Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HHX4_LEIBR

TriTrypDb:

LbrM.30.0310 , LBRM2903_300008900

Length:

150

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HHX4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHX4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	59	63	PF00656	0.436
CLV_PCSK_KEX2_1	64	66	PF00082	0.623
CLV_PCSK_PC1ET2_1	64	66	PF00082	0.503
DEG_SPOP_SBC_1	44	48	PF00917	0.553
DOC_CYCLIN_yCln2_LP_2	38	44	PF00134	0.573
DOC_PP2B_LxvP_1	38	41	PF13499	0.593
DOC_PP2B_PxIxI_1	52	58	PF00149	0.448
DOC_USP7_MATH_1	129	133	PF00917	0.538
DOC_WW_Pin1_4	106	111	PF00397	0.503
LIG_14-3-3_CanoR_1	30	40	PF00244	0.658
LIG_14-3-3_CanoR_1	9	17	PF00244	0.590
LIG_14-3-3_CanoR_1	95	101	PF00244	0.497
LIG_BIR_II_1	1	5	PF00653	0.590
LIG_BRCT_BRCA1_1	131	135	PF00533	0.594
LIG_Clathr_ClatBox_1	54	58	PF01394	0.450
LIG_deltaCOP1_diTrp_1	126	135	PF00928	0.614
LIG_FHA_1	37	43	PF00498	0.530
LIG_FHA_1	76	82	PF00498	0.637
LIG_FHA_2	82	88	PF00498	0.575
LIG_IRF3_LxIS_1	36	43	PF10401	0.587
LIG_LIR_Nem_3	108	114	PF02991	0.594
LIG_LIR_Nem_3	82	88	PF02991	0.591
LIG_NRBOX	2	8	PF00104	0.583
LIG_PTB_Apo_2	80	87	PF02174	0.594
LIG_SH2_STAT5	85	88	PF00017	0.463
MOD_CK1_1	29	35	PF00069	0.656
MOD_CK1_1	43	49	PF00069	0.675
MOD_CK2_1	73	79	PF00069	0.555
MOD_GlcNHglycan	3	6	PF01048	0.622
MOD_GlcNHglycan	42	45	PF01048	0.613
MOD_GSK3_1	26	33	PF00069	0.652
MOD_GSK3_1	36	43	PF00069	0.585
MOD_GSK3_1	56	63	PF00069	0.489
MOD_GSK3_1	75	82	PF00069	0.549
MOD_NEK2_1	1	6	PF00069	0.653
MOD_NEK2_1	36	41	PF00069	0.587
MOD_NEK2_1	60	65	PF00069	0.509
MOD_PKA_2	29	35	PF00069	0.617
MOD_PKA_2	60	66	PF00069	0.529
MOD_PKA_2	70	76	PF00069	0.467
MOD_PKA_2	8	14	PF00069	0.644
MOD_PKA_2	94	100	PF00069	0.481
MOD_Plk_1	112	118	PF00069	0.556
MOD_Plk_2-3	75	81	PF00069	0.550
MOD_Plk_4	47	53	PF00069	0.649
MOD_Plk_4	81	87	PF00069	0.633
MOD_ProDKin_1	106	112	PF00069	0.504
TRG_DiLeu_BaEn_2	130	136	PF01217	0.609
TRG_DiLeu_BaLyEn_6	139	144	PF01217	0.444
TRG_DiLeu_BaLyEn_6	50	55	PF01217	0.514
TRG_ENDOCYTIC_2	111	114	PF00928	0.625
TRG_ENDOCYTIC_2	85	88	PF00928	0.502

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM95	Leptomonas seymouri	51%	97%
A0A3S7X2Y5	Leishmania donovani	79%	100%
A0A422NMM9	Trypanosoma rangeli	42%	100%
A4I524	Leishmania infantum	79%	100%
C9ZQI2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9B0F4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
Q4Q7S9	Leishmania major	80%	99%