Rhodanese domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HHX7_LEIBR

TriTrypDb:

LbrM.30.0340 , LBRM2903_300009700

Length:

541

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005829	cytosol	2	7
GO:0110165	cellular anatomical entity	1	7
GO:0005802	trans-Golgi network	4	1
GO:0031984	organelle subcompartment	2	1
GO:0098791	Golgi apparatus subcompartment	3	1
GO:0005794	Golgi apparatus	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2

Expansion

Sequence features

A4HHX7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHX7

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	7
GO:0009987	cellular process	1	7
GO:0016192	vesicle-mediated transport	4	7
GO:0016197	endosomal transport	4	7
GO:0016482	cytosolic transport	4	7
GO:0042147	retrograde transport, endosome to Golgi	5	7
GO:0046907	intracellular transport	3	7
GO:0051179	localization	1	7
GO:0051234	establishment of localization	2	7
GO:0051641	cellular localization	2	7
GO:0051649	establishment of localization in cell	3	7
GO:0016043	cellular component organization	3	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0099022	vesicle tethering	4	1
GO:0099041	vesicle tethering to Golgi	5	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	48	52	PF00656	0.583
CLV_NRD_NRD_1	181	183	PF00675	0.524
CLV_NRD_NRD_1	469	471	PF00675	0.739
CLV_PCSK_KEX2_1	126	128	PF00082	0.631
CLV_PCSK_KEX2_1	181	183	PF00082	0.524
CLV_PCSK_KEX2_1	260	262	PF00082	0.596
CLV_PCSK_KEX2_1	325	327	PF00082	0.551
CLV_PCSK_KEX2_1	468	470	PF00082	0.749
CLV_PCSK_PC1ET2_1	126	128	PF00082	0.631
CLV_PCSK_PC1ET2_1	260	262	PF00082	0.596
CLV_PCSK_PC1ET2_1	325	327	PF00082	0.551
CLV_PCSK_SKI1_1	261	265	PF00082	0.443
CLV_PCSK_SKI1_1	64	68	PF00082	0.514
DEG_APCC_DBOX_1	13	21	PF00400	0.522
DEG_SCF_FBW7_1	76	81	PF00400	0.450
DEG_SPOP_SBC_1	363	367	PF00917	0.497
DEG_SPOP_SBC_1	370	374	PF00917	0.489
DOC_CKS1_1	463	468	PF01111	0.495
DOC_MAPK_MEF2A_6	218	225	PF00069	0.487
DOC_PP1_RVXF_1	81	88	PF00149	0.515
DOC_PP2B_LxvP_1	471	474	PF13499	0.630
DOC_PP4_FxxP_1	35	38	PF00568	0.412
DOC_USP7_MATH_1	315	319	PF00917	0.537
DOC_USP7_MATH_1	341	345	PF00917	0.644
DOC_USP7_MATH_1	370	374	PF00917	0.581
DOC_USP7_MATH_1	401	405	PF00917	0.471
DOC_USP7_MATH_1	455	459	PF00917	0.662
DOC_USP7_MATH_1	461	465	PF00917	0.692
DOC_USP7_MATH_1	490	494	PF00917	0.727
DOC_WW_Pin1_4	107	112	PF00397	0.442
DOC_WW_Pin1_4	244	249	PF00397	0.537
DOC_WW_Pin1_4	440	445	PF00397	0.666
DOC_WW_Pin1_4	462	467	PF00397	0.648
DOC_WW_Pin1_4	474	479	PF00397	0.715
DOC_WW_Pin1_4	480	485	PF00397	0.749
DOC_WW_Pin1_4	486	491	PF00397	0.520
DOC_WW_Pin1_4	525	530	PF00397	0.626
DOC_WW_Pin1_4	536	541	PF00397	0.615
DOC_WW_Pin1_4	74	79	PF00397	0.266
DOC_WW_Pin1_4	96	101	PF00397	0.424
LIG_14-3-3_CanoR_1	127	136	PF00244	0.420
LIG_14-3-3_CanoR_1	14	18	PF00244	0.537
LIG_14-3-3_CanoR_1	158	165	PF00244	0.274
LIG_14-3-3_CanoR_1	504	510	PF00244	0.708
LIG_14-3-3_CanoR_1	53	57	PF00244	0.466
LIG_Actin_WH2_2	82	99	PF00022	0.438
LIG_APCC_ABBA_1	87	92	PF00400	0.449
LIG_CORNRBOX	237	245	PF00104	0.276
LIG_EH1_1	239	247	PF00400	0.403
LIG_FHA_1	108	114	PF00498	0.450
LIG_FHA_1	159	165	PF00498	0.389
LIG_FHA_1	231	237	PF00498	0.496
LIG_FHA_1	53	59	PF00498	0.451
LIG_FHA_1	531	537	PF00498	0.473
LIG_FHA_2	23	29	PF00498	0.296
LIG_FHA_2	250	256	PF00498	0.417
LIG_FHA_2	97	103	PF00498	0.559
LIG_LIR_Apic_2	133	139	PF02991	0.420
LIG_LIR_Gen_1	152	162	PF02991	0.414
LIG_LIR_Gen_1	404	412	PF02991	0.725
LIG_LIR_Gen_1	515	525	PF02991	0.552
LIG_LIR_Gen_1	86	95	PF02991	0.299
LIG_LIR_Nem_3	152	157	PF02991	0.423
LIG_LIR_Nem_3	404	408	PF02991	0.689
LIG_LIR_Nem_3	515	521	PF02991	0.546
LIG_LIR_Nem_3	86	90	PF02991	0.316
LIG_Pex14_2	264	268	PF04695	0.419
LIG_Pex14_2	518	522	PF04695	0.551
LIG_RPA_C_Fungi	499	511	PF08784	0.421
LIG_SH2_CRK	136	140	PF00017	0.400
LIG_SH2_PTP2	156	159	PF00017	0.376
LIG_SH2_SRC	143	146	PF00017	0.477
LIG_SH2_STAT3	289	292	PF00017	0.671
LIG_SH2_STAT5	143	146	PF00017	0.353
LIG_SH2_STAT5	156	159	PF00017	0.367
LIG_SH2_STAT5	213	216	PF00017	0.436
LIG_SH2_STAT5	289	292	PF00017	0.671
LIG_SH2_STAT5	4	7	PF00017	0.366
LIG_SH2_STAT5	9	12	PF00017	0.367
LIG_SH3_3	108	114	PF00018	0.538
LIG_SH3_3	460	466	PF00018	0.669
LIG_SUMO_SIM_anti_2	419	427	PF11976	0.658
LIG_SxIP_EBH_1	227	238	PF03271	0.486
LIG_TRAF2_1	130	133	PF00917	0.426
LIG_TRAF2_1	99	102	PF00917	0.357
LIG_TRFH_1	87	91	PF08558	0.438
LIG_UBA3_1	17	23	PF00899	0.516
MOD_CDK_SPK_2	480	485	PF00069	0.478
MOD_CDK_SPxK_1	462	468	PF00069	0.492
MOD_CDK_SPxxK_3	462	469	PF00069	0.494
MOD_CK1_1	150	156	PF00069	0.451
MOD_CK1_1	284	290	PF00069	0.390
MOD_CK1_1	344	350	PF00069	0.597
MOD_CK1_1	373	379	PF00069	0.678
MOD_CK1_1	382	388	PF00069	0.671
MOD_CK1_1	488	494	PF00069	0.745
MOD_CK1_1	62	68	PF00069	0.330
MOD_CK2_1	22	28	PF00069	0.297
MOD_CK2_1	249	255	PF00069	0.412
MOD_CK2_1	410	416	PF00069	0.635
MOD_CK2_1	461	467	PF00069	0.774
MOD_CK2_1	96	102	PF00069	0.563
MOD_GlcNHglycan	121	124	PF01048	0.562
MOD_GlcNHglycan	283	286	PF01048	0.592
MOD_GlcNHglycan	343	346	PF01048	0.690
MOD_GlcNHglycan	373	376	PF01048	0.642
MOD_GlcNHglycan	378	381	PF01048	0.680
MOD_GlcNHglycan	384	387	PF01048	0.730
MOD_GlcNHglycan	451	454	PF01048	0.731
MOD_GlcNHglycan	458	461	PF01048	0.631
MOD_GlcNHglycan	492	495	PF01048	0.700
MOD_GlcNHglycan	505	508	PF01048	0.565
MOD_GlcNHglycan	61	64	PF01048	0.316
MOD_GSK3_1	115	122	PF00069	0.502
MOD_GSK3_1	249	256	PF00069	0.409
MOD_GSK3_1	311	318	PF00069	0.509
MOD_GSK3_1	337	344	PF00069	0.540
MOD_GSK3_1	351	358	PF00069	0.614
MOD_GSK3_1	369	376	PF00069	0.600
MOD_GSK3_1	451	458	PF00069	0.511
MOD_GSK3_1	485	492	PF00069	0.586
MOD_GSK3_1	74	81	PF00069	0.369
MOD_GSK3_1	9	16	PF00069	0.518
MOD_N-GLC_1	536	541	PF02516	0.477
MOD_N-GLC_1	96	101	PF02516	0.562
MOD_NEK2_1	19	24	PF00069	0.569
MOD_NEK2_1	193	198	PF00069	0.473
MOD_NEK2_1	230	235	PF00069	0.549
MOD_NEK2_1	33	38	PF00069	0.324
MOD_NEK2_1	451	456	PF00069	0.638
MOD_PIKK_1	147	153	PF00454	0.239
MOD_PIKK_1	78	84	PF00454	0.468
MOD_PKA_2	13	19	PF00069	0.537
MOD_PKA_2	157	163	PF00069	0.374
MOD_PKA_2	434	440	PF00069	0.740
MOD_PKA_2	503	509	PF00069	0.654
MOD_PKA_2	52	58	PF00069	0.567
MOD_Plk_1	523	529	PF00069	0.731
MOD_Plk_4	13	19	PF00069	0.334
MOD_Plk_4	434	440	PF00069	0.730
MOD_Plk_4	62	68	PF00069	0.490
MOD_ProDKin_1	107	113	PF00069	0.439
MOD_ProDKin_1	244	250	PF00069	0.533
MOD_ProDKin_1	440	446	PF00069	0.664
MOD_ProDKin_1	462	468	PF00069	0.651
MOD_ProDKin_1	474	480	PF00069	0.715
MOD_ProDKin_1	486	492	PF00069	0.521
MOD_ProDKin_1	525	531	PF00069	0.630
MOD_ProDKin_1	74	80	PF00069	0.261
MOD_ProDKin_1	96	102	PF00069	0.425
MOD_SUMO_rev_2	132	139	PF00179	0.421
TRG_DiLeu_BaEn_1	202	207	PF01217	0.408
TRG_DiLeu_BaEn_1	421	426	PF01217	0.717
TRG_DiLeu_BaEn_4	202	208	PF01217	0.407
TRG_DiLeu_BaLyEn_6	232	237	PF01217	0.407
TRG_ENDOCYTIC_2	156	159	PF00928	0.426
TRG_ER_diArg_1	180	182	PF00400	0.532
TRG_ER_diArg_1	468	470	PF00400	0.508
TRG_Pf-PMV_PEXEL_1	198	202	PF00026	0.458

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0P274	Trypanosomatidae	31%	71%
A0A3R7MQU5	Trypanosoma rangeli	34%	76%
C9ZQI6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	77%
Q4Q7S6	Leishmania major	74%	100%
V5DD41	Trypanosoma cruzi	34%	78%