Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

WD-40 repeat protein

Species:

Leishmania braziliensis

UniProt:

A4HHZ2_LEIBR

TriTrypDb:

LbrM.30.0490 , LBRM2903_300010700

Length:

479

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	11
GO:0005840	ribosome	5	12
GO:0032991	protein-containing complex	1	12
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	11
GO:0043228	non-membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043231	intracellular membrane-bounded organelle	4	11
GO:0043232	intracellular non-membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	12
GO:1990904	ribonucleoprotein complex	2	12
GO:0005654	nucleoplasm	2	1
GO:0005847	mRNA cleavage and polyadenylation specificity factor complex	4	1
GO:0005849	mRNA cleavage factor complex	3	1
GO:0140513	nuclear protein-containing complex	2	1

Expansion

Sequence features

A4HHZ2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHZ2

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006396	RNA processing	6	12
GO:0006397	mRNA processing	7	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016070	RNA metabolic process	5	12
GO:0016071	mRNA metabolic process	6	12
GO:0031123	RNA 3'-end processing	7	12
GO:0031124	mRNA 3'-end processing	8	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12
GO:0006378	mRNA polyadenylation	7	1
GO:0043631	RNA polyadenylation	6	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	383	387	PF00656	0.446
CLV_NRD_NRD_1	147	149	PF00675	0.314
CLV_NRD_NRD_1	188	190	PF00675	0.563
CLV_NRD_NRD_1	350	352	PF00675	0.533
CLV_NRD_NRD_1	43	45	PF00675	0.632
CLV_NRD_NRD_1	57	59	PF00675	0.455
CLV_NRD_NRD_1	8	10	PF00675	0.694
CLV_PCSK_KEX2_1	147	149	PF00082	0.314
CLV_PCSK_KEX2_1	188	190	PF00082	0.563
CLV_PCSK_KEX2_1	358	360	PF00082	0.499
CLV_PCSK_KEX2_1	42	44	PF00082	0.646
CLV_PCSK_KEX2_1	57	59	PF00082	0.460
CLV_PCSK_KEX2_1	7	9	PF00082	0.694
CLV_PCSK_PC1ET2_1	358	360	PF00082	0.499
CLV_PCSK_PC7_1	3	9	PF00082	0.627
CLV_PCSK_SKI1_1	147	151	PF00082	0.299
CLV_PCSK_SKI1_1	334	338	PF00082	0.311
CLV_PCSK_SKI1_1	358	362	PF00082	0.475
DEG_APCC_DBOX_1	133	141	PF00400	0.338
DEG_Nend_UBRbox_2	1	3	PF02207	0.717
DOC_ANK_TNKS_1	327	334	PF00023	0.517
DOC_CKS1_1	133	138	PF01111	0.474
DOC_MAPK_gen_1	188	194	PF00069	0.509
DOC_PP1_RVXF_1	180	187	PF00149	0.317
DOC_PP1_RVXF_1	221	228	PF00149	0.317
DOC_PP1_RVXF_1	367	373	PF00149	0.311
DOC_PP1_RVXF_1	62	69	PF00149	0.514
DOC_PP4_FxxP_1	68	71	PF00568	0.627
DOC_USP7_MATH_1	293	297	PF00917	0.439
DOC_USP7_MATH_1	374	378	PF00917	0.456
DOC_USP7_MATH_1	385	389	PF00917	0.316
DOC_USP7_UBL2_3	421	425	PF12436	0.562
DOC_WW_Pin1_4	132	137	PF00397	0.488
DOC_WW_Pin1_4	30	35	PF00397	0.481
DOC_WW_Pin1_4	432	437	PF00397	0.460
DOC_WW_Pin1_4	67	72	PF00397	0.567
DOC_WW_Pin1_4	82	87	PF00397	0.322
LIG_14-3-3_CanoR_1	148	158	PF00244	0.305
LIG_14-3-3_CanoR_1	351	355	PF00244	0.540
LIG_14-3-3_CanoR_1	43	51	PF00244	0.677
LIG_BRCT_BRCA1_1	26	30	PF00533	0.732
LIG_BRCT_BRCA1_1	376	380	PF00533	0.511
LIG_CSL_BTD_1	433	436	PF09270	0.458
LIG_deltaCOP1_diTrp_1	224	234	PF00928	0.335
LIG_eIF4E_1	96	102	PF01652	0.531
LIG_FHA_1	115	121	PF00498	0.208
LIG_FHA_1	246	252	PF00498	0.445
LIG_FHA_1	342	348	PF00498	0.496
LIG_FHA_1	359	365	PF00498	0.418
LIG_FHA_1	400	406	PF00498	0.674
LIG_FHA_1	76	82	PF00498	0.431
LIG_FHA_1	96	102	PF00498	0.308
LIG_FHA_2	351	357	PF00498	0.539
LIG_FHA_2	373	379	PF00498	0.492
LIG_FHA_2	381	387	PF00498	0.444
LIG_LIR_Apic_2	67	71	PF02991	0.632
LIG_LIR_Gen_1	157	166	PF02991	0.306
LIG_LIR_Gen_1	207	215	PF02991	0.316
LIG_LIR_Nem_3	157	161	PF02991	0.286
LIG_LIR_Nem_3	224	230	PF02991	0.420
LIG_LIR_Nem_3	282	288	PF02991	0.415
LIG_LIR_Nem_3	388	394	PF02991	0.354
LIG_PCNA_yPIPBox_3	74	83	PF02747	0.453
LIG_Pex14_1	205	209	PF04695	0.337
LIG_Pex14_2	26	30	PF04695	0.547
LIG_Pex14_2	45	49	PF04695	0.698
LIG_PTB_Apo_2	205	212	PF02174	0.488
LIG_SH2_CRK	288	292	PF00017	0.459
LIG_SH2_STAP1	138	142	PF00017	0.383
LIG_SH2_STAP1	87	91	PF00017	0.509
LIG_SH2_STAT3	138	141	PF00017	0.454
LIG_SH3_2	38	43	PF14604	0.682
LIG_SH3_3	35	41	PF00018	0.676
LIG_TRAF2_1	458	461	PF00917	0.436
LIG_TYR_ITIM	389	394	PF00017	0.383
MOD_CK1_1	18	24	PF00069	0.611
MOD_CK1_1	296	302	PF00069	0.344
MOD_CK1_1	310	316	PF00069	0.324
MOD_CK2_1	350	356	PF00069	0.540
MOD_CK2_1	441	447	PF00069	0.395
MOD_Cter_Amidation	145	148	PF01082	0.332
MOD_Cter_Amidation	186	189	PF01082	0.509
MOD_GlcNHglycan	142	145	PF01048	0.446
MOD_GlcNHglycan	17	20	PF01048	0.656
MOD_GlcNHglycan	194	197	PF01048	0.291
MOD_GlcNHglycan	240	244	PF01048	0.335
MOD_GlcNHglycan	25	29	PF01048	0.712
MOD_GlcNHglycan	337	340	PF01048	0.280
MOD_GlcNHglycan	443	446	PF01048	0.290
MOD_GSK3_1	100	107	PF00069	0.335
MOD_GSK3_1	110	117	PF00069	0.290
MOD_GSK3_1	210	217	PF00069	0.404
MOD_GSK3_1	318	325	PF00069	0.355
MOD_GSK3_1	337	344	PF00069	0.220
MOD_GSK3_1	81	88	PF00069	0.547
MOD_N-GLC_1	109	114	PF02516	0.434
MOD_N-GLC_1	120	125	PF02516	0.296
MOD_NEK2_1	140	145	PF00069	0.332
MOD_NEK2_1	149	154	PF00069	0.292
MOD_NEK2_1	15	20	PF00069	0.465
MOD_NEK2_1	204	209	PF00069	0.316
MOD_NEK2_1	291	296	PF00069	0.252
MOD_NEK2_1	379	384	PF00069	0.337
MOD_NEK2_1	441	446	PF00069	0.280
MOD_PIKK_1	114	120	PF00454	0.322
MOD_PIKK_1	293	299	PF00454	0.252
MOD_PIKK_1	318	324	PF00454	0.346
MOD_PIKK_1	350	356	PF00454	0.532
MOD_PKA_1	358	364	PF00069	0.513
MOD_PKA_2	310	316	PF00069	0.398
MOD_PKA_2	350	356	PF00069	0.532
MOD_PKA_2	358	364	PF00069	0.513
MOD_PKB_1	42	50	PF00069	0.701
MOD_Plk_1	120	126	PF00069	0.348
MOD_Plk_1	223	229	PF00069	0.325
MOD_Plk_4	385	391	PF00069	0.357
MOD_ProDKin_1	132	138	PF00069	0.484
MOD_ProDKin_1	30	36	PF00069	0.482
MOD_ProDKin_1	432	438	PF00069	0.314
MOD_ProDKin_1	67	73	PF00069	0.560
MOD_ProDKin_1	82	88	PF00069	0.328
MOD_SUMO_for_1	271	274	PF00179	0.379
MOD_SUMO_rev_2	165	173	PF00179	0.383
MOD_SUMO_rev_2	226	234	PF00179	0.418
MOD_SUMO_rev_2	269	273	PF00179	0.378
TRG_DiLeu_BaLyEn_6	145	150	PF01217	0.315
TRG_ENDOCYTIC_2	288	291	PF00928	0.313
TRG_ENDOCYTIC_2	391	394	PF00928	0.378
TRG_ER_diArg_1	147	149	PF00400	0.325
TRG_ER_diArg_1	41	44	PF00400	0.592
TRG_ER_diArg_1	56	58	PF00400	0.483
TRG_ER_diArg_1	6	9	PF00400	0.615
TRG_Pf-PMV_PEXEL_1	58	63	PF00026	0.599

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHN2	Leptomonas seymouri	23%	92%
A0A0N1PBX5	Leptomonas seymouri	88%	100%
A0A0S4JFE0	Bodo saltans	54%	100%
A0A0S4JRK0	Bodo saltans	23%	83%
A0A0S4KJ87	Bodo saltans	23%	80%
A0A1X0NVZ7	Trypanosomatidae	23%	92%
A0A1X0P2X5	Trypanosomatidae	63%	100%
A0A3Q8IE21	Leishmania donovani	92%	98%
A0A3Q8IGC4	Leishmania donovani	25%	92%
A0A3R7N6M9	Trypanosoma rangeli	23%	92%
A0A3R7NRU0	Trypanosoma rangeli	63%	100%
A4HDT7	Leishmania braziliensis	24%	92%
A4I135	Leishmania infantum	25%	92%
A4I569	Leishmania infantum	93%	100%
B5X212	Salmo salar	24%	100%
B5X9P2	Salmo salar	22%	100%
C9ZQJ5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	64%	100%
C9ZW72	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	78%
E9AX72	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	92%
E9B0G6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	99%
O76071	Homo sapiens	22%	100%
P0CS46	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	26%	67%
P0CS47	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	26%	67%
P42841	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	26%	100%
Q28DW0	Xenopus tropicalis	22%	100%
Q2TZG4	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	30%	79%
Q4I7X1	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	27%	78%
Q4Q7R7	Leishmania major	93%	100%
Q4QAA4	Leishmania major	25%	92%
Q4X1Y0	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	29%	94%
Q58D20	Bos taurus	24%	99%
Q59WJ4	Candida albicans (strain SC5314 / ATCC MYA-2876)	28%	88%
Q5AZX0	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	27%	84%
Q5DFU0	Schistosoma japonicum	23%	100%
Q5M7T1	Rattus norvegicus	23%	100%
Q5RFF8	Pongo abelii	23%	99%
Q6BVZ3	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	28%	95%
Q6CGP9	Yarrowia lipolytica (strain CLIB 122 / E 150)	28%	90%
Q6CP71	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	30%	100%
Q6FJS0	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	29%	100%
Q6NLV4	Arabidopsis thaliana	32%	74%
Q75AV4	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	28%	100%
Q75C26	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	24%	100%
Q7RY68	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	28%	73%
Q7T0P4	Xenopus laevis	23%	100%
Q8VEJ4	Mus musculus	24%	99%
Q9NVX2	Homo sapiens	24%	99%
Q9UTN4	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	30%	94%
V5DD51	Trypanosoma cruzi	62%	100%