NARG2_C domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HHW8_LEIBR

TriTrypDb:

LbrM.30.0250 , LBRM2903_300008200

Length:

596

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HHW8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHW8

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0016485	protein processing	5	1
GO:0016539	intein-mediated protein splicing	7	1
GO:0019538	protein metabolic process	3	1
GO:0030908	protein splicing	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044238	primary metabolic process	2	1
GO:0051604	protein maturation	4	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	98	102	PF00656	0.558
CLV_NRD_NRD_1	171	173	PF00675	0.447
CLV_NRD_NRD_1	209	211	PF00675	0.403
CLV_NRD_NRD_1	330	332	PF00675	0.563
CLV_NRD_NRD_1	556	558	PF00675	0.572
CLV_NRD_NRD_1	579	581	PF00675	0.520
CLV_PCSK_KEX2_1	171	173	PF00082	0.559
CLV_PCSK_KEX2_1	209	211	PF00082	0.322
CLV_PCSK_KEX2_1	267	269	PF00082	0.311
CLV_PCSK_KEX2_1	330	332	PF00082	0.517
CLV_PCSK_KEX2_1	362	364	PF00082	0.537
CLV_PCSK_KEX2_1	556	558	PF00082	0.561
CLV_PCSK_KEX2_1	578	580	PF00082	0.533
CLV_PCSK_KEX2_1	94	96	PF00082	0.561
CLV_PCSK_PC1ET2_1	171	173	PF00082	0.559
CLV_PCSK_PC1ET2_1	267	269	PF00082	0.311
CLV_PCSK_PC1ET2_1	362	364	PF00082	0.537
CLV_PCSK_PC1ET2_1	94	96	PF00082	0.561
CLV_PCSK_PC7_1	326	332	PF00082	0.572
CLV_PCSK_SKI1_1	134	138	PF00082	0.616
CLV_PCSK_SKI1_1	2	6	PF00082	0.516
CLV_PCSK_SKI1_1	226	230	PF00082	0.374
CLV_PCSK_SKI1_1	271	275	PF00082	0.381
CLV_PCSK_SKI1_1	335	339	PF00082	0.487
CLV_PCSK_SKI1_1	363	367	PF00082	0.514
CLV_PCSK_SKI1_1	54	58	PF00082	0.586
DEG_SCF_FBW7_1	198	205	PF00400	0.523
DEG_SPOP_SBC_1	530	534	PF00917	0.659
DOC_CDC14_PxL_1	230	238	PF14671	0.544
DOC_CKS1_1	136	141	PF01111	0.630
DOC_CKS1_1	199	204	PF01111	0.532
DOC_CKS1_1	538	543	PF01111	0.405
DOC_CYCLIN_RxL_1	330	341	PF00134	0.547
DOC_CYCLIN_RxL_1	361	372	PF00134	0.397
DOC_CYCLIN_yCln2_LP_2	304	310	PF00134	0.589
DOC_MAPK_DCC_7	134	142	PF00069	0.385
DOC_MAPK_gen_1	247	253	PF00069	0.553
DOC_MAPK_gen_1	266	276	PF00069	0.420
DOC_MAPK_gen_1	330	340	PF00069	0.479
DOC_MAPK_gen_1	362	370	PF00069	0.647
DOC_MAPK_gen_1	556	567	PF00069	0.609
DOC_MAPK_MEF2A_6	267	276	PF00069	0.392
DOC_MAPK_MEF2A_6	305	312	PF00069	0.566
DOC_MAPK_MEF2A_6	556	565	PF00069	0.623
DOC_MAPK_RevD_3	565	580	PF00069	0.524
DOC_PP2B_LxvP_1	304	307	PF13499	0.584
DOC_PP2B_LxvP_1	495	498	PF13499	0.515
DOC_PP2B_LxvP_1	518	521	PF13499	0.613
DOC_PP4_FxxP_1	181	184	PF00568	0.395
DOC_PP4_FxxP_1	19	22	PF00568	0.668
DOC_USP7_MATH_1	162	166	PF00917	0.276
DOC_USP7_MATH_1	415	419	PF00917	0.644
DOC_USP7_MATH_1	519	523	PF00917	0.609
DOC_USP7_MATH_1	530	534	PF00917	0.708
DOC_USP7_MATH_1	84	88	PF00917	0.442
DOC_USP7_UBL2_3	31	35	PF12436	0.641
DOC_USP7_UBL2_3	362	366	PF12436	0.639
DOC_WW_Pin1_4	135	140	PF00397	0.617
DOC_WW_Pin1_4	18	23	PF00397	0.535
DOC_WW_Pin1_4	198	203	PF00397	0.405
DOC_WW_Pin1_4	501	506	PF00397	0.316
DOC_WW_Pin1_4	526	531	PF00397	0.632
DOC_WW_Pin1_4	537	542	PF00397	0.430
DOC_WW_Pin1_4	545	550	PF00397	0.294
LIG_14-3-3_CanoR_1	213	223	PF00244	0.504
LIG_14-3-3_CanoR_1	226	231	PF00244	0.288
LIG_14-3-3_CanoR_1	524	530	PF00244	0.631
LIG_APCC_ABBA_1	419	424	PF00400	0.522
LIG_BRCT_BRCA1_1	164	168	PF00533	0.460
LIG_BRCT_BRCA1_1	347	351	PF00533	0.476
LIG_Clathr_ClatBox_1	337	341	PF01394	0.456
LIG_CSL_BTD_1	199	202	PF09270	0.416
LIG_DLG_GKlike_1	95	103	PF00625	0.557
LIG_FHA_1	199	205	PF00498	0.509
LIG_FHA_1	215	221	PF00498	0.463
LIG_FHA_1	282	288	PF00498	0.355
LIG_FHA_1	312	318	PF00498	0.526
LIG_FHA_1	488	494	PF00498	0.351
LIG_FHA_1	526	532	PF00498	0.493
LIG_FHA_1	585	591	PF00498	0.305
LIG_FHA_2	151	157	PF00498	0.423
LIG_FHA_2	502	508	PF00498	0.538
LIG_HCF-1_HBM_1	259	262	PF13415	0.409
LIG_Integrin_RGD_1	580	582	PF01839	0.552
LIG_LIR_Apic_2	16	22	PF02991	0.682
LIG_LIR_Apic_2	217	222	PF02991	0.317
LIG_LIR_Gen_1	104	113	PF02991	0.432
LIG_LIR_Gen_1	153	162	PF02991	0.421
LIG_LIR_Gen_1	403	409	PF02991	0.593
LIG_LIR_Gen_1	476	485	PF02991	0.577
LIG_LIR_Nem_3	104	109	PF02991	0.403
LIG_LIR_Nem_3	130	136	PF02991	0.613
LIG_LIR_Nem_3	153	157	PF02991	0.371
LIG_LIR_Nem_3	403	407	PF02991	0.578
LIG_LIR_Nem_3	471	477	PF02991	0.428
LIG_LYPXL_S_1	400	404	PF13949	0.481
LIG_MYND_1	3	7	PF01753	0.647
LIG_Pex14_1	473	477	PF04695	0.429
LIG_Pex14_2	74	78	PF04695	0.427
LIG_SH2_CRK	49	53	PF00017	0.508
LIG_SH2_PTP2	219	222	PF00017	0.327
LIG_SH2_STAP1	106	110	PF00017	0.467
LIG_SH2_STAP1	29	33	PF00017	0.461
LIG_SH2_STAP1	477	481	PF00017	0.466
LIG_SH2_STAT5	106	109	PF00017	0.293
LIG_SH2_STAT5	154	157	PF00017	0.390
LIG_SH2_STAT5	203	206	PF00017	0.585
LIG_SH2_STAT5	219	222	PF00017	0.558
LIG_SH2_STAT5	235	238	PF00017	0.498
LIG_SH2_STAT5	275	278	PF00017	0.427
LIG_SH2_STAT5	29	32	PF00017	0.486
LIG_SH2_STAT5	445	448	PF00017	0.497
LIG_SH2_STAT5	51	54	PF00017	0.425
LIG_SH2_STAT5	545	548	PF00017	0.515
LIG_SH2_STAT5	550	553	PF00017	0.610
LIG_SH2_STAT5	572	575	PF00017	0.475
LIG_SH3_3	133	139	PF00018	0.622
LIG_SH3_3	390	396	PF00018	0.404
LIG_SH3_3	4	10	PF00018	0.695
LIG_SH3_3	543	549	PF00018	0.570
LIG_SH3_3	63	69	PF00018	0.455
LIG_SH3_3	90	96	PF00018	0.532
LIG_SUMO_SIM_anti_2	566	571	PF11976	0.533
LIG_SUMO_SIM_par_1	336	341	PF11976	0.535
LIG_TRAF2_1	504	507	PF00917	0.573
LIG_TRFH_1	453	457	PF08558	0.420
LIG_WRC_WIRS_1	163	168	PF05994	0.276
LIG_WRC_WIRS_1	401	406	PF05994	0.582
LIG_WW_3	8	12	PF00397	0.500
MOD_CDK_SPK_2	537	542	PF00069	0.430
MOD_CK1_1	18	24	PF00069	0.574
MOD_CK1_1	237	243	PF00069	0.446
MOD_CK1_1	411	417	PF00069	0.677
MOD_CK1_1	427	433	PF00069	0.565
MOD_CK1_1	436	442	PF00069	0.647
MOD_CK1_1	522	528	PF00069	0.595
MOD_CK1_1	529	535	PF00069	0.606
MOD_CK2_1	150	156	PF00069	0.442
MOD_CK2_1	501	507	PF00069	0.532
MOD_CK2_1	568	574	PF00069	0.445
MOD_CMANNOS	285	288	PF00535	0.383
MOD_Cter_Amidation	554	557	PF01082	0.578
MOD_GlcNHglycan	22	25	PF01048	0.588
MOD_GlcNHglycan	410	413	PF01048	0.691
MOD_GlcNHglycan	415	418	PF01048	0.684
MOD_GlcNHglycan	426	429	PF01048	0.510
MOD_GlcNHglycan	435	438	PF01048	0.614
MOD_GlcNHglycan	553	556	PF01048	0.617
MOD_GlcNHglycan	63	66	PF01048	0.516
MOD_GSK3_1	198	205	PF00069	0.430
MOD_GSK3_1	353	360	PF00069	0.574
MOD_GSK3_1	411	418	PF00069	0.636
MOD_GSK3_1	522	529	PF00069	0.648
MOD_GSK3_1	536	543	PF00069	0.424
MOD_N-GLC_1	281	286	PF02516	0.289
MOD_N-GLC_1	357	362	PF02516	0.477
MOD_N-GLC_2	212	214	PF02516	0.274
MOD_NEK2_1	109	114	PF00069	0.437
MOD_NEK2_1	122	127	PF00069	0.388
MOD_NEK2_1	253	258	PF00069	0.478
MOD_NEK2_1	287	292	PF00069	0.361
MOD_NEK2_1	353	358	PF00069	0.577
MOD_NEK2_1	499	504	PF00069	0.479
MOD_NEK2_1	551	556	PF00069	0.618
MOD_NEK2_2	203	208	PF00069	0.560
MOD_PIKK_1	427	433	PF00454	0.601
MOD_PIKK_1	436	442	PF00454	0.747
MOD_PKA_1	267	273	PF00069	0.547
MOD_PKA_2	208	214	PF00069	0.431
MOD_PKA_2	267	273	PF00069	0.547
MOD_PKA_2	374	380	PF00069	0.666
MOD_PKA_2	381	387	PF00069	0.617
MOD_PKA_2	433	439	PF00069	0.721
MOD_PKA_2	559	565	PF00069	0.602
MOD_Plk_1	15	21	PF00069	0.460
MOD_Plk_1	237	243	PF00069	0.443
MOD_Plk_1	281	287	PF00069	0.511
MOD_Plk_1	59	65	PF00069	0.635
MOD_Plk_2-3	559	565	PF00069	0.593
MOD_Plk_2-3	568	574	PF00069	0.483
MOD_Plk_4	150	156	PF00069	0.458
MOD_Plk_4	162	168	PF00069	0.413
MOD_Plk_4	203	209	PF00069	0.442
MOD_Plk_4	237	243	PF00069	0.443
MOD_Plk_4	299	305	PF00069	0.713
MOD_Plk_4	400	406	PF00069	0.551
MOD_Plk_4	415	421	PF00069	0.712
MOD_Plk_4	476	482	PF00069	0.480
MOD_Plk_4	568	574	PF00069	0.517
MOD_Plk_4	68	74	PF00069	0.375
MOD_Plk_4	95	101	PF00069	0.473
MOD_ProDKin_1	135	141	PF00069	0.610
MOD_ProDKin_1	18	24	PF00069	0.533
MOD_ProDKin_1	198	204	PF00069	0.412
MOD_ProDKin_1	501	507	PF00069	0.310
MOD_ProDKin_1	526	532	PF00069	0.634
MOD_ProDKin_1	537	543	PF00069	0.414
MOD_ProDKin_1	545	551	PF00069	0.299
MOD_SUMO_for_1	184	187	PF00179	0.460
MOD_SUMO_rev_2	126	136	PF00179	0.600
MOD_SUMO_rev_2	259	269	PF00179	0.431
TRG_DiLeu_BaEn_1	507	512	PF01217	0.385
TRG_DiLeu_BaEn_1	513	518	PF01217	0.435
TRG_DiLeu_BaEn_4	463	469	PF01217	0.524
TRG_DiLeu_BaLyEn_6	268	273	PF01217	0.510
TRG_ENDOCYTIC_2	106	109	PF00928	0.398
TRG_ENDOCYTIC_2	154	157	PF00928	0.387
TRG_ENDOCYTIC_2	401	404	PF00928	0.519
TRG_ENDOCYTIC_2	477	480	PF00928	0.558
TRG_ENDOCYTIC_2	49	52	PF00928	0.392
TRG_ER_diArg_1	208	210	PF00400	0.504
TRG_ER_diArg_1	213	216	PF00400	0.491
TRG_ER_diArg_1	330	333	PF00400	0.609
TRG_ER_diArg_1	556	558	PF00400	0.572
TRG_ER_diArg_1	577	580	PF00400	0.563
TRG_NES_CRM1_1	509	523	PF08389	0.378

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8C2	Leptomonas seymouri	66%	100%
A0A1X0P2D9	Trypanosomatidae	40%	100%
A0A3S5IRH4	Trypanosoma rangeli	41%	100%
A0A3S7X2Z0	Leishmania donovani	81%	100%
A4I518	Leishmania infantum	81%	100%
C9ZQH7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
E9B0E8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
Q4Q7T5	Leishmania major	80%	100%
V5BLG2	Trypanosoma cruzi	44%	100%