LIM zinc-binding domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HHX2_LEIBR

TriTrypDb:

LbrM.30.0290 , LBRM2903_300008600

Length:

203

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HHX2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHX2

PDB structure(s): 7aih_Ax , 7am2_Ax , 7ane_Ax

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	10
GO:0043167	ion binding	2	10
GO:0043169	cation binding	3	10
GO:0046872	metal ion binding	4	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	167	169	PF00675	0.552
CLV_NRD_NRD_1	48	50	PF00675	0.621
CLV_PCSK_KEX2_1	167	169	PF00082	0.550
CLV_PCSK_KEX2_1	48	50	PF00082	0.607
CLV_PCSK_PC7_1	163	169	PF00082	0.582
CLV_PCSK_SKI1_1	128	132	PF00082	0.503
DEG_Nend_UBRbox_3	1	3	PF02207	0.524
DOC_MAPK_gen_1	190	197	PF00069	0.606
DOC_PP2B_LxvP_1	25	28	PF13499	0.683
DOC_PP4_FxxP_1	7	10	PF00568	0.677
DOC_USP7_MATH_1	10	14	PF00917	0.670
LIG_14-3-3_CanoR_1	11	19	PF00244	0.693
LIG_14-3-3_CanoR_1	116	125	PF00244	0.563
LIG_14-3-3_CanoR_1	168	174	PF00244	0.604
LIG_CSL_BTD_1	108	111	PF09270	0.546
LIG_FHA_1	169	175	PF00498	0.606
LIG_FHA_1	20	26	PF00498	0.650
LIG_FHA_1	3	9	PF00498	0.585
LIG_FHA_1	75	81	PF00498	0.718
LIG_LIR_Apic_2	5	10	PF02991	0.466
LIG_LIR_Gen_1	106	115	PF02991	0.560
LIG_LIR_Nem_3	106	110	PF02991	0.525
LIG_LIR_Nem_3	134	140	PF02991	0.349
LIG_Pex14_1	133	137	PF04695	0.507
LIG_Pex14_1	169	173	PF04695	0.588
LIG_PTB_Apo_2	139	146	PF02174	0.523
LIG_PTB_Phospho_1	139	145	PF10480	0.519
LIG_REV1ctd_RIR_1	122	132	PF16727	0.542
LIG_SH2_CRK	137	141	PF00017	0.539
LIG_SH2_GRB2like	173	176	PF00017	0.598
LIG_SH2_PTP2	107	110	PF00017	0.561
LIG_SH2_STAP1	76	80	PF00017	0.694
LIG_SH2_STAT5	107	110	PF00017	0.557
LIG_SH2_STAT5	123	126	PF00017	0.423
LIG_SH2_STAT5	173	176	PF00017	0.598
LIG_SH2_STAT5	76	79	PF00017	0.736
LIG_SH3_1	68	74	PF00018	0.608
LIG_SH3_3	105	111	PF00018	0.539
LIG_SH3_3	68	74	PF00018	0.592
LIG_SH3_3	77	83	PF00018	0.567
LIG_TRAF2_1	63	66	PF00917	0.706
MOD_CK1_1	181	187	PF00069	0.597
MOD_CK1_1	21	27	PF00069	0.619
MOD_GlcNHglycan	111	114	PF01048	0.645
MOD_GlcNHglycan	12	15	PF01048	0.734
MOD_GlcNHglycan	37	40	PF01048	0.732
MOD_GSK3_1	169	176	PF00069	0.604
MOD_LATS_1	33	39	PF00433	0.674
MOD_OFUCOSY	129	135	PF10250	0.455
MOD_PIKK_1	117	123	PF00454	0.574
MOD_PIKK_1	2	8	PF00454	0.474
MOD_PIKK_1	41	47	PF00454	0.649
MOD_PKA_2	10	16	PF00069	0.719
MOD_PKA_2	181	187	PF00069	0.576
MOD_Plk_4	103	109	PF00069	0.562
MOD_Plk_4	169	175	PF00069	0.606
TRG_ENDOCYTIC_2	107	110	PF00928	0.561
TRG_ENDOCYTIC_2	137	140	PF00928	0.498
TRG_ER_diArg_1	167	169	PF00400	0.585
TRG_ER_diArg_1	189	192	PF00400	0.643
TRG_ER_diArg_1	48	50	PF00400	0.621
TRG_ER_diArg_1	68	71	PF00400	0.399

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PF24	Leptomonas seymouri	79%	97%
A0A0S4JZ50	Bodo saltans	64%	92%
A0A1X0P3Q2	Trypanosomatidae	77%	100%
A0A3R7L3B1	Trypanosoma rangeli	76%	100%
A0A3S7X2Y9	Leishmania donovani	92%	94%
A4I522	Leishmania infantum	92%	94%
C9ZQI1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	75%	100%
E9B0F2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q7T1	Leishmania major	93%	100%