LeishMANIAdb
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Putative leucine-rich repeat protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Putative leucine-rich repeat protein
Gene product:
Leucine-rich repeat, ribonuclease inhibitor subtype domain-containing protein
Species:
Leishmania braziliensis
UniProt:
A4HHW0_LEIBR
TriTrypDb:
LbrM.30.0160 , LBRM2903_300007000
Length:
359

Annotations

LeishMANIAdb annotations

Leucine-rich repeat proteins with a hydrophobic terminal helix. Unlike its distant animal relatives, this cytoplasmic sensor protein might be anchored to the membrane.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 12
NetGPI no yes: 0, no: 12
Cellular components
Term Name Level Count
GO:0005929 cilium 4 13
GO:0016020 membrane 2 7
GO:0042995 cell projection 2 13
GO:0043226 organelle 2 13
GO:0043227 membrane-bounded organelle 3 13
GO:0110165 cellular anatomical entity 1 13
GO:0120025 plasma membrane bounded cell projection 3 13

Expansion

Sequence features

A4HHW0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHW0

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 178 182 PF00656 0.198
CLV_C14_Caspase3-7 66 70 PF00656 0.220
CLV_NRD_NRD_1 355 357 PF00675 0.380
CLV_NRD_NRD_1 53 55 PF00675 0.493
CLV_PCSK_KEX2_1 354 356 PF00082 0.357
CLV_PCSK_KEX2_1 53 55 PF00082 0.538
CLV_PCSK_SKI1_1 144 148 PF00082 0.467
CLV_PCSK_SKI1_1 232 236 PF00082 0.546
CLV_PCSK_SKI1_1 250 254 PF00082 0.336
CLV_PCSK_SKI1_1 279 283 PF00082 0.556
CLV_Separin_Metazoa 50 54 PF03568 0.402
DOC_MAPK_HePTP_8 141 153 PF00069 0.228
DOC_MAPK_MEF2A_6 144 153 PF00069 0.223
DOC_MAPK_MEF2A_6 203 211 PF00069 0.207
DOC_USP7_MATH_1 284 288 PF00917 0.280
DOC_USP7_MATH_1 324 328 PF00917 0.426
DOC_USP7_UBL2_3 71 75 PF12436 0.335
DOC_WW_Pin1_4 126 131 PF00397 0.252
DOC_WW_Pin1_4 41 46 PF00397 0.349
LIG_14-3-3_CanoR_1 119 124 PF00244 0.327
LIG_14-3-3_CanoR_1 144 153 PF00244 0.334
LIG_14-3-3_CanoR_1 232 239 PF00244 0.237
LIG_14-3-3_CanoR_1 261 267 PF00244 0.236
LIG_14-3-3_CanoR_1 286 295 PF00244 0.290
LIG_14-3-3_CanoR_1 325 329 PF00244 0.408
LIG_14-3-3_CterR_2 355 359 PF00244 0.565
LIG_BRCT_BRCA1_1 149 153 PF00533 0.263
LIG_DLG_GKlike_1 203 211 PF00625 0.220
LIG_eIF4E_1 107 113 PF01652 0.300
LIG_FHA_1 118 124 PF00498 0.260
LIG_FHA_1 280 286 PF00498 0.348
LIG_FHA_2 133 139 PF00498 0.277
LIG_FHA_2 143 149 PF00498 0.282
LIG_FHA_2 173 179 PF00498 0.306
LIG_FHA_2 233 239 PF00498 0.198
LIG_FHA_2 267 273 PF00498 0.181
LIG_FHA_2 32 38 PF00498 0.299
LIG_FHA_2 90 96 PF00498 0.234
LIG_LIR_Apic_2 296 301 PF02991 0.255
LIG_LIR_Gen_1 150 161 PF02991 0.222
LIG_LIR_Gen_1 216 226 PF02991 0.222
LIG_LIR_Gen_1 335 345 PF02991 0.357
LIG_LIR_Gen_1 92 101 PF02991 0.263
LIG_LIR_Nem_3 12 18 PF02991 0.350
LIG_LIR_Nem_3 150 156 PF02991 0.222
LIG_LIR_Nem_3 216 222 PF02991 0.220
LIG_LIR_Nem_3 335 340 PF02991 0.298
LIG_LIR_Nem_3 92 96 PF02991 0.253
LIG_NRBOX 108 114 PF00104 0.178
LIG_SH2_CRK 15 19 PF00017 0.388
LIG_SH2_CRK 298 302 PF00017 0.328
LIG_SH2_CRK 337 341 PF00017 0.233
LIG_SH2_NCK_1 312 316 PF00017 0.318
LIG_SH2_NCK_1 337 341 PF00017 0.180
LIG_SH2_SRC 93 96 PF00017 0.300
LIG_SH2_STAP1 107 111 PF00017 0.160
LIG_SH2_STAP1 264 268 PF00017 0.263
LIG_SH2_STAP1 337 341 PF00017 0.180
LIG_SH2_STAT5 47 50 PF00017 0.293
LIG_SH2_STAT5 55 58 PF00017 0.226
LIG_SH2_STAT5 93 96 PF00017 0.267
LIG_SUMO_SIM_anti_2 108 113 PF11976 0.318
LIG_SUMO_SIM_anti_2 120 125 PF11976 0.231
LIG_SUMO_SIM_par_1 119 125 PF11976 0.319
LIG_SUMO_SIM_par_1 8 14 PF11976 0.272
LIG_TRAF2_1 5 8 PF00917 0.391
LIG_TYR_ITIM 13 18 PF00017 0.345
LIG_TYR_ITIM 91 96 PF00017 0.220
LIG_TYR_ITSM 333 340 PF00017 0.160
LIG_WRC_WIRS_1 1 6 PF05994 0.341
LIG_WRC_WIRS_1 348 353 PF05994 0.410
MOD_CDK_SPK_2 126 131 PF00069 0.256
MOD_CK1_1 122 128 PF00069 0.320
MOD_CK1_1 199 205 PF00069 0.237
MOD_CK1_1 287 293 PF00069 0.293
MOD_CK1_1 332 338 PF00069 0.260
MOD_CK1_1 41 47 PF00069 0.341
MOD_CK2_1 142 148 PF00069 0.331
MOD_CK2_1 199 205 PF00069 0.219
MOD_CK2_1 2 8 PF00069 0.467
MOD_GlcNHglycan 37 41 PF01048 0.511
MOD_GSK3_1 122 129 PF00069 0.244
MOD_GSK3_1 173 180 PF00069 0.210
MOD_GSK3_1 199 206 PF00069 0.194
MOD_GSK3_1 262 269 PF00069 0.195
MOD_GSK3_1 284 291 PF00069 0.337
MOD_GSK3_1 32 39 PF00069 0.243
MOD_N-GLC_1 172 177 PF02516 0.502
MOD_N-GLC_1 207 212 PF02516 0.466
MOD_N-GLC_1 41 46 PF02516 0.507
MOD_NEK2_1 112 117 PF00069 0.277
MOD_NEK2_1 167 172 PF00069 0.222
MOD_NEK2_1 196 201 PF00069 0.360
MOD_NEK2_1 207 212 PF00069 0.256
MOD_NEK2_1 226 231 PF00069 0.199
MOD_NEK2_1 266 271 PF00069 0.287
MOD_NEK2_1 36 41 PF00069 0.292
MOD_PIKK_1 3 9 PF00454 0.471
MOD_PK_1 119 125 PF00069 0.194
MOD_PKA_2 285 291 PF00069 0.321
MOD_PKA_2 324 330 PF00069 0.368
MOD_Plk_1 11 17 PF00069 0.296
MOD_Plk_1 147 153 PF00069 0.198
MOD_Plk_1 172 178 PF00069 0.288
MOD_Plk_1 207 213 PF00069 0.282
MOD_Plk_1 330 336 PF00069 0.302
MOD_Plk_4 119 125 PF00069 0.337
MOD_Plk_4 332 338 PF00069 0.189
MOD_Plk_4 347 353 PF00069 0.225
MOD_Plk_4 89 95 PF00069 0.280
MOD_ProDKin_1 126 132 PF00069 0.249
MOD_ProDKin_1 41 47 PF00069 0.346
MOD_SUMO_rev_2 313 320 PF00179 0.309
MOD_SUMO_rev_2 63 72 PF00179 0.223
TRG_ENDOCYTIC_2 15 18 PF00928 0.345
TRG_ENDOCYTIC_2 312 315 PF00928 0.256
TRG_ENDOCYTIC_2 337 340 PF00928 0.379
TRG_ENDOCYTIC_2 93 96 PF00928 0.215
TRG_ER_diArg_1 353 356 PF00400 0.566
TRG_ER_diArg_1 52 54 PF00400 0.326
TRG_Pf-PMV_PEXEL_1 144 148 PF00026 0.435
TRG_Pf-PMV_PEXEL_1 279 283 PF00026 0.500

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I137 Leptomonas seymouri 77% 98%
A0A0S4J741 Bodo saltans 25% 76%
A0A0S4JXN4 Bodo saltans 42% 83%
A0A1X0P2M5 Trypanosomatidae 54% 100%
A0A1X0P364 Trypanosomatidae 26% 84%
A0A3Q8IDE6 Leishmania donovani 25% 91%
A0A3R7L7Y9 Trypanosoma rangeli 31% 81%
A0A3R7M4B1 Trypanosoma rangeli 53% 100%
A0A3R7P015 Trypanosoma rangeli 26% 76%
A0A3S5H5G2 Leishmania donovani 26% 81%
A0A3S7WZL6 Leishmania donovani 30% 84%
A0JPI9 Rattus norvegicus 23% 75%
A4H461 Leishmania braziliensis 26% 81%
A4HEQ6 Leishmania braziliensis 27% 86%
A4HSD0 Leishmania infantum 26% 81%
A4I1Y5 Leishmania infantum 30% 84%
A4I2T1 Leishmania infantum 25% 91%
C9ZQG3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 46% 100%
C9ZS33 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 31% 80%
E9ADA9 Leishmania major 26% 100%
E9AKB9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 26% 81%
E9AY32 Leishmania mexicana (strain MHOM/GT/2001/U1103) 30% 76%
P10775 Sus scrofa 26% 79%
Q4QHM3 Leishmania major 27% 100%
Q4QJI8 Leishmania major 27% 81%
Q91VI7 Mus musculus 28% 79%
Q9LE82 Arabidopsis thaliana 27% 67%
V5BCB6 Trypanosoma cruzi 52% 100%
V5BDE5 Trypanosoma cruzi 26% 100%
V5BJF0 Trypanosoma cruzi 27% 73%
V5DHF2 Trypanosoma cruzi 26% 91%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS