RanBP2-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HHW6_LEIBR

TriTrypDb:

LbrM.30.0230 , LBRM2903_300008000

Length:

432

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HHW6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHW6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	6
GO:0043167	ion binding	2	6
GO:0043169	cation binding	3	6
GO:0046872	metal ion binding	4	6
GO:0005515	protein binding	2	1
GO:0005543	phospholipid binding	3	1
GO:0008289	lipid binding	2	1
GO:0032182	ubiquitin-like protein binding	3	1
GO:0035091	phosphatidylinositol binding	4	1
GO:0043130	ubiquitin binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	282	286	PF00656	0.755
CLV_C14_Caspase3-7	358	362	PF00656	0.571
CLV_C14_Caspase3-7	42	46	PF00656	0.561
CLV_NRD_NRD_1	105	107	PF00675	0.367
CLV_NRD_NRD_1	112	114	PF00675	0.329
CLV_NRD_NRD_1	163	165	PF00675	0.668
CLV_PCSK_KEX2_1	105	107	PF00082	0.538
CLV_PCSK_KEX2_1	163	165	PF00082	0.693
CLV_PCSK_SKI1_1	193	197	PF00082	0.760
CLV_PCSK_SKI1_1	35	39	PF00082	0.456
DEG_Nend_UBRbox_3	1	3	PF02207	0.535
DOC_CKS1_1	251	256	PF01111	0.606
DOC_CYCLIN_RxL_1	193	202	PF00134	0.758
DOC_MAPK_gen_1	113	123	PF00069	0.554
DOC_MAPK_gen_1	163	172	PF00069	0.489
DOC_PP1_RVXF_1	161	168	PF00149	0.669
DOC_PP2B_LxvP_1	215	218	PF13499	0.587
DOC_PP4_FxxP_1	251	254	PF00568	0.575
DOC_USP7_MATH_1	187	191	PF00917	0.536
DOC_USP7_MATH_1	276	280	PF00917	0.718
DOC_USP7_MATH_1	342	346	PF00917	0.558
DOC_WW_Pin1_4	176	181	PF00397	0.542
DOC_WW_Pin1_4	237	242	PF00397	0.734
DOC_WW_Pin1_4	245	250	PF00397	0.733
DOC_WW_Pin1_4	259	264	PF00397	0.684
DOC_WW_Pin1_4	317	322	PF00397	0.512
DOC_WW_Pin1_4	349	354	PF00397	0.777
LIG_14-3-3_CanoR_1	120	124	PF00244	0.448
LIG_14-3-3_CanoR_1	149	155	PF00244	0.494
LIG_14-3-3_CanoR_1	406	410	PF00244	0.514
LIG_14-3-3_CanoR_1	5	15	PF00244	0.378
LIG_14-3-3_CterR_2	428	432	PF00244	0.537
LIG_BRCT_BRCA1_1	126	130	PF00533	0.460
LIG_BRCT_BRCA1_1	247	251	PF00533	0.789
LIG_Clathr_ClatBox_1	71	75	PF01394	0.535
LIG_EH1_1	300	308	PF00400	0.541
LIG_eIF4E_1	68	74	PF01652	0.338
LIG_FHA_1	298	304	PF00498	0.698
LIG_FHA_1	307	313	PF00498	0.545
LIG_FHA_1	36	42	PF00498	0.476
LIG_FHA_1	52	58	PF00498	0.364
LIG_FHA_2	120	126	PF00498	0.478
LIG_FHA_2	353	359	PF00498	0.692
LIG_FHA_2	40	46	PF00498	0.555
LIG_Integrin_RGD_1	283	285	PF01839	0.568
LIG_LIR_Apic_2	248	254	PF02991	0.614
LIG_LIR_Gen_1	125	131	PF02991	0.570
LIG_LIR_Nem_3	125	129	PF02991	0.573
LIG_LIR_Nem_3	32	36	PF02991	0.582
LIG_LIR_Nem_3	65	71	PF02991	0.317
LIG_PTB_Apo_2	79	86	PF02174	0.561
LIG_SH2_CRK	126	130	PF00017	0.562
LIG_SH2_CRK	68	72	PF00017	0.305
LIG_SH2_GRB2like	214	217	PF00017	0.592
LIG_SH2_NCK_1	126	130	PF00017	0.310
LIG_SH2_NCK_1	61	65	PF00017	0.574
LIG_SH2_SRC	214	217	PF00017	0.592
LIG_SH2_STAP1	126	130	PF00017	0.562
LIG_SH2_STAP1	83	87	PF00017	0.550
LIG_SH2_STAT5	214	217	PF00017	0.592
LIG_SH2_STAT5	3	6	PF00017	0.608
LIG_SH2_STAT5	58	61	PF00017	0.463
LIG_SH3_1	28	34	PF00018	0.559
LIG_SH3_2	241	246	PF14604	0.579
LIG_SH3_3	191	197	PF00018	0.567
LIG_SH3_3	238	244	PF00018	0.579
LIG_SH3_3	260	266	PF00018	0.760
LIG_SH3_3	268	274	PF00018	0.733
LIG_SH3_3	28	34	PF00018	0.559
LIG_SH3_3	347	353	PF00018	0.559
LIG_SUMO_SIM_anti_2	174	179	PF11976	0.440
LIG_SUMO_SIM_par_1	174	179	PF11976	0.398
LIG_SUMO_SIM_par_1	70	75	PF11976	0.431
LIG_TRAF2_1	179	182	PF00917	0.452
LIG_TYR_ITIM	124	129	PF00017	0.571
LIG_WRC_WIRS_1	143	148	PF05994	0.587
LIG_WW_2	271	274	PF00397	0.697
MOD_CK1_1	245	251	PF00069	0.746
MOD_CK1_1	262	268	PF00069	0.646
MOD_CK1_1	286	292	PF00069	0.755
MOD_CK1_1	317	323	PF00069	0.513
MOD_CK1_1	334	340	PF00069	0.714
MOD_CK1_1	345	351	PF00069	0.720
MOD_CK1_1	352	358	PF00069	0.619
MOD_CK1_1	402	408	PF00069	0.516
MOD_CK2_1	119	125	PF00069	0.550
MOD_CK2_1	141	147	PF00069	0.576
MOD_CK2_1	176	182	PF00069	0.688
MOD_CK2_1	199	205	PF00069	0.626
MOD_CK2_1	276	282	PF00069	0.672
MOD_CK2_1	305	311	PF00069	0.541
MOD_CK2_1	352	358	PF00069	0.691
MOD_CK2_1	388	394	PF00069	0.551
MOD_CK2_1	59	65	PF00069	0.314
MOD_GlcNHglycan	139	142	PF01048	0.518
MOD_GlcNHglycan	189	192	PF01048	0.656
MOD_GlcNHglycan	201	204	PF01048	0.724
MOD_GlcNHglycan	218	221	PF01048	0.329
MOD_GlcNHglycan	277	281	PF01048	0.580
MOD_GlcNHglycan	333	336	PF01048	0.595
MOD_GlcNHglycan	65	68	PF01048	0.358
MOD_GSK3_1	137	144	PF00069	0.493
MOD_GSK3_1	225	232	PF00069	0.629
MOD_GSK3_1	245	252	PF00069	0.504
MOD_GSK3_1	254	261	PF00069	0.798
MOD_GSK3_1	283	290	PF00069	0.728
MOD_GSK3_1	329	336	PF00069	0.727
MOD_GSK3_1	345	352	PF00069	0.613
MOD_GSK3_1	35	42	PF00069	0.563
MOD_GSK3_1	367	374	PF00069	0.568
MOD_GSK3_1	405	412	PF00069	0.509
MOD_GSK3_1	424	431	PF00069	0.460
MOD_GSK3_1	59	66	PF00069	0.311
MOD_NEK2_1	124	129	PF00069	0.410
MOD_NEK2_1	137	142	PF00069	0.412
MOD_NEK2_1	198	203	PF00069	0.735
MOD_NEK2_1	297	302	PF00069	0.739
MOD_NEK2_1	331	336	PF00069	0.551
MOD_NEK2_1	416	421	PF00069	0.504
MOD_NEK2_1	50	55	PF00069	0.475
MOD_NEK2_1	59	64	PF00069	0.410
MOD_NEK2_2	225	230	PF00069	0.634
MOD_PIKK_1	283	289	PF00454	0.728
MOD_PIKK_1	59	65	PF00454	0.314
MOD_PKA_2	119	125	PF00069	0.550
MOD_PKA_2	137	143	PF00069	0.337
MOD_PKA_2	15	21	PF00069	0.524
MOD_PKA_2	229	235	PF00069	0.727
MOD_PKA_2	405	411	PF00069	0.511
MOD_Plk_1	124	130	PF00069	0.420
MOD_Plk_1	276	282	PF00069	0.662
MOD_Plk_1	412	418	PF00069	0.495
MOD_Plk_2-3	39	45	PF00069	0.551
MOD_Plk_4	119	125	PF00069	0.551
MOD_Plk_4	210	216	PF00069	0.409
MOD_Plk_4	319	325	PF00069	0.531
MOD_ProDKin_1	176	182	PF00069	0.547
MOD_ProDKin_1	237	243	PF00069	0.734
MOD_ProDKin_1	245	251	PF00069	0.734
MOD_ProDKin_1	259	265	PF00069	0.684
MOD_ProDKin_1	317	323	PF00069	0.513
MOD_ProDKin_1	349	355	PF00069	0.779
MOD_SUMO_rev_2	9	13	PF00179	0.373
TRG_DiLeu_BaEn_2	31	37	PF01217	0.486
TRG_DiLeu_BaLyEn_6	421	426	PF01217	0.526
TRG_ENDOCYTIC_2	126	129	PF00928	0.571
TRG_ENDOCYTIC_2	68	71	PF00928	0.341
TRG_ER_diArg_1	104	106	PF00400	0.420
TRG_ER_diArg_1	163	166	PF00400	0.684
TRG_NES_CRM1_1	94	108	PF08389	0.472
TRG_Pf-PMV_PEXEL_1	156	161	PF00026	0.601
TRG_Pf-PMV_PEXEL_1	35	39	PF00026	0.539

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4JFL9	Bodo saltans	28%	100%
A0A3Q8IE12	Leishmania donovani	72%	100%
A4I516	Leishmania infantum	72%	100%
E9B0E6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	71%	100%
Q4Q7T7	Leishmania major	70%	100%