Cysteine protease

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Cysteine protease

Gene product:

AUT2/APG4/ATG4 cysteine peptidase, putative

Species:

Leishmania braziliensis

UniProt:

A4HHX1_LEIBR

TriTrypDb:

LbrM.30.0280 , LBRM2903_300008500

Length:

398

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	12
GO:0110165	cellular anatomical entity	1	12

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Expansion

Sequence features

A4HHX1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHX1

Function

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Biological processes
Term	Name	Level	Count
GO:0000045	autophagosome assembly	6	1
GO:0006508	proteolysis	4	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0006810	transport	3	12
GO:0006914	autophagy	3	11
GO:0006996	organelle organization	4	1
GO:0007033	vacuole organization	5	1
GO:0008104	protein localization	4	12
GO:0008152	metabolic process	1	12
GO:0009056	catabolic process	2	11

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0008233	peptidase activity	3	12
GO:0008234	cysteine-type peptidase activity	4	12
GO:0016787	hydrolase activity	2	12
GO:0140096	catalytic activity, acting on a protein	2	12

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	141	145	PF00656	0.378
CLV_C14_Caspase3-7	374	378	PF00656	0.750
CLV_C14_Caspase3-7	49	53	PF00656	0.559
CLV_NRD_NRD_1	357	359	PF00675	0.727
CLV_NRD_NRD_1	366	368	PF00675	0.753
CLV_NRD_NRD_1	94	96	PF00675	0.341
CLV_PCSK_FUR_1	364	368	PF00082	0.522
CLV_PCSK_KEX2_1	139	141	PF00082	0.264
CLV_PCSK_KEX2_1	357	359	PF00082	0.706
CLV_PCSK_KEX2_1	366	368	PF00082	0.687

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A098DRK7	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	26%	85%
A0A0G2QC33	Rattus norvegicus	24%	100%
A0A0N0P8C0	Leptomonas seymouri	63%	99%
A0A0S4JSC7	Bodo saltans	36%	100%
A0A1X0P2H1	Trypanosomatidae	37%	100%
A0A3R7NRV7	Trypanosoma rangeli	42%	100%
A0A3S7X2Y6	Leishmania donovani	84%	100%
A1CJ08	Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107)	27%	100%
A2QY50	Aspergillus niger (strain CBS 513.88 / FGSC A1513)	26%	99%
A4I521	Leishmania infantum	85%	100%

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