Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HHX8_LEIBR

TriTrypDb:

LbrM.30.0350 , LBRM2903_330034100

Length:

563

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HHX8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHX8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	196	200	PF00656	0.515
CLV_C14_Caspase3-7	22	26	PF00656	0.431
CLV_C14_Caspase3-7	283	287	PF00656	0.524
CLV_C14_Caspase3-7	494	498	PF00656	0.349
CLV_NRD_NRD_1	173	175	PF00675	0.478
CLV_NRD_NRD_1	23	25	PF00675	0.575
CLV_NRD_NRD_1	362	364	PF00675	0.603
CLV_NRD_NRD_1	399	401	PF00675	0.545
CLV_NRD_NRD_1	409	411	PF00675	0.441
CLV_NRD_NRD_1	505	507	PF00675	0.594
CLV_NRD_NRD_1	90	92	PF00675	0.577
CLV_PCSK_KEX2_1	173	175	PF00082	0.456
CLV_PCSK_KEX2_1	190	192	PF00082	0.513
CLV_PCSK_KEX2_1	23	25	PF00082	0.638
CLV_PCSK_KEX2_1	364	366	PF00082	0.466
CLV_PCSK_KEX2_1	409	411	PF00082	0.427
CLV_PCSK_KEX2_1	511	513	PF00082	0.522
CLV_PCSK_PC1ET2_1	190	192	PF00082	0.529
CLV_PCSK_PC1ET2_1	364	366	PF00082	0.421
CLV_PCSK_PC1ET2_1	511	513	PF00082	0.522
CLV_PCSK_SKI1_1	174	178	PF00082	0.481
CLV_PCSK_SKI1_1	299	303	PF00082	0.500
CLV_PCSK_SKI1_1	30	34	PF00082	0.535
CLV_PCSK_SKI1_1	390	394	PF00082	0.602
CLV_PCSK_SKI1_1	409	413	PF00082	0.241
CLV_PCSK_SKI1_1	515	519	PF00082	0.479
CLV_PCSK_SKI1_1	91	95	PF00082	0.523
DEG_APCC_DBOX_1	362	370	PF00400	0.558
DEG_APCC_DBOX_1	409	417	PF00400	0.498
DEG_SCF_FBW7_1	317	324	PF00400	0.511
DEG_SCF_TRCP1_1	199	205	PF00400	0.515
DEG_SPOP_SBC_1	207	211	PF00917	0.705
DEG_SPOP_SBC_1	256	260	PF00917	0.775
DEG_SPOP_SBC_1	316	320	PF00917	0.689
DOC_CYCLIN_RxL_1	158	166	PF00134	0.641
DOC_MAPK_gen_1	511	519	PF00069	0.369
DOC_MAPK_RevD_3	498	512	PF00069	0.374
DOC_PP1_RVXF_1	144	150	PF00149	0.657
DOC_PP1_RVXF_1	513	520	PF00149	0.586
DOC_PP4_FxxP_1	215	218	PF00568	0.681
DOC_USP7_MATH_1	19	23	PF00917	0.475
DOC_USP7_MATH_1	197	201	PF00917	0.689
DOC_USP7_MATH_1	227	231	PF00917	0.672
DOC_USP7_MATH_1	257	261	PF00917	0.767
DOC_USP7_MATH_1	285	289	PF00917	0.713
DOC_USP7_MATH_1	294	298	PF00917	0.640
DOC_USP7_MATH_1	3	7	PF00917	0.667
DOC_USP7_MATH_1	328	332	PF00917	0.691
DOC_USP7_MATH_1	340	344	PF00917	0.721
DOC_USP7_MATH_1	440	444	PF00917	0.595
DOC_USP7_MATH_1	457	461	PF00917	0.435
DOC_USP7_UBL2_3	507	511	PF12436	0.495
DOC_USP7_UBL2_3	518	522	PF12436	0.506
DOC_WW_Pin1_4	10	15	PF00397	0.646
DOC_WW_Pin1_4	219	224	PF00397	0.726
DOC_WW_Pin1_4	259	264	PF00397	0.704
DOC_WW_Pin1_4	303	308	PF00397	0.680
DOC_WW_Pin1_4	312	317	PF00397	0.692
DOC_WW_Pin1_4	98	103	PF00397	0.456
LIG_14-3-3_CanoR_1	15	21	PF00244	0.462
LIG_14-3-3_CanoR_1	174	183	PF00244	0.324
LIG_14-3-3_CanoR_1	97	102	PF00244	0.532
LIG_BIR_II_1	1	5	PF00653	0.700
LIG_BRCT_BRCA1_1	209	213	PF00533	0.618
LIG_BRCT_BRCA1_1	291	295	PF00533	0.645
LIG_BRCT_BRCA1_1	330	334	PF00533	0.496
LIG_BRCT_BRCA1_1	459	463	PF00533	0.426
LIG_deltaCOP1_diTrp_1	428	437	PF00928	0.595
LIG_deltaCOP1_diTrp_1	86	90	PF00928	0.570
LIG_EH_1	555	559	PF12763	0.592
LIG_FHA_1	203	209	PF00498	0.689
LIG_FHA_1	351	357	PF00498	0.593
LIG_FHA_1	440	446	PF00498	0.558
LIG_FHA_2	281	287	PF00498	0.684
LIG_FHA_2	456	462	PF00498	0.477
LIG_FHA_2	500	506	PF00498	0.555
LIG_LIR_Gen_1	460	470	PF02991	0.408
LIG_LIR_Gen_1	86	94	PF02991	0.482
LIG_LIR_Nem_3	311	317	PF02991	0.691
LIG_LIR_Nem_3	460	466	PF02991	0.422
LIG_LIR_Nem_3	513	517	PF02991	0.448
LIG_LIR_Nem_3	86	90	PF02991	0.475
LIG_MLH1_MIPbox_1	330	334	PF16413	0.496
LIG_OCRL_FandH_1	462	474	PF00620	0.564
LIG_PALB2_WD40_1	100	108	PF16756	0.466
LIG_PCNA_yPIPBox_3	33	45	PF02747	0.584
LIG_Pex14_2	265	269	PF04695	0.674
LIG_PTB_Apo_2	411	418	PF02174	0.389
LIG_SH2_NCK_1	151	155	PF00017	0.696
LIG_SH2_SRC	128	131	PF00017	0.620
LIG_SH2_STAT5	128	131	PF00017	0.584
LIG_SH2_STAT5	143	146	PF00017	0.407
LIG_SH3_3	144	150	PF00018	0.657
LIG_SH3_3	220	226	PF00018	0.674
LIG_SH3_3	322	328	PF00018	0.686
LIG_SH3_3	543	549	PF00018	0.618
LIG_TRAF2_1	36	39	PF00917	0.595
LIG_UBA3_1	357	364	PF00899	0.468
LIG_UBA3_1	412	419	PF00899	0.432
LIG_WRC_WIRS_1	330	335	PF05994	0.496
LIG_WRPW_2	528	531	PF00400	0.597
MOD_CDK_SPK_2	10	15	PF00069	0.498
MOD_CDK_SPK_2	98	103	PF00069	0.456
MOD_CDK_SPxxK_3	259	266	PF00069	0.513
MOD_CK1_1	200	206	PF00069	0.736
MOD_CK1_1	230	236	PF00069	0.700
MOD_CK1_1	288	294	PF00069	0.604
MOD_CK1_1	315	321	PF00069	0.744
MOD_CK1_1	332	338	PF00069	0.612
MOD_CK1_1	535	541	PF00069	0.595
MOD_CK1_1	6	12	PF00069	0.716
MOD_CK2_1	149	155	PF00069	0.577
MOD_CK2_1	499	505	PF00069	0.540
MOD_GlcNHglycan	195	198	PF01048	0.651
MOD_GlcNHglycan	199	202	PF01048	0.651
MOD_GlcNHglycan	210	213	PF01048	0.538
MOD_GlcNHglycan	227	230	PF01048	0.672
MOD_GlcNHglycan	259	262	PF01048	0.761
MOD_GlcNHglycan	296	299	PF01048	0.597
MOD_GlcNHglycan	341	345	PF01048	0.729
MOD_GlcNHglycan	374	377	PF01048	0.476
MOD_GlcNHglycan	442	445	PF01048	0.578
MOD_GlcNHglycan	534	537	PF01048	0.591
MOD_GlcNHglycan	66	69	PF01048	0.485
MOD_GSK3_1	189	196	PF00069	0.652
MOD_GSK3_1	202	209	PF00069	0.634
MOD_GSK3_1	227	234	PF00069	0.619
MOD_GSK3_1	252	259	PF00069	0.748
MOD_GSK3_1	280	287	PF00069	0.725
MOD_GSK3_1	289	296	PF00069	0.621
MOD_GSK3_1	299	306	PF00069	0.471
MOD_GSK3_1	312	319	PF00069	0.631
MOD_GSK3_1	328	335	PF00069	0.461
MOD_GSK3_1	6	13	PF00069	0.651
MOD_GSK3_1	93	100	PF00069	0.542
MOD_N-GLC_1	288	293	PF02516	0.676
MOD_NEK2_1	208	213	PF00069	0.638
MOD_NEK2_1	280	285	PF00069	0.714
MOD_NEK2_1	293	298	PF00069	0.673
MOD_NEK2_1	386	391	PF00069	0.577
MOD_NEK2_2	300	305	PF00069	0.500
MOD_NEK2_2	329	334	PF00069	0.747
MOD_PIKK_1	131	137	PF00454	0.496
MOD_PKA_2	14	20	PF00069	0.609
MOD_Plk_2-3	121	127	PF00069	0.496
MOD_Plk_4	300	306	PF00069	0.742
MOD_Plk_4	329	335	PF00069	0.496
MOD_Plk_4	426	432	PF00069	0.528
MOD_ProDKin_1	10	16	PF00069	0.642
MOD_ProDKin_1	219	225	PF00069	0.728
MOD_ProDKin_1	259	265	PF00069	0.706
MOD_ProDKin_1	303	309	PF00069	0.681
MOD_ProDKin_1	312	318	PF00069	0.694
MOD_ProDKin_1	98	104	PF00069	0.453
MOD_SUMO_for_1	472	475	PF00179	0.308
MOD_SUMO_rev_2	260	267	PF00179	0.514
MOD_SUMO_rev_2	341	348	PF00179	0.717
TRG_DiLeu_BaLyEn_6	407	412	PF01217	0.493
TRG_DiLeu_BaLyEn_6	47	52	PF01217	0.589
TRG_DiLeu_BaLyEn_6	512	517	PF01217	0.476
TRG_ER_diArg_1	172	174	PF00400	0.485
TRG_ER_diArg_1	363	366	PF00400	0.579
TRG_ER_diArg_1	408	410	PF00400	0.510
TRG_NLS_MonoExtC_3	362	368	PF00514	0.453
TRG_Pf-PMV_PEXEL_1	161	166	PF00026	0.533
TRG_Pf-PMV_PEXEL_1	30	34	PF00026	0.602
TRG_Pf-PMV_PEXEL_1	451	455	PF00026	0.568
TRG_Pf-PMV_PEXEL_1	506	510	PF00026	0.623

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8T0	Leptomonas seymouri	65%	100%
A0A0S4J4Z2	Bodo saltans	39%	100%
A0A1X0P580	Trypanosomatidae	49%	100%
A0A3R7NSX9	Trypanosoma rangeli	49%	100%
A0A3S7X6X9	Leishmania donovani	78%	100%
D0A676	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
E9AHQ5	Leishmania infantum	78%	100%
E9B476	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
Q4Q3V0	Leishmania major	76%	100%
V5BYJ7	Trypanosoma cruzi	45%	100%