SUN domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Sad1 / UNC-like C-terminal, putative

Species:

Leishmania braziliensis

UniProt:

A4HHX6_LEIBR

TriTrypDb:

LbrM.30.0330 , LBRM2903_300009100

Length:

575

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 5, no: 3
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

A4HHX6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHX6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	88	92	PF00656	0.389
CLV_NRD_NRD_1	101	103	PF00675	0.483
CLV_NRD_NRD_1	157	159	PF00675	0.598
CLV_NRD_NRD_1	169	171	PF00675	0.545
CLV_NRD_NRD_1	436	438	PF00675	0.568
CLV_NRD_NRD_1	490	492	PF00675	0.611
CLV_NRD_NRD_1	544	546	PF00675	0.405
CLV_PCSK_FUR_1	318	322	PF00082	0.641
CLV_PCSK_KEX2_1	157	159	PF00082	0.598
CLV_PCSK_KEX2_1	169	171	PF00082	0.456
CLV_PCSK_KEX2_1	320	322	PF00082	0.719
CLV_PCSK_KEX2_1	436	438	PF00082	0.568
CLV_PCSK_KEX2_1	490	492	PF00082	0.539
CLV_PCSK_KEX2_1	544	546	PF00082	0.418
CLV_PCSK_PC1ET2_1	320	322	PF00082	0.719
CLV_PCSK_PC7_1	486	492	PF00082	0.520
CLV_PCSK_SKI1_1	131	135	PF00082	0.503
CLV_PCSK_SKI1_1	172	176	PF00082	0.598
CLV_PCSK_SKI1_1	237	241	PF00082	0.619
CLV_PCSK_SKI1_1	439	443	PF00082	0.597
CLV_PCSK_SKI1_1	449	453	PF00082	0.599
CLV_PCSK_SKI1_1	486	490	PF00082	0.592
DEG_APCC_DBOX_1	469	477	PF00400	0.408
DEG_SPOP_SBC_1	322	326	PF00917	0.419
DOC_CYCLIN_RxL_1	446	453	PF00134	0.476
DOC_CYCLIN_RxL_1	483	493	PF00134	0.412
DOC_CYCLIN_yCln2_LP_2	297	303	PF00134	0.598
DOC_MAPK_DCC_7	31	41	PF00069	0.534
DOC_MAPK_gen_1	102	109	PF00069	0.284
DOC_MAPK_gen_1	169	176	PF00069	0.382
DOC_MAPK_MEF2A_6	33	41	PF00069	0.403
DOC_MAPK_MEF2A_6	511	520	PF00069	0.217
DOC_PP1_RVXF_1	167	174	PF00149	0.309
DOC_PP2B_LxvP_1	297	300	PF13499	0.595
DOC_PP4_FxxP_1	20	23	PF00568	0.471
DOC_PP4_FxxP_1	235	238	PF00568	0.510
DOC_USP7_MATH_1	220	224	PF00917	0.606
DOC_USP7_MATH_1	239	243	PF00917	0.375
DOC_USP7_MATH_1	252	256	PF00917	0.600
DOC_USP7_MATH_1	257	261	PF00917	0.556
DOC_USP7_MATH_1	266	270	PF00917	0.423
DOC_USP7_MATH_1	285	289	PF00917	0.536
DOC_USP7_MATH_1	312	316	PF00917	0.556
DOC_USP7_MATH_1	340	344	PF00917	0.505
DOC_USP7_MATH_1	389	393	PF00917	0.518
DOC_USP7_MATH_1	404	408	PF00917	0.496
DOC_WW_Pin1_4	163	168	PF00397	0.311
DOC_WW_Pin1_4	226	231	PF00397	0.583
DOC_WW_Pin1_4	262	267	PF00397	0.558
DOC_WW_Pin1_4	308	313	PF00397	0.506
DOC_WW_Pin1_4	32	37	PF00397	0.561
DOC_WW_Pin1_4	336	341	PF00397	0.433
DOC_WW_Pin1_4	382	387	PF00397	0.542
DOC_WW_Pin1_4	40	45	PF00397	0.572
DOC_WW_Pin1_4	560	565	PF00397	0.616
LIG_14-3-3_CanoR_1	131	136	PF00244	0.398
LIG_14-3-3_CanoR_1	31	36	PF00244	0.504
LIG_14-3-3_CanoR_1	321	331	PF00244	0.422
LIG_14-3-3_CanoR_1	372	382	PF00244	0.419
LIG_14-3-3_CanoR_1	422	428	PF00244	0.482
LIG_14-3-3_CanoR_1	490	496	PF00244	0.494
LIG_14-3-3_CanoR_1	551	556	PF00244	0.616
LIG_14-3-3_CanoR_1	6	10	PF00244	0.366
LIG_BRCT_BRCA1_1	536	540	PF00533	0.562
LIG_deltaCOP1_diTrp_1	185	193	PF00928	0.304
LIG_FHA_1	143	149	PF00498	0.360
LIG_FHA_1	263	269	PF00498	0.528
LIG_FHA_1	291	297	PF00498	0.513
LIG_FHA_1	323	329	PF00498	0.448
LIG_FHA_1	394	400	PF00498	0.444
LIG_FHA_1	416	422	PF00498	0.483
LIG_FHA_1	440	446	PF00498	0.431
LIG_FHA_1	513	519	PF00498	0.335
LIG_FHA_2	203	209	PF00498	0.428
LIG_FHA_2	355	361	PF00498	0.524
LIG_FHA_2	460	466	PF00498	0.419
LIG_GBD_Chelix_1	412	420	PF00786	0.509
LIG_GBD_Chelix_1	522	530	PF00786	0.346
LIG_LIR_Apic_2	233	238	PF02991	0.424
LIG_LIR_Apic_2	563	569	PF02991	0.626
LIG_LIR_Gen_1	143	154	PF02991	0.398
LIG_LIR_Gen_1	185	195	PF02991	0.294
LIG_LIR_Gen_1	25	30	PF02991	0.466
LIG_LIR_Gen_1	357	364	PF02991	0.388
LIG_LIR_Gen_1	407	417	PF02991	0.488
LIG_LIR_Nem_3	143	149	PF02991	0.301
LIG_LIR_Nem_3	185	190	PF02991	0.288
LIG_LIR_Nem_3	191	196	PF02991	0.283
LIG_LIR_Nem_3	25	29	PF02991	0.463
LIG_LIR_Nem_3	276	281	PF02991	0.579
LIG_LIR_Nem_3	357	361	PF02991	0.391
LIG_LIR_Nem_3	407	412	PF02991	0.345
LIG_LIR_Nem_3	453	459	PF02991	0.409
LIG_LIR_Nem_3	463	469	PF02991	0.327
LIG_LIR_Nem_3	537	543	PF02991	0.578
LIG_LIR_Nem_3	547	552	PF02991	0.789
LIG_MYND_1	565	569	PF01753	0.792
LIG_NRBOX	416	422	PF00104	0.483
LIG_NRBOX	9	15	PF00104	0.408
LIG_Pex14_1	178	182	PF04695	0.360
LIG_Pex14_1	549	553	PF04695	0.798
LIG_Pex14_2	26	30	PF04695	0.402
LIG_PTAP_UEV_1	240	245	PF05743	0.418
LIG_SH2_CRK	409	413	PF00017	0.366
LIG_SH2_GRB2like	349	352	PF00017	0.400
LIG_SH2_STAP1	62	66	PF00017	0.342
LIG_SH2_STAT3	469	472	PF00017	0.305
LIG_SH2_STAT5	162	165	PF00017	0.398
LIG_SH2_STAT5	66	69	PF00017	0.359
LIG_SH2_STAT5	93	96	PF00017	0.385
LIG_SH3_2	241	246	PF14604	0.419
LIG_SH3_3	235	241	PF00018	0.498
LIG_SH3_3	244	250	PF00018	0.490
LIG_SH3_3	38	44	PF00018	0.530
LIG_SH3_3	540	546	PF00018	0.742
LIG_SH3_3	71	77	PF00018	0.380
LIG_SH3_3	91	97	PF00018	0.375
LIG_SUMO_SIM_anti_2	323	332	PF11976	0.407
LIG_SUMO_SIM_anti_2	4	11	PF11976	0.567
LIG_SUMO_SIM_anti_2	430	435	PF11976	0.479
LIG_SUMO_SIM_anti_2	512	520	PF11976	0.323
LIG_SUMO_SIM_par_1	529	539	PF11976	0.599
LIG_SUMO_SIM_par_1	70	75	PF11976	0.270
LIG_TRFH_1	93	97	PF08558	0.360
LIG_WRC_WIRS_1	190	195	PF05994	0.301
LIG_WRC_WIRS_1	47	52	PF05994	0.371
MOD_CDC14_SPxK_1	45	48	PF00782	0.568
MOD_CDK_SPxK_1	163	169	PF00069	0.286
MOD_CDK_SPxK_1	42	48	PF00069	0.580
MOD_CDK_SPxxK_3	163	170	PF00069	0.245
MOD_CK1_1	262	268	PF00069	0.424
MOD_CK1_1	323	329	PF00069	0.558
MOD_CK1_1	341	347	PF00069	0.359
MOD_CK1_1	359	365	PF00069	0.468
MOD_CK1_1	377	383	PF00069	0.552
MOD_CK1_1	390	396	PF00069	0.478
MOD_CK1_1	415	421	PF00069	0.467
MOD_CK1_1	42	48	PF00069	0.533
MOD_CK1_1	450	456	PF00069	0.281
MOD_CK1_1	505	511	PF00069	0.581
MOD_CK1_1	51	57	PF00069	0.461
MOD_CK1_1	512	518	PF00069	0.407
MOD_CK1_1	535	541	PF00069	0.703
MOD_CK2_1	266	272	PF00069	0.538
MOD_CK2_1	459	465	PF00069	0.378
MOD_CK2_1	544	550	PF00069	0.773
MOD_Cter_Amidation	167	170	PF01082	0.418
MOD_GlcNHglycan	127	130	PF01048	0.546
MOD_GlcNHglycan	221	225	PF01048	0.797
MOD_GlcNHglycan	241	244	PF01048	0.591
MOD_GlcNHglycan	250	253	PF01048	0.787
MOD_GlcNHglycan	255	258	PF01048	0.767
MOD_GlcNHglycan	259	262	PF01048	0.737
MOD_GlcNHglycan	305	308	PF01048	0.713
MOD_GlcNHglycan	314	317	PF01048	0.728
MOD_GlcNHglycan	389	392	PF01048	0.724
MOD_GlcNHglycan	501	505	PF01048	0.770
MOD_GlcNHglycan	53	56	PF01048	0.606
MOD_GlcNHglycan	560	563	PF01048	0.505
MOD_GlcNHglycan	82	85	PF01048	0.636
MOD_GlcNHglycan	88	91	PF01048	0.467
MOD_GSK3_1	131	138	PF00069	0.350
MOD_GSK3_1	248	255	PF00069	0.577
MOD_GSK3_1	262	269	PF00069	0.549
MOD_GSK3_1	281	288	PF00069	0.587
MOD_GSK3_1	308	315	PF00069	0.537
MOD_GSK3_1	320	327	PF00069	0.440
MOD_GSK3_1	336	343	PF00069	0.499
MOD_GSK3_1	350	357	PF00069	0.462
MOD_GSK3_1	368	375	PF00069	0.448
MOD_GSK3_1	377	384	PF00069	0.542
MOD_GSK3_1	389	396	PF00069	0.420
MOD_GSK3_1	404	411	PF00069	0.499
MOD_GSK3_1	42	49	PF00069	0.472
MOD_GSK3_1	505	512	PF00069	0.569
MOD_GSK3_1	532	539	PF00069	0.541
MOD_GSK3_1	80	87	PF00069	0.362
MOD_N-GLC_1	131	136	PF02516	0.544
MOD_N-GLC_1	350	355	PF02516	0.640
MOD_N-GLC_1	445	450	PF02516	0.679
MOD_NEK2_1	135	140	PF00069	0.317
MOD_NEK2_1	200	205	PF00069	0.386
MOD_NEK2_1	354	359	PF00069	0.489
MOD_NEK2_1	445	450	PF00069	0.466
MOD_NEK2_1	532	537	PF00069	0.590
MOD_NEK2_1	67	72	PF00069	0.291
MOD_NEK2_2	404	409	PF00069	0.501
MOD_PIKK_1	310	316	PF00454	0.623
MOD_PIKK_1	415	421	PF00454	0.365
MOD_PIKK_1	464	470	PF00454	0.441
MOD_PK_1	551	557	PF00069	0.617
MOD_PKA_1	320	326	PF00069	0.427
MOD_PKA_1	490	496	PF00069	0.355
MOD_PKA_1	544	550	PF00069	0.651
MOD_PKA_2	285	291	PF00069	0.573
MOD_PKA_2	320	326	PF00069	0.427
MOD_PKA_2	490	496	PF00069	0.536
MOD_PKA_2	5	11	PF00069	0.529
MOD_PKA_2	544	550	PF00069	0.696
MOD_PKB_1	437	445	PF00069	0.308
MOD_Plk_1	131	137	PF00069	0.344
MOD_Plk_1	350	356	PF00069	0.536
MOD_Plk_1	359	365	PF00069	0.524
MOD_Plk_1	429	435	PF00069	0.413
MOD_Plk_1	464	470	PF00069	0.455
MOD_Plk_1	512	518	PF00069	0.217
MOD_Plk_4	142	148	PF00069	0.362
MOD_Plk_4	25	31	PF00069	0.457
MOD_Plk_4	344	350	PF00069	0.482
MOD_Plk_4	412	418	PF00069	0.416
MOD_Plk_4	429	435	PF00069	0.244
MOD_Plk_4	5	11	PF00069	0.541
MOD_Plk_4	505	511	PF00069	0.589
MOD_Plk_4	514	520	PF00069	0.352
MOD_Plk_4	62	68	PF00069	0.421
MOD_ProDKin_1	163	169	PF00069	0.311
MOD_ProDKin_1	226	232	PF00069	0.583
MOD_ProDKin_1	262	268	PF00069	0.559
MOD_ProDKin_1	308	314	PF00069	0.509
MOD_ProDKin_1	32	38	PF00069	0.564
MOD_ProDKin_1	336	342	PF00069	0.434
MOD_ProDKin_1	382	388	PF00069	0.542
MOD_ProDKin_1	40	46	PF00069	0.571
MOD_ProDKin_1	560	566	PF00069	0.619
TRG_DiLeu_BaEn_1	209	214	PF01217	0.381
TRG_ENDOCYTIC_2	162	165	PF00928	0.385
TRG_ENDOCYTIC_2	17	20	PF00928	0.492
TRG_ENDOCYTIC_2	409	412	PF00928	0.344
TRG_ENDOCYTIC_2	552	555	PF00928	0.799
TRG_ER_diArg_1	157	160	PF00400	0.398
TRG_ER_diArg_1	169	172	PF00400	0.256
TRG_ER_diArg_1	30	33	PF00400	0.397
TRG_ER_diArg_1	436	439	PF00400	0.400
TRG_ER_diArg_1	489	491	PF00400	0.327
TRG_ER_diArg_1	543	545	PF00400	0.638
TRG_NES_CRM1_1	472	485	PF08389	0.402
TRG_Pf-PMV_PEXEL_1	406	410	PF00026	0.629
TRG_Pf-PMV_PEXEL_1	425	430	PF00026	0.556
TRG_Pf-PMV_PEXEL_1	439	443	PF00026	0.648
TRG_Pf-PMV_PEXEL_1	474	479	PF00026	0.563

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3R7NHR9	Trypanosoma rangeli	30%	100%
A0A3S7X320	Leishmania donovani	68%	98%
A4I526	Leishmania infantum	68%	98%
C9ZQI5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9B0F6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	66%	98%
Q4Q7S7	Leishmania major	66%	100%
V5AWZ8	Trypanosoma cruzi	29%	100%