ORC_WH_C domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HHW3_LEIBR

TriTrypDb:

LbrM.30.0200 , LBRM2903_300007600

Length:

492

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HHW3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHW3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	149	153	PF00656	0.431
CLV_C14_Caspase3-7	305	309	PF00656	0.555
CLV_MEL_PAP_1	101	107	PF00089	0.279
CLV_NRD_NRD_1	120	122	PF00675	0.391
CLV_NRD_NRD_1	188	190	PF00675	0.598
CLV_NRD_NRD_1	276	278	PF00675	0.579
CLV_NRD_NRD_1	319	321	PF00675	0.511
CLV_NRD_NRD_1	438	440	PF00675	0.595
CLV_NRD_NRD_1	489	491	PF00675	0.564
CLV_PCSK_KEX2_1	120	122	PF00082	0.346
CLV_PCSK_KEX2_1	187	189	PF00082	0.516
CLV_PCSK_KEX2_1	276	278	PF00082	0.579
CLV_PCSK_KEX2_1	319	321	PF00082	0.508
CLV_PCSK_KEX2_1	338	340	PF00082	0.514
CLV_PCSK_KEX2_1	468	470	PF00082	0.591
CLV_PCSK_KEX2_1	479	481	PF00082	0.552
CLV_PCSK_KEX2_1	489	491	PF00082	0.595
CLV_PCSK_PC1ET2_1	338	340	PF00082	0.514
CLV_PCSK_PC1ET2_1	468	470	PF00082	0.591
CLV_PCSK_PC1ET2_1	479	481	PF00082	0.552
CLV_PCSK_SKI1_1	121	125	PF00082	0.522
CLV_PCSK_SKI1_1	236	240	PF00082	0.565
CLV_PCSK_SKI1_1	320	324	PF00082	0.489
CLV_PCSK_SKI1_1	338	342	PF00082	0.317
CLV_PCSK_SKI1_1	374	378	PF00082	0.417
CLV_PCSK_SKI1_1	457	461	PF00082	0.432
CLV_PCSK_SKI1_1	468	472	PF00082	0.469
CLV_PCSK_SKI1_1	89	93	PF00082	0.441
CLV_Separin_Metazoa	133	137	PF03568	0.592
DEG_APCC_DBOX_1	235	243	PF00400	0.459
DEG_APCC_DBOX_1	438	446	PF00400	0.607
DEG_SCF_FBW7_2	275	282	PF00400	0.586
DOC_CDC14_PxL_1	221	229	PF14671	0.530
DOC_CKS1_1	128	133	PF01111	0.527
DOC_CYCLIN_RxL_1	476	487	PF00134	0.515
DOC_CYCLIN_yClb1_LxF_4	201	207	PF00134	0.281
DOC_CYCLIN_yCln2_LP_2	238	244	PF00134	0.536
DOC_MAPK_MEF2A_6	451	460	PF00069	0.427
DOC_PP2B_LxvP_1	238	241	PF13499	0.441
DOC_PP4_FxxP_1	35	38	PF00568	0.632
DOC_PP4_MxPP_1	242	245	PF00568	0.579
DOC_USP7_MATH_1	162	166	PF00917	0.690
DOC_USP7_MATH_1	178	182	PF00917	0.520
DOC_USP7_MATH_1	39	43	PF00917	0.574
DOC_USP7_MATH_1	396	400	PF00917	0.685
DOC_USP7_MATH_1	415	419	PF00917	0.678
DOC_USP7_UBL2_3	468	472	PF12436	0.512
DOC_WW_Pin1_4	127	132	PF00397	0.518
DOC_WW_Pin1_4	253	258	PF00397	0.603
DOC_WW_Pin1_4	275	280	PF00397	0.586
DOC_WW_Pin1_4	78	83	PF00397	0.567
DOC_WW_Pin1_4	9	14	PF00397	0.726
LIG_14-3-3_CanoR_1	263	271	PF00244	0.318
LIG_14-3-3_CanoR_1	283	292	PF00244	0.284
LIG_14-3-3_CanoR_1	319	329	PF00244	0.544
LIG_14-3-3_CanoR_1	331	340	PF00244	0.363
LIG_14-3-3_CanoR_1	50	55	PF00244	0.445
LIG_14-3-3_CterR_2	489	492	PF00244	0.419
LIG_Actin_WH2_2	453	470	PF00022	0.514
LIG_Actin_WH2_2	474	491	PF00022	0.378
LIG_BRCT_BRCA1_1	212	216	PF00533	0.413
LIG_EH1_1	427	435	PF00400	0.577
LIG_EVH1_1	240	244	PF00568	0.537
LIG_FHA_1	109	115	PF00498	0.427
LIG_FHA_1	153	159	PF00498	0.616
LIG_FHA_1	17	23	PF00498	0.568
LIG_FHA_1	199	205	PF00498	0.456
LIG_FHA_1	259	265	PF00498	0.564
LIG_FHA_1	276	282	PF00498	0.365
LIG_FHA_1	332	338	PF00498	0.475
LIG_FHA_1	444	450	PF00498	0.475
LIG_FHA_1	451	457	PF00498	0.507
LIG_FHA_1	472	478	PF00498	0.475
LIG_FHA_2	128	134	PF00498	0.540
LIG_FHA_2	147	153	PF00498	0.446
LIG_FHA_2	323	329	PF00498	0.504
LIG_FHA_2	366	372	PF00498	0.524
LIG_FHA_2	388	394	PF00498	0.442
LIG_FHA_2	61	67	PF00498	0.319
LIG_LIR_Apic_2	32	38	PF02991	0.638
LIG_LIR_Gen_1	209	217	PF02991	0.434
LIG_LIR_Nem_3	209	215	PF02991	0.434
LIG_LIR_Nem_3	287	292	PF02991	0.464
LIG_LIR_Nem_3	369	375	PF02991	0.519
LIG_Pex14_2	212	216	PF04695	0.504
LIG_Pex14_2	471	475	PF04695	0.467
LIG_PTAP_UEV_1	12	17	PF05743	0.430
LIG_PTB_Apo_2	109	116	PF02174	0.514
LIG_SH2_NCK_1	208	212	PF00017	0.462
LIG_SH2_SRC	208	211	PF00017	0.418
LIG_SH2_SRC	64	67	PF00017	0.319
LIG_SH2_STAP1	208	212	PF00017	0.456
LIG_SH2_STAP1	64	68	PF00017	0.566
LIG_SH2_STAT5	23	26	PF00017	0.440
LIG_SH3_3	10	16	PF00018	0.701
LIG_SH3_3	125	131	PF00018	0.578
LIG_SH3_3	238	244	PF00018	0.431
LIG_SH3_3	382	388	PF00018	0.499
LIG_SH3_3	43	49	PF00018	0.456
LIG_SH3_3	71	77	PF00018	0.449
LIG_SUMO_SIM_par_1	154	159	PF11976	0.608
LIG_SUMO_SIM_par_1	175	181	PF11976	0.560
LIG_SUMO_SIM_par_1	2	8	PF11976	0.533
MOD_CK1_1	146	152	PF00069	0.370
MOD_CK1_1	165	171	PF00069	0.559
MOD_CK1_1	253	259	PF00069	0.507
MOD_CK1_1	351	357	PF00069	0.594
MOD_CK1_1	389	395	PF00069	0.674
MOD_CK1_1	400	406	PF00069	0.622
MOD_CK1_1	8	14	PF00069	0.599
MOD_CK2_1	127	133	PF00069	0.458
MOD_CK2_1	28	34	PF00069	0.605
MOD_CK2_1	285	291	PF00069	0.531
MOD_CK2_1	351	357	PF00069	0.528
MOD_CK2_1	365	371	PF00069	0.568
MOD_CK2_1	387	393	PF00069	0.419
MOD_CK2_1	60	66	PF00069	0.465
MOD_GlcNHglycan	13	16	PF01048	0.652
MOD_GlcNHglycan	145	148	PF01048	0.465
MOD_GlcNHglycan	164	168	PF01048	0.567
MOD_GlcNHglycan	212	215	PF01048	0.331
MOD_GlcNHglycan	400	403	PF01048	0.737
MOD_GlcNHglycan	412	415	PF01048	0.687
MOD_GlcNHglycan	417	420	PF01048	0.684
MOD_GSK3_1	152	159	PF00069	0.475
MOD_GSK3_1	225	232	PF00069	0.354
MOD_GSK3_1	24	31	PF00069	0.381
MOD_GSK3_1	258	265	PF00069	0.545
MOD_GSK3_1	344	351	PF00069	0.495
MOD_GSK3_1	396	403	PF00069	0.670
MOD_GSK3_1	471	478	PF00069	0.547
MOD_GSK3_1	5	12	PF00069	0.640
MOD_N-GLC_1	191	196	PF02516	0.434
MOD_NEK2_1	24	29	PF00069	0.521
MOD_NEK2_1	258	263	PF00069	0.529
MOD_NEK2_1	285	290	PF00069	0.538
MOD_NEK2_1	410	415	PF00069	0.526
MOD_NEK2_1	445	450	PF00069	0.538
MOD_NEK2_1	471	476	PF00069	0.468
MOD_NEK2_1	60	65	PF00069	0.412
MOD_PIKK_1	344	350	PF00454	0.594
MOD_PIKK_1	37	43	PF00454	0.595
MOD_PK_1	50	56	PF00069	0.545
MOD_PKA_2	143	149	PF00069	0.566
MOD_PKA_2	262	268	PF00069	0.334
MOD_PKA_2	330	336	PF00069	0.428
MOD_PKA_2	450	456	PF00069	0.556
MOD_PKA_2	8	14	PF00069	0.599
MOD_Plk_4	18	24	PF00069	0.572
MOD_Plk_4	226	232	PF00069	0.475
MOD_ProDKin_1	127	133	PF00069	0.523
MOD_ProDKin_1	253	259	PF00069	0.592
MOD_ProDKin_1	275	281	PF00069	0.584
MOD_ProDKin_1	78	84	PF00069	0.567
MOD_ProDKin_1	9	15	PF00069	0.714
MOD_SUMO_rev_2	29	38	PF00179	0.630
MOD_SUMO_rev_2	463	470	PF00179	0.446
TRG_DiLeu_BaEn_1	20	25	PF01217	0.342
TRG_DiLeu_BaLyEn_6	254	259	PF01217	0.582
TRG_ENDOCYTIC_2	208	211	PF00928	0.437
TRG_ENDOCYTIC_2	289	292	PF00928	0.429
TRG_ER_diArg_1	119	121	PF00400	0.337
TRG_ER_diArg_1	187	189	PF00400	0.570
TRG_ER_diArg_1	275	277	PF00400	0.560
TRG_ER_diArg_1	313	316	PF00400	0.399
TRG_ER_diArg_1	319	321	PF00400	0.446
TRG_ER_diArg_1	488	490	PF00400	0.339
TRG_Pf-PMV_PEXEL_1	319	324	PF00026	0.539
TRG_Pf-PMV_PEXEL_1	339	343	PF00026	0.369

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDH5	Leptomonas seymouri	64%	83%
A0A0S4JF66	Bodo saltans	27%	97%
A0A1X0P302	Trypanosomatidae	35%	95%
A0A3R7LKS4	Trypanosoma rangeli	35%	96%
A0A3S5H7M2	Leishmania donovani	84%	100%
A4I513	Leishmania infantum	84%	100%
C9ZQG8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	96%
E9B0E3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	99%
Q4Q7V1	Leishmania major	82%	100%
V5BLF7	Trypanosoma cruzi	36%	88%