Hydrolase_4 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Alpha/beta hydrolase family, putative

Species:

Leishmania braziliensis

UniProt:

A4HHZ0_LEIBR

TriTrypDb:

LbrM.30.0470 , LBRM2903_300010500

Length:

383

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HHZ0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHZ0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	3
GO:0016787	hydrolase activity	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	148	152	PF00656	0.362
CLV_C14_Caspase3-7	231	235	PF00656	0.379
CLV_C14_Caspase3-7	3	7	PF00656	0.589
CLV_NRD_NRD_1	218	220	PF00675	0.384
CLV_NRD_NRD_1	224	226	PF00675	0.396
CLV_NRD_NRD_1	310	312	PF00675	0.554
CLV_PCSK_KEX2_1	220	222	PF00082	0.344
CLV_PCSK_KEX2_1	224	226	PF00082	0.360
CLV_PCSK_KEX2_1	310	312	PF00082	0.690
CLV_PCSK_PC1ET2_1	220	222	PF00082	0.344
CLV_PCSK_SKI1_1	225	229	PF00082	0.382
CLV_PCSK_SKI1_1	237	241	PF00082	0.370
CLV_PCSK_SKI1_1	266	270	PF00082	0.487
CLV_PCSK_SKI1_1	330	334	PF00082	0.584
CLV_PCSK_SKI1_1	5	9	PF00082	0.405
DEG_APCC_DBOX_1	132	140	PF00400	0.269
DEG_APCC_DBOX_1	4	12	PF00400	0.371
DEG_COP1_1	333	342	PF00400	0.509
DEG_Nend_Nbox_1	1	3	PF02207	0.537
DEG_SPOP_SBC_1	375	379	PF00917	0.691
DOC_CKS1_1	276	281	PF01111	0.527
DOC_CYCLIN_RxL_1	310	324	PF00134	0.603
DOC_MAPK_DCC_7	240	249	PF00069	0.453
DOC_MAPK_gen_1	201	211	PF00069	0.436
DOC_MAPK_MEF2A_6	240	249	PF00069	0.453
DOC_PP1_RVXF_1	62	69	PF00149	0.463
DOC_PP4_FxxP_1	256	259	PF00568	0.350
DOC_PP4_FxxP_1	269	272	PF00568	0.383
DOC_USP7_MATH_1	144	148	PF00917	0.394
DOC_USP7_MATH_1	183	187	PF00917	0.413
DOC_USP7_MATH_1	259	263	PF00917	0.263
DOC_USP7_MATH_1	321	325	PF00917	0.549
DOC_USP7_MATH_1	331	335	PF00917	0.605
DOC_USP7_MATH_1	375	379	PF00917	0.712
DOC_WW_Pin1_4	179	184	PF00397	0.284
DOC_WW_Pin1_4	255	260	PF00397	0.543
DOC_WW_Pin1_4	275	280	PF00397	0.233
DOC_WW_Pin1_4	309	314	PF00397	0.435
DOC_WW_Pin1_4	362	367	PF00397	0.775
DOC_WW_Pin1_4	371	376	PF00397	0.753
LIG_14-3-3_CanoR_1	105	111	PF00244	0.249
LIG_14-3-3_CanoR_1	27	35	PF00244	0.536
LIG_14-3-3_CanoR_1	286	294	PF00244	0.270
LIG_14-3-3_CanoR_1	67	73	PF00244	0.362
LIG_BIR_III_2	267	271	PF00653	0.420
LIG_BIR_III_2	357	361	PF00653	0.512
LIG_BRCT_BRCA1_1	126	130	PF00533	0.273
LIG_Clathr_ClatBox_1	110	114	PF01394	0.284
LIG_eIF4E_1	131	137	PF01652	0.337
LIG_FHA_1	200	206	PF00498	0.337
LIG_FHA_1	310	316	PF00498	0.656
LIG_FHA_2	258	264	PF00498	0.359
LIG_LIR_Apic_2	253	259	PF02991	0.363
LIG_LIR_Apic_2	267	272	PF02991	0.376
LIG_LIR_Apic_2	71	75	PF02991	0.267
LIG_LIR_Gen_1	122	131	PF02991	0.223
LIG_LIR_Gen_1	141	150	PF02991	0.413
LIG_LIR_Gen_1	181	191	PF02991	0.269
LIG_LIR_Gen_1	295	303	PF02991	0.473
LIG_LIR_Nem_3	122	128	PF02991	0.230
LIG_LIR_Nem_3	141	145	PF02991	0.413
LIG_LIR_Nem_3	181	187	PF02991	0.278
LIG_LIR_Nem_3	295	300	PF02991	0.440
LIG_LIR_Nem_3	71	76	PF02991	0.354
LIG_PCNA_PIPBox_1	291	300	PF02747	0.328
LIG_PCNA_yPIPBox_3	286	298	PF02747	0.341
LIG_Pex14_1	72	76	PF04695	0.442
LIG_Pex14_2	111	115	PF04695	0.413
LIG_Pex14_2	68	72	PF04695	0.429
LIG_SH2_PTP2	125	128	PF00017	0.328
LIG_SH2_STAT3	131	134	PF00017	0.269
LIG_SH2_STAT5	125	128	PF00017	0.331
LIG_SH2_STAT5	301	304	PF00017	0.349
LIG_SH2_STAT5	86	89	PF00017	0.295
LIG_SH3_3	333	339	PF00018	0.745
LIG_SUMO_SIM_anti_2	135	141	PF11976	0.337
LIG_SUMO_SIM_par_1	135	141	PF11976	0.337
LIG_SUMO_SIM_par_1	346	352	PF11976	0.514
LIG_WRPW_2	73	76	PF00400	0.302
LIG_WW_3	27	31	PF00397	0.432
MOD_CDK_SPxxK_3	309	316	PF00069	0.428
MOD_CK1_1	118	124	PF00069	0.277
MOD_CK1_1	334	340	PF00069	0.606
MOD_CK1_1	349	355	PF00069	0.593
MOD_CK1_1	374	380	PF00069	0.642
MOD_CK2_1	118	124	PF00069	0.269
MOD_CK2_1	257	263	PF00069	0.346
MOD_CK2_1	28	34	PF00069	0.416
MOD_GlcNHglycan	117	120	PF01048	0.275
MOD_GlcNHglycan	12	15	PF01048	0.507
MOD_GlcNHglycan	2	5	PF01048	0.517
MOD_GlcNHglycan	294	297	PF01048	0.494
MOD_GlcNHglycan	333	336	PF01048	0.657
MOD_GSK3_1	179	186	PF00069	0.318
MOD_GSK3_1	255	262	PF00069	0.302
MOD_GSK3_1	321	328	PF00069	0.557
MOD_GSK3_1	330	337	PF00069	0.615
MOD_GSK3_1	348	355	PF00069	0.715
MOD_GSK3_1	362	369	PF00069	0.653
MOD_GSK3_1	371	378	PF00069	0.685
MOD_N-GLC_1	321	326	PF02516	0.483
MOD_N-GLC_2	20	22	PF02516	0.285
MOD_NEK2_1	115	120	PF00069	0.312
MOD_NEK2_1	68	73	PF00069	0.365
MOD_NEK2_1	9	14	PF00069	0.530
MOD_NEK2_2	183	188	PF00069	0.284
MOD_PKA_2	285	291	PF00069	0.413
MOD_PKA_2	29	35	PF00069	0.494
MOD_Plk_4	68	74	PF00069	0.286
MOD_ProDKin_1	179	185	PF00069	0.284
MOD_ProDKin_1	255	261	PF00069	0.537
MOD_ProDKin_1	275	281	PF00069	0.231
MOD_ProDKin_1	309	315	PF00069	0.442
MOD_ProDKin_1	362	368	PF00069	0.776
MOD_ProDKin_1	371	377	PF00069	0.752
TRG_DiLeu_BaEn_1	132	137	PF01217	0.337
TRG_DiLeu_BaLyEn_6	185	190	PF01217	0.303
TRG_ENDOCYTIC_2	125	128	PF00928	0.356
TRG_ENDOCYTIC_2	95	98	PF00928	0.303
TRG_ER_diArg_1	218	221	PF00400	0.337
TRG_ER_diArg_1	223	225	PF00400	0.360
TRG_NES_CRM1_1	134	149	PF08389	0.413
TRG_NES_CRM1_1	289	304	PF08389	0.426
TRG_NES_CRM1_1	99	114	PF08389	0.284
TRG_NLS_MonoExtN_4	217	223	PF00514	0.340
TRG_Pf-PMV_PEXEL_1	188	192	PF00026	0.274
TRG_Pf-PMV_PEXEL_1	212	216	PF00026	0.294
TRG_Pf-PMV_PEXEL_1	64	69	PF00026	0.391

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HRJ3	Leptomonas seymouri	70%	100%
A0A0S4JBE5	Bodo saltans	50%	88%
A0A1X0P2B9	Trypanosomatidae	55%	93%
A0A3S5H7M3	Leishmania donovani	80%	77%
A0A422NMM6	Trypanosoma rangeli	58%	96%
A4I567	Leishmania infantum	86%	77%
C9ZQJ3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	93%
E9B0G4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	80%
Q4Q7R9	Leishmania major	78%	100%
V5BCE0	Trypanosoma cruzi	53%	95%