Transmembrane 9 superfamily member

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

endosomal integral membrane protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HHY3_LEIBR

TriTrypDb:

LbrM.30.0400 , LBRM2903_300010000

Length:

642

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 6, no: 4
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

A4HHY3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHY3

Function

Biological processes
Term	Name	Level	Count
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0033036	macromolecule localization	2	1
GO:0051179	localization	1	1
GO:0051641	cellular localization	2	1
GO:0051668	localization within membrane	3	1
GO:0070727	cellular macromolecule localization	3	1
GO:0072657	protein localization to membrane	4	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	117	119	PF00675	0.355
CLV_NRD_NRD_1	3	5	PF00675	0.670
CLV_NRD_NRD_1	309	311	PF00675	0.217
CLV_NRD_NRD_1	341	343	PF00675	0.165
CLV_NRD_NRD_1	408	410	PF00675	0.306
CLV_PCSK_KEX2_1	138	140	PF00082	0.511
CLV_PCSK_KEX2_1	2	4	PF00082	0.700
CLV_PCSK_KEX2_1	309	311	PF00082	0.234
CLV_PCSK_KEX2_1	341	343	PF00082	0.176
CLV_PCSK_KEX2_1	407	409	PF00082	0.306
CLV_PCSK_PC1ET2_1	138	140	PF00082	0.511
CLV_PCSK_SKI1_1	119	123	PF00082	0.494
CLV_PCSK_SKI1_1	138	142	PF00082	0.519
CLV_PCSK_SKI1_1	18	22	PF00082	0.574
CLV_PCSK_SKI1_1	210	214	PF00082	0.375
CLV_PCSK_SKI1_1	310	314	PF00082	0.234
CLV_PCSK_SKI1_1	342	346	PF00082	0.155
CLV_PCSK_SKI1_1	377	381	PF00082	0.415
CLV_PCSK_SKI1_1	498	502	PF00082	0.306
CLV_PCSK_SKI1_1	570	574	PF00082	0.224
CLV_PCSK_SKI1_1	597	601	PF00082	0.530
CLV_PCSK_SKI1_1	633	637	PF00082	0.267
CLV_PCSK_SKI1_1	75	79	PF00082	0.521
DEG_APCC_DBOX_1	17	25	PF00400	0.510
DEG_APCC_DBOX_1	341	349	PF00400	0.355
DEG_APCC_DBOX_1	376	384	PF00400	0.306
DEG_MDM2_SWIB_1	522	530	PF02201	0.241
DEG_Nend_UBRbox_1	1	4	PF02207	0.406
DEG_SCF_FBW7_1	156	163	PF00400	0.155
DEG_SCF_FBW7_1	259	266	PF00400	0.257
DOC_CDC14_PxL_1	150	158	PF14671	0.257
DOC_MAPK_gen_1	143	150	PF00069	0.224
DOC_MAPK_gen_1	165	172	PF00069	0.215
DOC_MAPK_gen_1	338	348	PF00069	0.424
DOC_MAPK_gen_1	407	416	PF00069	0.411
DOC_MAPK_MEF2A_6	341	350	PF00069	0.441
DOC_MAPK_MEF2A_6	377	385	PF00069	0.186
DOC_MAPK_MEF2A_6	532	541	PF00069	0.155
DOC_MAPK_MEF2A_6	597	606	PF00069	0.304
DOC_PP1_RVXF_1	208	215	PF00149	0.224
DOC_PP1_RVXF_1	278	284	PF00149	0.167
DOC_PP1_RVXF_1	631	637	PF00149	0.458
DOC_PP4_FxxP_1	337	340	PF00568	0.411
DOC_USP7_MATH_1	14	18	PF00917	0.393
DOC_USP7_MATH_1	160	164	PF00917	0.240
DOC_USP7_MATH_1	182	186	PF00917	0.224
DOC_USP7_MATH_1	446	450	PF00917	0.245
DOC_USP7_MATH_1	549	553	PF00917	0.467
DOC_USP7_MATH_1	574	578	PF00917	0.218
DOC_USP7_MATH_1	9	13	PF00917	0.458
DOC_WW_Pin1_4	156	161	PF00397	0.155
DOC_WW_Pin1_4	259	264	PF00397	0.294
LIG_14-3-3_CanoR_1	219	227	PF00244	0.155
LIG_14-3-3_CanoR_1	250	256	PF00244	0.310
LIG_14-3-3_CanoR_1	4	13	PF00244	0.385
LIG_14-3-3_CanoR_1	407	412	PF00244	0.467
LIG_14-3-3_CanoR_1	532	537	PF00244	0.257
LIG_Actin_WH2_2	483	500	PF00022	0.355
LIG_BRCT_BRCA1_1	362	366	PF00533	0.356
LIG_BRCT_BRCA1_1	616	620	PF00533	0.239
LIG_BRCT_BRCA1_1	627	631	PF00533	0.294
LIG_EH1_1	365	373	PF00400	0.255
LIG_eIF4E_1	315	321	PF01652	0.506
LIG_eIF4E_1	557	563	PF01652	0.506
LIG_FHA_1	206	212	PF00498	0.231
LIG_FHA_1	254	260	PF00498	0.203
LIG_FHA_1	384	390	PF00498	0.241
LIG_FHA_1	397	403	PF00498	0.266
LIG_FHA_1	53	59	PF00498	0.405
LIG_FHA_2	157	163	PF00498	0.155
LIG_FHA_2	242	248	PF00498	0.306
LIG_FHA_2	264	270	PF00498	0.214
LIG_LIR_Apic_2	335	340	PF02991	0.411
LIG_LIR_Gen_1	187	196	PF02991	0.275
LIG_LIR_Gen_1	288	298	PF02991	0.259
LIG_LIR_Gen_1	363	372	PF02991	0.168
LIG_LIR_Gen_1	386	394	PF02991	0.193
LIG_LIR_Gen_1	410	419	PF02991	0.561
LIG_LIR_Gen_1	444	455	PF02991	0.252
LIG_LIR_Gen_1	502	511	PF02991	0.319
LIG_LIR_Gen_1	514	522	PF02991	0.292
LIG_LIR_Gen_1	535	544	PF02991	0.389
LIG_LIR_Gen_1	628	639	PF02991	0.323
LIG_LIR_Gen_1	8	15	PF02991	0.426
LIG_LIR_Nem_3	187	192	PF02991	0.240
LIG_LIR_Nem_3	197	201	PF02991	0.187
LIG_LIR_Nem_3	232	238	PF02991	0.202
LIG_LIR_Nem_3	266	271	PF02991	0.242
LIG_LIR_Nem_3	288	293	PF02991	0.259
LIG_LIR_Nem_3	297	302	PF02991	0.205
LIG_LIR_Nem_3	326	332	PF02991	0.434
LIG_LIR_Nem_3	363	369	PF02991	0.448
LIG_LIR_Nem_3	386	391	PF02991	0.171
LIG_LIR_Nem_3	410	414	PF02991	0.422
LIG_LIR_Nem_3	444	450	PF02991	0.252
LIG_LIR_Nem_3	502	506	PF02991	0.307
LIG_LIR_Nem_3	514	518	PF02991	0.231
LIG_LIR_Nem_3	520	525	PF02991	0.171
LIG_LIR_Nem_3	529	534	PF02991	0.193
LIG_LIR_Nem_3	535	539	PF02991	0.288
LIG_LIR_Nem_3	552	557	PF02991	0.251
LIG_LIR_Nem_3	617	623	PF02991	0.261
LIG_LIR_Nem_3	628	634	PF02991	0.305
LIG_LIR_Nem_3	8	13	PF02991	0.434
LIG_MAD2	210	218	PF02301	0.267
LIG_MLH1_MIPbox_1	362	366	PF16413	0.168
LIG_MYND_3	153	157	PF01753	0.306
LIG_NRBOX	290	296	PF00104	0.277
LIG_NRBOX	379	385	PF00104	0.405
LIG_NRBOX	449	455	PF00104	0.241
LIG_PCNA_yPIPBox_3	94	105	PF02747	0.147
LIG_Pex14_1	568	572	PF04695	0.411
LIG_Pex14_1	581	585	PF04695	0.243
LIG_Pex14_1	74	78	PF04695	0.358
LIG_Pex14_2	387	391	PF04695	0.272
LIG_Pex14_2	522	526	PF04695	0.217
LIG_REV1ctd_RIR_1	403	413	PF16727	0.420
LIG_SH2_CRK	284	288	PF00017	0.244
LIG_SH2_CRK	585	589	PF00017	0.365
LIG_SH2_CRK	608	612	PF00017	0.419
LIG_SH2_PTP2	302	305	PF00017	0.288
LIG_SH2_PTP2	515	518	PF00017	0.398
LIG_SH2_SRC	199	202	PF00017	0.155
LIG_SH2_SRC	271	274	PF00017	0.171
LIG_SH2_STAP1	136	140	PF00017	0.249
LIG_SH2_STAP1	253	257	PF00017	0.214
LIG_SH2_STAT5	199	202	PF00017	0.155
LIG_SH2_STAT5	271	274	PF00017	0.306
LIG_SH2_STAT5	302	305	PF00017	0.264
LIG_SH2_STAT5	429	432	PF00017	0.245
LIG_SH2_STAT5	452	455	PF00017	0.378
LIG_SH2_STAT5	496	499	PF00017	0.401
LIG_SH2_STAT5	515	518	PF00017	0.317
LIG_SH2_STAT5	585	588	PF00017	0.281
LIG_SH3_1	488	494	PF00018	0.411
LIG_SH3_3	233	239	PF00018	0.283
LIG_SH3_3	333	339	PF00018	0.506
LIG_SH3_3	457	463	PF00018	0.245
LIG_SH3_3	488	494	PF00018	0.408
LIG_SUMO_SIM_anti_2	39	45	PF11976	0.279
LIG_SUMO_SIM_anti_2	615	620	PF11976	0.310
LIG_SUMO_SIM_par_1	291	297	PF11976	0.401
LIG_TYR_ITIM	196	201	PF00017	0.241
LIG_TYR_ITIM	300	305	PF00017	0.264
LIG_TYR_ITIM	555	560	PF00017	0.259
LIG_TYR_ITIM	588	593	PF00017	0.307
LIG_Vh1_VBS_1	13	31	PF01044	0.310
LIG_WRC_WIRS_1	384	389	PF05994	0.204
LIG_WRC_WIRS_1	533	538	PF05994	0.257
LIG_WW_3	338	342	PF00397	0.506
MOD_CDK_SPxK_1	259	265	PF00069	0.257
MOD_CK1_1	276	282	PF00069	0.298
MOD_CK1_1	285	291	PF00069	0.332
MOD_CK1_1	373	379	PF00069	0.204
MOD_CK1_1	415	421	PF00069	0.168
MOD_CK1_1	520	526	PF00069	0.288
MOD_CK1_1	61	67	PF00069	0.259
MOD_CK1_1	85	91	PF00069	0.300
MOD_CK2_1	199	205	PF00069	0.208
MOD_CK2_1	241	247	PF00069	0.316
MOD_CK2_1	311	317	PF00069	0.523
MOD_CK2_1	511	517	PF00069	0.288
MOD_GlcNHglycan	106	110	PF01048	0.467
MOD_GlcNHglycan	124	127	PF01048	0.510
MOD_GlcNHglycan	223	226	PF01048	0.430
MOD_GlcNHglycan	574	577	PF01048	0.245
MOD_GlcNHglycan	80	83	PF01048	0.466
MOD_GSK3_1	156	163	PF00069	0.193
MOD_GSK3_1	201	208	PF00069	0.233
MOD_GSK3_1	217	224	PF00069	0.257
MOD_GSK3_1	249	256	PF00069	0.204
MOD_GSK3_1	259	266	PF00069	0.278
MOD_GSK3_1	379	386	PF00069	0.235
MOD_GSK3_1	436	443	PF00069	0.240
MOD_GSK3_1	48	55	PF00069	0.296
MOD_GSK3_1	5	12	PF00069	0.462
MOD_GSK3_1	517	524	PF00069	0.382
MOD_GSK3_1	549	556	PF00069	0.288
MOD_GSK3_1	568	575	PF00069	0.339
MOD_GSK3_1	58	65	PF00069	0.311
MOD_GSK3_1	78	85	PF00069	0.332
MOD_N-GLC_1	175	180	PF02516	0.457
MOD_NEK2_1	105	110	PF00069	0.229
MOD_NEK2_1	122	127	PF00069	0.241
MOD_NEK2_1	194	199	PF00069	0.230
MOD_NEK2_1	251	256	PF00069	0.182
MOD_NEK2_1	294	299	PF00069	0.256
MOD_NEK2_1	304	309	PF00069	0.268
MOD_NEK2_1	349	354	PF00069	0.190
MOD_NEK2_1	357	362	PF00069	0.150
MOD_NEK2_1	379	384	PF00069	0.383
MOD_NEK2_1	38	43	PF00069	0.431
MOD_NEK2_1	390	395	PF00069	0.254
MOD_NEK2_1	458	463	PF00069	0.308
MOD_NEK2_1	48	53	PF00069	0.410
MOD_NEK2_1	511	516	PF00069	0.268
MOD_NEK2_1	572	577	PF00069	0.258
MOD_NEK2_1	59	64	PF00069	0.344
MOD_NEK2_1	625	630	PF00069	0.259
MOD_NEK2_1	635	640	PF00069	0.488
MOD_NEK2_1	92	97	PF00069	0.172
MOD_NEK2_2	526	531	PF00069	0.167
MOD_NEK2_2	549	554	PF00069	0.370
MOD_NEK2_2	568	573	PF00069	0.548
MOD_PIKK_1	48	54	PF00454	0.319
MOD_PIKK_1	85	91	PF00454	0.304
MOD_PKA_1	407	413	PF00069	0.506
MOD_PKA_2	249	255	PF00069	0.311
MOD_PKA_2	407	413	PF00069	0.506
MOD_Plk_2-3	311	317	PF00069	0.506
MOD_Plk_4	194	200	PF00069	0.338
MOD_Plk_4	282	288	PF00069	0.254
MOD_Plk_4	294	300	PF00069	0.204
MOD_Plk_4	344	350	PF00069	0.496
MOD_Plk_4	360	366	PF00069	0.211
MOD_Plk_4	379	385	PF00069	0.140
MOD_Plk_4	38	44	PF00069	0.301
MOD_Plk_4	398	404	PF00069	0.220
MOD_Plk_4	446	452	PF00069	0.240
MOD_Plk_4	499	505	PF00069	0.267
MOD_Plk_4	511	517	PF00069	0.267
MOD_Plk_4	521	527	PF00069	0.187
MOD_Plk_4	549	555	PF00069	0.259
MOD_Plk_4	558	564	PF00069	0.420
MOD_Plk_4	614	620	PF00069	0.285
MOD_Plk_4	625	631	PF00069	0.308
MOD_ProDKin_1	156	162	PF00069	0.155
MOD_ProDKin_1	259	265	PF00069	0.294
MOD_SUMO_for_1	212	215	PF00179	0.155
MOD_SUMO_rev_2	116	121	PF00179	0.238
TRG_ENDOCYTIC_2	189	192	PF00928	0.267
TRG_ENDOCYTIC_2	198	201	PF00928	0.206
TRG_ENDOCYTIC_2	284	287	PF00928	0.411
TRG_ENDOCYTIC_2	302	305	PF00928	0.200
TRG_ENDOCYTIC_2	429	432	PF00928	0.245
TRG_ENDOCYTIC_2	503	506	PF00928	0.373
TRG_ENDOCYTIC_2	515	518	PF00928	0.303
TRG_ENDOCYTIC_2	531	534	PF00928	0.152
TRG_ENDOCYTIC_2	557	560	PF00928	0.421
TRG_ENDOCYTIC_2	585	588	PF00928	0.248
TRG_ENDOCYTIC_2	589	592	PF00928	0.243
TRG_ENDOCYTIC_2	608	611	PF00928	0.153
TRG_ER_diArg_1	1	4	PF00400	0.552
TRG_ER_diArg_1	165	168	PF00400	0.269
TRG_ER_diArg_1	308	310	PF00400	0.434
TRG_ER_diArg_1	340	342	PF00400	0.376
TRG_ER_diArg_1	406	409	PF00400	0.467
TRG_Pf-PMV_PEXEL_1	94	98	PF00026	0.433

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P948	Leptomonas seymouri	30%	96%
A0A0N1I2B1	Leptomonas seymouri	58%	100%
A0A0N1I6Y7	Leptomonas seymouri	29%	100%
A0A0N1IME8	Leptomonas seymouri	21%	100%
A0A0S4IV41	Bodo saltans	34%	100%
A0A0S4J9X2	Bodo saltans	31%	99%
A0A0S4JBB1	Bodo saltans	39%	100%
A0A0S4JCH7	Bodo saltans	29%	94%
A0A0S4JEU5	Bodo saltans	31%	100%
A0A0S4JIF4	Bodo saltans	36%	100%
A0A0S4JWZ9	Bodo saltans	28%	100%
A0A0S4JZ31	Bodo saltans	29%	100%
A0A1X0NJN3	Trypanosomatidae	24%	100%
A0A1X0NK64	Trypanosomatidae	32%	100%
A0A1X0NLM6	Trypanosomatidae	24%	100%
A0A1X0NZX5	Trypanosomatidae	31%	99%
A0A1X0P2G3	Trypanosomatidae	45%	100%
A0A1X0PA12	Trypanosomatidae	33%	100%
A0A3Q8IBT4	Leishmania donovani	28%	100%
A0A3Q8IFM1	Leishmania donovani	78%	100%
A0A3Q8IHT3	Leishmania donovani	28%	100%
A0A3R7MBZ3	Trypanosoma rangeli	33%	100%
A0A3S7X2L7	Leishmania donovani	29%	94%
A0A422NED2	Trypanosoma rangeli	31%	99%
A0A422NMS9	Trypanosoma rangeli	44%	98%
A0A422P482	Trypanosoma rangeli	26%	100%
A4H7C1	Leishmania braziliensis	23%	93%
A4HB85	Leishmania braziliensis	29%	100%
A4HHH4	Leishmania braziliensis	29%	100%
A4HVR6	Leishmania infantum	28%	100%
A4I4M3	Leishmania infantum	29%	94%
A4I563	Leishmania infantum	77%	100%
A4IAD3	Leishmania infantum	28%	100%
A4IFE9	Bos taurus	28%	100%
A5D7E2	Bos taurus	33%	100%
C9ZLB0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	88%
C9ZLW2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
C9ZUX0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
D0A6H3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
E9AE21	Leishmania major	29%	100%
E9ALR2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	94%
E9APG2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
E9B0G0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	98%
E9B5F7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
F4HW17	Arabidopsis thaliana	27%	100%
F4JRE0	Arabidopsis thaliana	33%	98%
F4KIB2	Arabidopsis thaliana	31%	99%
O15321	Homo sapiens	29%	100%
P32802	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	32%	96%
P40071	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	25%	91%
P58021	Mus musculus	32%	97%
Q04562	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	31%	96%
Q4KLL4	Rattus norvegicus	33%	100%
Q4Q2H8	Leishmania major	28%	97%
Q4Q7S3	Leishmania major	77%	100%
Q4QG16	Leishmania major	23%	95%
Q54ZW0	Dictyostelium discoideum	27%	100%
Q55FP0	Dictyostelium discoideum	30%	100%
Q5R8F1	Pongo abelii	29%	100%
Q5R8Y6	Pongo abelii	32%	97%
Q5RDY2	Pongo abelii	33%	100%
Q66HF2	Rattus norvegicus	29%	100%
Q66HG5	Rattus norvegicus	32%	97%
Q7YTA6	Dictyostelium discoideum	27%	98%
Q8BH24	Mus musculus	32%	100%
Q8RWW1	Arabidopsis thaliana	33%	100%
Q92544	Homo sapiens	33%	100%
Q940G0	Arabidopsis thaliana	28%	100%
Q940S0	Arabidopsis thaliana	29%	100%
Q99805	Homo sapiens	32%	97%
Q9C5N2	Arabidopsis thaliana	32%	100%
Q9C720	Arabidopsis thaliana	33%	100%
Q9DBU0	Mus musculus	29%	100%
Q9ET30	Mus musculus	26%	100%
Q9FHT4	Arabidopsis thaliana	28%	100%
Q9FYQ8	Arabidopsis thaliana	32%	98%
Q9HD45	Homo sapiens	26%	100%
Q9LIC2	Arabidopsis thaliana	32%	100%
Q9Y819	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	36%	100%
Q9ZPS7	Arabidopsis thaliana	29%	100%
V5BCD5	Trypanosoma cruzi	45%	100%
V5BHS7	Trypanosoma cruzi	32%	100%
V5D9U0	Trypanosoma cruzi	31%	99%
V5DII3	Trypanosoma cruzi	24%	100%