Putative KU80 protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

KU80 protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HHY1_LEIBR

TriTrypDb:

LbrM.30.0380 , LBRM2903_300009800

Length:

792

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0032991	protein-containing complex	1	12
GO:0043564	Ku70:Ku80 complex	3	12
GO:0140513	nuclear protein-containing complex	2	12
GO:0005694	chromosome	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HHY1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHY1

Function

Biological processes
Term	Name	Level	Count
GO:0000723	telomere maintenance	5	12
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006259	DNA metabolic process	4	12
GO:0006281	DNA repair	5	12
GO:0006302	double-strand break repair	6	12
GO:0006303	double-strand break repair via nonhomologous end joining	7	12
GO:0006310	DNA recombination	5	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0006950	response to stress	2	12
GO:0006974	DNA damage response	4	12
GO:0006996	organelle organization	4	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016043	cellular component organization	3	12
GO:0032200	telomere organization	6	12
GO:0033554	cellular response to stress	3	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044260	obsolete cellular macromolecule metabolic process	3	12
GO:0046483	heterocycle metabolic process	3	12
GO:0050896	response to stimulus	1	12
GO:0051276	chromosome organization	5	12
GO:0051716	cellular response to stimulus	2	12
GO:0071704	organic substance metabolic process	2	12
GO:0071840	cellular component organization or biogenesis	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12
GO:0009314	response to radiation	3	1
GO:0009628	response to abiotic stimulus	2	1
GO:0010165	response to X-ray	5	1
GO:0010212	response to ionizing radiation	4	1
GO:0010332	response to gamma radiation	5	1
GO:0071214	cellular response to abiotic stimulus	3	1
GO:0071478	cellular response to radiation	4	1
GO:0071479	cellular response to ionizing radiation	5	1
GO:0071480	cellular response to gamma radiation	6	1
GO:0071481	cellular response to X-ray	6	1
GO:0104004	cellular response to environmental stimulus	3	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003676	nucleic acid binding	3	12
GO:0003677	DNA binding	4	12
GO:0003684	damaged DNA binding	5	12
GO:0003824	catalytic activity	1	12
GO:0004386	helicase activity	2	12
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0016787	hydrolase activity	2	12
GO:0017076	purine nucleotide binding	4	12
GO:0030554	adenyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032559	adenyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0042162	telomeric DNA binding	6	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0043565	sequence-specific DNA binding	5	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:0140640	catalytic activity, acting on a nucleic acid	2	12
GO:0140657	ATP-dependent activity	1	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	111	115	PF00656	0.559
CLV_C14_Caspase3-7	277	281	PF00656	0.476
CLV_C14_Caspase3-7	452	456	PF00656	0.533
CLV_C14_Caspase3-7	549	553	PF00656	0.636
CLV_C14_Caspase3-7	743	747	PF00656	0.562
CLV_C14_Caspase3-7	786	790	PF00656	0.401
CLV_NRD_NRD_1	130	132	PF00675	0.194
CLV_NRD_NRD_1	201	203	PF00675	0.580
CLV_NRD_NRD_1	238	240	PF00675	0.461
CLV_NRD_NRD_1	275	277	PF00675	0.352
CLV_NRD_NRD_1	693	695	PF00675	0.359
CLV_NRD_NRD_1	743	745	PF00675	0.359
CLV_PCSK_KEX2_1	130	132	PF00082	0.252
CLV_PCSK_KEX2_1	275	277	PF00082	0.302
CLV_PCSK_PC7_1	126	132	PF00082	0.288
CLV_PCSK_SKI1_1	104	108	PF00082	0.327
CLV_PCSK_SKI1_1	248	252	PF00082	0.380
CLV_PCSK_SKI1_1	257	261	PF00082	0.273
CLV_PCSK_SKI1_1	29	33	PF00082	0.300
CLV_PCSK_SKI1_1	3	7	PF00082	0.356
CLV_PCSK_SKI1_1	358	362	PF00082	0.315
CLV_PCSK_SKI1_1	385	389	PF00082	0.315
CLV_PCSK_SKI1_1	535	539	PF00082	0.530
CLV_PCSK_SKI1_1	54	58	PF00082	0.359
CLV_PCSK_SKI1_1	606	610	PF00082	0.477
CLV_PCSK_SKI1_1	689	693	PF00082	0.308
DEG_SCF_FBW7_1	572	577	PF00400	0.458
DOC_CKS1_1	290	295	PF01111	0.379
DOC_CYCLIN_RxL_1	481	492	PF00134	0.329
DOC_CYCLIN_yCln2_LP_2	223	229	PF00134	0.535
DOC_MAPK_DCC_7	416	425	PF00069	0.559
DOC_MAPK_gen_1	130	138	PF00069	0.492
DOC_MAPK_gen_1	147	155	PF00069	0.604
DOC_MAPK_gen_1	305	313	PF00069	0.503
DOC_MAPK_gen_1	332	342	PF00069	0.495
DOC_MAPK_MEF2A_6	3	12	PF00069	0.428
DOC_MAPK_MEF2A_6	305	313	PF00069	0.379
DOC_MAPK_MEF2A_6	433	442	PF00069	0.531
DOC_MAPK_MEF2A_6	65	73	PF00069	0.379
DOC_MAPK_MEF2A_6	775	784	PF00069	0.577
DOC_MAPK_NFAT4_5	775	783	PF00069	0.319
DOC_PIKK_1	446	453	PF02985	0.532
DOC_PP1_RVXF_1	428	435	PF00149	0.536
DOC_PP2B_LxvP_1	217	220	PF13499	0.505
DOC_PP4_FxxP_1	736	739	PF00568	0.559
DOC_USP7_MATH_1	125	129	PF00917	0.526
DOC_USP7_MATH_1	379	383	PF00917	0.516
DOC_USP7_MATH_1	522	526	PF00917	0.564
DOC_USP7_MATH_1	533	537	PF00917	0.450
DOC_USP7_MATH_1	574	578	PF00917	0.727
DOC_USP7_MATH_1	768	772	PF00917	0.379
DOC_USP7_UBL2_3	494	498	PF12436	0.737
DOC_WW_Pin1_4	222	227	PF00397	0.500
DOC_WW_Pin1_4	289	294	PF00397	0.457
DOC_WW_Pin1_4	35	40	PF00397	0.475
DOC_WW_Pin1_4	395	400	PF00397	0.508
DOC_WW_Pin1_4	570	575	PF00397	0.653
LIG_14-3-3_CanoR_1	104	113	PF00244	0.379
LIG_14-3-3_CanoR_1	232	236	PF00244	0.363
LIG_14-3-3_CanoR_1	257	265	PF00244	0.569
LIG_14-3-3_CanoR_1	275	284	PF00244	0.323
LIG_14-3-3_CanoR_1	29	37	PF00244	0.483
LIG_14-3-3_CanoR_1	390	400	PF00244	0.540
LIG_14-3-3_CanoR_1	433	440	PF00244	0.541
LIG_14-3-3_CanoR_1	514	521	PF00244	0.519
LIG_BIR_II_1	1	5	PF00653	0.441
LIG_BRCT_BRCA1_1	516	520	PF00533	0.489
LIG_Clathr_ClatBox_1	153	157	PF01394	0.287
LIG_CSL_BTD_1	736	739	PF09270	0.476
LIG_eIF4E_1	715	721	PF01652	0.515
LIG_FHA_1	163	169	PF00498	0.270
LIG_FHA_1	26	32	PF00498	0.452
LIG_FHA_1	355	361	PF00498	0.540
LIG_FHA_1	396	402	PF00498	0.464
LIG_FHA_1	4	10	PF00498	0.342
LIG_FHA_1	68	74	PF00498	0.535
LIG_FHA_1	77	83	PF00498	0.521
LIG_FHA_2	264	270	PF00498	0.528
LIG_FHA_2	290	296	PF00498	0.533
LIG_FHA_2	344	350	PF00498	0.481
LIG_FHA_2	514	520	PF00498	0.601
LIG_FHA_2	645	651	PF00498	0.525
LIG_FHA_2	707	713	PF00498	0.476
LIG_FHA_2	752	758	PF00498	0.479
LIG_FHA_2	765	771	PF00498	0.479
LIG_FHA_2	786	792	PF00498	0.654
LIG_GBD_Chelix_1	600	608	PF00786	0.475
LIG_LIR_Apic_2	287	293	PF02991	0.379
LIG_LIR_Apic_2	733	739	PF02991	0.559
LIG_LIR_Gen_1	107	118	PF02991	0.518
LIG_LIR_Gen_1	172	181	PF02991	0.608
LIG_LIR_Gen_1	525	533	PF02991	0.577
LIG_LIR_Gen_1	567	574	PF02991	0.571
LIG_LIR_Gen_1	654	663	PF02991	0.515
LIG_LIR_LC3C_4	165	168	PF02991	0.248
LIG_LIR_Nem_3	107	113	PF02991	0.518
LIG_LIR_Nem_3	172	176	PF02991	0.516
LIG_LIR_Nem_3	194	200	PF02991	0.596
LIG_LIR_Nem_3	435	440	PF02991	0.477
LIG_LIR_Nem_3	468	473	PF02991	0.479
LIG_LIR_Nem_3	525	531	PF02991	0.568
LIG_LIR_Nem_3	567	572	PF02991	0.490
LIG_LIR_Nem_3	654	658	PF02991	0.515
LIG_LIR_Nem_3	735	740	PF02991	0.540
LIG_LYPXL_yS_3	437	440	PF13949	0.673
LIG_MYND_1	507	511	PF01753	0.625
LIG_NBox_RRM_1	112	122	PF00076	0.540
LIG_PCNA_yPIPBox_3	371	381	PF02747	0.533
LIG_PCNA_yPIPBox_3	471	484	PF02747	0.460
LIG_SH2_CRK	478	482	PF00017	0.404
LIG_SH2_CRK	569	573	PF00017	0.418
LIG_SH2_NCK_1	528	532	PF00017	0.561
LIG_SH2_PTP2	290	293	PF00017	0.559
LIG_SH2_SRC	66	69	PF00017	0.379
LIG_SH2_STAP1	547	551	PF00017	0.599
LIG_SH2_STAP1	716	720	PF00017	0.379
LIG_SH2_STAT5	137	140	PF00017	0.468
LIG_SH2_STAT5	290	293	PF00017	0.506
LIG_SH2_STAT5	740	743	PF00017	0.559
LIG_SH3_3	328	334	PF00018	0.571
LIG_SH3_3	33	39	PF00018	0.467
LIG_SH3_3	416	422	PF00018	0.536
LIG_SH3_3	460	466	PF00018	0.463
LIG_SH3_3	656	662	PF00018	0.559
LIG_SH3_3	91	97	PF00018	0.421
LIG_SH3_3	99	105	PF00018	0.402
LIG_Sin3_3	373	380	PF02671	0.559
LIG_SUMO_SIM_anti_2	162	168	PF11976	0.309
LIG_SUMO_SIM_anti_2	231	237	PF11976	0.445
LIG_SUMO_SIM_anti_2	41	47	PF11976	0.514
LIG_SUMO_SIM_anti_2	6	11	PF11976	0.322
LIG_SUMO_SIM_par_1	4	11	PF11976	0.391
LIG_SUMO_SIM_par_1	69	74	PF11976	0.379
LIG_TRAF2_1	181	184	PF00917	0.531
LIG_TRAF2_1	19	22	PF00917	0.379
LIG_TRAF2_1	266	269	PF00917	0.479
LIG_TRAF2_1	304	307	PF00917	0.559
LIG_TRAF2_1	546	549	PF00917	0.482
LIG_TRAF2_1	754	757	PF00917	0.555
LIG_UBA3_1	604	609	PF00899	0.474
LIG_WRC_WIRS_1	652	657	PF05994	0.479
MOD_CK1_1	540	546	PF00069	0.521
MOD_CK1_1	564	570	PF00069	0.524
MOD_CK1_1	618	624	PF00069	0.696
MOD_CK1_1	629	635	PF00069	0.620
MOD_CK2_1	179	185	PF00069	0.650
MOD_CK2_1	222	228	PF00069	0.478
MOD_CK2_1	263	269	PF00069	0.505
MOD_CK2_1	317	323	PF00069	0.511
MOD_CK2_1	343	349	PF00069	0.481
MOD_CK2_1	440	446	PF00069	0.497
MOD_CK2_1	523	529	PF00069	0.502
MOD_CK2_1	751	757	PF00069	0.479
MOD_CK2_1	764	770	PF00069	0.479
MOD_GlcNHglycan	193	197	PF01048	0.649
MOD_GlcNHglycan	382	385	PF01048	0.252
MOD_GlcNHglycan	412	415	PF01048	0.341
MOD_GlcNHglycan	531	534	PF01048	0.501
MOD_GlcNHglycan	535	538	PF01048	0.533
MOD_GlcNHglycan	54	57	PF01048	0.321
MOD_GlcNHglycan	542	545	PF01048	0.552
MOD_GlcNHglycan	587	590	PF01048	0.722
MOD_GlcNHglycan	59	63	PF01048	0.308
MOD_GlcNHglycan	592	595	PF01048	0.629
MOD_GlcNHglycan	610	613	PF01048	0.591
MOD_GlcNHglycan	617	620	PF01048	0.659
MOD_GlcNHglycan	638	641	PF01048	0.719
MOD_GlcNHglycan	746	749	PF01048	0.314
MOD_GlcNHglycan	759	762	PF01048	0.251
MOD_GSK3_1	187	194	PF00069	0.733
MOD_GSK3_1	218	225	PF00069	0.446
MOD_GSK3_1	25	32	PF00069	0.445
MOD_GSK3_1	257	264	PF00069	0.474
MOD_GSK3_1	391	398	PF00069	0.433
MOD_GSK3_1	455	462	PF00069	0.479
MOD_GSK3_1	488	495	PF00069	0.555
MOD_GSK3_1	529	536	PF00069	0.465
MOD_GSK3_1	564	571	PF00069	0.500
MOD_GSK3_1	574	581	PF00069	0.557
MOD_GSK3_1	618	625	PF00069	0.723
MOD_GSK3_1	636	643	PF00069	0.671
MOD_GSK3_1	764	771	PF00069	0.459
MOD_N-GLC_1	488	493	PF02516	0.626
MOD_N-GLC_1	615	620	PF02516	0.484
MOD_N-GLC_2	133	135	PF02516	0.324
MOD_NEK2_1	10	15	PF00069	0.436
MOD_NEK2_1	274	279	PF00069	0.477
MOD_NEK2_1	354	359	PF00069	0.540
MOD_NEK2_1	380	385	PF00069	0.540
MOD_NEK2_1	391	396	PF00069	0.540
MOD_NEK2_1	513	518	PF00069	0.482
MOD_NEK2_1	644	649	PF00069	0.576
MOD_NEK2_1	683	688	PF00069	0.486
MOD_PIKK_1	125	131	PF00454	0.531
MOD_PIKK_1	179	185	PF00454	0.710
MOD_PIKK_1	257	263	PF00454	0.513
MOD_PIKK_1	275	281	PF00454	0.323
MOD_PIKK_1	587	593	PF00454	0.760
MOD_PIKK_1	706	712	PF00454	0.476
MOD_PKA_1	275	281	PF00069	0.515
MOD_PKA_1	744	750	PF00069	0.490
MOD_PKA_2	125	131	PF00069	0.559
MOD_PKA_2	231	237	PF00069	0.314
MOD_PKA_2	274	280	PF00069	0.498
MOD_PKA_2	317	323	PF00069	0.531
MOD_PKA_2	432	438	PF00069	0.531
MOD_PKA_2	440	446	PF00069	0.427
MOD_PKA_2	513	519	PF00069	0.536
MOD_Plk_1	10	16	PF00069	0.453
MOD_Plk_1	192	198	PF00069	0.595
MOD_Plk_1	3	9	PF00069	0.445
MOD_Plk_1	564	570	PF00069	0.426
MOD_Plk_2-3	455	461	PF00069	0.494
MOD_Plk_2-3	523	529	PF00069	0.584
MOD_Plk_2-3	785	791	PF00069	0.603
MOD_Plk_4	219	225	PF00069	0.466
MOD_Plk_4	231	237	PF00069	0.466
MOD_Plk_4	3	9	PF00069	0.289
MOD_Plk_4	459	465	PF00069	0.498
MOD_Plk_4	523	529	PF00069	0.413
MOD_Plk_4	564	570	PF00069	0.545
MOD_Plk_4	574	580	PF00069	0.692
MOD_Plk_4	640	646	PF00069	0.537
MOD_Plk_4	768	774	PF00069	0.379
MOD_ProDKin_1	222	228	PF00069	0.504
MOD_ProDKin_1	289	295	PF00069	0.457
MOD_ProDKin_1	35	41	PF00069	0.475
MOD_ProDKin_1	395	401	PF00069	0.508
MOD_ProDKin_1	570	576	PF00069	0.658
MOD_SUMO_for_1	304	307	PF00179	0.559
MOD_SUMO_rev_2	195	204	PF00179	0.618
MOD_SUMO_rev_2	322	331	PF00179	0.379
MOD_SUMO_rev_2	491	495	PF00179	0.568
TRG_DiLeu_BaEn_1	349	354	PF01217	0.540
TRG_DiLeu_BaEn_1	550	555	PF01217	0.680
TRG_DiLeu_BaEn_2	107	113	PF01217	0.559
TRG_DiLeu_BaEn_2	149	155	PF01217	0.448
TRG_DiLeu_BaEn_2	337	343	PF01217	0.540
TRG_DiLeu_BaEn_4	21	27	PF01217	0.379
TRG_DiLeu_BaLyEn_6	396	401	PF01217	0.379
TRG_DiLeu_BaLyEn_6	508	513	PF01217	0.512
TRG_ENDOCYTIC_2	110	113	PF00928	0.540
TRG_ENDOCYTIC_2	37	40	PF00928	0.485
TRG_ENDOCYTIC_2	437	440	PF00928	0.593
TRG_ENDOCYTIC_2	478	481	PF00928	0.402
TRG_ENDOCYTIC_2	528	531	PF00928	0.526
TRG_ENDOCYTIC_2	569	572	PF00928	0.661
TRG_ENDOCYTIC_2	66	69	PF00928	0.497
TRG_ENDOCYTIC_2	716	719	PF00928	0.559
TRG_ER_diArg_1	274	276	PF00400	0.551
TRG_NES_CRM1_1	111	124	PF08389	0.540
TRG_NES_CRM1_1	447	460	PF08389	0.478
TRG_Pf-PMV_PEXEL_1	104	108	PF00026	0.335
TRG_Pf-PMV_PEXEL_1	239	243	PF00026	0.478
TRG_Pf-PMV_PEXEL_1	29	33	PF00026	0.342
TRG_Pf-PMV_PEXEL_1	301	306	PF00026	0.179

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HUA9	Leptomonas seymouri	56%	100%
A0A0S4JHV4	Bodo saltans	27%	96%
A0A1X0P2Y5	Trypanosomatidae	29%	94%
A0A3Q8IRQ2	Leishmania donovani	78%	99%
A0A422NMK3	Trypanosoma rangeli	33%	100%
A4I561	Leishmania infantum	78%	99%
C9ZQI7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
E9B0F8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	99%
P27641	Mus musculus	24%	100%
Q2H6C5	Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)	23%	100%
Q4Q7S5	Leishmania major	77%	100%
Q54LY5	Dictyostelium discoideum	22%	99%
V5BGZ6	Trypanosoma cruzi	33%	100%