Putative Zn finger protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mitochondrial RNA binding protein 1, putative

Species:

Leishmania braziliensis

UniProt:

A4HHX0_LEIBR

TriTrypDb:

LbrM.30.0270 , LBRM2903_300008400

Length:

641

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HHX0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHX0

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006396	RNA processing	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	3
GO:0008270	zinc ion binding	6	1
GO:0043167	ion binding	2	3
GO:0043169	cation binding	3	3
GO:0046872	metal ion binding	4	3
GO:0046914	transition metal ion binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	128	132	PF00656	0.428
CLV_C14_Caspase3-7	325	329	PF00656	0.616
CLV_C14_Caspase3-7	586	590	PF00656	0.533
CLV_NRD_NRD_1	221	223	PF00675	0.538
CLV_NRD_NRD_1	408	410	PF00675	0.462
CLV_NRD_NRD_1	624	626	PF00675	0.615
CLV_NRD_NRD_1	629	631	PF00675	0.612
CLV_PCSK_KEX2_1	221	223	PF00082	0.581
CLV_PCSK_KEX2_1	408	410	PF00082	0.527
CLV_PCSK_KEX2_1	513	515	PF00082	0.214
CLV_PCSK_KEX2_1	629	631	PF00082	0.566
CLV_PCSK_PC1ET2_1	513	515	PF00082	0.214
CLV_PCSK_PC7_1	625	631	PF00082	0.583
CLV_PCSK_SKI1_1	130	134	PF00082	0.427
CLV_PCSK_SKI1_1	211	215	PF00082	0.436
CLV_PCSK_SKI1_1	301	305	PF00082	0.276
CLV_PCSK_SKI1_1	372	376	PF00082	0.512
CLV_PCSK_SKI1_1	46	50	PF00082	0.437
CLV_PCSK_SKI1_1	551	555	PF00082	0.452
CLV_PCSK_SKI1_1	576	580	PF00082	0.694
CLV_PCSK_SKI1_1	625	629	PF00082	0.611
DEG_APCC_DBOX_1	102	110	PF00400	0.455
DEG_APCC_DBOX_1	300	308	PF00400	0.288
DEG_COP1_1	80	90	PF00400	0.448
DEG_SCF_FBW7_1	579	584	PF00400	0.431
DEG_SPOP_SBC_1	278	282	PF00917	0.606
DOC_CDC14_PxL_1	465	473	PF14671	0.417
DOC_CKS1_1	346	351	PF01111	0.580
DOC_CKS1_1	578	583	PF01111	0.572
DOC_CYCLIN_RxL_1	525	537	PF00134	0.562
DOC_CYCLIN_yClb5_NLxxxL_5	304	313	PF00134	0.421
DOC_MAPK_gen_1	513	524	PF00069	0.413
DOC_MAPK_MEF2A_6	139	146	PF00069	0.548
DOC_MAPK_MEF2A_6	517	526	PF00069	0.413
DOC_MAPK_RevD_3	616	631	PF00069	0.626
DOC_PP1_RVXF_1	141	147	PF00149	0.334
DOC_PP4_FxxP_1	387	390	PF00568	0.424
DOC_PP4_FxxP_1	578	581	PF00568	0.569
DOC_USP7_MATH_1	107	111	PF00917	0.481
DOC_USP7_MATH_1	121	125	PF00917	0.357
DOC_USP7_MATH_1	126	130	PF00917	0.244
DOC_USP7_MATH_1	157	161	PF00917	0.568
DOC_USP7_MATH_1	163	167	PF00917	0.594
DOC_USP7_MATH_1	169	173	PF00917	0.689
DOC_USP7_MATH_1	203	207	PF00917	0.521
DOC_USP7_MATH_1	330	334	PF00917	0.666
DOC_USP7_MATH_1	354	358	PF00917	0.658
DOC_USP7_MATH_1	440	444	PF00917	0.530
DOC_USP7_MATH_1	456	460	PF00917	0.695
DOC_USP7_MATH_1	574	578	PF00917	0.545
DOC_USP7_MATH_1	602	606	PF00917	0.653
DOC_USP7_MATH_1	608	612	PF00917	0.688
DOC_USP7_MATH_1	616	620	PF00917	0.678
DOC_USP7_MATH_1	77	81	PF00917	0.728
DOC_USP7_UBL2_3	139	143	PF12436	0.466
DOC_WW_Pin1_4	187	192	PF00397	0.467
DOC_WW_Pin1_4	215	220	PF00397	0.440
DOC_WW_Pin1_4	328	333	PF00397	0.468
DOC_WW_Pin1_4	339	344	PF00397	0.717
DOC_WW_Pin1_4	345	350	PF00397	0.737
DOC_WW_Pin1_4	577	582	PF00397	0.561
DOC_WW_Pin1_4	611	616	PF00397	0.631
DOC_WW_Pin1_4	64	69	PF00397	0.593
LIG_14-3-3_CanoR_1	175	185	PF00244	0.467
LIG_14-3-3_CanoR_1	301	310	PF00244	0.530
LIG_14-3-3_CanoR_1	376	385	PF00244	0.510
LIG_14-3-3_CanoR_1	439	445	PF00244	0.584
LIG_Actin_WH2_2	445	460	PF00022	0.425
LIG_BIR_II_1	1	5	PF00653	0.456
LIG_BIR_III_2	168	172	PF00653	0.459
LIG_BIR_III_4	607	611	PF00653	0.621
LIG_BIR_III_4	78	82	PF00653	0.439
LIG_BRCT_BRCA1_1	123	127	PF00533	0.456
LIG_BRCT_BRCA1_1	378	382	PF00533	0.362
LIG_BRCT_BRCA1_1	461	465	PF00533	0.414
LIG_FHA_1	13	19	PF00498	0.565
LIG_FHA_1	230	236	PF00498	0.597
LIG_FHA_1	59	65	PF00498	0.606
LIG_FHA_2	106	112	PF00498	0.563
LIG_FHA_2	175	181	PF00498	0.505
LIG_FHA_2	226	232	PF00498	0.595
LIG_FHA_2	28	34	PF00498	0.448
LIG_FHA_2	584	590	PF00498	0.695
LIG_FHA_2	632	638	PF00498	0.527
LIG_IRF3_LxIS_1	522	527	PF10401	0.350
LIG_LIR_Apic_2	577	581	PF02991	0.659
LIG_LIR_Gen_1	116	127	PF02991	0.405
LIG_LIR_Gen_1	145	154	PF02991	0.568
LIG_LIR_Gen_1	379	390	PF02991	0.398
LIG_LIR_Gen_1	462	473	PF02991	0.667
LIG_LIR_Gen_1	97	107	PF02991	0.378
LIG_LIR_Nem_3	116	122	PF02991	0.578
LIG_LIR_Nem_3	145	149	PF02991	0.564
LIG_LIR_Nem_3	297	303	PF02991	0.530
LIG_LIR_Nem_3	379	385	PF02991	0.380
LIG_LIR_Nem_3	462	468	PF02991	0.680
LIG_LIR_Nem_3	515	519	PF02991	0.521
LIG_LIR_Nem_3	97	102	PF02991	0.515
LIG_RPA_C_Fungi	202	214	PF08784	0.441
LIG_SH2_CRK	44	48	PF00017	0.374
LIG_SH2_NCK_1	50	54	PF00017	0.535
LIG_SH2_STAP1	115	119	PF00017	0.490
LIG_SH2_STAP1	44	48	PF00017	0.319
LIG_SH2_STAT5	105	108	PF00017	0.510
LIG_SH2_STAT5	115	118	PF00017	0.416
LIG_SH3_2	621	626	PF14604	0.594
LIG_SH3_3	101	107	PF00018	0.662
LIG_SH3_3	150	156	PF00018	0.457
LIG_SH3_3	213	219	PF00018	0.577
LIG_SH3_3	252	258	PF00018	0.488
LIG_SH3_3	334	340	PF00018	0.487
LIG_SH3_3	343	349	PF00018	0.460
LIG_SH3_3	541	547	PF00018	0.522
LIG_SH3_3	568	574	PF00018	0.398
LIG_SH3_3	615	621	PF00018	0.547
LIG_SUMO_SIM_anti_2	360	366	PF11976	0.294
LIG_SUMO_SIM_par_1	212	218	PF11976	0.437
LIG_TRAF2_1	228	231	PF00917	0.453
LIG_TYR_ITIM	42	47	PF00017	0.263
LIG_UBA3_1	23	32	PF00899	0.499
LIG_UBA3_1	309	316	PF00899	0.519
LIG_WRC_WIRS_1	575	580	PF05994	0.682
MOD_CDC14_SPxK_1	218	221	PF00782	0.442
MOD_CDK_SPxK_1	215	221	PF00069	0.549
MOD_CDK_SPxxK_3	215	222	PF00069	0.552
MOD_CK1_1	276	282	PF00069	0.665
MOD_CK1_1	342	348	PF00069	0.647
MOD_CK1_1	355	361	PF00069	0.640
MOD_CK1_1	441	447	PF00069	0.547
MOD_CK1_1	459	465	PF00069	0.634
MOD_CK1_1	487	493	PF00069	0.359
MOD_CK1_1	577	583	PF00069	0.589
MOD_CK1_1	609	615	PF00069	0.623
MOD_CK2_1	105	111	PF00069	0.485
MOD_CK2_1	174	180	PF00069	0.471
MOD_CK2_1	225	231	PF00069	0.582
MOD_CK2_1	27	33	PF00069	0.497
MOD_CK2_1	354	360	PF00069	0.562
MOD_CK2_1	517	523	PF00069	0.159
MOD_CK2_1	555	561	PF00069	0.492
MOD_CK2_1	77	83	PF00069	0.437
MOD_Cter_Amidation	370	373	PF01082	0.329
MOD_GlcNHglycan	111	114	PF01048	0.363
MOD_GlcNHglycan	123	126	PF01048	0.381
MOD_GlcNHglycan	170	174	PF01048	0.581
MOD_GlcNHglycan	282	285	PF01048	0.596
MOD_GlcNHglycan	3	6	PF01048	0.440
MOD_GlcNHglycan	324	327	PF01048	0.643
MOD_GlcNHglycan	354	357	PF01048	0.707
MOD_GlcNHglycan	378	381	PF01048	0.345
MOD_GlcNHglycan	445	448	PF01048	0.690
MOD_GlcNHglycan	458	461	PF01048	0.698
MOD_GlcNHglycan	465	468	PF01048	0.396
MOD_GlcNHglycan	489	492	PF01048	0.438
MOD_GlcNHglycan	607	611	PF01048	0.753
MOD_GlcNHglycan	618	621	PF01048	0.641
MOD_GlcNHglycan	78	82	PF01048	0.499
MOD_GlcNHglycan	96	99	PF01048	0.592
MOD_GSK3_1	105	112	PF00069	0.389
MOD_GSK3_1	121	128	PF00069	0.437
MOD_GSK3_1	169	176	PF00069	0.500
MOD_GSK3_1	183	190	PF00069	0.689
MOD_GSK3_1	225	232	PF00069	0.665
MOD_GSK3_1	273	280	PF00069	0.633
MOD_GSK3_1	315	322	PF00069	0.568
MOD_GSK3_1	338	345	PF00069	0.695
MOD_GSK3_1	376	383	PF00069	0.440
MOD_GSK3_1	456	463	PF00069	0.706
MOD_GSK3_1	577	584	PF00069	0.440
MOD_GSK3_1	602	609	PF00069	0.661
MOD_GSK3_1	631	638	PF00069	0.648
MOD_N-GLC_1	487	492	PF02516	0.433
MOD_N-GLC_2	118	120	PF02516	0.362
MOD_N-GLC_2	480	482	PF02516	0.430
MOD_NEK2_1	1	6	PF00069	0.621
MOD_NEK2_1	185	190	PF00069	0.561
MOD_NEK2_1	244	249	PF00069	0.629
MOD_NEK2_1	273	278	PF00069	0.738
MOD_NEK2_1	375	380	PF00069	0.471
MOD_NEK2_1	42	47	PF00069	0.338
MOD_NEK2_1	524	529	PF00069	0.170
MOD_NEK2_1	91	96	PF00069	0.555
MOD_NEK2_2	460	465	PF00069	0.403
MOD_PKA_1	315	321	PF00069	0.381
MOD_PKA_1	625	631	PF00069	0.583
MOD_PKA_2	174	180	PF00069	0.471
MOD_PKA_2	375	381	PF00069	0.475
MOD_PKA_2	438	444	PF00069	0.477
MOD_PKA_2	51	57	PF00069	0.468
MOD_Plk_1	441	447	PF00069	0.597
MOD_Plk_1	487	493	PF00069	0.438
MOD_Plk_1	517	523	PF00069	0.163
MOD_Plk_2-3	518	524	PF00069	0.240
MOD_Plk_2-3	555	561	PF00069	0.333
MOD_Plk_4	148	154	PF00069	0.578
MOD_Plk_4	460	466	PF00069	0.675
MOD_Plk_4	567	573	PF00069	0.534
MOD_ProDKin_1	187	193	PF00069	0.465
MOD_ProDKin_1	215	221	PF00069	0.443
MOD_ProDKin_1	328	334	PF00069	0.472
MOD_ProDKin_1	339	345	PF00069	0.718
MOD_ProDKin_1	347	353	PF00069	0.731
MOD_ProDKin_1	577	583	PF00069	0.562
MOD_ProDKin_1	611	617	PF00069	0.632
MOD_ProDKin_1	64	70	PF00069	0.594
MOD_SUMO_for_1	237	240	PF00179	0.579
MOD_SUMO_rev_2	366	374	PF00179	0.449
TRG_ENDOCYTIC_2	300	303	PF00928	0.570
TRG_ENDOCYTIC_2	44	47	PF00928	0.425
TRG_ENDOCYTIC_2	50	53	PF00928	0.432
TRG_ENDOCYTIC_2	99	102	PF00928	0.383
TRG_ER_diArg_1	220	222	PF00400	0.539
TRG_ER_diArg_1	408	410	PF00400	0.369
TRG_ER_diArg_1	474	477	PF00400	0.466
TRG_NLS_MonoExtN_4	629	634	PF00514	0.494
TRG_Pf-PMV_PEXEL_1	400	404	PF00026	0.535

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7W2	Leptomonas seymouri	39%	88%
A0A0S4JVS9	Bodo saltans	27%	95%
A0A1X0P2C9	Trypanosomatidae	32%	100%
A0A3Q8IEK7	Leishmania donovani	72%	100%
A0A3R7MIW1	Trypanosoma rangeli	33%	100%
A4I520	Leishmania infantum	72%	100%
C9ZQH9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9B0F0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	71%	100%
O75467	Homo sapiens	26%	100%
Q4Q7T3	Leishmania major	71%	100%
Q585P3	Trypanosoma brucei brucei (strain 927/4 GUTat10.1)	33%	100%
V5DD36	Trypanosoma cruzi	33%	100%