Histone H4

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Histone H4

Gene product:

histone H4

Species:

Leishmania braziliensis

UniProt:

A4HHY8_LEIBR

TriTrypDb:

LbrM.30.0450 , LBRM2903_300009500

Length:

131

Annotations

LeishMANIAdb annotations

Histone H4 protein, nuclear without any membrane association

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 1
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 38

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 4

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 4

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 21
NetGPI	no	yes: 0, no: 21

Cellular components
Term	Name	Level	Count
GO:0000786	nucleosome	3	22
GO:0005634	nucleus	5	22
GO:0032991	protein-containing complex	1	22
GO:0032993	protein-DNA complex	2	22
GO:0043226	organelle	2	22
GO:0043227	membrane-bounded organelle	3	22
GO:0043229	intracellular organelle	3	22
GO:0043231	intracellular membrane-bounded organelle	4	22
GO:0044815	DNA packaging complex	2	22
GO:0110165	cellular anatomical entity	1	22

Expansion

Sequence features

A4HHY8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHY8

Function

Biological processes
Term	Name	Level	Count
GO:0006325	chromatin organization	4	2
GO:0006334	nucleosome assembly	7	2
GO:0006338	chromatin remodeling	5	2
GO:0009987	cellular process	1	2
GO:0016043	cellular component organization	3	2
GO:0022607	cellular component assembly	4	2
GO:0034728	nucleosome organization	6	2
GO:0043933	protein-containing complex organization	4	2
GO:0065003	protein-containing complex assembly	5	2
GO:0065004	protein-DNA complex assembly	6	2
GO:0071824	protein-DNA complex subunit organization	5	2
GO:0071840	cellular component organization or biogenesis	2	2

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	22
GO:0003677	DNA binding	4	22
GO:0005198	structural molecule activity	1	22
GO:0005488	binding	1	22
GO:0005515	protein binding	2	22
GO:0030527	structural constituent of chromatin	2	22
GO:0046982	protein heterodimerization activity	4	22
GO:0046983	protein dimerization activity	3	22
GO:0097159	organic cyclic compound binding	2	22
GO:1901363	heterocyclic compound binding	2	22

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	98	104	PF00089	0.499
CLV_NRD_NRD_1	122	124	PF00675	0.555
CLV_NRD_NRD_1	35	37	PF00675	0.384
CLV_NRD_NRD_1	55	57	PF00675	0.348
CLV_NRD_NRD_1	76	78	PF00675	0.373
CLV_PCSK_FUR_1	120	124	PF00082	0.496
CLV_PCSK_KEX2_1	104	106	PF00082	0.548
CLV_PCSK_KEX2_1	122	124	PF00082	0.804
CLV_PCSK_KEX2_1	35	37	PF00082	0.384
CLV_PCSK_KEX2_1	44	46	PF00082	0.406
CLV_PCSK_KEX2_1	55	57	PF00082	0.341
CLV_PCSK_PC1ET2_1	104	106	PF00082	0.543
CLV_PCSK_PC1ET2_1	44	46	PF00082	0.418
CLV_PCSK_SKI1_1	55	59	PF00082	0.367
CLV_PCSK_SKI1_1	79	83	PF00082	0.385
DEG_Nend_Nbox_1	1	3	PF02207	0.474
DOC_ANK_TNKS_1	104	111	PF00023	0.534
DOC_CYCLIN_yCln2_LP_2	2	8	PF00134	0.460
DOC_MAPK_gen_1	120	129	PF00069	0.471
DOC_MAPK_HePTP_8	119	131	PF00069	0.479
DOC_MAPK_MEF2A_6	122	131	PF00069	0.474
DOC_MAPK_MEF2A_6	94	102	PF00069	0.472
DOC_USP7_MATH_1	7	11	PF00917	0.468
DOC_WW_Pin1_4	1	6	PF00397	0.462
DOC_WW_Pin1_4	110	115	PF00397	0.550
LIG_14-3-3_CanoR_1	105	109	PF00244	0.541
LIG_14-3-3_CanoR_1	67	75	PF00244	0.352
LIG_14-3-3_CanoR_1	77	82	PF00244	0.387
LIG_FHA_2	80	86	PF00498	0.371
LIG_HP1_1	7	11	PF01393	0.468
LIG_Integrin_RGD_1	24	26	PF01839	0.457
LIG_LIR_Gen_1	49	58	PF02991	0.358
LIG_LIR_Nem_3	49	54	PF02991	0.367
LIG_PDZ_Class_2	126	131	PF00595	0.474
LIG_SH2_SRC	51	54	PF00017	0.359
LIG_SH2_STAT5	61	64	PF00017	0.345
LIG_SH3_3	106	112	PF00018	0.545
LIG_SUMO_SIM_par_1	7	12	PF11976	0.469
MOD_Cter_Amidation	120	123	PF01082	0.660
MOD_GlcNHglycan	11	14	PF01048	0.478
MOD_GlcNHglycan	46	49	PF01048	0.414
MOD_GlcNHglycan	68	71	PF01048	0.335
MOD_GSK3_1	100	107	PF00069	0.520
MOD_GSK3_1	110	117	PF00069	0.579
MOD_GSK3_1	77	84	PF00069	0.383
MOD_NEK2_1	100	105	PF00069	0.523
MOD_PK_1	104	110	PF00069	0.531
MOD_PKA_1	104	110	PF00069	0.536
MOD_PKA_1	44	50	PF00069	0.391
MOD_PKA_1	77	83	PF00069	0.383
MOD_PKA_2	100	106	PF00069	0.530
MOD_PKA_2	44	50	PF00069	0.391
MOD_PKA_2	66	72	PF00069	0.342
MOD_ProDKin_1	1	7	PF00069	0.461
MOD_ProDKin_1	110	116	PF00069	0.549
TRG_ENDOCYTIC_2	51	54	PF00928	0.359
TRG_ER_diArg_1	119	122	PF00400	0.517
TRG_ER_diArg_1	34	36	PF00400	0.371
TRG_ER_diArg_1	54	56	PF00400	0.342
TRG_ER_diArg_1	98	101	PF00400	0.490
TRG_Pf-PMV_PEXEL_1	28	32	PF00026	0.395

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IFP7	Leishmania donovani	63%	100%
A0A3S7WTF1	Leishmania donovani	64%	100%
A0A3S7X8Y8	Leishmania donovani	62%	100%
A0A451EJE0	Leishmania donovani	65%	100%
A4H399	Leishmania braziliensis	67%	100%
A4H3A0	Leishmania braziliensis	66%	100%
A4H7X1	Leishmania braziliensis	66%	100%
A4HD43	Leishmania braziliensis	60%	100%
A4HMF3	Leishmania braziliensis	65%	100%
A4HNK4	Leishmania braziliensis	65%	70%
A4HNK8	Leishmania braziliensis	65%	90%
A4HNL3	Leishmania braziliensis	61%	67%
A4HW98	Leishmania infantum	66%	100%
A4IB25	Leishmania infantum	62%	100%
E9AKM9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	100%
E9APZ8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	62%	100%
E9ASB9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	64%	100%
Q4JHM5	Leishmania donovani	66%	100%
Q4Q277	Leishmania major	64%	100%
Q4QFI3	Leishmania major	65%	100%