Putative dolichyl pyrophosphate phosphatase

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

dolichyl pyrophosphate phosphatase, putative

Species:

Leishmania braziliensis

UniProt:

A4HHZ1_LEIBR

TriTrypDb:

LbrM.30.0480 , LBRM2903_300010600

Length:

272

Annotations

LeishMANIAdb annotations

Involved in N-glycan biogenesis, conserved eukaryotic protein.. Localization: ER (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

A4HHZ1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHZ1

Function

Biological processes
Term	Name	Level	Count
GO:0008152	metabolic process	1	9
GO:0044238	primary metabolic process	2	9
GO:0071704	organic substance metabolic process	2	9
GO:0006486	protein glycosylation	4	5
GO:0006487	protein N-linked glycosylation	5	5
GO:0006629	lipid metabolic process	3	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0006807	nitrogen compound metabolic process	2	5
GO:0009987	cellular process	1	1
GO:0016311	dephosphorylation	5	1
GO:0019538	protein metabolic process	3	5
GO:0030258	lipid modification	4	1
GO:0036211	protein modification process	4	5
GO:0043170	macromolecule metabolic process	3	5
GO:0043412	macromolecule modification	4	5
GO:0043413	macromolecule glycosylation	3	5
GO:0044237	cellular metabolic process	2	1
GO:0044255	cellular lipid metabolic process	3	1
GO:0046839	phospholipid dephosphorylation	5	1
GO:0070085	glycosylation	2	5
GO:1901564	organonitrogen compound metabolic process	3	5

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	9
GO:0008195	phosphatidate phosphatase activity	6	4
GO:0016787	hydrolase activity	2	9
GO:0016788	hydrolase activity, acting on ester bonds	3	5
GO:0016791	phosphatase activity	5	5
GO:0042578	phosphoric ester hydrolase activity	4	5
GO:0016462	pyrophosphatase activity	5	5
GO:0016817	hydrolase activity, acting on acid anhydrides	3	5
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	5
GO:0042392	sphingosine-1-phosphate phosphatase activity	7	1
GO:0042577	lipid phosphatase activity	6	1
GO:0047874	dolichyldiphosphatase activity	6	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	161	163	PF00675	0.251
CLV_NRD_NRD_1	169	171	PF00675	0.266
CLV_NRD_NRD_1	173	175	PF00675	0.272
CLV_NRD_NRD_1	181	183	PF00675	0.228
CLV_NRD_NRD_1	99	101	PF00675	0.342
CLV_PCSK_FUR_1	97	101	PF00082	0.355
CLV_PCSK_KEX2_1	161	163	PF00082	0.275
CLV_PCSK_KEX2_1	168	170	PF00082	0.288
CLV_PCSK_KEX2_1	99	101	PF00082	0.342
CLV_PCSK_SKI1_1	247	251	PF00082	0.338
DEG_SCF_FBW7_1	38	44	PF00400	0.348
DOC_CKS1_1	38	43	PF01111	0.345
DOC_CYCLIN_yClb5_NLxxxL_5	101	110	PF00134	0.494
DOC_MAPK_gen_1	97	106	PF00069	0.493
DOC_MAPK_MEF2A_6	255	262	PF00069	0.485
DOC_MAPK_MEF2A_6	99	108	PF00069	0.458
DOC_USP7_MATH_1	45	49	PF00917	0.562
DOC_WW_Pin1_4	123	128	PF00397	0.251
DOC_WW_Pin1_4	192	197	PF00397	0.556
DOC_WW_Pin1_4	37	42	PF00397	0.382
DOC_WW_Pin1_4	48	53	PF00397	0.380
LIG_14-3-3_CanoR_1	182	191	PF00244	0.503
LIG_14-3-3_CanoR_1	244	250	PF00244	0.496
LIG_Actin_WH2_2	105	123	PF00022	0.340
LIG_BIR_II_1	1	5	PF00653	0.303
LIG_BRCT_BRCA1_1	70	74	PF00533	0.301
LIG_eIF4E_1	198	204	PF01652	0.340
LIG_eIF4E_1	64	70	PF01652	0.356
LIG_FHA_1	206	212	PF00498	0.366
LIG_FHA_1	240	246	PF00498	0.354
LIG_FHA_1	266	272	PF00498	0.512
LIG_FHA_1	58	64	PF00498	0.389
LIG_LIR_Gen_1	195	206	PF02991	0.498
LIG_LIR_Gen_1	248	257	PF02991	0.609
LIG_LIR_Gen_1	68	76	PF02991	0.267
LIG_LIR_Nem_3	195	201	PF02991	0.530
LIG_LIR_Nem_3	248	252	PF02991	0.608
LIG_LIR_Nem_3	68	73	PF02991	0.246
LIG_NRBOX	199	205	PF00104	0.340
LIG_PCNA_yPIPBox_3	117	128	PF02747	0.259
LIG_Pex14_2	151	155	PF04695	0.310
LIG_Pex14_2	206	210	PF04695	0.400
LIG_Pex14_2	70	74	PF04695	0.218
LIG_RPA_C_Fungi	27	39	PF08784	0.514
LIG_SH2_CRK	198	202	PF00017	0.384
LIG_SH2_CRK	220	224	PF00017	0.286
LIG_SH2_NCK_1	198	202	PF00017	0.340
LIG_SH2_STAT5	109	112	PF00017	0.357
LIG_SH2_STAT5	13	16	PF00017	0.413
LIG_SH2_STAT5	138	141	PF00017	0.357
LIG_SH2_STAT5	158	161	PF00017	0.377
LIG_SH3_3	126	132	PF00018	0.280
LIG_SH3_3	253	259	PF00018	0.369
LIG_TYR_ITIM	107	112	PF00017	0.357
LIG_WRC_WIRS_1	263	268	PF05994	0.408
MOD_CDK_SPK_2	123	128	PF00069	0.298
MOD_CDK_SPxK_1	37	43	PF00069	0.422
MOD_CDK_SPxxK_3	48	55	PF00069	0.429
MOD_CK1_1	194	200	PF00069	0.424
MOD_CK1_1	48	54	PF00069	0.559
MOD_CK2_1	14	20	PF00069	0.428
MOD_CMANNOS	54	57	PF00535	0.498
MOD_Cter_Amidation	172	175	PF01082	0.240
MOD_GlcNHglycan	16	19	PF01048	0.440
MOD_GlcNHglycan	185	188	PF01048	0.410
MOD_GlcNHglycan	48	51	PF01048	0.487
MOD_GlcNHglycan	92	95	PF01048	0.389
MOD_GSK3_1	181	188	PF00069	0.411
MOD_GSK3_1	37	44	PF00069	0.657
MOD_GSK3_1	53	60	PF00069	0.438
MOD_N-GLC_1	136	141	PF02516	0.241
MOD_NEK2_1	110	115	PF00069	0.389
MOD_NEK2_1	136	141	PF00069	0.264
MOD_NEK2_1	191	196	PF00069	0.342
MOD_NEK2_1	205	210	PF00069	0.263
MOD_NEK2_1	238	243	PF00069	0.350
MOD_NEK2_1	262	267	PF00069	0.453
MOD_NEK2_1	74	79	PF00069	0.298
MOD_NEK2_2	153	158	PF00069	0.340
MOD_NEK2_2	3	8	PF00069	0.290
MOD_PIKK_1	163	169	PF00454	0.182
MOD_PKA_1	168	174	PF00069	0.371
MOD_PKA_2	168	174	PF00069	0.375
MOD_PKA_2	181	187	PF00069	0.348
MOD_Plk_1	136	142	PF00069	0.197
MOD_Plk_4	205	211	PF00069	0.312
MOD_Plk_4	262	268	PF00069	0.453
MOD_ProDKin_1	123	129	PF00069	0.298
MOD_ProDKin_1	192	198	PF00069	0.444
MOD_ProDKin_1	37	43	PF00069	0.485
MOD_ProDKin_1	48	54	PF00069	0.480
TRG_DiLeu_BaEn_2	4	10	PF01217	0.284
TRG_ENDOCYTIC_2	109	112	PF00928	0.357
TRG_ENDOCYTIC_2	13	16	PF00928	0.413
TRG_ENDOCYTIC_2	138	141	PF00928	0.328
TRG_ENDOCYTIC_2	198	201	PF00928	0.384
TRG_ENDOCYTIC_2	220	223	PF00928	0.326
TRG_ER_diArg_1	160	162	PF00400	0.331
TRG_ER_diArg_1	168	170	PF00400	0.351
TRG_ER_diArg_1	99	101	PF00400	0.425

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IGH8	Leptomonas seymouri	56%	100%
A0A1X0P264	Trypanosomatidae	31%	100%
A0A3S7X373	Leishmania donovani	79%	100%
A0A422NMI8	Trypanosoma rangeli	34%	100%
A4I568	Leishmania infantum	79%	100%
B0CM95	Papio anubis	29%	100%
B0KWE9	Callithrix jacchus	30%	100%
B1MTH4	Plecturocebus moloch	30%	100%
B2KI79	Rhinolophus ferrumequinum	30%	100%
C9ZQJ4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9B0G5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
P53223	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	27%	100%
Q4Q7R8	Leishmania major	78%	100%
Q86YN1	Homo sapiens	31%	100%
Q9JMF7	Mus musculus	28%	100%