Kinesin-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

kinesin, putative

Species:

Leishmania braziliensis

UniProt:

A4HHY2_LEIBR

TriTrypDb:

LbrM.30.0390 , LBRM2903_300009900

Length:

607

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 7

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005874	microtubule	6	11
GO:0099080	supramolecular complex	2	11
GO:0099081	supramolecular polymer	3	11
GO:0099512	supramolecular fiber	4	11
GO:0099513	polymeric cytoskeletal fiber	5	11
GO:0110165	cellular anatomical entity	1	11
GO:0005737	cytoplasm	2	1
GO:0005871	kinesin complex	3	1
GO:0005875	microtubule associated complex	2	1
GO:0032991	protein-containing complex	1	1

Expansion

Sequence features

A4HHY2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHY2

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	12
GO:0007018	microtubule-based movement	3	12
GO:0009987	cellular process	1	12
GO:0006810	transport	3	1
GO:0030705	cytoskeleton-dependent intracellular transport	4	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003774	cytoskeletal motor activity	1	12
GO:0003777	microtubule motor activity	2	12
GO:0003824	catalytic activity	1	7
GO:0005488	binding	1	12
GO:0005515	protein binding	2	12
GO:0005524	ATP binding	5	12
GO:0008017	microtubule binding	5	12
GO:0008092	cytoskeletal protein binding	3	12
GO:0015631	tubulin binding	4	12
GO:0016787	hydrolase activity	2	7
GO:0017076	purine nucleotide binding	4	12
GO:0030554	adenyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032559	adenyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:0140657	ATP-dependent activity	1	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12
GO:0008574	plus-end-directed microtubule motor activity	3	1
GO:0016462	pyrophosphatase activity	5	1
GO:0016817	hydrolase activity, acting on acid anhydrides	3	1
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	1
GO:0016887	ATP hydrolysis activity	7	1
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	597	601	PF00656	0.402
CLV_NRD_NRD_1	207	209	PF00675	0.313
CLV_NRD_NRD_1	49	51	PF00675	0.341
CLV_NRD_NRD_1	493	495	PF00675	0.626
CLV_NRD_NRD_1	519	521	PF00675	0.485
CLV_NRD_NRD_1	603	605	PF00675	0.647
CLV_PCSK_KEX2_1	360	362	PF00082	0.431
CLV_PCSK_KEX2_1	519	521	PF00082	0.531
CLV_PCSK_PC1ET2_1	360	362	PF00082	0.431
CLV_PCSK_SKI1_1	106	110	PF00082	0.353
CLV_PCSK_SKI1_1	190	194	PF00082	0.394
CLV_PCSK_SKI1_1	256	260	PF00082	0.383
CLV_PCSK_SKI1_1	286	290	PF00082	0.423
CLV_PCSK_SKI1_1	394	398	PF00082	0.652
CLV_PCSK_SKI1_1	409	413	PF00082	0.343
CLV_PCSK_SKI1_1	44	48	PF00082	0.386
CLV_PCSK_SKI1_1	484	488	PF00082	0.590
CLV_PCSK_SKI1_1	60	64	PF00082	0.213
DEG_APCC_DBOX_1	255	263	PF00400	0.383
DEG_APCC_DBOX_1	481	489	PF00400	0.533
DEG_SCF_TRCP1_1	245	250	PF00400	0.201
DOC_CYCLIN_RxL_1	283	290	PF00134	0.423
DOC_MAPK_gen_1	161	169	PF00069	0.327
DOC_MAPK_gen_1	233	242	PF00069	0.321
DOC_MAPK_gen_1	482	489	PF00069	0.516
DOC_MAPK_gen_1	586	594	PF00069	0.607
DOC_MAPK_MEF2A_6	161	169	PF00069	0.355
DOC_MAPK_MEF2A_6	482	489	PF00069	0.556
DOC_MAPK_NFAT4_5	482	490	PF00069	0.626
DOC_USP7_MATH_1	4	8	PF00917	0.589
DOC_USP7_UBL2_3	356	360	PF12436	0.439
DOC_USP7_UBL2_3	51	55	PF12436	0.354
DOC_USP7_UBL2_3	9	13	PF12436	0.560
DOC_WW_Pin1_4	330	335	PF00397	0.309
DOC_WW_Pin1_4	437	442	PF00397	0.685
DOC_WW_Pin1_4	545	550	PF00397	0.614
LIG_14-3-3_CanoR_1	222	227	PF00244	0.270
LIG_14-3-3_CanoR_1	286	292	PF00244	0.399
LIG_14-3-3_CanoR_1	3	12	PF00244	0.674
LIG_14-3-3_CanoR_1	400	405	PF00244	0.633
LIG_14-3-3_CanoR_1	44	49	PF00244	0.357
LIG_14-3-3_CanoR_1	593	603	PF00244	0.398
LIG_Actin_WH2_2	422	437	PF00022	0.656
LIG_Actin_WH2_2	460	478	PF00022	0.568
LIG_Actin_WH2_2	588	606	PF00022	0.524
LIG_APCC_ABBA_1	147	152	PF00400	0.314
LIG_BIR_II_1	1	5	PF00653	0.681
LIG_FHA_1	105	111	PF00498	0.328
LIG_FHA_1	12	18	PF00498	0.579
LIG_FHA_1	153	159	PF00498	0.323
LIG_FHA_1	226	232	PF00498	0.363
LIG_FHA_1	248	254	PF00498	0.367
LIG_FHA_1	311	317	PF00498	0.311
LIG_FHA_1	324	330	PF00498	0.314
LIG_FHA_1	523	529	PF00498	0.523
LIG_FHA_1	532	538	PF00498	0.488
LIG_FHA_2	134	140	PF00498	0.374
LIG_FHA_2	269	275	PF00498	0.313
LIG_FHA_2	383	389	PF00498	0.572
LIG_FHA_2	434	440	PF00498	0.460
LIG_FHA_2	475	481	PF00498	0.391
LIG_FHA_2	70	76	PF00498	0.388
LIG_HCF-1_HBM_1	137	140	PF13415	0.323
LIG_IRF3_LxIS_1	226	232	PF10401	0.183
LIG_LIR_Gen_1	127	133	PF02991	0.383
LIG_LIR_Gen_1	143	154	PF02991	0.153
LIG_LIR_Gen_1	16	26	PF02991	0.223
LIG_LIR_Gen_1	340	348	PF02991	0.201
LIG_LIR_Gen_1	559	567	PF02991	0.516
LIG_LIR_Gen_1	75	85	PF02991	0.335
LIG_LIR_Nem_3	127	132	PF02991	0.309
LIG_LIR_Nem_3	143	149	PF02991	0.212
LIG_LIR_Nem_3	16	21	PF02991	0.284
LIG_LIR_Nem_3	340	346	PF02991	0.201
LIG_LIR_Nem_3	366	370	PF02991	0.468
LIG_LIR_Nem_3	559	564	PF02991	0.528
LIG_LIR_Nem_3	75	80	PF02991	0.332
LIG_NRBOX	153	159	PF00104	0.309
LIG_PCNA_yPIPBox_3	151	164	PF02747	0.309
LIG_PCNA_yPIPBox_3	459	468	PF02747	0.634
LIG_Pex14_2	63	67	PF04695	0.314
LIG_PTB_Apo_2	61	68	PF02174	0.352
LIG_REV1ctd_RIR_1	199	207	PF16727	0.238
LIG_SH2_CRK	367	371	PF00017	0.482
LIG_SH2_PTP2	146	149	PF00017	0.309
LIG_SH2_STAP1	140	144	PF00017	0.328
LIG_SH2_STAP1	77	81	PF00017	0.328
LIG_SH2_STAT5	146	149	PF00017	0.318
LIG_SH2_STAT5	371	374	PF00017	0.475
LIG_SH2_STAT5	536	539	PF00017	0.533
LIG_SH3_1	20	26	PF00018	0.352
LIG_SH3_3	20	26	PF00018	0.329
LIG_SH3_3	546	552	PF00018	0.716
LIG_SH3_3	63	69	PF00018	0.354
LIG_SUMO_SIM_anti_2	176	184	PF11976	0.232
LIG_SUMO_SIM_par_1	176	184	PF11976	0.309
LIG_SUMO_SIM_par_1	249	254	PF11976	0.392
LIG_TRAF2_1	389	392	PF00917	0.633
LIG_TRAF2_1	460	463	PF00917	0.426
LIG_TYR_ITIM	144	149	PF00017	0.309
LIG_TYR_ITIM	365	370	PF00017	0.468
LIG_UBA3_1	153	162	PF00899	0.328
LIG_UBA3_1	288	293	PF00899	0.309
LIG_UBA3_1	374	381	PF00899	0.509
LIG_WRC_WIRS_1	540	545	PF05994	0.679
MOD_CDK_SPK_2	548	553	PF00069	0.597
MOD_CK1_1	104	110	PF00069	0.296
MOD_CK1_1	181	187	PF00069	0.388
MOD_CK1_1	220	226	PF00069	0.297
MOD_CK1_1	232	238	PF00069	0.260
MOD_CK1_1	287	293	PF00069	0.397
MOD_CK1_1	310	316	PF00069	0.310
MOD_CK1_1	545	551	PF00069	0.614
MOD_CK1_1	7	13	PF00069	0.632
MOD_CK2_1	204	210	PF00069	0.290
MOD_CK2_1	268	274	PF00069	0.309
MOD_CK2_1	433	439	PF00069	0.580
MOD_CK2_1	474	480	PF00069	0.426
MOD_CK2_1	553	559	PF00069	0.478
MOD_CK2_1	69	75	PF00069	0.272
MOD_GlcNHglycan	103	106	PF01048	0.298
MOD_GlcNHglycan	182	186	PF01048	0.229
MOD_GlcNHglycan	245	248	PF01048	0.238
MOD_GlcNHglycan	343	346	PF01048	0.342
MOD_GlcNHglycan	442	445	PF01048	0.721
MOD_GlcNHglycan	451	454	PF01048	0.515
MOD_GlcNHglycan	537	540	PF01048	0.578
MOD_GlcNHglycan	565	568	PF01048	0.610
MOD_GlcNHglycan	9	12	PF01048	0.646
MOD_GSK3_1	104	111	PF00069	0.305
MOD_GSK3_1	138	145	PF00069	0.333
MOD_GSK3_1	216	223	PF00069	0.325
MOD_GSK3_1	225	232	PF00069	0.283
MOD_GSK3_1	243	250	PF00069	0.367
MOD_GSK3_1	262	269	PF00069	0.298
MOD_GSK3_1	332	339	PF00069	0.341
MOD_GSK3_1	433	440	PF00069	0.622
MOD_GSK3_1	527	534	PF00069	0.483
MOD_GSK3_1	535	542	PF00069	0.503
MOD_GSK3_1	7	14	PF00069	0.635
MOD_LATS_1	27	33	PF00433	0.201
MOD_N-GLC_1	133	138	PF02516	0.386
MOD_N-GLC_1	195	200	PF02516	0.201
MOD_N-GLC_1	216	221	PF02516	0.309
MOD_N-GLC_1	229	234	PF02516	0.309
MOD_N-GLC_1	284	289	PF02516	0.314
MOD_N-GLC_1	324	329	PF02516	0.314
MOD_N-GLC_1	330	335	PF02516	0.302
MOD_N-GLC_1	34	39	PF02516	0.348
MOD_N-GLC_1	69	74	PF02516	0.394
MOD_NEK2_1	121	126	PF00069	0.408
MOD_NEK2_1	201	206	PF00069	0.367
MOD_NEK2_1	211	216	PF00069	0.304
MOD_NEK2_1	229	234	PF00069	0.250
MOD_NEK2_1	307	312	PF00069	0.319
MOD_NEK2_1	316	321	PF00069	0.331
MOD_NEK2_1	543	548	PF00069	0.690
MOD_PIKK_1	350	356	PF00454	0.423
MOD_PIKK_1	69	75	PF00454	0.352
MOD_PK_1	13	19	PF00069	0.308
MOD_PKA_1	50	56	PF00069	0.291
MOD_PKA_2	232	238	PF00069	0.323
MOD_PKA_2	266	272	PF00069	0.314
MOD_PKA_2	307	313	PF00069	0.308
MOD_PKA_2	350	356	PF00069	0.423
MOD_PKA_2	49	55	PF00069	0.334
MOD_Plk_1	279	285	PF00069	0.332
MOD_Plk_1	324	330	PF00069	0.323
MOD_Plk_1	339	345	PF00069	0.268
MOD_Plk_1	34	40	PF00069	0.346
MOD_Plk_1	382	388	PF00069	0.593
MOD_Plk_1	543	549	PF00069	0.599
MOD_Plk_2-3	274	280	PF00069	0.328
MOD_Plk_2-3	336	342	PF00069	0.328
MOD_Plk_4	142	148	PF00069	0.309
MOD_Plk_4	222	228	PF00069	0.314
MOD_Plk_4	316	322	PF00069	0.331
MOD_Plk_4	324	330	PF00069	0.338
MOD_ProDKin_1	330	336	PF00069	0.309
MOD_ProDKin_1	437	443	PF00069	0.687
MOD_ProDKin_1	545	551	PF00069	0.615
MOD_SUMO_for_1	115	118	PF00179	0.238
MOD_SUMO_rev_2	111	117	PF00179	0.298
MOD_SUMO_rev_2	269	278	PF00179	0.330
MOD_SUMO_rev_2	363	370	PF00179	0.466
MOD_SUMO_rev_2	466	475	PF00179	0.502
TRG_DiLeu_BaEn_1	577	582	PF01217	0.563
TRG_DiLeu_BaEn_4	413	419	PF01217	0.600
TRG_DiLeu_BaEn_4	480	486	PF01217	0.403
TRG_ENDOCYTIC_2	146	149	PF00928	0.309
TRG_ENDOCYTIC_2	150	153	PF00928	0.309
TRG_ENDOCYTIC_2	318	321	PF00928	0.328
TRG_ENDOCYTIC_2	367	370	PF00928	0.479
TRG_ENDOCYTIC_2	371	374	PF00928	0.486
TRG_ENDOCYTIC_2	561	564	PF00928	0.526
TRG_ENDOCYTIC_2	77	80	PF00928	0.293
TRG_ER_diArg_1	20	23	PF00400	0.318
TRG_ER_diArg_1	482	485	PF00400	0.625
TRG_NES_CRM1_1	399	414	PF08389	0.613
TRG_Pf-PMV_PEXEL_1	276	280	PF00026	0.328
TRG_Pf-PMV_PEXEL_1	409	413	PF00026	0.458
TRG_Pf-PMV_PEXEL_1	476	480	PF00026	0.487
TRG_Pf-PMV_PEXEL_1	572	577	PF00026	0.557
TRG_Pf-PMV_PEXEL_1	593	598	PF00026	0.523

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P569	Leptomonas seymouri	25%	69%
A0A0N1I0Y5	Leptomonas seymouri	74%	99%
A0A0S4IP49	Bodo saltans	25%	75%
A0A0S4IR67	Bodo saltans	26%	78%
A0A0S4JEF6	Bodo saltans	52%	90%
A0A0S4JJ54	Bodo saltans	25%	87%
A0A1X0NQ03	Trypanosomatidae	23%	73%
A0A1X0P2B6	Trypanosomatidae	59%	99%
A0A1X0P9E3	Trypanosomatidae	29%	100%
A0A1X0P9H3	Trypanosomatidae	31%	70%
A0A1X0P9T0	Trypanosomatidae	31%	100%
A0A3Q8IBS7	Leishmania donovani	76%	100%
A0A3Q8IEL2	Leishmania donovani	29%	100%
A0A3Q8IG88	Leishmania donovani	26%	87%
A0A3Q8IHG6	Leishmania donovani	29%	100%
A0A3R7KSK0	Trypanosoma rangeli	28%	82%
A0A3R7LER1	Trypanosoma rangeli	26%	66%
A0A3R7MDH9	Trypanosoma rangeli	28%	85%
A0A3R7R330	Trypanosoma rangeli	31%	100%
A0A3S5IRH3	Trypanosoma rangeli	57%	100%
A0A3S7WPL3	Leishmania donovani	26%	68%
A0A3S7X2P9	Leishmania donovani	28%	100%
A0A3S7X9Y1	Leishmania donovani	28%	100%
A0A422MZ05	Trypanosoma rangeli	29%	90%
A2ZRG4	Oryza sativa subsp. japonica	31%	73%
A4H4R6	Leishmania braziliensis	25%	69%
A4HAQ7	Leishmania braziliensis	26%	100%
A4HCA1	Leishmania braziliensis	25%	68%
A4HHN8	Leishmania braziliensis	30%	100%
A4HMM9	Leishmania braziliensis	27%	87%
A4HND6	Leishmania braziliensis	26%	100%
A4HSA6	Leishmania infantum	35%	100%
A4HSZ5	Leishmania infantum	26%	68%
A4I4V2	Leishmania infantum	29%	100%
A4I4V3	Leishmania infantum	29%	100%
A4I562	Leishmania infantum	76%	100%
A4IBA7	Leishmania infantum	26%	87%
A4IC09	Leishmania infantum	28%	100%
B9G2X9	Oryza sativa subsp. japonica	34%	100%
C9ZQI8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	97%
C9ZV26	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	81%
C9ZZN5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	89%
E9AEA1	Leishmania major	29%	100%
E9AF32	Leishmania major	27%	87%
E9AFU7	Leishmania major	28%	100%
E9AKP6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	92%
E9AKY2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	68%
E9ALI5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9B0F9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	100%
E9B6Z9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
F4I1T9	Arabidopsis thaliana	29%	71%
P28743	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	27%	86%
P46870	Chlamydomonas reinhardtii	31%	78%
Q10E64	Oryza sativa subsp. japonica	31%	83%
Q1MTQ1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	30%	97%
Q2R2P7	Oryza sativa subsp. japonica	33%	95%
Q4Q7S4	Leishmania major	74%	100%
Q4QJ61	Leishmania major	27%	90%
Q4R918	Macaca fascicularis	26%	100%
Q6H638	Oryza sativa subsp. japonica	30%	69%
Q965T6	Caenorhabditis elegans	32%	94%
Q96FN5	Homo sapiens	31%	94%
Q9HAQ2	Homo sapiens	29%	77%
Q9V877	Drosophila melanogaster	28%	97%
Q9WV04	Mus musculus	31%	77%
V5AP02	Trypanosoma cruzi	28%	81%
V5B8M1	Trypanosoma cruzi	29%	99%
V5BHY4	Trypanosoma cruzi	29%	81%
V5BK25	Trypanosoma cruzi	27%	84%
V5D733	Trypanosoma cruzi	28%	81%
V5DTU1	Trypanosoma cruzi	30%	100%