic process	6	1
GO:0006793	phosphorus metabolic process	3	3
GO:0006796	phosphate-containing compound metabolic process	4	3
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	3
GO:0008610	lipid biosynthetic process	4	1
GO:0009058	biosynthetic process	2	1
GO:0009987	cellular process	1	3
GO:0016310	phosphorylation	5	3
GO:0019751	polyol metabolic process	4	1
GO:0030148	sphingolipid biosynthetic process	5	1
GO:0034311	diol metabolic process	5	1
GO:0034312	diol biosynthetic process	6	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0044237	cellular metabolic process	2	3
GO:0044238	primary metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044255	cellular lipid metabolic process	3	1
GO:0044271	cellular nitrogen compound biosynthetic process	4	1
GO:0044281	small molecule metabolic process	2	1
GO:0044283	small molecule biosynthetic process	3	1
GO:0046165	alcohol biosynthetic process	4	1
GO:0046173	polyol biosynthetic process	5	1
GO:0046467	membrane lipid biosynthetic process	4	1
GO:0046512	sphingosine biosynthetic process	5	1
GO:0046519	sphingoid metabolic process	5	1
GO:0046520	sphingoid biosynthetic process	6	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901566	organonitrogen compound biosynthetic process	4	1
GO:1901576	organic substance biosynthetic process	3	1
GO:1901615	organic hydroxy compound metabolic process	3	1
GO:1901617	organic hydroxy compound biosynthetic process	4	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0016301	kinase activity	4	10
GO:0016740	transferase activity	2	10
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	10
GO:0001727	lipid kinase activity	5	1
GO:0003951	NAD+ kinase activity	5	1
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	312	316	PF00656	0.581
CLV_NRD_NRD_1	147	149	PF00675	0.397
CLV_NRD_NRD_1	17	19	PF00675	0.199
CLV_NRD_NRD_1	258	260	PF00675	0.469
CLV_PCSK_KEX2_1	147	149	PF00082	0.397
CLV_PCSK_KEX2_1	17	19	PF00082	0.393
CLV_PCSK_KEX2_1	258	260	PF00082	0.525
CLV_PCSK_KEX2_1	5	7	PF00082	0.490
CLV_PCSK_PC1ET2_1	5	7	PF00082	0.490
CLV_PCSK_SKI1_1	259	263	PF00082	0.425
CLV_PCSK_SKI1_1	6	10	PF00082	0.393
CLV_PCSK_SKI1_1	96	100	PF00082	0.308
DEG_APCC_DBOX_1	137	145	PF00400	0.537
DEG_APCC_DBOX_1	95	103	PF00400	0.308
DEG_SCF_FBW7_1	250	255	PF00400	0.385
DEG_SPOP_SBC_1	149	153	PF00917	0.372
DEG_SPOP_SBC_1	316	320	PF00917	0.462
DOC_CDC14_PxL_1	99	107	PF14671	0.275
DOC_CYCLIN_RxL_1	71	81	PF00134	0.199
DOC_MAPK_gen_1	5	11	PF00069	0.344
DOC_MAPK_MEF2A_6	229	237	PF00069	0.370
DOC_PP1_RVXF_1	302	308	PF00149	0.474
DOC_PP2B_LxvP_1	105	108	PF13499	0.316
DOC_USP7_MATH_1	127	131	PF00917	0.286
DOC_USP7_MATH_1	149	153	PF00917	0.372
DOC_USP7_MATH_1	268	272	PF00917	0.306
DOC_USP7_MATH_1	316	320	PF00917	0.701
DOC_USP7_MATH_1	333	337	PF00917	0.625
DOC_USP7_MATH_1	348	352	PF00917	0.496
DOC_USP7_MATH_1	80	84	PF00917	0.369
DOC_WW_Pin1_4	248	253	PF00397	0.476
DOC_WW_Pin1_4	329	334	PF00397	0.670
DOC_WW_Pin1_4	353	358	PF00397	0.403
DOC_WW_Pin1_4	91	96	PF00397	0.352
LIG_14-3-3_CanoR_1	126	132	PF00244	0.276
LIG_14-3-3_CanoR_1	147	157	PF00244	0.513
LIG_14-3-3_CanoR_1	159	165	PF00244	0.354
LIG_14-3-3_CanoR_1	17	22	PF00244	0.295
LIG_14-3-3_CanoR_1	176	181	PF00244	0.302
LIG_14-3-3_CanoR_1	258	264	PF00244	0.418
LIG_BRCT_BRCA1_1	152	156	PF00533	0.390
LIG_BRCT_BRCA1_1	80	84	PF00533	0.245
LIG_Clathr_ClatBox_1	337	341	PF01394	0.422
LIG_FHA_1	134	140	PF00498	0.311
LIG_FHA_1	212	218	PF00498	0.429
LIG_FHA_1	265	271	PF00498	0.335
LIG_FHA_2	120	126	PF00498	0.341
LIG_FHA_2	202	208	PF00498	0.445
LIG_FHA_2	354	360	PF00498	0.452
LIG_LIR_Gen_1	185	194	PF02991	0.472
LIG_LIR_Gen_1	200	211	PF02991	0.455
LIG_LIR_Gen_1	306	313	PF02991	0.339
LIG_LIR_LC3C_4	129	133	PF02991	0.393
LIG_LIR_Nem_3	185	190	PF02991	0.417
LIG_LIR_Nem_3	200	206	PF02991	0.419
LIG_LIR_Nem_3	306	310	PF02991	0.360
LIG_MYND_1	242	246	PF01753	0.431
LIG_SH2_PTP2	187	190	PF00017	0.411
LIG_SH2_STAP1	170	174	PF00017	0.351
LIG_SH2_STAT5	164	167	PF00017	0.307
LIG_SH2_STAT5	187	190	PF00017	0.456
LIG_SH2_STAT5	31	34	PF00017	0.311
LIG_SH3_3	185	191	PF00018	0.495
LIG_SH3_3	342	348	PF00018	0.505
LIG_SH3_3	39	45	PF00018	0.393
LIG_SUMO_SIM_par_1	103	109	PF11976	0.362
LIG_SUMO_SIM_par_1	334	341	PF11976	0.517
LIG_SUMO_SIM_par_1	7	13	PF11976	0.199
LIG_TRAF2_1	295	298	PF00917	0.427
LIG_TRFH_1	248	252	PF08558	0.354
LIG_WRC_WIRS_1	21	26	PF05994	0.243
MOD_CDK_SPK_2	91	96	PF00069	0.199
MOD_CK1_1	114	120	PF00069	0.335
MOD_CK1_1	151	157	PF00069	0.540
MOD_CK1_1	163	169	PF00069	0.233
MOD_CK1_1	311	317	PF00069	0.488
MOD_CK1_1	332	338	PF00069	0.556
MOD_CK1_1	351	357	PF00069	0.347
MOD_CK1_1	94	100	PF00069	0.275
MOD_CK2_1	119	125	PF00069	0.341
MOD_CK2_1	176	182	PF00069	0.309
MOD_CK2_1	201	207	PF00069	0.433
MOD_CK2_1	306	312	PF00069	0.452
MOD_CK2_1	353	359	PF00069	0.451
MOD_CK2_1	94	100	PF00069	0.341
MOD_Cter_Amidation	15	18	PF01082	0.199
MOD_GlcNHglycan	122	125	PF01048	0.205
MOD_GlcNHglycan	14	17	PF01048	0.300
MOD_GlcNHglycan	153	156	PF01048	0.609
MOD_GSK3_1	111	118	PF00069	0.280
MOD_GSK3_1	160	167	PF00069	0.491
MOD_GSK3_1	197	204	PF00069	0.436
MOD_GSK3_1	20	27	PF00069	0.286
MOD_GSK3_1	206	213	PF00069	0.465
MOD_GSK3_1	246	253	PF00069	0.385
MOD_GSK3_1	264	271	PF00069	0.461
MOD_GSK3_1	311	318	PF00069	0.499
MOD_GSK3_1	329	336	PF00069	0.431
MOD_GSK3_1	349	356	PF00069	0.406
MOD_GSK3_1	78	85	PF00069	0.366
MOD_GSK3_1	87	94	PF00069	0.349
MOD_LATS_1	257	263	PF00433	0.443
MOD_N-GLC_1	211	216	PF02516	0.452
MOD_NEK2_1	111	116	PF00069	0.276
MOD_NEK2_1	119	124	PF00069	0.276
MOD_NEK2_1	197	202	PF00069	0.445
MOD_NEK2_1	236	241	PF00069	0.445
MOD_NEK2_1	24	29	PF00069	0.275
MOD_NEK2_1	261	266	PF00069	0.332
MOD_NEK2_1	78	83	PF00069	0.369
MOD_NEK2_1	84	89	PF00069	0.350
MOD_PIKK_1	206	212	PF00454	0.339
MOD_PIKK_1	236	242	PF00454	0.397
MOD_PIKK_1	318	324	PF00454	0.701
MOD_PKA_1	17	23	PF00069	0.199
MOD_PKA_2	17	23	PF00069	0.199
MOD_PKA_2	175	181	PF00069	0.325
MOD_Plk_1	211	217	PF00069	0.543
MOD_Plk_1	268	274	PF00069	0.432
MOD_Plk_1	333	339	PF00069	0.358
MOD_Plk_1	358	364	PF00069	0.393
MOD_Plk_2-3	306	312	PF00069	0.350
MOD_Plk_4	127	133	PF00069	0.393
MOD_Plk_4	160	166	PF00069	0.305
MOD_Plk_4	333	339	PF00069	0.473
MOD_ProDKin_1	248	254	PF00069	0.474
MOD_ProDKin_1	329	335	PF00069	0.654
MOD_ProDKin_1	353	359	PF00069	0.410
MOD_ProDKin_1	91	97	PF00069	0.352
TRG_DiLeu_BaEn_1	334	339	PF01217	0.403
TRG_DiLeu_BaEn_2	184	190	PF01217	0.408
TRG_DiLeu_BaLyEn_6	231	236	PF01217	0.413
TRG_DiLeu_LyEn_5	100	105	PF01217	0.341
TRG_ENDOCYTIC_2	187	190	PF00928	0.457
TRG_ER_diArg_1	146	148	PF00400	0.367
TRG_ER_diArg_1	272	275	PF00400	0.392
TRG_Pf-PMV_PEXEL_1	96	100	PF00026	0.227

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHE5	Leptomonas seymouri	57%	95%
A0A1X0P2A6	Trypanosomatidae	39%	100%
A0A3R7L399	Trypanosoma rangeli	36%	100%
A0A3S7X308	Leishmania donovani	77%	100%
A4I570	Leishmania infantum	77%	100%
C9ZQJ6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9B0G7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
Q4Q7R6	Leishmania major	78%	100%