Putative 2-hydroxy-3-oxopropionate reductase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

2-hydroxy-3-oxopropionate reductase, putative

Species:

Leishmania braziliensis

UniProt:

A4HHW2_LEIBR

TriTrypDb:

LbrM.30.0180 , LBRM2903_300007200

Length:

299

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 14

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HHW2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHW2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003824	catalytic activity	1	12
GO:0005488	binding	1	12
GO:0008679	2-hydroxy-3-oxopropionate reductase activity	5	7
GO:0016491	oxidoreductase activity	2	12
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	3	8
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	4	8
GO:0036094	small molecule binding	2	12
GO:0050661	NADP binding	4	12
GO:0051287	NAD binding	4	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12
GO:0004412	homoserine dehydrogenase activity	5	2
GO:0004616	phosphogluconate dehydrogenase (decarboxylating) activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	106	108	PF00675	0.498
CLV_PCSK_KEX2_1	106	108	PF00082	0.474
CLV_PCSK_SKI1_1	156	160	PF00082	0.387
CLV_PCSK_SKI1_1	233	237	PF00082	0.388
DEG_Nend_UBRbox_1	1	4	PF02207	0.514
DOC_MAPK_MEF2A_6	129	137	PF00069	0.352
DOC_MAPK_MEF2A_6	2	10	PF00069	0.353
DOC_PP2B_LxvP_1	117	120	PF13499	0.353
DOC_PP4_FxxP_1	251	254	PF00568	0.388
DOC_USP7_MATH_1	235	239	PF00917	0.416
DOC_USP7_MATH_1	254	258	PF00917	0.411
DOC_USP7_MATH_1	280	284	PF00917	0.474
DOC_USP7_MATH_1	54	58	PF00917	0.474
DOC_WW_Pin1_4	46	51	PF00397	0.353
DOC_WW_Pin1_4	64	69	PF00397	0.397
LIG_APCC_ABBA_1	188	193	PF00400	0.388
LIG_eIF4E_1	5	11	PF01652	0.353
LIG_FHA_1	130	136	PF00498	0.353
LIG_FHA_1	213	219	PF00498	0.357
LIG_FHA_2	199	205	PF00498	0.498
LIG_FHA_2	47	53	PF00498	0.474
LIG_GBD_Chelix_1	100	108	PF00786	0.474
LIG_LIR_Apic_2	250	254	PF02991	0.369
LIG_LIR_Gen_1	262	269	PF02991	0.439
LIG_LIR_Gen_1	58	68	PF02991	0.379
LIG_LIR_Nem_3	58	64	PF02991	0.379
LIG_PCNA_yPIPBox_3	276	285	PF02747	0.353
LIG_SH2_PTP2	5	8	PF00017	0.353
LIG_SH2_STAT5	5	8	PF00017	0.353
LIG_SH3_3	194	200	PF00018	0.455
LIG_SH3_3	250	256	PF00018	0.411
LIG_SUMO_SIM_anti_2	132	137	PF11976	0.353
LIG_SUMO_SIM_par_1	181	187	PF11976	0.498
LIG_SUMO_SIM_par_1	279	286	PF11976	0.474
LIG_TYR_ITIM	3	8	PF00017	0.353
LIG_UBA3_1	151	157	PF00899	0.258
MOD_CK2_1	198	204	PF00069	0.498
MOD_CK2_1	244	250	PF00069	0.346
MOD_CK2_1	280	286	PF00069	0.474
MOD_CK2_1	46	52	PF00069	0.427
MOD_Cter_Amidation	154	157	PF01082	0.474
MOD_GlcNHglycan	121	124	PF01048	0.353
MOD_GlcNHglycan	163	166	PF01048	0.354
MOD_GlcNHglycan	209	212	PF01048	0.299
MOD_GlcNHglycan	246	249	PF01048	0.393
MOD_GlcNHglycan	277	281	PF01048	0.353
MOD_GSK3_1	255	262	PF00069	0.414
MOD_GSK3_1	276	283	PF00069	0.445
MOD_GSK3_1	42	49	PF00069	0.481
MOD_GSK3_1	92	99	PF00069	0.353
MOD_N-GLC_1	129	134	PF02516	0.340
MOD_N-GLC_1	29	34	PF02516	0.353
MOD_N-GLC_1	62	67	PF02516	0.369
MOD_N-GLC_1	92	97	PF02516	0.353
MOD_PIKK_1	259	265	PF00454	0.439
MOD_PKA_1	156	162	PF00069	0.474
MOD_Plk_1	276	282	PF00069	0.353
MOD_Plk_1	91	97	PF00069	0.353
MOD_Plk_4	131	137	PF00069	0.350
MOD_Plk_4	198	204	PF00069	0.489
MOD_Plk_4	24	30	PF00069	0.468
MOD_Plk_4	280	286	PF00069	0.450
MOD_ProDKin_1	46	52	PF00069	0.353
MOD_ProDKin_1	64	70	PF00069	0.397
MOD_SUMO_for_1	218	221	PF00179	0.258
MOD_SUMO_rev_2	110	114	PF00179	0.353
MOD_SUMO_rev_2	294	299	PF00179	0.595
TRG_DiLeu_BaEn_2	85	91	PF01217	0.447
TRG_ENDOCYTIC_2	5	8	PF00928	0.353
TRG_ER_diArg_1	106	108	PF00400	0.498
TRG_Pf-PMV_PEXEL_1	106	110	PF00026	0.401

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0H2VA68	Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)	31%	99%
A0A0N0P3F4	Leptomonas seymouri	29%	72%
A0A0N1IM93	Leptomonas seymouri	85%	100%
A0A0S4IU65	Bodo saltans	28%	92%
A0A0S4J121	Bodo saltans	70%	100%
A0A0S4JYX1	Bodo saltans	31%	80%
A0A1X0NMG5	Trypanosomatidae	33%	72%
A0A1X0P2E9	Trypanosomatidae	73%	99%
A0A3Q8IFE7	Leishmania donovani	92%	100%
A0A3S7WYZ8	Leishmania donovani	30%	70%
A0A422N119	Trypanosoma rangeli	72%	99%
A0A422NXA0	Trypanosoma rangeli	31%	75%
A4HE38	Leishmania braziliensis	29%	70%
A4I1E4	Leishmania infantum	30%	70%
A4I512	Leishmania infantum	92%	100%
C9ZJW2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	81%
C9ZQG6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	75%	100%
E9AXI1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	69%
E9B0E2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
F4I907	Arabidopsis thaliana	31%	84%
G5EBD7	Gluconobacter oxydans (strain 621H)	24%	90%
O33730	Shewanella frigidimarina (strain NCIMB 400)	40%	100%
O34948	Bacillus subtilis (strain 168)	39%	100%
O34969	Bacillus subtilis (strain 168)	32%	100%
P0A9V8	Escherichia coli (strain K12)	32%	100%
P0A9V9	Shigella flexneri	32%	100%
P0ABQ2	Escherichia coli (strain K12)	41%	100%
P0ABQ3	Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)	41%	100%
P28811	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)	33%	100%
P29266	Rattus norvegicus	34%	89%
P31937	Homo sapiens	33%	89%
P44979	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	31%	99%
P54448	Bacillus subtilis (strain 168)	28%	100%
P63936	Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)	33%	100%
P77161	Escherichia coli (strain K12)	43%	100%
P9WNY4	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	33%	100%
P9WNY5	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	33%	100%
Q0KBC7	Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier 337)	33%	100%
Q0QLF5	Eubacterium barkeri	41%	99%
Q2HJD7	Bos taurus	33%	89%
Q46888	Escherichia coli (strain K12)	31%	99%
Q4Q7T9	Leishmania major	92%	100%
Q4Q9Z1	Leishmania major	30%	69%
Q54CX6	Dictyostelium discoideum	37%	93%
Q55702	Synechocystis sp. (strain PCC 6803 / Kazusa)	35%	100%
Q5R5E7	Pongo abelii	33%	89%
Q6CZ26	Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672)	29%	98%
Q949M8	Arabidopsis thaliana	39%	94%
Q99L13	Mus musculus	34%	89%
Q9C991	Arabidopsis thaliana	39%	100%
Q9I5I6	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)	35%	100%
Q9L7S0	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	31%	100%
Q9LSV0	Arabidopsis thaliana	34%	100%
Q9SUC0	Arabidopsis thaliana	35%	86%
Q9SZE1	Arabidopsis thaliana	39%	90%
Q9V8M5	Drosophila melanogaster	35%	92%
Q9XTI0	Caenorhabditis elegans	31%	100%
V5BKU7	Trypanosoma cruzi	31%	100%
V5DD27	Trypanosoma cruzi	69%	99%