Mitochondrial carrier protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mitochondrial carrier protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HHW7_LEIBR

TriTrypDb:

LbrM.30.0240 , LBRM2903_300008100

Length:

355

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

A4HHW7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHW7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	136	138	PF00675	0.530
CLV_NRD_NRD_1	278	280	PF00675	0.364
CLV_NRD_NRD_1	313	315	PF00675	0.275
CLV_NRD_NRD_1	351	353	PF00675	0.528
CLV_PCSK_KEX2_1	135	137	PF00082	0.610
CLV_PCSK_KEX2_1	277	279	PF00082	0.365
CLV_PCSK_KEX2_1	313	315	PF00082	0.281
CLV_PCSK_KEX2_1	83	85	PF00082	0.319
CLV_PCSK_PC1ET2_1	83	85	PF00082	0.319
CLV_PCSK_SKI1_1	16	20	PF00082	0.355
CLV_PCSK_SKI1_1	188	192	PF00082	0.275
CLV_PCSK_SKI1_1	270	274	PF00082	0.426
CLV_PCSK_SKI1_1	293	297	PF00082	0.322
CLV_PCSK_SKI1_1	313	317	PF00082	0.234
CLV_PCSK_SKI1_1	89	93	PF00082	0.307
DEG_APCC_DBOX_1	251	259	PF00400	0.571
DOC_MAPK_gen_1	184	191	PF00069	0.481
DOC_MAPK_MEF2A_6	184	193	PF00069	0.493
DOC_MAPK_MEF2A_6	225	232	PF00069	0.382
DOC_MAPK_NFAT4_5	225	233	PF00069	0.302
DOC_PP1_RVXF_1	202	209	PF00149	0.333
DOC_PP1_RVXF_1	87	93	PF00149	0.590
DOC_PP1_RVXF_1	98	105	PF00149	0.589
DOC_USP7_MATH_1	247	251	PF00917	0.565
DOC_USP7_MATH_1	72	76	PF00917	0.568
DOC_WW_Pin1_4	16	21	PF00397	0.700
LIG_14-3-3_CanoR_1	160	166	PF00244	0.468
LIG_14-3-3_CanoR_1	195	200	PF00244	0.303
LIG_14-3-3_CanoR_1	225	229	PF00244	0.376
LIG_14-3-3_CanoR_1	28	36	PF00244	0.583
LIG_14-3-3_CanoR_1	313	321	PF00244	0.532
LIG_14-3-3_CanoR_1	7	15	PF00244	0.670
LIG_14-3-3_CanoR_1	77	87	PF00244	0.544
LIG_Actin_WH2_2	145	162	PF00022	0.366
LIG_BIR_II_1	1	5	PF00653	0.702
LIG_BRCT_BRCA1_1	204	208	PF00533	0.360
LIG_EVH1_2	346	350	PF00568	0.664
LIG_FHA_1	123	129	PF00498	0.314
LIG_FHA_1	143	149	PF00498	0.390
LIG_FHA_1	314	320	PF00498	0.532
LIG_FHA_1	54	60	PF00498	0.501
LIG_FHA_2	304	310	PF00498	0.488
LIG_HP1_1	187	191	PF01393	0.389
LIG_LIR_Apic_2	19	24	PF02991	0.649
LIG_LIR_Apic_2	316	321	PF02991	0.550
LIG_LIR_Gen_1	115	123	PF02991	0.313
LIG_LIR_Gen_1	330	341	PF02991	0.558
LIG_LIR_Nem_3	108	112	PF02991	0.276
LIG_LIR_Nem_3	115	119	PF02991	0.235
LIG_LIR_Nem_3	238	242	PF02991	0.296
LIG_LIR_Nem_3	268	272	PF02991	0.556
LIG_LIR_Nem_3	283	289	PF02991	0.509
LIG_LIR_Nem_3	312	318	PF02991	0.566
LIG_LIR_Nem_3	330	336	PF02991	0.560
LIG_LIR_Nem_3	63	68	PF02991	0.543
LIG_PCNA_yPIPBox_3	204	218	PF02747	0.397
LIG_Pex14_2	208	212	PF04695	0.298
LIG_Pex14_2	88	92	PF04695	0.505
LIG_Rb_pABgroove_1	280	288	PF01858	0.560
LIG_REV1ctd_RIR_1	287	293	PF16727	0.512
LIG_REV1ctd_RIR_1	85	93	PF16727	0.524
LIG_SH2_CRK	109	113	PF00017	0.360
LIG_SH2_CRK	156	160	PF00017	0.464
LIG_SH2_CRK	21	25	PF00017	0.726
LIG_SH2_CRK	220	224	PF00017	0.321
LIG_SH2_CRK	269	273	PF00017	0.621
LIG_SH2_SRC	318	321	PF00017	0.617
LIG_SH2_STAT5	233	236	PF00017	0.284
LIG_SH2_STAT5	31	34	PF00017	0.566
LIG_SH2_STAT5	318	321	PF00017	0.604
LIG_SH2_STAT5	341	344	PF00017	0.665
LIG_SH2_STAT5	66	69	PF00017	0.518
LIG_SH3_3	333	339	PF00018	0.649
LIG_SH3_3	52	58	PF00018	0.537
LIG_SUMO_SIM_anti_2	198	203	PF11976	0.420
LIG_WRC_WIRS_1	113	118	PF05994	0.360
LIG_WRC_WIRS_1	236	241	PF05994	0.400
LIG_WW_1	345	348	PF00397	0.651
MOD_CK1_1	2	8	PF00069	0.630
MOD_CK1_1	268	274	PF00069	0.459
MOD_CK1_1	332	338	PF00069	0.687
MOD_GlcNHglycan	74	77	PF01048	0.306
MOD_GSK3_1	122	129	PF00069	0.395
MOD_GSK3_1	309	316	PF00069	0.516
MOD_GSK3_1	31	38	PF00069	0.678
MOD_GSK3_1	321	328	PF00069	0.645
MOD_NEK2_1	112	117	PF00069	0.345
MOD_NEK2_1	148	153	PF00069	0.360
MOD_NEK2_1	202	207	PF00069	0.432
MOD_NEK2_1	289	294	PF00069	0.521
MOD_NEK2_1	3	8	PF00069	0.660
MOD_NEK2_1	303	308	PF00069	0.539
MOD_NEK2_2	247	252	PF00069	0.499
MOD_PIKK_1	31	37	PF00454	0.613
MOD_PIKK_1	327	333	PF00454	0.664
MOD_PK_1	195	201	PF00069	0.231
MOD_PKA_1	313	319	PF00069	0.483
MOD_PKA_2	159	165	PF00069	0.490
MOD_PKA_2	224	230	PF00069	0.371
MOD_PKA_2	313	319	PF00069	0.483
MOD_PKA_2	9	15	PF00069	0.673
MOD_Plk_1	321	327	PF00069	0.645
MOD_Plk_4	224	230	PF00069	0.364
MOD_Plk_4	235	241	PF00069	0.330
MOD_ProDKin_1	16	22	PF00069	0.700
TRG_ENDOCYTIC_2	109	112	PF00928	0.344
TRG_ENDOCYTIC_2	149	152	PF00928	0.274
TRG_ENDOCYTIC_2	156	159	PF00928	0.458
TRG_ENDOCYTIC_2	194	197	PF00928	0.284
TRG_ENDOCYTIC_2	215	218	PF00928	0.259
TRG_ENDOCYTIC_2	220	223	PF00928	0.303
TRG_ENDOCYTIC_2	233	236	PF00928	0.217
TRG_ENDOCYTIC_2	269	272	PF00928	0.622
TRG_ENDOCYTIC_2	286	289	PF00928	0.498
TRG_ENDOCYTIC_2	348	351	PF00928	0.571
TRG_ER_diArg_1	135	137	PF00400	0.328
TRG_ER_diArg_1	186	189	PF00400	0.448
TRG_ER_diArg_1	276	279	PF00400	0.501
TRG_ER_diArg_1	313	315	PF00400	0.481
TRG_Pf-PMV_PEXEL_1	270	275	PF00026	0.396

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD65	Leptomonas seymouri	68%	100%
A0A1X0P2B3	Trypanosomatidae	55%	99%
A0A3S7X2Y8	Leishmania donovani	82%	100%
A4I517	Leishmania infantum	82%	100%
C9ZQH4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
E9B0E7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4Q7T6	Leishmania major	84%	100%
V5DD32	Trypanosoma cruzi	54%	100%