Rubis-subs-bind domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Rubisco LSMT substrate-binding, putative

Species:

Leishmania braziliensis

UniProt:

A4HHW1_LEIBR

TriTrypDb:

LbrM.30.0170 , LBRM2903_300007100

Length:

623

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HHW1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHW1

Function

Biological processes
Term	Name	Level	Count
GO:0008152	metabolic process	1	11
GO:0032259	methylation	2	11
GO:0006479	protein methylation	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008213	protein alkylation	5	1
GO:0009987	cellular process	1	1
GO:0018022	peptidyl-lysine methylation	5	1
GO:0018026	peptidyl-lysine monomethylation	6	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018205	peptidyl-lysine modification	6	1
GO:0019538	protein metabolic process	3	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043414	macromolecule methylation	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0008168	methyltransferase activity	4	11
GO:0016740	transferase activity	2	11
GO:0016741	transferase activity, transferring one-carbon groups	3	11
GO:0008170	N-methyltransferase activity	5	1
GO:0008276	protein methyltransferase activity	3	1
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	1
GO:0016278	lysine N-methyltransferase activity	6	1
GO:0016279	protein-lysine N-methyltransferase activity	4	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	169	173	PF00656	0.505
CLV_MEL_PAP_1	602	608	PF00089	0.339
CLV_NRD_NRD_1	392	394	PF00675	0.376
CLV_NRD_NRD_1	487	489	PF00675	0.343
CLV_NRD_NRD_1	493	495	PF00675	0.335
CLV_NRD_NRD_1	535	537	PF00675	0.291
CLV_PCSK_KEX2_1	27	29	PF00082	0.348
CLV_PCSK_KEX2_1	303	305	PF00082	0.411
CLV_PCSK_KEX2_1	487	489	PF00082	0.345
CLV_PCSK_KEX2_1	493	495	PF00082	0.338
CLV_PCSK_KEX2_1	535	537	PF00082	0.291
CLV_PCSK_KEX2_1	609	611	PF00082	0.307
CLV_PCSK_PC1ET2_1	27	29	PF00082	0.348
CLV_PCSK_PC1ET2_1	303	305	PF00082	0.411
CLV_PCSK_PC1ET2_1	609	611	PF00082	0.324
CLV_PCSK_PC7_1	605	611	PF00082	0.290
CLV_PCSK_SKI1_1	130	134	PF00082	0.361
CLV_PCSK_SKI1_1	166	170	PF00082	0.611
CLV_PCSK_SKI1_1	177	181	PF00082	0.496
CLV_PCSK_SKI1_1	237	241	PF00082	0.485
CLV_PCSK_SKI1_1	488	492	PF00082	0.371
CLV_PCSK_SKI1_1	494	498	PF00082	0.341
DEG_APCC_DBOX_1	604	612	PF00400	0.462
DEG_APCC_DBOX_1	67	75	PF00400	0.437
DOC_CYCLIN_yCln2_LP_2	448	454	PF00134	0.416
DOC_MAPK_gen_1	493	499	PF00069	0.457
DOC_MAPK_MEF2A_6	142	151	PF00069	0.346
DOC_MAPK_MEF2A_6	596	604	PF00069	0.487
DOC_MAPK_RevD_3	289	304	PF00069	0.389
DOC_PP1_RVXF_1	104	110	PF00149	0.384
DOC_PP1_RVXF_1	612	619	PF00149	0.323
DOC_PP2B_LxvP_1	207	210	PF13499	0.367
DOC_PP2B_LxvP_1	497	500	PF13499	0.479
DOC_USP7_MATH_1	117	121	PF00917	0.640
DOC_USP7_MATH_1	122	126	PF00917	0.520
DOC_USP7_MATH_1	143	147	PF00917	0.483
DOC_USP7_MATH_1	162	166	PF00917	0.434
DOC_USP7_MATH_1	199	203	PF00917	0.442
DOC_USP7_MATH_1	232	236	PF00917	0.437
DOC_USP7_MATH_1	302	306	PF00917	0.554
DOC_USP7_MATH_1	335	339	PF00917	0.464
DOC_USP7_MATH_1	340	344	PF00917	0.373
DOC_USP7_MATH_1	550	554	PF00917	0.575
DOC_WW_Pin1_4	333	338	PF00397	0.342
DOC_WW_Pin1_4	541	546	PF00397	0.561
LIG_14-3-3_CanoR_1	166	171	PF00244	0.535
LIG_Actin_WH2_2	595	611	PF00022	0.515
LIG_AP2alpha_2	97	99	PF02296	0.418
LIG_BIR_III_2	161	165	PF00653	0.441
LIG_BRCT_BRCA1_1	342	346	PF00533	0.430
LIG_BRCT_BRCA1_1	359	363	PF00533	0.212
LIG_Clathr_ClatBox_1	180	184	PF01394	0.286
LIG_Clathr_ClatBox_1	71	75	PF01394	0.440
LIG_FHA_1	13	19	PF00498	0.516
LIG_FHA_1	195	201	PF00498	0.417
LIG_FHA_1	276	282	PF00498	0.416
LIG_FHA_1	314	320	PF00498	0.343
LIG_FHA_1	334	340	PF00498	0.457
LIG_FHA_1	386	392	PF00498	0.473
LIG_FHA_1	410	416	PF00498	0.506
LIG_FHA_1	466	472	PF00498	0.517
LIG_FHA_2	129	135	PF00498	0.529
LIG_FHA_2	167	173	PF00498	0.594
LIG_FHA_2	409	415	PF00498	0.412
LIG_FHA_2	574	580	PF00498	0.449
LIG_FHA_2	59	65	PF00498	0.551
LIG_FHA_2	76	82	PF00498	0.447
LIG_LIR_Apic_2	58	63	PF02991	0.494
LIG_LIR_Gen_1	527	534	PF02991	0.457
LIG_LIR_Gen_1	78	88	PF02991	0.366
LIG_LIR_Nem_3	263	268	PF02991	0.339
LIG_LIR_Nem_3	418	423	PF02991	0.322
LIG_LIR_Nem_3	78	83	PF02991	0.346
LIG_LYPXL_yS_3	276	279	PF13949	0.314
LIG_NRBOX	216	222	PF00104	0.267
LIG_NRBOX	235	241	PF00104	0.369
LIG_NRBOX	514	520	PF00104	0.480
LIG_PCNA_yPIPBox_3	556	564	PF02747	0.379
LIG_RPA_C_Fungi	65	77	PF08784	0.217
LIG_SH2_CRK	223	227	PF00017	0.349
LIG_SH2_CRK	423	427	PF00017	0.311
LIG_SH2_CRK	435	439	PF00017	0.330
LIG_SH2_NCK_1	136	140	PF00017	0.422
LIG_SH2_SRC	498	501	PF00017	0.276
LIG_SH2_STAP1	253	257	PF00017	0.339
LIG_SH2_STAP1	495	499	PF00017	0.372
LIG_SH2_STAT5	110	113	PF00017	0.349
LIG_SH2_STAT5	195	198	PF00017	0.418
LIG_SH2_STAT5	223	226	PF00017	0.384
LIG_SH2_STAT5	30	33	PF00017	0.389
LIG_SH2_STAT5	498	501	PF00017	0.276
LIG_SH2_STAT5	598	601	PF00017	0.303
LIG_SH3_1	536	542	PF00018	0.350
LIG_SH3_3	274	280	PF00018	0.318
LIG_SH3_3	435	441	PF00018	0.253
LIG_SH3_3	507	513	PF00018	0.303
LIG_SH3_3	536	542	PF00018	0.350
LIG_SH3_3	92	98	PF00018	0.438
LIG_Sin3_3	69	76	PF02671	0.217
LIG_SUMO_SIM_anti_2	175	182	PF11976	0.263
LIG_SUMO_SIM_anti_2	468	477	PF11976	0.466
LIG_SUMO_SIM_par_1	450	455	PF11976	0.436
LIG_SUMO_SIM_par_1	468	477	PF11976	0.418
LIG_SUMO_SIM_par_1	70	75	PF11976	0.414
LIG_TRFH_1	437	441	PF08558	0.417
LIG_TYR_ITIM	221	226	PF00017	0.400
MOD_CK1_1	120	126	PF00069	0.520
MOD_CK1_1	154	160	PF00069	0.678
MOD_CK1_1	190	196	PF00069	0.493
MOD_CK1_1	202	208	PF00069	0.475
MOD_CK1_1	385	391	PF00069	0.260
MOD_CK1_1	465	471	PF00069	0.634
MOD_CK1_1	544	550	PF00069	0.309
MOD_CK1_1	565	571	PF00069	0.424
MOD_CK1_1	592	598	PF00069	0.318
MOD_CK2_1	566	572	PF00069	0.368
MOD_CK2_1	573	579	PF00069	0.309
MOD_CK2_1	58	64	PF00069	0.498
MOD_CK2_1	75	81	PF00069	0.251
MOD_GlcNHglycan	153	156	PF01048	0.648
MOD_GlcNHglycan	201	204	PF01048	0.548
MOD_GlcNHglycan	3	6	PF01048	0.680
MOD_GlcNHglycan	341	345	PF01048	0.409
MOD_GlcNHglycan	454	457	PF01048	0.603
MOD_GlcNHglycan	464	467	PF01048	0.664
MOD_GSK3_1	117	124	PF00069	0.461
MOD_GSK3_1	143	150	PF00069	0.585
MOD_GSK3_1	162	169	PF00069	0.401
MOD_GSK3_1	190	197	PF00069	0.450
MOD_GSK3_1	353	360	PF00069	0.431
MOD_GSK3_1	550	557	PF00069	0.346
MOD_GSK3_1	562	569	PF00069	0.341
MOD_N-GLC_1	18	23	PF02516	0.428
MOD_N-GLC_1	187	192	PF02516	0.445
MOD_N-GLC_1	382	387	PF02516	0.347
MOD_N-GLC_1	555	560	PF02516	0.259
MOD_N-GLC_2	613	615	PF02516	0.339
MOD_NEK2_1	121	126	PF00069	0.633
MOD_NEK2_1	147	152	PF00069	0.453
MOD_NEK2_1	194	199	PF00069	0.473
MOD_NEK2_1	215	220	PF00069	0.307
MOD_NEK2_1	314	319	PF00069	0.473
MOD_NEK2_1	419	424	PF00069	0.354
MOD_NEK2_1	452	457	PF00069	0.364
MOD_NEK2_1	562	567	PF00069	0.233
MOD_NEK2_2	137	142	PF00069	0.459
MOD_PIKK_1	13	19	PF00454	0.402
MOD_PIKK_1	302	308	PF00454	0.451
MOD_Plk_1	117	123	PF00069	0.450
MOD_Plk_1	260	266	PF00069	0.433
MOD_Plk_1	324	330	PF00069	0.403
MOD_Plk_1	555	561	PF00069	0.453
MOD_Plk_1	573	579	PF00069	0.402
MOD_Plk_2-3	573	579	PF00069	0.388
MOD_Plk_2-3	75	81	PF00069	0.449
MOD_Plk_4	166	172	PF00069	0.566
MOD_Plk_4	190	196	PF00069	0.332
MOD_Plk_4	202	208	PF00069	0.417
MOD_Plk_4	216	222	PF00069	0.294
MOD_Plk_4	314	320	PF00069	0.383
MOD_Plk_4	367	373	PF00069	0.456
MOD_Plk_4	550	556	PF00069	0.444
MOD_ProDKin_1	333	339	PF00069	0.333
MOD_ProDKin_1	541	547	PF00069	0.447
TRG_DiLeu_BaEn_1	243	248	PF01217	0.370
TRG_DiLeu_BaEn_1	45	50	PF01217	0.497
TRG_DiLeu_BaLyEn_6	264	269	PF01217	0.460
TRG_DiLeu_BaLyEn_6	317	322	PF01217	0.361
TRG_DiLeu_BaLyEn_6	44	49	PF01217	0.523
TRG_ENDOCYTIC_2	223	226	PF00928	0.384
TRG_ENDOCYTIC_2	253	256	PF00928	0.421
TRG_ENDOCYTIC_2	276	279	PF00928	0.339
TRG_ENDOCYTIC_2	423	426	PF00928	0.312
TRG_ENDOCYTIC_2	435	438	PF00928	0.323
TRG_ER_diArg_1	487	489	PF00400	0.439
TRG_ER_diArg_1	492	494	PF00400	0.434
TRG_ER_diArg_1	67	70	PF00400	0.404
TRG_NES_CRM1_1	287	299	PF08389	0.371
TRG_Pf-PMV_PEXEL_1	237	241	PF00026	0.502
TRG_Pf-PMV_PEXEL_1	77	81	PF00026	0.344

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8B9	Leptomonas seymouri	60%	99%
A0A0S4JJX6	Bodo saltans	33%	90%
A0A1X0P2C3	Trypanosomatidae	42%	100%
A0A3Q8IFL1	Leishmania donovani	81%	100%
A0A422N122	Trypanosoma rangeli	45%	100%
A4I511	Leishmania infantum	81%	100%
C9ZQG5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9B0E1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
Q4Q7U0	Leishmania major	79%	100%
V5AWY0	Trypanosoma cruzi	45%	100%