Type III endosome membrane protein TEMP

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HHY6_LEIBR

TriTrypDb:

LbrM.30.0430 , LBRM2903_300010400

Length:

244

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 1, no: 4
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

A4HHY6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHY6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	229	231	PF00675	0.475
CLV_NRD_NRD_1	233	235	PF00675	0.457
CLV_PCSK_KEX2_1	2	4	PF00082	0.579
CLV_PCSK_KEX2_1	229	231	PF00082	0.475
CLV_PCSK_PC1ET2_1	2	4	PF00082	0.566
CLV_PCSK_SKI1_1	2	6	PF00082	0.645
DEG_Nend_UBRbox_1	1	4	PF02207	0.433
DOC_CKS1_1	63	68	PF01111	0.418
DOC_PP4_FxxP_1	199	202	PF00568	0.711
DOC_SPAK_OSR1_1	83	87	PF12202	0.243
DOC_USP7_MATH_1	14	18	PF00917	0.433
DOC_USP7_MATH_1	204	208	PF00917	0.623
DOC_USP7_MATH_1	22	26	PF00917	0.394
DOC_WW_Pin1_4	156	161	PF00397	0.687
DOC_WW_Pin1_4	165	170	PF00397	0.726
DOC_WW_Pin1_4	59	64	PF00397	0.530
DOC_WW_Pin1_4	67	72	PF00397	0.465
LIG_14-3-3_CanoR_1	222	226	PF00244	0.759
LIG_deltaCOP1_diTrp_1	74	84	PF00928	0.441
LIG_FHA_1	120	126	PF00498	0.703
LIG_FHA_2	114	120	PF00498	0.745
LIG_FHA_2	160	166	PF00498	0.629
LIG_FHA_2	169	175	PF00498	0.703
LIG_LIR_Apic_2	197	202	PF02991	0.711
LIG_LIR_Apic_2	32	38	PF02991	0.399
LIG_LIR_Gen_1	175	186	PF02991	0.611
LIG_LIR_Nem_3	110	114	PF02991	0.653
LIG_LIR_Nem_3	175	181	PF02991	0.606
LIG_LIR_Nem_3	74	80	PF02991	0.509
LIG_LIR_Nem_3	81	87	PF02991	0.374
LIG_Pex14_2	84	88	PF04695	0.442
LIG_Rb_LxCxE_1	165	188	PF01857	0.616
LIG_SH2_CRK	233	237	PF00017	0.604
LIG_SH2_CRK	35	39	PF00017	0.404
LIG_SH2_SRC	59	62	PF00017	0.436
LIG_SH2_STAT3	39	42	PF00017	0.404
LIG_SH2_STAT5	107	110	PF00017	0.692
LIG_SH3_3	58	64	PF00018	0.520
LIG_SUMO_SIM_par_1	19	25	PF11976	0.453
MOD_CDK_SPxxK_3	62	69	PF00069	0.420
MOD_CK1_1	117	123	PF00069	0.697
MOD_CK1_1	124	130	PF00069	0.660
MOD_CK1_1	136	142	PF00069	0.593
MOD_CK1_1	159	165	PF00069	0.630
MOD_CK1_1	192	198	PF00069	0.722
MOD_CK1_1	206	212	PF00069	0.631
MOD_CK1_1	218	224	PF00069	0.669
MOD_CK1_1	27	33	PF00069	0.484
MOD_CK1_1	62	68	PF00069	0.440
MOD_CK2_1	117	123	PF00069	0.724
MOD_CK2_1	139	145	PF00069	0.693
MOD_CK2_1	159	165	PF00069	0.630
MOD_CK2_1	168	174	PF00069	0.703
MOD_GlcNHglycan	135	138	PF01048	0.516
MOD_GlcNHglycan	16	19	PF01048	0.596
MOD_GlcNHglycan	26	29	PF01048	0.661
MOD_GSK3_1	113	120	PF00069	0.687
MOD_GSK3_1	136	143	PF00069	0.657
MOD_GSK3_1	185	192	PF00069	0.686
MOD_GSK3_1	202	209	PF00069	0.712
MOD_GSK3_1	211	218	PF00069	0.684
MOD_GSK3_1	22	29	PF00069	0.542
MOD_GSK3_1	221	228	PF00069	0.799
MOD_N-GLC_1	192	197	PF02516	0.520
MOD_N-GLC_1	78	83	PF02516	0.631
MOD_NEK2_1	213	218	PF00069	0.683
MOD_NEK2_1	225	230	PF00069	0.672
MOD_NEK2_1	7	12	PF00069	0.375
MOD_NEK2_2	78	83	PF00069	0.392
MOD_PIKK_1	187	193	PF00454	0.711
MOD_PIKK_1	213	219	PF00454	0.623
MOD_PIKK_1	238	244	PF00454	0.613
MOD_PKA_2	221	227	PF00069	0.703
MOD_Plk_1	78	84	PF00069	0.530
MOD_Plk_2-3	140	146	PF00069	0.680
MOD_Plk_4	30	36	PF00069	0.406
MOD_Plk_4	7	13	PF00069	0.405
MOD_ProDKin_1	156	162	PF00069	0.686
MOD_ProDKin_1	165	171	PF00069	0.726
MOD_ProDKin_1	59	65	PF00069	0.529
MOD_ProDKin_1	67	73	PF00069	0.463
TRG_DiLeu_BaEn_2	173	179	PF01217	0.607
TRG_DiLeu_BaEn_4	176	182	PF01217	0.677
TRG_ENDOCYTIC_2	111	114	PF00928	0.667
TRG_ENDOCYTIC_2	233	236	PF00928	0.602

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X330	Leishmania donovani	64%	98%
A4I566	Leishmania infantum	64%	98%
E9B0G3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	57%	92%
Q4Q7S0	Leishmania major	55%	100%